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Cheap flights from San Diego to Panama from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Panama departing on 12/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
10:30 pm - 7:59 pmSAN-PTY
18h 29m1 stop
Delta Logo
8:05 am - 11:35 pmPTY-SAN
18h 30m1 stop
$384Delta
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Thu, Dec 4 - Sun, Dec 7
Delta Logo
10:30 pm - 2:12 pmSAN-PTY
12h 42m1 stop
Delta Logo
3:46 pm - 11:35 pmPTY-SAN
10h 49m1 stop
$404Delta
Find Deal
Fri, Nov 28 - Wed, Dec 3
Copa Airlines Logo
8:12 pm - 5:20 amSAN-PTY
6h 08mnonstop
Copa Airlines Logo
1:45 pm - 5:37 pmPTY-SAN
6h 52mnonstop
$409Copa Airlines
Find Deal
Sun, Dec 7 - Tue, Dec 16
United Airlines Logo
8:00 pm - 7:38 pmSAN-PTY
20h 38m2 stops
United Airlines Logo
8:55 am - 6:21 pmPTY-SAN
12h 26m1 stop
$424United Airlines
Find Deal
Tue, Dec 2 - Wed, Dec 10
American Airlines Logo
10:35 pm - 1:47 pmSAN-PTY
12h 12m1 stop
American Airlines Logo
4:43 pm - 9:54 amPTY-SAN
20h 11m2 stops
$428American Airlines
Find Deal
Sun, Dec 7 - Tue, Dec 16
United Airlines Logo
8:00 am - 7:38 pmSAN-PTY
8h 38m1 stop
United Airlines Logo
4:41 pm - 11:05 amPTY-SAN
21h 24m1 stop
$433United Airlines
Find Deal
Wed, Jan 7 - Wed, Jan 21
Copa Airlines Logo
8:16 pm - 5:20 amSAN-PTY
6h 04mnonstop
Copa Airlines Logo
1:45 pm - 5:41 pmPTY-SAN
6h 56mnonstop
$457Copa Airlines
Find Deal
Wed, Jan 14 - Sun, Jan 18
Multiple Airlines Logo
6:25 am - 6:55 pmSAN-PTY
33h 30m3 stops
Multiple Airlines Logo
1:45 pm - 5:37 pmPTY-SAN
6h 52mnonstop
$462Multiple Airlines
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Wed, Dec 3 - Wed, Dec 10
Multiple Airlines Logo
8:10 pm - 5:20 amSAN-PTY
6h 10mnonstop
Multiple Airlines Logo
2:55 am - 11:51 pmPTY-SAN
23h 56m3 stops
$533Multiple Airlines
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Sun, Nov 30 - Wed, Dec 3
American Airlines Logo
10:45 pm - 3:42 pmSAN-PTY
13h 57m2 stops
American Airlines Logo
2:50 pm - 11:00 pmPTY-SAN
11h 10m1 stop
$544American Airlines
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Fri, Dec 12 - Mon, Dec 15

Delta flights from San Diego to Panama

Our best Delta deals on San Diego to Panama flight tickets
Delta
Dec 4
SAN10:30 pmSan Diego
18h 29m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Dec 7
PTY8:05 amPanama City Tocumen Intl
18h 30m
1 stop
SAN11:35 pmSan Diego
$384
Find similar
Delta
Nov 28
SAN10:30 pmSan Diego
12h 42m
1 stop
PTY2:12 pmPanama City Tocumen Intl
Dec 3
PTY3:46 pmPanama City Tocumen Intl
10h 49m
1 stop
SAN11:35 pmSan Diego
$404
Find similar
Delta
Nov 10
SAN10:30 pmSan Diego
12h 42m
1 stop
PTY2:12 pmPanama City Tocumen Intl
Nov 13
PTY3:37 pmPanama City Tocumen Intl
11h 06m
1 stop
SAN11:43 pmSan Diego
$414
Find similar

American Airlines flights from San Diego to Panama

Our best American Airlines deals on San Diego to Panama flight tickets
American Airlines
Dec 7
SAN10:35 pmSan Diego
12h 12m
1 stop
PTY1:47 pmPanama City Tocumen Intl
Dec 16
PTY4:43 pmPanama City Tocumen Intl
20h 11m
2 stops
SAN9:54 amSan Diego
$428
Find similar
American Airlines
Dec 12
SAN10:45 pmSan Diego
13h 57m
2 stops
PTY3:42 pmPanama City Tocumen Intl
Dec 15
PTY2:50 pmPanama City Tocumen Intl
11h 10m
1 stop
SAN11:00 pmSan Diego
$544
Find similar
American Airlines
Nov 5
SAN10:35 pmSan Diego
12h 14m
1 stop
PTY1:49 pmPanama City Tocumen Intl
Nov 8
PTY2:49 pmPanama City Tocumen Intl
11h 18m
1 stop
SAN11:07 pmSan Diego
$774
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from San Diego to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Thu 12/4

