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Cheap flights from Knoxville to Panama from $256

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 6/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:32 pm - 12:14 pm
TYS
-
PTY
18h 42m
2 stops
American Airlines Logo
1:14 pm - 10:38 am
PTY
-
TYS
20h 24m
2 stops
$531American Airlines
Thu, Jul 23 - Thu, Jul 30
American Airlines Logo
7:25 pm - 12:14 pm
TYS
-
PTY
17h 49m
1 stop
American Airlines Logo
1:14 pm - 1:10 pm
PTY
-
TYS
22h 56m
2 stops
$542American Airlines
Thu, Jul 23 - Thu, Jul 30
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 10:08 am
PTY
-
TYS
17h 38m
2 stops
$561United Airlines
Mon, Aug 17 - Fri, Aug 21
Delta Logo
5:40 am - 1:09 pm
TYS
-
PTY
8h 29m
1 stop
Delta Logo
2:24 pm - 11:54 pm
PTY
-
TYS
8h 30m
1 stop
$567Delta
Wed, Jun 17 - Wed, Jun 24
United Airlines Logo
5:45 am - 4:04 am
TYS
-
PTY
23h 19m
2 stops
United Airlines Logo
3:30 pm - 11:12 pm
PTY
-
TYS
30h 42m
1 stop
$572United Airlines
Mon, Jul 6 - Fri, Jul 10
American Airlines Logo
6:00 am - 12:14 pm
TYS
-
PTY
7h 14m
1 stop
American Airlines Logo
1:24 pm - 11:59 pm
PTY
-
TYS
9h 35m
1 stop
$587American Airlines
Mon, Aug 3 - Mon, Aug 10
United Airlines Logo
7:19 pm - 2:14 pm
TYS
-
PTY
19h 55m
2 stops
United Airlines Logo
3:30 pm - 9:43 am
PTY
-
TYS
17h 13m
2 stops
$641United Airlines
Mon, Jul 6 - Fri, Jul 10
American Airlines Logo
5:33 pm - 12:13 pm
TYS
-
PTY
19h 40m
2 stops
American Airlines Logo
1:15 pm - 8:34 am
PTY
-
TYS
18h 19m
2 stops
$651American Airlines
Wed, Jun 17 - Wed, Jun 24
American Airlines Logo
7:25 pm - 12:14 pm
TYS
-
PTY
17h 49m
1 stop
American Airlines Logo
1:14 pm - 11:59 pm
PTY
-
TYS
9h 45m
1 stop
$658American Airlines
Thu, Jul 23 - Thu, Jul 30
United Airlines Logo
7:19 pm - 2:14 pm
TYS
-
PTY
19h 55m
2 stops
United Airlines Logo
3:30 pm - 9:43 am
PTY
-
TYS
17h 13m
2 stops
$681United Airlines
Mon, Jul 6 - Fri, Jul 10

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United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets
United Airlines
Aug 17
TYS7:19 pmKnoxville McGhee Tyson
19h 55m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Aug 21
PTY3:30 pmPanama City Tocumen Intl
17h 38m
2 stops
TYS10:08 amKnoxville McGhee Tyson
$561
United Airlines
Jul 6
TYS5:45 amKnoxville McGhee Tyson
23h 19m
2 stops
PTY4:04 amPanama City Tocumen Intl
Jul 10
PTY3:30 pmPanama City Tocumen Intl
30h 42m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$572
United Airlines
Jul 6
TYS7:19 pmKnoxville McGhee Tyson
19h 55m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Jul 10
PTY3:30 pmPanama City Tocumen Intl
17h 13m
2 stops
TYS9:43 amKnoxville McGhee Tyson
$641

American Airlines flights from Knoxville to Panama

Our best American Airlines deals on Knoxville to Panama flight tickets
American Airlines
Jul 23
TYS6:32 pmKnoxville McGhee Tyson
18h 42m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 30
PTY1:14 pmPanama City Tocumen Intl
20h 24m
2 stops
TYS10:38 amKnoxville McGhee Tyson
$531
American Airlines
Jul 23
TYS7:25 pmKnoxville McGhee Tyson
17h 49m
1 stop
PTY12:14 pmPanama City Tocumen Intl
Jul 30
PTY1:14 pmPanama City Tocumen Intl
22h 56m
2 stops
TYS1:10 pmKnoxville McGhee Tyson
$542
American Airlines
Aug 3
TYS6:00 amKnoxville McGhee Tyson
7h 14m
1 stop
PTY12:14 pmPanama City Tocumen Intl
Aug 10
PTY1:24 pmPanama City Tocumen Intl
9h 35m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$587

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 7/23

6:32 pm-12:14 pm

2 stops18h 42m

Panama City Tocumen Intl

Thu 7/30

1:14 pm-10:38 am

2 stops20h 24m

$531

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 7/23

7:25 pm-12:14 pm

1 stop17h 49m

Panama City Tocumen Intl

Thu 7/30

1:14 pm-1:10 pm

2 stops22h 56m

$542

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/17

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 8/21

3:30 pm-10:08 am

2 stops17h 38m

$561

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 6/17

5:40 am-1:09 pm

1 stop8h 29m

Panama City Tocumen Intl

Wed 6/24

2:24 pm-11:54 pm

1 stop8h 30m

$567

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 7/6

5:45 am-4:04 am

2 stops23h 19m

Panama City Tocumen Intl

Fri 7/10

3:30 pm-11:12 pm

1 stop30h 42m

$572
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/3

6:00 am-12:14 pm

1 stop7h 14m

Panama City Tocumen Intl

Mon 8/10

1:24 pm-11:59 pm

1 stop9h 35m

$587

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 7/6

7:19 pm-2:14 pm

2 stops19h 55m

Panama City Tocumen Intl

Fri 7/10

3:30 pm-9:43 am

2 stops17h 13m

$641

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 6/17

5:33 pm-12:13 pm

2 stops19h 40m

Panama City Tocumen Intl

Wed 6/24

1:15 pm-8:34 am

2 stops18h 19m

$651

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 7/23

7:25 pm-12:14 pm

1 stop17h 49m

Panama City Tocumen Intl

Thu 7/30

1:14 pm-11:59 pm

1 stop9h 45m

$658

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 7/6

7:19 pm-2:14 pm

2 stops19h 55m

Panama City Tocumen Intl

Fri 7/10

3:30 pm-9:43 am

2 stops17h 13m

$681

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of December is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $261. If you don’t want to visit Panama in December, then you should wait until February to fly from Knoxville, when ticket prices are also cheap, with an average price of $455.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Fastest flight time

7h 16m

Direct flights

None
The fastest flight from Knoxville to Panama takes 7h 16m
There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.
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Frequently asked questions about flying from Knoxville to Panama

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $261Free CancellationRating
7.4
9,684 reviews
Search United Airlines flights
American AirlinesPriceFrom $504Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

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Find better results for your trip to Panama

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