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Cheap flights from San Diego to Santiago from $258

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Santiago departing on 11/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Copa Airlines Logo
8:10 pm - 8:21 pmSAN-SCL
19h 11m1 stop
Copa Airlines Logo
5:24 am - 5:03 pmSCL-SAN
16h 39m1 stop
$542Copa Airlines
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Mon, Nov 3 - Wed, Nov 19
United Airlines Logo
10:20 am - 8:50 amSAN-SCL
17h 30m1 stop
United Airlines Logo
10:45 pm - 11:01 amSCL-SAN
17h 16m1 stop
$554United Airlines
Find Deal
Mon, Nov 3 - Wed, Nov 12
LATAM Airlines Logo
9:59 am - 5:35 amSAN-SCL
14h 36m1 stop
LATAM Airlines Logo
11:55 pm - 9:16 amSCL-SAN
14h 21m1 stop
$650LATAM Airlines
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Thu, Dec 4 - Tue, Dec 9
LATAM Airlines Logo
6:15 am - 4:30 amSAN-SCL
17h 15m2 stops
LATAM Airlines Logo
11:25 pm - 1:02 pmSCL-SAN
18h 37m2 stops
$655LATAM Airlines
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Thu, Dec 4 - Tue, Dec 9
Delta Logo
7:00 am - 6:55 amSAN-SCL
18h 55m1 stop
Delta Logo
11:10 pm - 9:54 amSCL-SAN
15h 44m1 stop
$664Delta
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Mon, Dec 1 - Thu, Dec 4
American Airlines Logo
10:47 am - 7:55 amSAN-SCL
16h 08m1 stop
American Airlines Logo
11:15 pm - 9:55 amSCL-SAN
15h 40m1 stop
$684American Airlines
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Mon, Nov 17 - Fri, Nov 28
American Airlines Logo
10:07 am - 8:55 amSAN-SCL
17h 48m2 stops
American Airlines Logo
11:55 pm - 11:53 amSCL-SAN
16h 58m1 stop
$729American Airlines
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Thu, Dec 11 - Sat, Dec 27
Delta Logo
6:20 am - 6:35 amSAN-SCL
20h 15m2 stops
Delta Logo
11:55 pm - 6:56 pmSCL-SAN
23h 01m1 stop
$804Delta
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Sat, Mar 14 - Sun, Mar 22
Multiple Airlines Logo
12:16 pm - 7:40 amSAN-SCL
14h 24m1 stop
Multiple Airlines Logo
4:25 pm - 5:37 pmSCL-SAN
30h 12m2 stops
$805Multiple Airlines
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Sun, Nov 23 - Sun, Nov 30
Multiple Airlines Logo
6:10 pm - 5:35 amSAN-SCL
30h 25m1 stop
Multiple Airlines Logo
4:35 am - 9:55 pmSCL-SAN
22h 20m2 stops
$810Multiple Airlines
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Sat, Feb 28 - Sat, Mar 7

Delta flights from San Diego to Santiago

Our best Delta deals on San Diego to Santiago flight tickets
Delta
Dec 1
SAN7:00 amSan Diego
18h 55m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Dec 4
SCL11:10 pmSantiago Arturo Merino Benitez
15h 44m
1 stop
SAN9:54 amSan Diego
$664
Find similar
Delta
Mar 14
SAN6:20 amSan Diego
20h 15m
2 stops
SCL6:35 amSantiago Arturo Merino Benitez
Mar 22
SCL11:55 pmSantiago Arturo Merino Benitez
23h 01m
1 stop
SAN6:56 pmSan Diego
$804
Find similar
Delta
Mar 7
SAN9:40 pmSan Diego
28h 20m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Mar 16
SCL11:15 pmSantiago Arturo Merino Benitez
20h 37m
1 stop
SAN3:52 pmSan Diego
$809
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LATAM Airlines flights from San Diego to Santiago

