Cheap flights from San Diego to Panama from $374

The month of May is, on average, the cheapest month to fly to Panama from San Diego, with most prices found around $620. If you don’t want to visit Panama in May, then you should wait until October to fly from San Diego, when ticket prices are also cheap, with an average price of $640.

According to our data, Tuesday is the cheapest day to fly to Panama from San Diego. The lowest ticket price found for a Tuesday departure recently was $589. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Panama for around $849.

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama flight prices

You are more likely to see cheaper flights to Panama from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $762 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Diego for as low as $335 on momondo.

There are 3 cabin classes available to choose from on San Diego to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 68% on your flight if you consider stops on a San Diego to Panama flight.

American Airlines is the most popular carrier operating from San Diego to Panama

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to Panama from San Diego according to our data. Copa Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

1 flights are operational daily from San Diego to Panama as of November 2026. The most popular departure time for this route is 10:00PM, with 100% of flights per day taking off in the evening.

As of November 2026, 9 flights take off from San Diego and land in Panama each week. The most common flight departure day for this route is Mon, with 22% of weekly flights taking off on this day.