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Cheap flights from San Diego to Santiago from $306

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Santiago departing on 1/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:08 am - 8:50 am
SAN
-
SCL
16h 42m2 stops
United Airlines Logo
10:45 pm - 2:52 pm
SCL
-
SAN
21h 07m2 stops
$669United Airlines
Tue, Jan 13 - Mon, Feb 2
Copa Airlines Logo
8:16 pm - 8:20 pm
SAN
-
SCL
19h 04m1 stop
Copa Airlines Logo
5:44 am - 5:41 pm
SCL
-
SAN
16h 57m1 stop
$692Copa Airlines
Fri, Jan 23 - Fri, Jan 30
American Airlines Logo
9:21 am - 8:15 am
SAN
-
SCL
17h 54m1 stop
American Airlines Logo
8:50 pm - 11:01 am
SCL
-
SAN
17h 11m1 stop
$734American Airlines
Wed, Jan 21 - Wed, Apr 15
LATAM Airlines Logo
10:16 am - 5:35 am
SAN
-
SCL
16h 19m1 stop
LATAM Airlines Logo
5:40 am - 10:46 pm
SCL
-
SAN
20h 06m2 stops
$736LATAM Airlines
Wed, Apr 22 - Sat, May 2
American Airlines Logo
9:21 am - 7:50 am
SAN
-
SCL
17h 29m2 stops
American Airlines Logo
8:50 pm - 11:01 am
SCL
-
SAN
17h 11m1 stop
$739American Airlines
Wed, Jan 21 - Wed, Apr 15
American Airlines Logo
1:19 pm - 8:15 am
SAN
-
SCL
13h 56m1 stop
American Airlines Logo
10:00 pm - 12:16 pm
SCL
-
SAN
19h 16m1 stop
$741American Airlines
Tue, Feb 10 - Sat, Feb 28
United Airlines Logo
6:30 am - 8:50 am
SAN
-
SCL
21h 20m2 stops
United Airlines Logo
10:45 pm - 5:28 pm
SCL
-
SAN
23h 43m2 stops
$748United Airlines
Fri, Jan 23 - Fri, Jan 30
LATAM Airlines Logo
6:15 am - 5:25 am
SAN
-
SCL
20h 10m2 stops
LATAM Airlines Logo
5:40 am - 10:46 pm
SCL
-
SAN
20h 06m2 stops
$754LATAM Airlines
Wed, Apr 22 - Sat, May 2
American Airlines Logo
9:21 am - 9:00 am
SAN
-
SCL
18h 39m2 stops
American Airlines Logo
10:30 pm - 11:44 am
SCL
-
SAN
18h 14m2 stops
$759American Airlines
Sat, Jan 24 - Sat, Jan 31
LATAM Airlines Logo
6:15 am - 5:25 am
SAN
-
SCL
20h 10m2 stops
LATAM Airlines Logo
11:25 pm - 7:14 pm
SCL
-
SAN
22h 49m1 stop
$787LATAM Airlines
Wed, Apr 22 - Sat, May 2

Copa Airlines flights from San Diego to Santiago

Our best Copa Airlines deals on San Diego to Santiago flight tickets
Copa Airlines
Jan 23
SAN8:16 pmSan Diego
19h 04m
1 stop
SCL8:20 pmSantiago Arturo Merino Benitez
Jan 30
SCL5:44 amSantiago Arturo Merino Benitez
16h 57m
1 stop
SAN5:41 pmSan Diego
$692
Find similar
Copa Airlines
Apr 16
SAN8:39 pmSan Diego
27h 21m
2 stops
SCL3:00 amSantiago Arturo Merino Benitez
Apr 20
SCL12:46 amSantiago Arturo Merino Benitez
22h 26m
2 stops
SAN8:12 pmSan Diego
$867
Find similar
Copa Airlines
Dec 29
SAN8:12 pmSan Diego
19h 09m
1 stop
SCL8:21 pmSantiago Arturo Merino Benitez
Jan 6
SCL1:46 amSantiago Arturo Merino Benitez
23h 08m
2 stops
SAN7:54 pmSan Diego
$1,499
Find similar

