Cheap flights from San Diego to Panama from $355

The month of September is, on average, the cheapest month to fly to Panama from San Diego, with most prices found around $145. If you don’t want to visit Panama in September, then you should wait until December to fly from San Diego, when ticket prices are also cheap, with an average price of $179.

According to our data, Wednesday is the cheapest day to fly to Panama from San Diego. The lowest ticket price found for a Wednesday departure recently was $513. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Panama for around $1,200.

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama flight prices

You are more likely to see cheaper flights to Panama from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $627 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Diego for as low as $426 on momondo.

There are 3 cabin classes available to choose from on San Diego to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 39% on your flight if you consider stops on a San Diego to Panama flight.

1 flights are operational daily from San Diego to Panama as of June 2026. The most popular departure time for this route is 10:00PM, with 100% of flights per day taking off in the evening.

As of June 2026, 8 flights take off from San Diego and land in Panama each week. The most common flight departure day for this route is Mon, with 25% of weekly flights taking off on this day.