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Cheap flights from Knoxville to Panama from $335

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:15 am - 6:37 pm
TYS
-
PTY
12h 22m
1 stop
United Airlines Logo
10:55 pm - 4:59 pm
PTY
-
TYS
17h 04m
2 stops
$531United Airlines
ma, aug. 17 - do, aug. 20
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 9:30 pm
PTY
-
TYS
29h 00m
1 stop
$536United Airlines
ma, aug. 17 - do, aug. 20
United Airlines Logo
7:00 am - 7:31 pm
TYS
-
PTY
13h 31m
2 stops
United Airlines Logo
7:55 am - 6:11 pm
PTY
-
TYS
9h 16m
1 stop
$547United Airlines
di, mei. 5 - di, mei. 12
United Airlines Logo
7:18 pm - 6:37 pm
TYS
-
PTY
24h 19m
2 stops
United Airlines Logo
3:30 pm - 8:45 pm
PTY
-
TYS
28h 15m
2 stops
$551United Airlines
di, mei. 5 - di, mei. 12
American Airlines Logo
5:40 am - 2:10 pm
TYS
-
PTY
9h 30m
1 stop
American Airlines Logo
3:40 pm - 11:31 pm
PTY
-
TYS
6h 51m
1 stop
$557American Airlines
za, sep. 19 - vr, sep. 25
American Airlines Logo
4:01 pm - 2:10 pm
TYS
-
PTY
23h 09m
2 stops
American Airlines Logo
3:40 pm - 10:25 am
PTY
-
TYS
17h 45m
2 stops
$561American Airlines
za, sep. 19 - vr, sep. 25
American Airlines Logo
7:10 pm - 2:20 pm
TYS
-
PTY
20h 10m
1 stop
American Airlines Logo
3:20 pm - 2:31 pm
PTY
-
TYS
22h 11m
2 stops
$573American Airlines
za, aug. 8 - vr, aug. 14
American Airlines Logo
5:40 am - 2:10 pm
TYS
-
PTY
9h 30m
1 stop
American Airlines Logo
3:40 pm - 11:31 pm
PTY
-
TYS
6h 51m
1 stop
$587American Airlines
zo, sep. 20 - ma, sep. 28
United Airlines Logo
6:30 am - 7:31 pm
TYS
-
PTY
14h 01m
2 stops
United Airlines Logo
3:30 pm - 10:05 am
PTY
-
TYS
17h 35m
2 stops
$591United Airlines
za, mei. 23 - za, mei. 30
United Airlines Logo
7:00 am - 6:37 pm
TYS
-
PTY
12h 37m
2 stops
United Airlines Logo
10:55 pm - 4:54 pm
PTY
-
TYS
16h 59m
2 stops
$601United Airlines
do, apr. 30 - zo, mei. 10

United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets
United Airlines
Aug 17
TYS7:15 amKnoxville McGhee Tyson
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Aug 20
PTY10:55 pmPanama City Tocumen Intl
17h 04m
2 stops
TYS4:59 pmKnoxville McGhee Tyson
$531
United Airlines
Aug 17
TYS7:15 amKnoxville McGhee Tyson
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 20
PTY3:30 pmPanama City Tocumen Intl
29h 00m
1 stop
TYS9:30 pmKnoxville McGhee Tyson
$536
United Airlines
May 5
TYS7:00 amKnoxville McGhee Tyson
13h 31m
2 stops
PTY7:31 pmPanama City Tocumen Intl
May 12
PTY7:55 amPanama City Tocumen Intl
9h 16m
1 stop
TYS6:11 pmKnoxville McGhee Tyson
$547

American Airlines flights from Knoxville to Panama

Our best American Airlines deals on Knoxville to Panama flight tickets
American Airlines
Sep 19
TYS5:40 amKnoxville McGhee Tyson
9h 30m
1 stop
PTY2:10 pmPanama City Tocumen Intl
Sep 25
PTY3:40 pmPanama City Tocumen Intl
6h 51m
1 stop
TYS11:31 pmKnoxville McGhee Tyson
$557
American Airlines
Sep 19
TYS4:01 pmKnoxville McGhee Tyson
23h 09m
2 stops
PTY2:10 pmPanama City Tocumen Intl
Sep 25
PTY3:40 pmPanama City Tocumen Intl
17h 45m
2 stops
TYS10:25 amKnoxville McGhee Tyson
$561
American Airlines
Aug 8
TYS7:10 pmKnoxville McGhee Tyson
20h 10m
1 stop
PTY2:20 pmPanama City Tocumen Intl
Aug 14
PTY3:20 pmPanama City Tocumen Intl
22h 11m
2 stops
TYS2:31 pmKnoxville McGhee Tyson
$573

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated maart 25, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

ma 8/17

7:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

do 8/20

10:55 pm-4:59 pm

2 stops17h 04m

$531

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

ma 8/17

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

do 8/20

3:30 pm-9:30 pm

1 stop29h 00m

$536

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

di 5/5

7:00 am-7:31 pm

2 stops13h 31m

Panama City Tocumen Intl

di 5/12

7:55 am-6:11 pm

1 stop9h 16m

$547

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

di 5/5

7:18 pm-6:37 pm

2 stops24h 19m

Panama City Tocumen Intl

di 5/12

3:30 pm-8:45 pm

2 stops28h 15m

$551
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

za 9/19

5:40 am-2:10 pm

1 stop9h 30m

Panama City Tocumen Intl

vr 9/25

3:40 pm-11:31 pm

1 stop6h 51m

$557

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

za 9/19

4:01 pm-2:10 pm

2 stops23h 09m

Panama City Tocumen Intl

vr 9/25

3:40 pm-10:25 am

2 stops17h 45m

$561

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

za 8/8

7:10 pm-2:20 pm

1 stop20h 10m

Panama City Tocumen Intl

vr 8/14

3:20 pm-2:31 pm

2 stops22h 11m

$573

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

zo 9/20

5:40 am-2:10 pm

1 stop9h 30m

Panama City Tocumen Intl

ma 9/28

3:40 pm-11:31 pm

1 stop6h 51m

$587

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

za 5/23

6:30 am-7:31 pm

2 stops14h 01m

Panama City Tocumen Intl

za 5/30

3:30 pm-10:05 am

2 stops17h 35m

$591

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

do 4/30

7:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

zo 5/10

10:55 pm-4:54 pm

2 stops16h 59m

$601

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $471. If you don’t want to visit Panama in September, then you should wait until April to fly from Knoxville, when ticket prices are also cheap, with an average price of $496.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Fastest flight time

7h 59m

Direct flights

None
The fastest flight from Knoxville to Panama takes 7h 59m
There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $261Free CancellationRating
7.4
9,478 reviews
Search United Airlines flights
American AirlinesPriceFrom $475Free CancellationRating
7.1
11,493 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

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