Cheap flights from Chicago O'Hare Intl Airport to Panama from $114

The month of October is, on average, the cheapest month to fly to Panama from Chicago O'Hare Intl Airport, with most prices found around $479. If you don’t want to visit Panama in October, then you should wait until September to fly from Chicago O'Hare Intl Airport, when ticket prices are also cheap, with an average price of $509.

According to our data, Tuesday is the cheapest day to fly to Panama from Chicago O'Hare Intl Airport. The lowest ticket price found for a Tuesday departure recently was $523. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago O'Hare Intl Airport to Panama for around $582.

In the evening is the cheapest time of day to fly from Chicago O'Hare Intl Airport to Panama when you can find flight prices for as low as $494. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $574 per ticket.

Fly from Chicago O'Hare Intl to Panama City Tocumen Intl for the best Chicago O'Hare Intl - Panama flight prices

You are more likely to see cheaper flights to Panama from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $577 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Chicago O'Hare Intl Airport for as low as $523 on momondo.

There are 3 cabin classes available to choose from on Chicago O'Hare Intl to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Avianca is the most popular carrier operating from Chicago O'Hare Intl to Panama

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to Panama from Chicago O'Hare Intl Airport according to our data. Copa Airlines is the first choice among our users, with 86% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 5 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Historically, on average around 10% of flights between Chicago and Panama have experienced a delay on any given week. The average delay length over the past 12 months has been 124 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights at night have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 10% of their flights experiencing any sort of delay.

As of March 2026, 3 flights take off from Chicago O'Hare Intl Airport and land in Panama each day. The most common flight departure time for this route is 7:00AM, with 84% of daily flights taking off at noon.

27 flights are operational weekly from Chicago O'Hare Intl Airport to Panama as of March 2026. The most popular departure day for this route is Tue, with 19% of flights per week taking off on this day.