What airlines fly to Panama?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama from Knoxville according to our data. Delta is the first choice among our users, with 61% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

As of August 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Panama.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

What documentation or ID do you need to fly to Panama?

The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$631 Cheap Flights from Knoxville to Panama in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Panama

Round-trip

Cheap round-trip flights

Enter your travel dates to find the best prices.

12:00 pm - 8:00 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

8h 00m1 stop Atlanta Hartsfield-Jackson

3:20 pm - 11:46 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

8h 26m1 stop Atlanta Hartsfield-Jackson

$631Delta

Wed, Dec 30 - Wed, Jan 13

10:05 am - 8:00 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

9h 55m1 stop Atlanta Hartsfield-Jackson

3:20 pm - 11:46 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

8h 26m1 stop Atlanta Hartsfield-Jackson

$631Delta

Wed, Dec 30 - Wed, Jan 13

10:05 am - 8:00 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

9h 55m1 stop Atlanta Hartsfield-Jackson

3:20 pm - 11:46 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

8h 26m1 stop Atlanta Hartsfield-Jackson

$631Delta

Wed, Dec 30 - Tue, Jan 12

7:15 am - 6:37 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

12h 22m1 stop Houston George Bush Intcntl

10:00 am - 9:55 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

10h 55m1 stop Houston George Bush Intcntl

$662United Airlines

Mon, Sep 21 - Mon, Sep 28

6:02 pm - 2:14 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

21h 12m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:00 am - 9:45 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

22h 45m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$666United Airlines

Mon, Sep 21 - Mon, Sep 28

12:05 pm - 6:37 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 32m1 stop Houston George Bush Intcntl

3:30 pm - 9:45 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

17h 15m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$666United Airlines

Thu, Sep 24 - Thu, Oct 1

6:05 am - 12:16 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 11m1 stop Miami

1:16 pm - 11:07 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

8h 51m1 stop Miami

$697American Airlines

Sun, Sep 20 - Fri, Sep 25

6:09 pm - 12:16 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

19h 07m2 stops Charlotte Douglas Miami

1:16 pm - 11:26 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

21h 10m2 stops Miami Washington, D.C. Reagan-National

$701American Airlines

Sun, Sep 20 - Fri, Sep 25

6:55 pm - 8:19 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

26h 24m1 stop Fort Lauderdale

12:03 pm - 10:14 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

21h 11m1 stop Fort Lauderdale

$704Multiple Airlines

Sat, Sep 5 - Fri, Sep 11

7:20 pm - 2:55 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

20h 35m3 stops Washington, D.C. Dulles Intl Guatemala City La Aurora San José Juan Santamaria Intl

5:30 am - 11:59 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

17h 29m2 stops San Salvador El Salvador Intl Washington, D.C. Dulles Intl

$853Avianca

Sat, Sep 5 - Fri, Sep 11

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Delta flights from Knoxville to Panama

