Which layover airport offers the lowest fares from San Diego to Santiago?

Flights via Panama City (PTY) offer the lowest average round-trip price of $550.

Which airport is the most popular layover for flights between San Diego and Santiago?

Panama City (PTY) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Santiago?

LATAM Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Santiago from San Diego according to our data. LATAM Airlines is the first choice among our users, with 37% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 5 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from San Diego to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 1h 28m.

Which layover airport has the shortest travel time from San Diego to Santiago?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 14h 10m.

When did momondo last update prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

How many operators does momondo search for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

There are 5 operators available for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport as of April 2026.

How old do you have to be to fly from San Diego Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Diego Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$324 Cheap Flights from San Diego to Santiago in 2026

Q: What is the typical price of a round-trip flight between San Diego and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $1,138 to $684. The lowest price recently found on this route was $740.

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Find the cheapest flights from San Diego to Santiago

Round-trip

One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

10:00 am - 5:35 am

SAN

SCL

16h 35m

1 stop

11:25 pm - 10:27 am

SCL

SAN

14h 02m

1 stop

$740LATAM Airlines

Fri, Aug 14 - Fri, Aug 21

10:00 am - 5:35 am

SAN

SCL

15h 35m

1 stop

7:45 am - 10:55 pm

SCL

SAN

19h 10m

2 stops

$756LATAM Airlines

Mon, Sep 28 - Wed, Oct 7

10:00 am - 5:35 am

SAN

SCL

16h 35m

1 stop

11:25 pm - 10:27 am

SCL

SAN

14h 02m

1 stop

$757LATAM Airlines

Fri, Aug 14 - Fri, Aug 21

10:00 pm - 11:26 pm

SAN

SCL

22h 26m

1 stop

4:09 am - 6:30 pm

SCL

SAN

17h 21m

1 stop

$762Copa Airlines

Mon, May 11 - Mon, May 18

9:05 am - 5:35 am

SAN

SCL

16h 30m

2 stops

11:25 pm - 8:29 pm

SCL

SAN

25h 04m

2 stops

$768Multiple Airlines

Mon, Sep 28 - Wed, Oct 7

7:56 pm - 3:25 pm

SAN

SCL

40h 29m

2 stops

8:40 pm - 7:42 pm

SCL

SAN

26h 02m

1 stop

$770LATAM Airlines

Fri, Jun 12 - Sun, Jun 14

10:00 am - 5:35 am

SAN

SCL

16h 35m

1 stop

11:25 pm - 10:27 am

SCL

SAN

14h 02m

1 stop

$773LATAM Airlines

Fri, Aug 14 - Fri, Aug 21

6:15 am - 7:15 am

SAN

SCL

22h 00m

1 stop

7:55 pm - 4:30 pm

SCL

SAN

23h 35m

2 stops

$774Delta

Mon, May 11 - Mon, May 18

7:00 am - 5:35 am

SAN

SCL

18h 35m

2 stops

11:25 pm - 4:27 pm

SCL

SAN

21h 02m

2 stops

$776Multiple Airlines

Mon, Sep 28 - Wed, Oct 7

10:53 am - 6:55 am

SAN

SCL

17h 02m

2 stops

7:55 pm - 11:16 am

SCL

SAN

18h 21m

2 stops

$779Delta

Mon, May 11 - Mon, May 18

Copa Airlines flights from San Diego to Santiago

Our best Copa Airlines deals on San Diego to Santiago flight tickets

Copa Airlines

May 11

SAN10:00 pmSan Diego

22h 26m

1 stop

SCL11:26 pmSantiago Arturo Merino Benitez

May 18

SCL4:09 amSantiago Arturo Merino Benitez

17h 21m

1 stop

SAN6:30 pmSan Diego

$762

Copa Airlines

May 6

SAN10:00 pmSan Diego

18h 23m

1 stop

SCL7:23 pmSantiago Arturo Merino Benitez

May 13

SCL4:41 amSantiago Arturo Merino Benitez

16h 49m

1 stop

SAN6:30 pmSan Diego

$797

Copa Airlines

Sep 11

SAN9:03 pmSan Diego

19h 16m

1 stop

SCL8:19 pmSantiago Arturo Merino Benitez

Sep 19

SCL1:06 amSantiago Arturo Merino Benitez

21h 24m

1 stop

SAN6:30 pmSan Diego

$833

American Airlines flights from San Diego to Santiago

Our best American Airlines deals on San Diego to Santiago flight tickets

American Airlines

May 3

SAN12:53 pmSan Diego

15h 12m

1 stop

SCL7:05 amSantiago Arturo Merino Benitez

May 10

SCL8:35 pmSantiago Arturo Merino Benitez

28h 53m

1 stop

SAN10:28 pmSan Diego

$824

American Airlines

May 4

SAN12:53 pmSan Diego

15h 12m

1 stop

SCL7:05 amSantiago Arturo Merino Benitez

May 11

SCL8:35 pmSantiago Arturo Merino Benitez

17h 41m

1 stop

SAN11:16 amSan Diego

$827

American Airlines

May 4

SAN9:28 amSan Diego

18h 37m

2 stops

SCL7:05 amSantiago Arturo Merino Benitez

May 11

SCL8:35 pmSantiago Arturo Merino Benitez

18h 38m

2 stops

SAN12:13 pmSan Diego

$832

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 8/14

10:00 am-5:35 am

1 stop16h 35m

Santiago Arturo Merino Benitez

Fri 8/21

11:25 pm-10:27 am

1 stop14h 02m

$740

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 9/28

