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Cheap flights from Knoxville to Panama from $311

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 9/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:15 pm - 12:16 pm
TYS
-
PTY
17h 01m
2 stops
American Airlines Logo
1:16 pm - 11:19 am
PTY
-
TYS
21h 03m
2 stops
$579American Airlines
Thu, Sep 24 - Fri, Oct 2
American Airlines Logo
6:00 am - 12:39 pm
TYS
-
PTY
7h 39m
1 stop
American Airlines Logo
1:39 pm - 11:51 pm
PTY
-
TYS
9h 12m
1 stop
$587American Airlines
Tue, Aug 18 - Fri, Sep 4
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 2:37 pm
PTY
-
TYS
22h 07m
2 stops
$591United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 6:17 pm
PTY
-
TYS
25h 47m
1 stop
$597United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:00 am - 4:04 am
TYS
-
PTY
22h 04m
2 stops
United Airlines Logo
3:30 pm - 9:45 pm
PTY
-
TYS
29h 15m
1 stop
$602United Airlines
Mon, Aug 17 - Wed, Aug 19
United Airlines Logo
7:00 am - 6:37 pm
TYS
-
PTY
12h 37m
2 stops
United Airlines Logo
10:55 pm - 11:59 pm
PTY
-
TYS
24h 04m
2 stops
$606United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
2:21 pm - 2:14 pm
TYS
-
PTY
24h 53m
1 stop
United Airlines Logo
3:30 pm - 9:45 pm
PTY
-
TYS
29h 15m
1 stop
$608United Airlines
Mon, Aug 17 - Wed, Aug 19
Delta Logo
5:35 am - 12:58 pm
TYS
-
PTY
8h 23m
1 stop
Delta Logo
2:23 pm - 11:55 pm
PTY
-
TYS
8h 32m
1 stop
$617Delta
Thu, Sep 24 - Fri, Oct 2
American Airlines Logo
6:27 pm - 1:36 pm
TYS
-
PTY
19h 09m
2 stops
American Airlines Logo
2:43 pm - 10:19 am
PTY
-
TYS
19h 36m
2 stops
$621American Airlines
Sun, Nov 8 - Thu, Nov 12
United Airlines Logo
7:15 am - 4:12 pm
TYS
-
PTY
9h 57m
1 stop
United Airlines Logo
7:55 am - 11:12 pm
PTY
-
TYS
14h 17m
1 stop
$627United Airlines
Tue, Jul 28 - Mon, Aug 3

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United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets
United Airlines
Aug 26
TYS7:15 amKnoxville McGhee Tyson
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 27
PTY3:30 pmPanama City Tocumen Intl
22h 07m
2 stops
TYS2:37 pmKnoxville McGhee Tyson
$591
United Airlines
Aug 26
TYS7:15 amKnoxville McGhee Tyson
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 27
PTY3:30 pmPanama City Tocumen Intl
25h 47m
1 stop
TYS6:17 pmKnoxville McGhee Tyson
$597
United Airlines
Aug 17
TYS7:00 amKnoxville McGhee Tyson
22h 04m
2 stops
PTY4:04 amPanama City Tocumen Intl
Aug 19
PTY3:30 pmPanama City Tocumen Intl
29h 15m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
$602

Delta flights from Knoxville to Panama

Our best Delta deals on Knoxville to Panama flight tickets
Delta
Sep 24
TYS5:35 amKnoxville McGhee Tyson
8h 23m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Oct 2
PTY2:23 pmPanama City Tocumen Intl
8h 32m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$617
Delta
Jul 26
TYS10:26 amKnoxville McGhee Tyson
27h 39m
1 stop
PTY1:05 pmPanama City Tocumen Intl
Aug 4
PTY2:20 pmPanama City Tocumen Intl
8h 32m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$633
Delta
Jul 25
TYS6:00 amKnoxville McGhee Tyson
8h 00m
1 stop
PTY1:00 pmPanama City Tocumen Intl
Jul 30
PTY2:24 pmPanama City Tocumen Intl
8h 28m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$657

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 9/24

8:15 pm-12:16 pm

2 stops17h 01m

Panama City Tocumen Intl

Fri 10/2

1:16 pm-11:19 am

2 stops21h 03m

$579
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 8/18

6:00 am-12:39 pm

1 stop7h 39m

Panama City Tocumen Intl

Fri 9/4

1:39 pm-11:51 pm

1 stop9h 12m

$587

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-2:37 pm

2 stops22h 07m

$591

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-6:17 pm

1 stop25h 47m

$597

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/17

7:00 am-4:04 am

2 stops22h 04m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-9:45 pm

1 stop29h 15m

$602

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Thu 8/27

10:55 pm-11:59 pm

2 stops24h 04m

$606

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/17

2:21 pm-2:14 pm

1 stop24h 53m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-9:45 pm

1 stop29h 15m

$608

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 9/24

5:35 am-12:58 pm

1 stop8h 23m

Panama City Tocumen Intl

Fri 10/2

2:23 pm-11:55 pm

1 stop8h 32m

$617

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 11/8

6:27 pm-1:36 pm

2 stops19h 09m

Panama City Tocumen Intl

Thu 11/12

2:43 pm-10:19 am

2 stops19h 36m

$621

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 7/28

7:15 am-4:12 pm

1 stop9h 57m

Panama City Tocumen Intl

Mon 8/3

7:55 am-11:12 pm

1 stop14h 17m

$627

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of December is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $261. If you don’t want to visit Panama in December, then you should wait until February to fly from Knoxville, when ticket prices are also cheap, with an average price of $455.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Fastest flight time

7h 59m

Direct flights

None
The fastest flight from Knoxville to Panama takes 7h 59m
There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.
Search flight deals

Frequently asked questions about flying from Knoxville to Panama

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $261Free CancellationRating
7.4
9,896 reviews
Search United Airlines flights
American AirlinesPriceFrom $504Free CancellationRating
7.1
11,779 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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Find better results for your trip to Panama

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