Our best Delta deals on Knoxville to Panama flight tickets

Delta

Dec 30

TYS10:05 amKnoxville McGhee Tyson

9h 55m

1 stop

PTY8:00 pmPanama City Tocumen Intl

Jan 13

PTY3:20 pmPanama City Tocumen Intl

8h 26m

1 stop

TYS11:46 pmKnoxville McGhee Tyson

$631

Delta

Dec 29

TYS10:05 amKnoxville McGhee Tyson

27h 55m

1 stop

PTY2:00 pmPanama City Tocumen Intl

Jan 13

PTY3:20 pmPanama City Tocumen Intl

8h 26m

1 stop

TYS11:46 pmKnoxville McGhee Tyson

$637

Delta

Dec 30

TYS10:05 amKnoxville McGhee Tyson

9h 55m

1 stop

PTY8:00 pmPanama City Tocumen Intl

Jan 8

PTY3:20 pmPanama City Tocumen Intl

8h 26m

1 stop

TYS11:46 pmKnoxville McGhee Tyson

$654

United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets

United Airlines

Sep 21

TYS7:15 amKnoxville McGhee Tyson

12h 22m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Sep 28

PTY10:00 amPanama City Tocumen Intl

10h 55m

1 stop

TYS9:55 pmKnoxville McGhee Tyson

$662

United Airlines

Dec 30

TYS9:45 amKnoxville McGhee Tyson

19h 25m

2 stops

PTY5:10 amPanama City Tocumen Intl

Jan 13

PTY4:41 pmPanama City Tocumen Intl

20h 37m

2 stops

TYS1:18 pmKnoxville McGhee Tyson

$666

United Airlines

Sep 24

TYS12:05 pmKnoxville McGhee Tyson

7h 32m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Oct 1

PTY3:30 pmPanama City Tocumen Intl

29h 25m

1 stop

TYS9:55 pmKnoxville McGhee Tyson

$673

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 12/30

12:00 pm-8:00 pm

1 stop8h 00m

Panama City Tocumen Intl

Wed 1/13

3:20 pm-11:46 pm

1 stop8h 26m

$631

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 12/30

10:05 am-8:00 pm

1 stop9h 55m

Panama City Tocumen Intl

Wed 1/13

3:20 pm-11:46 pm

1 stop8h 26m

$631

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 12/30

10:05 am-8:00 pm

1 stop9h 55m

Panama City Tocumen Intl

Tue 1/12

3:20 pm-11:46 pm

1 stop8h 26m

$631

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Mon 9/21

7:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 9/28

10:00 am-9:55 pm

1 stop10h 55m

$662

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Mon 9/21

6:02 pm-2:14 pm

2 stops21h 12m

Panama City Tocumen Intl

Mon 9/28

10:00 am-9:45 am

2 stops22h 45m

$666

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Thu 9/24

12:05 pm-6:37 pm

1 stop7h 32m

Panama City Tocumen Intl

Thu 10/1

3:30 pm-9:45 am

2 stops17h 15m

$666

Quickest round-trip

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sun 9/20

6:05 am-12:16 pm

1 stop7h 11m

Panama City Tocumen Intl

Fri 9/25

1:16 pm-11:07 pm

1 stop8h 51m

$697

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sun 9/20

6:09 pm-12:16 pm

2 stops19h 07m

Panama City Tocumen Intl

Fri 9/25

1:16 pm-11:26 am

2 stops21h 10m

$701

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sat 9/5

6:55 pm-8:19 pm

1 stop26h 24m

Panama City Tocumen Intl

Fri 9/11

12:03 pm-10:14 am

1 stop21h 11m

$704

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sat 9/5

7:20 pm-2:55 pm

3 stops20h 35m

Panama City Tocumen Intl

Fri 9/11

5:30 am-11:59 pm

2 stops17h 29m

$853

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of July is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $0. If you don’t want to visit Panama in July, then you should wait until April to fly from Knoxville, when ticket prices are also cheap, with an average price of $496.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Fastest flight time	12h 22m
Direct flights	None

The fastest flight from Knoxville to Panama takes 12h 22m

There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.

Search flight deals

Frequently asked questions about flying from Knoxville to Panama

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?
Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?
As of August 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Panama.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.
What documentation or ID do you need to fly to Panama?
The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $261	Free Cancellation	Rating 7.4 10,095 reviews	Search United Airlines flights
American Airlines	PriceFrom $504	Free Cancellation	Rating 7.1 11,897 reviews	Search American Airlines flights
Delta	PriceFrom $547	Free Cancellation	Rating 7.8 8,497 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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Flights to Panama Cityfrom $453

Flights to Bocas del Torofrom $705

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Flights to Changuinola

Cheap flights from Knoxville to Panama from $631

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 12/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from Knoxville to Panama

Our best Delta deals on Knoxville to Panama flight tickets

United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets

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How to get the cheapest flight ticket from Knoxville to Panama

What is the cheapest month to fly to Panama?

What airlines fly to Panama?

Cheap Knoxville to Panama flight deals and tips

Fastest flight time

Direct flights

Frequently asked questions about flying from Knoxville to Panama

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

Knoxville flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

Complete your trip to Panama

Explore popular destinations other users love

According to popular flight searches on momondo this year