10:00 am-5:35 am

1 stop15h 35m

Santiago Arturo Merino Benitez

Wed 10/7

7:45 am-10:55 pm

2 stops19h 10m

$756

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 8/14

10:00 am-5:35 am

1 stop16h 35m

Santiago Arturo Merino Benitez

Fri 8/21

11:25 pm-10:27 am

1 stop14h 02m

$757

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 5/11

10:00 pm-11:26 pm

1 stop22h 26m

Santiago Arturo Merino Benitez

Mon 5/18

4:09 am-6:30 pm

1 stop17h 21m

$762

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 9/28

9:05 am-5:35 am

2 stops16h 30m

Santiago Arturo Merino Benitez

Wed 10/7

11:25 pm-8:29 pm

2 stops25h 04m

$768

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 6/12

7:56 pm-3:25 pm

2 stops40h 29m

Santiago Arturo Merino Benitez

Sun 6/14

8:40 pm-7:42 pm

1 stop26h 02m

$770

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 8/14

10:00 am-5:35 am

1 stop16h 35m

Santiago Arturo Merino Benitez

Fri 8/21

11:25 pm-10:27 am

1 stop14h 02m

$773

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 5/11

6:15 am-7:15 am

1 stop22h 00m

Santiago Arturo Merino Benitez

Mon 5/18

7:55 pm-4:30 pm

2 stops23h 35m

$774

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 9/28

7:00 am-5:35 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Wed 10/7

11:25 pm-4:27 pm

2 stops21h 02m

$776

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 5/11

10:53 am-6:55 am

2 stops17h 02m

Santiago Arturo Merino Benitez

Mon 5/18

7:55 pm-11:16 am

2 stops18h 21m

$779

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Diego to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between San Diego and Santiago?

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from San Diego to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $573. If you don’t want to visit Santiago in September, then you should wait until November to fly from San Diego, when ticket prices are also cheap, with an average price of $671.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $965 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Diego for as low as $453 on momondo.

How have San Diego to Santiago flight prices changed over time?

When to book flights from San Diego to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Diego to Santiago (SAN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Santiago

Fastest flight time	18h 35m
Direct flights	None

The fastest flight from San Diego to Santiago takes 18h 35m

There are no direct flights from San Diego to Santiago. There are no popular flight routes from San Diego to Santiago.

Search flight deals

Frequently asked questions about flying from San Diego to Santiago

How far is San Diego to Santiago Arturo Merino Benitez by plane?
There are 5476.6 mi between San Diego and Santiago Arturo Merino Benitez. In terms of flight time, this usually takes a little over 18h 35m.
When did momondo last update prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.
How many operators does momondo search for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?
There are 5 operators available for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport as of April 2026.
How old do you have to be to fly from San Diego Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Diego Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from San Diego to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Diego to Santiago is LATAM Airlines (33% of total bookings). The next most popular airlines are American Airlines (32%), United Airlines (13%), and Delta (12%).

Best airlines flying from San Diego to Santiago

Compare and see reviews for airlines that fly from San Diego to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Copa Airlines	PriceFrom $453	Free Cancellation	Rating 7.5 1,574 reviews	Search Copa Airlines flights
LATAM Airlines	PriceFrom $504	Free Cancellation	Rating 7.4 1,910 reviews	Search LATAM Airlines flights
American Airlines	PriceFrom $563	Free Cancellation	Rating 7.1 11,565 reviews	Search American Airlines flights
Delta	PriceFrom $574	Free Cancellation	Rating 7.9 8,406 reviews	Search Delta flights
United Airlines	PriceFrom $574	Free Cancellation	Rating 7.4 9,579 reviews	Search United Airlines flights

Viña del Mar

Valparaíso

Santa Cruz

Valle Nevado

San Fernando

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Santiago?

It is quick and easy to find San Diego to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from San Diego to Santiago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Santiago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to Santiago.

I’m not ready to book a flight from San Diego to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from San Diego and alert you when they change.