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Cheap flights from San Diego to Panama from $275

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Panama departing on 4/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
8:17 pm - 5:20 am
SAN
-
PTY
6h 03mnonstop
Copa Airlines Logo
1:15 pm - 5:13 pm
PTY
-
SAN
6h 58mnonstop
$609Copa Airlines
Sun, Feb 15 - Fri, Feb 20
United Airlines Logo
5:50 pm - 1:45 pm
SAN
-
PTY
17h 55m1 stop
United Airlines Logo
7:55 am - 6:05 pm
PTY
-
SAN
12h 10m1 stop
$624United Airlines
Sun, Mar 22 - Tue, Mar 31
United Airlines Logo
6:55 pm - 6:38 pm
SAN
-
PTY
21h 43m2 stops
United Airlines Logo
7:55 am - 11:59 pm
PTY
-
SAN
18h 04m2 stops
$628United Airlines
Fri, Mar 27 - Sun, Apr 5
American Airlines Logo
10:00 pm - 2:22 pm
SAN
-
PTY
14h 22m2 stops
American Airlines Logo
1:44 pm - 8:39 am
PTY
-
SAN
20h 55m2 stops
$633American Airlines
Sun, Mar 8 - Sun, Mar 15
United Airlines Logo
3:40 pm - 5:07 pm
SAN
-
PTY
22h 27m1 stop
United Airlines Logo
8:55 am - 4:38 pm
PTY
-
SAN
10h 43m1 stop
$637United Airlines
Sun, Feb 15 - Fri, Feb 20
American Airlines Logo
10:30 pm - 12:22 pm
SAN
-
PTY
11h 52m1 stop
American Airlines Logo
1:44 pm - 12:08 pm
PTY
-
SAN
24h 24m1 stop
$646American Airlines
Sun, Mar 8 - Sun, Mar 15
United Airlines Logo
8:00 am - 7:38 pm
SAN
-
PTY
8h 38m1 stop
United Airlines Logo
8:55 am - 10:00 pm
PTY
-
SAN
16h 05m1 stop
$659United Airlines
Mon, Feb 9 - Sat, Feb 21
United Airlines Logo
7:52 pm - 7:38 pm
SAN
-
PTY
20h 46m2 stops
United Airlines Logo
8:55 am - 10:00 pm
PTY
-
SAN
16h 05m1 stop
$663United Airlines
Mon, Feb 9 - Sat, Feb 21
United Airlines Logo
8:00 am - 7:38 pm
SAN
-
PTY
8h 38m1 stop
United Airlines Logo
4:41 pm - 11:14 am
PTY
-
SAN
21h 33m1 stop
$672United Airlines
Mon, Feb 9 - Sat, Feb 21
Copa Airlines Logo
9:18 pm - 5:20 am
SAN
-
PTY
6h 02mnonstop
Copa Airlines Logo
1:33 pm - 6:30 pm
PTY
-
SAN
6h 57mnonstop
$678Copa Airlines
Fri, Mar 27 - Sun, Apr 5

American Airlines flights from San Diego to Panama

Our best American Airlines deals on San Diego to Panama flight tickets
American Airlines
Mar 8
SAN10:00 pmSan Diego
14h 22m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Mar 15
PTY1:44 pmPanama City Tocumen Intl
20h 55m
2 stops
SAN8:39 amSan Diego
$633
Find similar
American Airlines
Mar 8
SAN10:30 pmSan Diego
11h 52m
1 stop
PTY12:22 pmPanama City Tocumen Intl
Mar 15
PTY1:44 pmPanama City Tocumen Intl
24h 24m
1 stop
SAN12:08 pmSan Diego
$646
Find similar
American Airlines
Mar 6
SAN10:30 pmSan Diego
12h 20m
1 stop
PTY1:50 pmPanama City Tocumen Intl
Mar 15
PTY1:44 pmPanama City Tocumen Intl
20h 55m
2 stops
SAN8:39 amSan Diego
$726
Find similar

Copa Airlines flights from San Diego to Panama

Our best Copa Airlines deals on San Diego to Panama flight tickets
Copa Airlines
Feb 15
SAN8:17 pmSan Diego
6h 03m
PTY5:20 amPanama City Tocumen Intl
Feb 20
PTY1:15 pmPanama City Tocumen Intl
6h 58m
SAN5:13 pmSan Diego
$609
Find similar
Copa Airlines
Mar 27
SAN9:18 pmSan Diego
6h 02m
PTY5:20 amPanama City Tocumen Intl
Apr 5
PTY1:33 pmPanama City Tocumen Intl
6h 57m
SAN6:30 pmSan Diego
$678
Find similar
Copa Airlines
Jan 25
SAN8:16 pmSan Diego
6h 04m
PTY5:20 amPanama City Tocumen Intl
Feb 1
PTY1:15 pmPanama City Tocumen Intl
6h 58m
SAN5:13 pmSan Diego
$717
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from San Diego to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 2/15

