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Cheap flights from San Diego to Santiago from $268

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Santiago departing on 11/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Copa Airlines Logo
8:10 pm - 11:41 pmSAN-SCL
22h 31m1 stop
Copa Airlines Logo
5:12 am - 5:03 pmSCL-SAN
16h 51m1 stop
$551Copa Airlines
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Sun, Nov 16 - Sun, Nov 23
American Airlines Logo
6:15 am - 7:55 amSAN-SCL
20h 40m1 stop
American Airlines Logo
11:15 pm - 3:54 pmSCL-SAN
21h 39m1 stop
$563American Airlines
Find Deal
Sun, Nov 16 - Sat, Nov 22
LATAM Airlines Logo
12:16 pm - 7:40 amSAN-SCL
14h 24m1 stop
LATAM Airlines Logo
4:35 am - 11:35 pmSCL-SAN
24h 00m2 stops
$574LATAM Airlines
Find Deal
Thu, Nov 27 - Sat, Dec 6
United Airlines Logo
11:02 am - 8:50 amSAN-SCL
16h 48m2 stops
United Airlines Logo
10:45 pm - 3:04 pmSCL-SAN
21h 19m2 stops
$579United Airlines
Find Deal
Thu, Nov 27 - Sun, Dec 7
LATAM Airlines Logo
10:30 pm - 7:00 amSAN-SCL
27h 30m1 stop
LATAM Airlines Logo
4:35 am - 10:51 pmSCL-SAN
23h 16m2 stops
$609LATAM Airlines
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Sat, Feb 28 - Fri, Mar 6
Delta Logo
6:30 am - 6:10 amSAN-SCL
18h 40m1 stop
Delta Logo
11:55 pm - 9:57 amSCL-SAN
15h 02m1 stop
$664Delta
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Fri, Jan 16 - Sat, Jan 24
Delta Logo
10:30 pm - 7:40 amSAN-SCL
28h 10m1 stop
Delta Logo
9:30 pm - 10:15 amSCL-SAN
17h 45m1 stop
$669Delta
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Sat, Dec 13 - Fri, Dec 26
United Airlines Logo
5:23 pm - 8:50 amSAN-SCL
34h 27m1 stop
United Airlines Logo
10:45 pm - 4:01 pmSCL-SAN
22h 16m1 stop
$674United Airlines
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Fri, Dec 12 - Fri, Dec 26
Multiple Airlines Logo
8:12 pm - 3:27 amSAN-SCL
26h 15m1 stop
Multiple Airlines Logo
11:10 pm - 6:38 pmSCL-SAN
24h 28m1 stop
$690Multiple Airlines
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Mon, Dec 15 - Thu, Dec 25
Multiple Airlines Logo
8:12 pm - 11:41 pmSAN-SCL
22h 29m1 stop
Multiple Airlines Logo
9:30 pm - 3:40 pmSCL-SAN
23h 10m2 stops
$719Multiple Airlines
Find Deal
Mon, Dec 15 - Tue, Jan 13

Copa Airlines flights from San Diego to Santiago

Our best Copa Airlines deals on San Diego to Santiago flight tickets
Copa Airlines
Nov 16
SAN8:10 pmSan Diego
22h 31m
1 stop
SCL11:41 pmSantiago Arturo Merino Benitez
Nov 23
SCL5:12 amSantiago Arturo Merino Benitez
16h 51m
1 stop
SAN5:03 pmSan Diego
$551
Find similar
Copa Airlines
Dec 5
SAN8:12 pmSan Diego
19h 09m
1 stop
SCL8:21 pmSantiago Arturo Merino Benitez
Dec 23
SCL3:23 amSantiago Arturo Merino Benitez
19h 14m
1 stop
SAN5:37 pmSan Diego
$571
Find similar
Copa Airlines
Dec 15
SAN8:12 pmSan Diego
19h 09m
1 stop
SCL8:21 pmSantiago Arturo Merino Benitez
Dec 24
SCL5:44 amSantiago Arturo Merino Benitez
16h 53m
1 stop
SAN5:37 pmSan Diego
$601
Find similar