United Airlines flights from San Diego to Santiago

Our best United Airlines deals on San Diego to Santiago flight tickets
United Airlines
Jan 13
SAN11:08 amSan Diego
16h 42m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Feb 2
SCL10:45 pmSantiago Arturo Merino Benitez
21h 07m
2 stops
SAN2:52 pmSan Diego
$669
Find similar
United Airlines
Jan 23
SAN6:30 amSan Diego
21h 20m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Jan 30
SCL10:45 pmSantiago Arturo Merino Benitez
23h 43m
2 stops
SAN5:28 pmSan Diego
$748
Find similar
United Airlines
Feb 28
SAN7:50 pmSan Diego
32h 00m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Mar 7
SCL9:45 pmSantiago Arturo Merino Benitez
21h 15m
2 stops
SAN2:00 pmSan Diego
$873
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from San Diego to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Tue 1/13

11:08 am-8:50 am

2 stops16h 42m

Santiago Arturo Merino Benitez

Mon 2/2

10:45 pm-2:52 pm

2 stops21h 07m

$669

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 1/23

8:16 pm-8:20 pm

1 stop19h 04m

Santiago Arturo Merino Benitez

Fri 1/30

5:44 am-5:41 pm

1 stop16h 57m

$692

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Wed 1/21

9:21 am-8:15 am

1 stop17h 54m

Santiago Arturo Merino Benitez

Wed 4/15

8:50 pm-11:01 am

1 stop17h 11m

$734

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Wed 4/22

10:16 am-5:35 am

1 stop16h 19m

Santiago Arturo Merino Benitez

Sat 5/2

5:40 am-10:46 pm

2 stops20h 06m

$736

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Wed 1/21

9:21 am-7:50 am

2 stops17h 29m

Santiago Arturo Merino Benitez

Wed 4/15

8:50 pm-11:01 am

1 stop17h 11m

$739

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Tue 2/10

1:19 pm-8:15 am

1 stop13h 56m

Santiago Arturo Merino Benitez

Sat 2/28

10:00 pm-12:16 pm

1 stop19h 16m

$741

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Fri 1/23

6:30 am-8:50 am

2 stops21h 20m

Santiago Arturo Merino Benitez

Fri 1/30

10:45 pm-5:28 pm

2 stops23h 43m

$748

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Wed 4/22

6:15 am-5:25 am

2 stops20h 10m

Santiago Arturo Merino Benitez

Sat 5/2

5:40 am-10:46 pm

2 stops20h 06m

$754

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Sat 1/24

9:21 am-9:00 am

2 stops18h 39m

Santiago Arturo Merino Benitez

Sat 1/31

10:30 pm-11:44 am

2 stops18h 14m

$759

San DiegoSantiago

SAN - SCL

SANSCL

San Diego

Wed 4/22

6:15 am-5:25 am

2 stops20h 10m

Santiago Arturo Merino Benitez

Sat 5/2

11:25 pm-7:14 pm

1 stop22h 49m

$787

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Diego to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Santiago?

What is the cheapest month to fly to Santiago?

In general, November is the cheapest month to fly from San Diego to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $635. If you don’t want to visit Santiago in November, then you should wait until August to fly from San Diego, when ticket prices are also cheap, with an average price of $654.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from San Diego to Santiago when you can find flight prices for as low as $882. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,072 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $946 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Diego for as low as $453 on momondo.

How have San Diego to Santiago flight prices changed over time?

As of December 2025, prices for San Diego to Santiago flights are approximately 13% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Santiago (SAN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Santiago

Fastest flight time

15h 25m

Direct flights

None
The fastest flight from San Diego to Santiago takes 15h 25m
There are no direct flights from San Diego to Santiago. There are no popular flight routes from San Diego to Santiago.
Search flight deals

  • How far is San Diego to Santiago Arturo Merino Benitez by plane?

    There are 5476.6 mi between San Diego and Santiago Arturo Merino Benitez. In terms of flight time, this usually takes a little over 15h 25m.

  • When did momondo last update prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Diego Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Diego Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Diego to Santiago?

Best airlines flying from San Diego to Santiago

Compare and see reviews for airlines that fly from San Diego to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $453Free CancellationRating
7.6
1,561 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $507Free CancellationRating
7.5
1,895 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $563Free CancellationRating
7.2
11,070 reviews
Search American Airlines flights
United AirlinesPriceFrom $574Free CancellationRating
7.4
9,114 reviews
Search United Airlines flights
DeltaPriceFrom $642Free CancellationRating
7.9
8,017 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Santiago?

It is quick and easy to find San Diego to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from San Diego to Santiago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Santiago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to Santiago.

I’m not ready to book a flight from San Diego to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from San Diego and alert you when they change.

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