Cheap flights from San Diego to Panama from $228

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Panama departing on 6/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:00 am - 1:55 am
SAN
-
PTY
12h 55m
2 stops
Multiple Airlines Logo
3:50 pm - 7:43 am
PTY
-
SAN
17h 53m
2 stops
$548Multiple Airlines
Thu, Oct 22 - Thu, Oct 29
American Airlines Logo
10:05 pm - 12:46 pm
SAN
-
PTY
12h 41m
1 stop
American Airlines Logo
1:14 pm - 10:20 pm
PTY
-
SAN
11h 06m
1 stop
$610American Airlines
Sat, May 16 - Sat, May 23
American Airlines Logo
7:20 pm - 12:46 pm
SAN
-
PTY
15h 26m
2 stops
American Airlines Logo
1:14 pm - 8:22 am
PTY
-
SAN
21h 08m
2 stops
$614American Airlines
Sat, May 16 - Sat, May 23
Multiple Airlines Logo
1:00 pm - 10:30 am
SAN
-
PTY
19h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 8:48 am
PTY
-
SAN
18h 58m
2 stops
$619Multiple Airlines
Tue, Sep 15 - Tue, Sep 22
Multiple Airlines Logo
11:05 am - 10:30 am
SAN
-
PTY
21h 25m
2 stops
Multiple Airlines Logo
5:30 am - 7:41 pm
PTY
-
SAN
16h 11m
2 stops
$620Multiple Airlines
Tue, May 5 - Sat, May 9
American Airlines Logo
7:20 pm - 12:46 pm
SAN
-
PTY
15h 26m
2 stops
American Airlines Logo
1:14 pm - 9:04 am
PTY
-
SAN
21h 50m
2 stops
$631American Airlines
Mon, May 18 - Fri, May 22
Delta Logo
1:50 pm - 12:50 pm
SAN
-
PTY
21h 00m
1 stop
Delta Logo
2:15 pm - 9:39 am
PTY
-
SAN
21h 24m
1 stop
$635Delta
Tue, May 19 - Sat, May 23
United Airlines Logo
5:00 pm - 8:58 am
SAN
-
DAV
37h 58m
2 stops
United Airlines Logo
9:38 am - 9:24 pm
DAV
-
SAN
37h 46m
2 stops
$1,239United Airlines
Sun, May 17 - Wed, May 20
United Airlines Logo
5:00 pm - 8:58 am
SAN
-
DAV
37h 58m
2 stops
United Airlines Logo
9:38 am - 7:50 pm
DAV
-
SAN
36h 12m
2 stops
$1,271United Airlines
Sun, May 17 - Wed, May 20
Copa Airlines Logo
8:45 pm - 7:38 pm
SAN
-
DAV
20h 53m
2 stops
Copa Airlines Logo
8:18 pm - 6:30 pm
DAV
-
SAN
24h 12m
1 stop
$1,286Copa Airlines
Fri, May 8 - Tue, May 12

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American Airlines flights from San Diego to Panama

Our best American Airlines deals on San Diego to Panama flight tickets
American Airlines
May 16
SAN10:05 pmSan Diego
12h 41m
1 stop
PTY12:46 pmPanama City Tocumen Intl
May 23
PTY1:14 pmPanama City Tocumen Intl
11h 06m
1 stop
SAN10:20 pmSan Diego
$610
American Airlines
May 16
SAN7:20 pmSan Diego
15h 26m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 23
PTY1:14 pmPanama City Tocumen Intl
21h 08m
2 stops
SAN8:22 amSan Diego
$614
American Airlines
May 18
SAN7:20 pmSan Diego
15h 26m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 22
PTY1:14 pmPanama City Tocumen Intl
21h 50m
2 stops
SAN9:04 amSan Diego
$631

Copa Airlines flights from San Diego to Panama

Our best Copa Airlines deals on San Diego to Panama flight tickets
Copa Airlines
May 10
SAN10:00 pmSan Diego
6h 07m
PTY6:07 amPanama City Tocumen Intl
May 15
PTY1:39 pmPanama City Tocumen Intl
6h 51m
SAN6:30 pmSan Diego
$670
Copa Airlines
Sep 11
SAN9:03 pmSan Diego
6h 17m
PTY5:20 amPanama City Tocumen Intl
Sep 18
PTY1:55 pmPanama City Tocumen Intl
6h 35m
SAN6:30 pmSan Diego
$676
Copa Airlines
Jul 6
SAN10:00 pmSan Diego
6h 22m
PTY6:22 amPanama City Tocumen Intl
Jul 13
PTY2:01 pmPanama City Tocumen Intl
6h 29m
SAN6:30 pmSan Diego
$706

