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Cheap flights from Mobile to Des Moines from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mobile to Des Moines departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Mobile to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 10:18 am
MOB
-
DSM
4h 18m
1 stop
Delta Logo
6:30 pm - 10:57 pm
DSM
-
MOB
4h 27m
1 stop
$311Delta
Tue, Oct 6 - Tue, Oct 13
American Airlines Logo
4:29 pm - 12:07 am
MOB
-
DSM
7h 38m
1 stop
American Airlines Logo
6:02 am - 4:03 pm
DSM
-
MOB
10h 01m
2 stops
$316American Airlines
Wed, Jul 1 - Sat, Jul 11
Delta Logo
6:00 am - 10:14 am
MOB
-
DSM
4h 14m
1 stop
Delta Logo
5:45 am - 11:29 am
DSM
-
MOB
5h 44m
1 stop
$317Delta
Wed, Aug 26 - Sun, Aug 30
Delta Logo
6:00 am - 10:18 am
MOB
-
DSM
4h 18m
1 stop
Delta Logo
6:30 pm - 10:57 pm
DSM
-
MOB
4h 27m
1 stop
$320Delta
Thu, Oct 8 - Tue, Oct 13
Delta Logo
6:18 am - 11:08 am
MOB
-
DSM
4h 50m
1 stop
Delta Logo
5:27 am - 12:05 pm
DSM
-
MOB
6h 38m
1 stop
$339Delta
Tue, May 12 - Sat, May 16
American Airlines Logo
10:49 am - 8:21 pm
MOB
-
DSM
9h 32m
2 stops
American Airlines Logo
12:03 pm - 7:01 pm
DSM
-
MOB
6h 58m
1 stop
$344American Airlines
Tue, May 12 - Sat, May 16
American Airlines Logo
12:46 pm - 11:58 pm
MOB
-
DSM
11h 12m
2 stops
American Airlines Logo
4:13 pm - 11:03 pm
DSM
-
MOB
6h 50m
1 stop
$396American Airlines
Wed, Oct 7 - Tue, Oct 13
American Airlines Logo
4:29 pm - 12:35 am
MOB
-
DSM
8h 06m
2 stops
American Airlines Logo
1:34 pm - 9:40 pm
DSM
-
MOB
8h 06m
2 stops
$398American Airlines
Wed, Jul 1 - Sat, Jul 11
Delta Logo
4:15 pm - 10:29 pm
MOB
-
DSM
6h 14m
1 stop
Delta Logo
6:30 pm - 10:57 pm
DSM
-
MOB
4h 27m
1 stop
$400Delta
Tue, Oct 6 - Mon, Oct 12
Delta Logo
6:00 am - 10:18 am
MOB
-
DSM
4h 18m
1 stop
Delta Logo
5:45 am - 11:33 am
DSM
-
MOB
5h 48m
1 stop
$409Delta
Thu, Oct 8 - Wed, Oct 14

United Airlines flights from Mobile to Des Moines

Our best United Airlines deals on Mobile to Des Moines flight tickets
United Airlines
Sep 2
MOB7:00 amMobile
7h 17m
1 stop
DSM2:17 pmDes Moines
Sep 9
DSM5:00 amDes Moines
13h 17m
2 stops
MOB6:17 pmMobile
$394
United Airlines
Sep 2
MOB9:30 amMobile
10h 47m
2 stops
DSM8:17 pmDes Moines
Sep 9
DSM6:00 amDes Moines
12h 17m
2 stops
MOB6:17 pmMobile
$444
United Airlines
Oct 5
MOB5:10 pmMobile
5h 13m
1 stop
DSM10:23 pmDes Moines
Oct 14
DSM6:15 amDes Moines
5h 21m
1 stop
MOB11:36 amMobile
$479