8:17 pm-5:20 am

Nonstop6h 03m

Panama City Tocumen Intl

Fri 2/20

1:15 pm-5:13 pm

Nonstop6h 58m

$609

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 3/22

5:50 pm-1:45 pm

1 stop17h 55m

Panama City Tocumen Intl

Tue 3/31

7:55 am-6:05 pm

1 stop12h 10m

$624

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Fri 3/27

6:55 pm-6:38 pm

2 stops21h 43m

Panama City Tocumen Intl

Sun 4/5

7:55 am-11:59 pm

2 stops18h 04m

$628

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 3/8

10:00 pm-2:22 pm

2 stops14h 22m

Panama City Tocumen Intl

Sun 3/15

1:44 pm-8:39 am

2 stops20h 55m

$633

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 2/15

3:40 pm-5:07 pm

1 stop22h 27m

Panama City Tocumen Intl

Fri 2/20

8:55 am-4:38 pm

1 stop10h 43m

$637

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 3/8

10:30 pm-12:22 pm

1 stop11h 52m

Panama City Tocumen Intl

Sun 3/15

1:44 pm-12:08 pm

1 stop24h 24m

$646

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Mon 2/9

8:00 am-7:38 pm

1 stop8h 38m

Panama City Tocumen Intl

Sat 2/21

8:55 am-10:00 pm

1 stop16h 05m

$659

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Mon 2/9

7:52 pm-7:38 pm

2 stops20h 46m

Panama City Tocumen Intl

Sat 2/21

8:55 am-10:00 pm

1 stop16h 05m

$663

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Mon 2/9

8:00 am-7:38 pm

1 stop8h 38m

Panama City Tocumen Intl

Sat 2/21

4:41 pm-11:14 am

1 stop21h 33m

$672

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Fri 3/27

9:18 pm-5:20 am

Nonstop6h 02m

Panama City Tocumen Intl

Sun 4/5

1:33 pm-6:30 pm

Nonstop6h 57m

$678

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from San Diego to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from San Diego, with most prices found around $388. If you don’t want to visit Panama in September, then you should wait until August to fly from San Diego, when ticket prices are also cheap, with an average price of $423.

What is the cheapest day to depart on your flight to Panama?

According to our data, Thursday is the cheapest day to fly to Panama from San Diego. The lowest ticket price found for a Thursday departure recently was $230. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Panama for around $1,200.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from San Diego to Panama when you can find flight prices for as low as $491. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $687 per ticket.

What is the cheapest San Diego to Panama flight route?

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $537 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Diego for as low as $364 on momondo.

What cabin class options are available on San Diego to Panama flights?

There are 3 cabin classes available to choose from on San Diego to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Panama flights?

You could potentially save up to 17% on your flight if you consider stops on a San Diego to Panama flight.

Cheap San Diego to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Panama

Best Price Found

$209

Fastest flight time

6h 02m

Direct flights

Mon, Tue, Wed, Thu and Sat

Airports in Panama

21 airports
The best one-way flight to Panama from San Diego in the past 72 hours is $209. The best round-trip flight deal from San Diego to Panama found on momondo in the last 72 hours is $421.
The fastest flight from San Diego to Panama takes 6h 02m
Direct flights go from San Diego to Panama on Monday, Tuesday, Wednesday, Thursday and Saturday. There are no airlines offering direct flights.
There are 21 airports in Panama. From San Diego there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • When did momondo last update prices for flights from San Diego Airport to Panama?

    Prices for flights from San Diego Airport to Panama refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Panama?

  • How old do you have to be to fly from San Diego Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from San Diego to Panama?

Best airlines flying from San Diego to Panama

Compare and see reviews for airlines that fly from San Diego to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $334Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $355Free CancellationRating
7.4
9,115 reviews
Search United Airlines flights
DeltaPriceFrom $355Free CancellationRating
7.9
8,013 reviews
Search Delta flights
American AirlinesPriceFrom $489Free CancellationRating
7.2
11,062 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from San Diego with this policy.

How can momondo help me find flights from San Diego to Panama?

Once all potential San Diego to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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