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from San Diego to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Thu 10/22

11:00 am-1:55 am

2 stops12h 55m

Panama City Tocumen Intl

Thu 10/29

3:50 pm-7:43 am

2 stops17h 53m

$548
Quickest round-trip

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sat 5/16

10:05 pm-12:46 pm

1 stop12h 41m

Panama City Tocumen Intl

Sat 5/23

1:14 pm-10:20 pm

1 stop11h 06m

$610

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Sat 5/16

7:20 pm-12:46 pm

2 stops15h 26m

Panama City Tocumen Intl

Sat 5/23

1:14 pm-8:22 am

2 stops21h 08m

$614

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Tue 9/15

1:00 pm-10:30 am

2 stops19h 30m

Panama City Tocumen Intl

Tue 9/22

3:50 pm-8:48 am

2 stops18h 58m

$619

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Tue 5/5

11:05 am-10:30 am

2 stops21h 25m

Panama City Tocumen Intl

Sat 5/9

5:30 am-7:41 pm

2 stops16h 11m

$620

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Mon 5/18

7:20 pm-12:46 pm

2 stops15h 26m

Panama City Tocumen Intl

Fri 5/22

1:14 pm-9:04 am

2 stops21h 50m

$631

San DiegoPanama City

SAN - PTY

SANPTY

San Diego

Tue 5/19

1:50 pm-12:50 pm

1 stop21h 00m

Panama City Tocumen Intl

Sat 5/23

2:15 pm-9:39 am

1 stop21h 24m

$635

San DiegoDavid

SAN - DAV

SANDAV

San Diego

Sun 5/17

5:00 pm-8:58 am

2 stops37h 58m

David Enrique Malek

Wed 5/20

9:38 am-9:24 pm

2 stops37h 46m

$1,239

San DiegoDavid

SAN - DAV

SANDAV

San Diego

Sun 5/17

5:00 pm-8:58 am

2 stops37h 58m

David Enrique Malek

Wed 5/20

9:38 am-7:50 pm

2 stops36h 12m

$1,271

San DiegoDavid

SAN - DAV

SANDAV

San Diego

Fri 5/8

8:45 pm-7:38 pm

2 stops20h 53m

David Enrique Malek

Tue 5/12

8:18 pm-6:30 pm

1 stop24h 12m

$1,286

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from San Diego to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from San Diego, with most prices found around $388. If you don’t want to visit Panama in September, then you should wait until August to fly from San Diego, when ticket prices are also cheap, with an average price of $423.

What is the cheapest day to depart on your flight to Panama?

According to our data, Thursday is the cheapest day to fly to Panama from San Diego. The lowest ticket price found for a Thursday departure recently was $404. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Panama for around $869.

What is the cheapest San Diego to Panama flight route?

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama flight prices

How far in advance should I book a flight from San Diego to Panama?

You are more likely to see cheaper flights to Panama from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $582 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Diego for as low as $418 on momondo.

What cabin class options are available on San Diego to Panama flights?

There are 3 cabin classes available to choose from on San Diego to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Panama flights?

You could potentially save up to 39% on your flight if you consider stops on a San Diego to Panama flight.

Cheap San Diego to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Panama

Best Price Found

$256

Fastest flight time

6h 02m

Direct flights

Mon, Tue, Thu and Sat

Airports in Panama

21 airports
The best one-way flight to Panama from San Diego in the past 72 hours is $256. The best round-trip flight deal from San Diego to Panama found on momondo in the last 72 hours is $463.
The fastest flight from San Diego to Panama takes 6h 02m
Direct flights go from San Diego to Panama on Monday, Tuesday, Thursday and Saturday. There are no airlines offering direct flights.
There are 21 airports in Panama. From San Diego there are direct flights to Panama City Tocumen Intl (PTY).

Frequently asked questions about flying from San Diego to Panama

  • When did momondo last update prices for flights from San Diego Airport to Panama?

    Prices for flights from San Diego Airport to Panama refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Panama?

  • How old do you have to be to fly from San Diego Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from San Diego to Panama?

Best airlines flying from San Diego to Panama

Compare and see reviews for airlines that fly from San Diego to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $243Free CancellationRating
7.4
9,650 reviews
Search United Airlines flights
DeltaPriceFrom $285Free CancellationRating
7.9
8,459 reviews
Search Delta flights
Copa AirlinesPriceFrom $334Free CancellationRating
7.5
1,578 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from San Diego with this policy.

How can momondo help me find flights from San Diego to Panama?

Once all potential San Diego to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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1 adult
Mon 5/25
Mon 6/1

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