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Cheap flights from Knoxville to Panama from $331

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 3:42 pmTYS-PTY
9h 42m1 stop
American Airlines Logo
4:55 pm - 12:38 amPTY-TYS
7h 43m1 stop
$456American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 31
American Airlines Logo
6:18 pm - 1:47 pmTYS-PTY
19h 29m2 stops
American Airlines Logo
4:55 pm - 12:38 amPTY-TYS
7h 43m1 stop
$460American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 31
United Airlines Logo
7:05 am - 7:38 pmTYS-PTY
12h 33m1 stop
United Airlines Logo
8:55 am - 11:44 pmPTY-TYS
14h 49m1 stop
$476United Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
4:59 pm - 1:47 pmTYS-PTY
20h 48m2 stops
American Airlines Logo
2:50 pm - 11:57 pmPTY-TYS
9h 07m1 stop
$480American Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
6:25 pm - 1:53 pmTYS-PTY
19h 28m2 stops
American Airlines Logo
4:50 pm - 9:45 amPTY-TYS
16h 55m2 stops
$485American Airlines
Find Deal
Sun, Jan 4 - Sun, Jan 18
American Airlines Logo
6:25 pm - 1:53 pmTYS-PTY
19h 28m2 stops
American Airlines Logo
4:50 pm - 10:49 amPTY-TYS
17h 59m2 stops
$510American Airlines
Find Deal
Fri, Jan 2 - Fri, Jan 9
Delta Logo
5:30 am - 12:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
2:20 pm - 11:44 pmPTY-TYS
8h 24m1 stop
$516Delta
Find Deal
Mon, Apr 6 - Tue, Apr 7
United Airlines Logo
9:05 am - 2:45 pmTYS-PTY
29h 40m1 stop
United Airlines Logo
4:41 pm - 7:50 pmPTY-TYS
27h 09m1 stop
$623United Airlines
Find Deal
Sun, Jan 4 - Sun, Jan 18
Multiple Airlines Logo
12:53 pm - 4:55 pmTYS-PTY
28h 02m3 stops
Multiple Airlines Logo
5:50 pm - 4:22 pmPTY-TYS
22h 32m3 stops
$716Multiple Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
Multiple Airlines Logo
12:53 pm - 4:55 pmTYS-PTY
28h 02m3 stops
Multiple Airlines Logo
7:50 pm - 9:37 pmPTY-TYS
25h 47m2 stops
$719Multiple Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10

American Airlines flights from Knoxville to Panama

Our best American Airlines deals on Knoxville to Panama flight tickets
American Airlines
Dec 10
TYS6:00 amKnoxville McGhee Tyson
9h 42m
1 stop
PTY3:42 pmPanama City Tocumen Intl
Dec 31
PTY4:55 pmPanama City Tocumen Intl
7h 43m
1 stop
TYS12:38 amKnoxville McGhee Tyson
$456
Find similar
American Airlines
Dec 10
TYS6:18 pmKnoxville McGhee Tyson
19h 29m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Dec 31
PTY4:55 pmPanama City Tocumen Intl
7h 43m
1 stop
TYS12:38 amKnoxville McGhee Tyson
$460
Find similar
American Airlines
Dec 3
TYS4:59 pmKnoxville McGhee Tyson
20h 48m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Dec 10
PTY2:50 pmPanama City Tocumen Intl
9h 07m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
$480
Find similar

United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets
United Airlines
Dec 3
TYS7:05 amKnoxville McGhee Tyson
12h 33m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Dec 10
PTY8:55 amPanama City Tocumen Intl
14h 49m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$476
Find similar
United Airlines
Jan 4
TYS9:05 amKnoxville McGhee Tyson
29h 40m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Jan 18
PTY4:41 pmPanama City Tocumen Intl
27h 09m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
$623
Find similar
United Airlines
Jan 4
TYS7:00 amKnoxville McGhee Tyson
12h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Jan 18
PTY4:41 pmPanama City Tocumen Intl
27h 09m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
$635
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/10

6:00 am-3:42 pm

1 stop9h 42m

Panama City Tocumen Intl

Wed 12/31

4:55 pm-12:38 am

1 stop7h 43m

$456

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/10

6:18 pm-1:47 pm

2 stops19h 29m

Panama City Tocumen Intl

Wed 12/31

4:55 pm-12:38 am

1 stop7h 43m

$460

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/3

7:05 am-7:38 pm

1 stop12h 33m

Panama City Tocumen Intl

Wed 12/10

8:55 am-11:44 pm

1 stop14h 49m

$476

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/3

4:59 pm-1:47 pm

2 stops20h 48m

Panama City Tocumen Intl

Wed 12/10

2:50 pm-11:57 pm

1 stop9h 07m

$480

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

6:25 pm-1:53 pm

2 stops19h 28m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-9:45 am

2 stops16h 55m

$485

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 1/2

6:25 pm-1:53 pm

2 stops19h 28m

Panama City Tocumen Intl

Fri 1/9

4:50 pm-10:49 am

2 stops17h 59m

$510

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 4/6

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Tue 4/7

2:20 pm-11:44 pm

1 stop8h 24m

$516

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

9:05 am-2:45 pm

1 stop29h 40m

Panama City Tocumen Intl

Sun 1/18

4:41 pm-7:50 pm

1 stop27h 09m

$623

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-4:55 pm

3 stops28h 02m

Panama City Tocumen Intl

Wed 12/10

5:50 pm-4:22 pm

3 stops22h 32m

$716

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-4:55 pm

3 stops28h 02m

Panama City Tocumen Intl

Wed 12/10

7:50 pm-9:37 pm

2 stops25h 47m

$719

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $471. If you don’t want to visit Panama in September, then you should wait until February to fly from Knoxville, when ticket prices are also cheap, with an average price of $497.

What is the cheapest day to depart on your flight to Panama?

According to our data, Friday is the cheapest day to fly to Panama from Knoxville. The lowest ticket price found for a Friday departure recently was $517. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Panama for around $818.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Direct flights

None
There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $387Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights
American AirlinesPriceFrom $440Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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