Cheap flights from San Diego to Rome from $399

The cheapest month to fly to Rome from San Diego is in February. Flight prices, which tend to average around $509, are often lower during this time because this is during the off-season. If you aren’t able to travel to Rome during the month of February, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $582.

You are more likely to see cheaper flights to Rome from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Rome for around $867 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Rome from San Diego for as low as $687 on momondo.

You could potentially save up to 13% on your flight if you consider stops on a San Diego to Rome flight.

As of April 2026, prices for San Diego to Rome flights are approximately 18% cheaper when compared to flights at the same time last year.

United Airlines and British Airways are the most popular carriers operating from San Diego to Rome

United Airlines, British Airways and Lufthansa are the top three most popular airlines that fly to Rome from San Diego according to our data. United Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Rome. Keep in mind that there are 8 different airlines that fly to Rome on a routine basis, so you have a few additional options to choose from.

London (LHR) was the most common stop: 43% of momondo users choosing 1-stop flights on this route connected there.

Flights via Atlanta (ATL) offer the lowest average round-trip price of $553.

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 14h 30m.

Denver (DEN) has the shortest average layover time for this route: 1h 29m.