10:30 pm-7:59 pm

1 stop18h 29m

Panama City Tocumen Intl

Sun 12/7

8:05 am-11:35 pm

1 stop18h 30m

$384

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Fri 11/28

10:30 pm-2:12 pm

1 stop12h 42m

Panama City Tocumen Intl

Wed 12/3

3:46 pm-11:35 pm

1 stop10h 49m

$404

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 12/7

8:12 pm-5:20 am

Nonstop6h 08m

Panama City Tocumen Intl

Tue 12/16

1:45 pm-5:37 pm

Nonstop6h 52m

$409

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Tue 12/2

8:00 pm-7:38 pm

2 stops20h 38m

Panama City Tocumen Intl

Wed 12/10

8:55 am-6:21 pm

1 stop12h 26m

$424

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 12/7

10:35 pm-1:47 pm

1 stop12h 12m

Panama City Tocumen Intl

Tue 12/16

4:43 pm-9:54 am

2 stops20h 11m

$428

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Wed 1/7

8:00 am-7:38 pm

1 stop8h 38m

Panama City Tocumen Intl

Wed 1/21

4:41 pm-11:05 am

1 stop21h 24m

$433

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Wed 1/14

8:16 pm-5:20 am

Nonstop6h 04m

Panama City Tocumen Intl

Sun 1/18

1:45 pm-5:41 pm

Nonstop6h 56m

$457

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Wed 12/3

6:25 am-6:55 pm

3 stops33h 30m

Panama City Tocumen Intl

Wed 12/10

1:45 pm-5:37 pm

Nonstop6h 52m

$462

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sun 11/30

8:10 pm-5:20 am

Nonstop6h 10m

Panama City Tocumen Intl

Wed 12/3

2:55 am-11:51 pm

3 stops23h 56m

$533

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Fri 12/12

10:45 pm-3:42 pm

2 stops13h 57m

Panama City Tocumen Intl

Mon 12/15

2:50 pm-11:00 pm

1 stop11h 10m

$544

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from San Diego to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from San Diego, with most prices found around $388. If you don’t want to visit Panama in September, then you should wait until August to fly from San Diego, when ticket prices are also cheap, with an average price of $410.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from San Diego. The lowest ticket price found for a Tuesday departure recently was $467. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Panama for around $537.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from San Diego to Panama when you can find flight prices for as low as $493. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $687 per ticket.

What is the cheapest San Diego to Panama flight route?

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $554 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Diego for as low as $364 on momondo.

What cabin class options are available on San Diego to Panama flights?

There are 3 cabin classes available to choose from on San Diego to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Panama flights?

You could potentially save up to 17% on your flight if you consider stops on a San Diego to Panama flight.

Cheap San Diego to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Panama

Best Price Found

$189

Fastest flight time

6h 03m

Direct flights

Mon, Tue, Wed, Thu and Sat

Airports in Panama

1 airport
The best one-way flight to Panama from San Diego in the past 72 hours is $189. The best round-trip flight deal from San Diego to Panama found on momondo in the last 72 hours is $438.
The fastest flight from San Diego to Panama takes 6h 03m
Direct flights go from San Diego to Panama on Monday, Tuesday, Wednesday, Thursday and Saturday. There are no airlines offering direct flights.
There is 1 airport near Panama: Panama City Tocumen Intl (PTY)
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  • When did momondo last update prices for flights from San Diego Airport to Panama?

    Prices for flights from San Diego Airport to Panama refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Panama?

  • How old do you have to be to fly from San Diego Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from San Diego to Panama?

Best airlines flying from San Diego to Panama

Compare and see reviews for airlines that fly from San Diego to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $270Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
DeltaPriceFrom $355Free CancellationRating
7.9
7,993 reviews
Search Delta flights
United AirlinesPriceFrom $403Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
American AirlinesPriceFrom $528Free CancellationRating
7.2
11,030 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from San Diego with this policy.

How can momondo help me find flights from San Diego to Panama?

Once all potential San Diego to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

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Sat 11/29
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