American Airlines flights from Mobile to Des Moines

Our best American Airlines deals on Mobile to Des Moines flight tickets
American Airlines
Jul 1
MOB4:29 pmMobile
7h 38m
1 stop
DSM12:07 amDes Moines
Jul 11
DSM6:02 amDes Moines
10h 01m
2 stops
MOB4:03 pmMobile
$316
American Airlines
May 12
MOB10:49 amMobile
9h 32m
2 stops
DSM8:21 pmDes Moines
May 16
DSM12:03 pmDes Moines
6h 58m
1 stop
MOB7:01 pmMobile
$344
American Airlines
Oct 7
MOB12:46 pmMobile
11h 12m
2 stops
DSM11:58 pmDes Moines
Oct 13
DSM4:13 pmDes Moines
6h 50m
1 stop
MOB11:03 pmMobile
$396

momondo Fare Finder

 
Customize your flight search to find flights from Mobile to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Mobile to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 10/6

6:00 am-10:18 am

1 stop4h 18m

Des Moines

Tue 10/13

6:30 pm-10:57 pm

1 stop4h 27m

$311

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 7/1

4:29 pm-12:07 am

1 stop7h 38m

Des Moines

Sat 7/11

6:02 am-4:03 pm

2 stops10h 01m

$316

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 8/26

6:00 am-10:14 am

1 stop4h 14m

Des Moines

Sun 8/30

5:45 am-11:29 am

1 stop5h 44m

$317

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Thu 10/8

6:00 am-10:18 am

1 stop4h 18m

Des Moines

Tue 10/13

6:30 pm-10:57 pm

1 stop4h 27m

$320

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 5/12

6:18 am-11:08 am

1 stop4h 50m

Des Moines

Sat 5/16

5:27 am-12:05 pm

1 stop6h 38m

$339

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 5/12

10:49 am-8:21 pm

2 stops9h 32m

Des Moines

Sat 5/16

12:03 pm-7:01 pm

1 stop6h 58m

$344

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 10/7

12:46 pm-11:58 pm

2 stops11h 12m

Des Moines

Tue 10/13

4:13 pm-11:03 pm

1 stop6h 50m

$396

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 7/1

4:29 pm-12:35 am

2 stops8h 06m

Des Moines

Sat 7/11

1:34 pm-9:40 pm

2 stops8h 06m

$398

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 10/6

4:15 pm-10:29 pm

1 stop6h 14m

Des Moines

Mon 10/12

6:30 pm-10:57 pm

1 stop4h 27m

$400

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Thu 10/8

6:00 am-10:18 am

1 stop4h 18m

Des Moines

Wed 10/14

5:45 am-11:33 am

1 stop5h 48m

$409

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Mobile to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Mobile to Des Moines flights?

You could potentially save up to 20% on your flight if you consider stops on a Mobile to Des Moines flight.

When to book flights from Mobile to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Mobile to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mobile to Des Moines (MOB to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mobile to Des Moines

Fastest flight time

4h 14m

Direct flights

None
The fastest flight from Mobile to Des Moines takes 4h 14m
There are no direct flights from Mobile to Des Moines. There are no popular flight routes from Mobile to Des Moines.
Search flight deals

Frequently asked questions about flying from Mobile to Des Moines

  • How far is Mobile to Des Moines by plane?

    There are 813.4 mi between Mobile and Des Moines. Typically, this will take 4h 14m by plane in normal conditions.

  • When did momondo last update prices for flights from Mobile Airport to Des Moines Airport?

    Prices for flights from Mobile Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Mobile Airport to Des Moines Airport?

  • How old do you have to be to fly from Mobile Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Mobile Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Mobile to Des Moines?

Best airlines flying from Mobile to Des Moines

Compare and see reviews for airlines that fly from Mobile to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,678 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Mobile to Des Moines?

Finding the right flight to Des Moines from Mobile is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Mobile to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Mobile with this policy.

How can momondo help me find flights from Mobile to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Mobile. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mobile to Des Moines right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Des Moines from Mobile. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Des Moines trip

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