Our best LATAM Airlines deals on San Diego to Santiago flight tickets
LATAM Airlines
Dec 4
SAN9:59 amSan Diego
14h 36m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
Dec 9
SCL11:55 pmSantiago Arturo Merino Benitez
14h 21m
1 stop
SAN9:16 amSan Diego
$650
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LATAM Airlines
Dec 4
SAN6:15 amSan Diego
17h 15m
2 stops
SCL4:30 amSantiago Arturo Merino Benitez
Dec 9
SCL11:25 pmSantiago Arturo Merino Benitez
18h 37m
2 stops
SAN1:02 pmSan Diego
$655
Find similar
LATAM Airlines
Nov 3
SAN7:48 pmSan Diego
29h 42m
1 stop
SCL6:30 amSantiago Arturo Merino Benitez
Nov 11
SCL4:35 amSantiago Arturo Merino Benitez
39h 52m
2 stops
SAN3:27 pmSan Diego
$665
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momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from San Diego to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 11/3

8:10 pm-8:21 pm

1 stop19h 11m

Santiago Arturo Merino Benitez

Wed 11/19

5:24 am-5:03 pm

1 stop16h 39m

$542

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 11/3

10:20 am-8:50 am

1 stop17h 30m

Santiago Arturo Merino Benitez

Wed 11/12

10:45 pm-11:01 am

1 stop17h 16m

$554

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Thu 12/4

9:59 am-5:35 am

1 stop14h 36m

Santiago Arturo Merino Benitez

Tue 12/9

11:55 pm-9:16 am

1 stop14h 21m

$650

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Thu 12/4

6:15 am-4:30 am

2 stops17h 15m

Santiago Arturo Merino Benitez

Tue 12/9

11:25 pm-1:02 pm

2 stops18h 37m

$655

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 12/1

7:00 am-6:55 am

1 stop18h 55m

Santiago Arturo Merino Benitez

Thu 12/4

11:10 pm-9:54 am

1 stop15h 44m

$664

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Mon 11/17

10:47 am-7:55 am

1 stop16h 08m

Santiago Arturo Merino Benitez

Fri 11/28

11:15 pm-9:55 am

1 stop15h 40m

$684

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Thu 12/11

10:07 am-8:55 am

2 stops17h 48m

Santiago Arturo Merino Benitez

Sat 12/27

11:55 pm-11:53 am

1 stop16h 58m

$729

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sat 3/14

6:20 am-6:35 am

2 stops20h 15m

Santiago Arturo Merino Benitez

Sun 3/22

11:55 pm-6:56 pm

1 stop23h 01m

$804

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sun 11/23

12:16 pm-7:40 am

1 stop14h 24m

Santiago Arturo Merino Benitez

Sun 11/30

4:25 pm-5:37 pm

2 stops30h 12m

$805

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sat 2/28

6:10 pm-5:35 am

1 stop30h 25m

Santiago Arturo Merino Benitez

Sat 3/7

4:35 am-9:55 pm

2 stops22h 20m

$810

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Diego to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Santiago?

What is the cheapest month to fly to Santiago?

In general, August is the cheapest month to fly from San Diego to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $654. If you don’t want to visit Santiago in August, then you should wait until October to fly from San Diego, when ticket prices are also cheap, with an average price of $683.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Sunday when prices can be found for as low as $1,003. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Tuesday is $1,131.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from San Diego to Santiago when you can find flight prices for as low as $882. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,072 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $936 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Diego for as low as $453 on momondo.

How have San Diego to Santiago flight prices changed over time?

As of October 2025, prices for San Diego to Santiago flights are approximately 137% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Santiago (SAN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Santiago

Direct flights

None
There are no direct flights from San Diego to Santiago. There are no popular flight routes from San Diego to Santiago.
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  • How far is San Diego to Santiago Arturo Merino Benitez by plane?

    There are 5476.6 mi between San Diego and Santiago Arturo Merino Benitez. In terms of flight time, this usually takes a little over 13h 57m.

  • When did momondo last update prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Diego Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Diego Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Diego to Santiago?

Best airlines flying from San Diego to Santiago

Compare and see reviews for airlines that fly from San Diego to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $453Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $556Free CancellationRating
7.5
1,870 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $574Free CancellationRating
7.4
8,991 reviews
Search United Airlines flights
American AirlinesPriceFrom $598Free CancellationRating
7.2
11,028 reviews
Search American Airlines flights
DeltaPriceFrom $792Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Santiago?

It is quick and easy to find San Diego to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from San Diego to Santiago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Santiago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to Santiago.

I’m not ready to book a flight from San Diego to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from San Diego and alert you when they change.

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