American Airlines flights from San Diego to Santiago

Our best American Airlines deals on San Diego to Santiago flight tickets
American Airlines
Nov 16
SAN6:15 amSan Diego
20h 40m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Nov 22
SCL11:15 pmSantiago Arturo Merino Benitez
21h 39m
1 stop
SAN3:54 pmSan Diego
$563
Find similar
American Airlines
Nov 16
SAN10:47 amSan Diego
16h 08m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Nov 23
SCL10:25 pmSantiago Arturo Merino Benitez
19h 20m
2 stops
SAN12:45 pmSan Diego
$568
Find similar
American Airlines
Dec 5
SAN8:25 amSan Diego
18h 45m
2 stops
SCL8:10 amSantiago Arturo Merino Benitez
Dec 12
SCL10:30 pmSantiago Arturo Merino Benitez
18h 27m
2 stops
SAN11:57 amSan Diego
$581
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momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from San Diego to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sun 11/16

8:10 pm-11:41 pm

1 stop22h 31m

Santiago Arturo Merino Benitez

Sun 11/23

5:12 am-5:03 pm

1 stop16h 51m

$551

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sun 11/16

6:15 am-7:55 am

1 stop20h 40m

Santiago Arturo Merino Benitez

Sat 11/22

11:15 pm-3:54 pm

1 stop21h 39m

$563

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Thu 11/27

12:16 pm-7:40 am

1 stop14h 24m

Santiago Arturo Merino Benitez

Sat 12/6

4:35 am-11:35 pm

2 stops24h 00m

$574

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Thu 11/27

11:02 am-8:50 am

2 stops16h 48m

Santiago Arturo Merino Benitez

Sun 12/7

10:45 pm-3:04 pm

2 stops21h 19m

$579

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sat 2/28

10:30 pm-7:00 am

1 stop27h 30m

Santiago Arturo Merino Benitez

Fri 3/6

4:35 am-10:51 pm

2 stops23h 16m

$609

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 1/16

6:30 am-6:10 am

1 stop18h 40m

Santiago Arturo Merino Benitez

Sat 1/24

11:55 pm-9:57 am

1 stop15h 02m

$664

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sat 12/13

10:30 pm-7:40 am

1 stop28h 10m

Santiago Arturo Merino Benitez

Fri 12/26

9:30 pm-10:15 am

1 stop17h 45m

$669

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 12/12

5:23 pm-8:50 am

1 stop34h 27m

Santiago Arturo Merino Benitez

Fri 12/26

10:45 pm-4:01 pm

1 stop22h 16m

$674

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 12/15

8:12 pm-3:27 am

1 stop26h 15m

Santiago Arturo Merino Benitez

Thu 12/25

11:10 pm-6:38 pm

1 stop24h 28m

$690

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 12/15

8:12 pm-11:41 pm

1 stop22h 29m

Santiago Arturo Merino Benitez

Tue 1/13

9:30 pm-3:40 pm

2 stops23h 10m

$719

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Diego to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Santiago?

What is the cheapest month to fly to Santiago?

In general, August is the cheapest month to fly from San Diego to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $654. If you don’t want to visit Santiago in August, then you should wait until October to fly from San Diego, when ticket prices are also cheap, with an average price of $683.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Sunday when prices can be found for as low as $1,003. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Tuesday is $1,131.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from San Diego to Santiago when you can find flight prices for as low as $882. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,072 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $936 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Diego for as low as $453 on momondo.

How have San Diego to Santiago flight prices changed over time?

As of November 2025, prices for San Diego to Santiago flights are approximately 43% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Santiago (SAN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Santiago

Direct flights

None
There are no direct flights from San Diego to Santiago. There are no popular flight routes from San Diego to Santiago.
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  • How far is San Diego to Santiago Arturo Merino Benitez by plane?

    There are 5476.6 mi between San Diego and Santiago Arturo Merino Benitez. In terms of flight time, this usually takes a little over 13h 57m.

  • When did momondo last update prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Diego Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Diego Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Diego to Santiago?

Best airlines flying from San Diego to Santiago

Compare and see reviews for airlines that fly from San Diego to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $453Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $507Free CancellationRating
7.5
1,872 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $563Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
United AirlinesPriceFrom $574Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights
DeltaPriceFrom $802Free CancellationRating
7.9
8,001 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Santiago?

It is quick and easy to find San Diego to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from San Diego to Santiago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Santiago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to Santiago.

I’m not ready to book a flight from San Diego to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from San Diego and alert you when they change.

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