What is the cheapest airline that flies from Knoxville McGhee Tyson to Panama?

American Airlines and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Panama

What airlines fly to Panama?

United Airlines, Delta and American Airlines are the top three most popular airlines that fly to Panama from Knoxville according to our data. United Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

As of December 2025, there are 2 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Panama.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

What documentation or ID do you need to fly to Panama?

The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$301 Cheap Flights from Knoxville to Panama in 2025/26

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Find the cheapest flights from Knoxville to Panama

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

9:05 am - 2:45 pm

TYS

PTY

29h 40m1 stop

8:55 am - 6:05 pm

PTY

TYS

9h 10m1 stop

$485United Airlines

Sun, Jan 25 - Sun, Feb 1

5:14 pm - 1:27 pm

TYS

PTY

20h 13m2 stops

4:50 pm - 12:46 pm

PTY

TYS

19h 56m2 stops

$505American Airlines

Sun, Jan 25 - Sun, Feb 1

6:25 pm - 1:53 pm

TYS

PTY

19h 28m2 stops

4:50 pm - 10:49 am

PTY

TYS

17h 59m2 stops

$565American Airlines

Sun, Jan 4 - Sun, Jan 18

6:25 pm - 1:53 pm

TYS

PTY

19h 28m2 stops

2:27 pm - 11:34 am

PTY

TYS

21h 07m2 stops

$575American Airlines

Sun, Jan 4 - Sun, Jan 18

9:05 am - 5:07 pm

TYS

PTY

8h 02m1 stop

4:41 pm - 11:11 am

PTY

TYS

18h 30m1 stop

$626United Airlines

Mon, Dec 22 - Mon, Dec 29

1:39 pm - 4:55 pm

TYS

PTY

27h 16m3 stops

2:55 am - 5:53 pm

PTY

TYS

14h 58m2 stops

$650Multiple Airlines

Sun, Jan 25 - Sat, Jan 31

1:39 pm - 4:55 pm

TYS

PTY

27h 16m3 stops

11:25 am - 12:05 pm

PTY

TYS

24h 40m3 stops

$663Multiple Airlines

Sun, Jan 25 - Sun, Feb 1

4:22 pm - 1:53 pm

TYS

PTY

21h 31m2 stops

2:53 pm - 12:38 am

PTY

TYS

9h 45m1 stop

$720American Airlines

Mon, Dec 22 - Mon, Dec 29

5:15 am - 1:53 pm

TYS

PTY

8h 38m1 stop

4:50 pm - 11:34 am

PTY

TYS

18h 44m2 stops

$721American Airlines

Sun, Jan 4 - Sun, Jan 18

7:01 pm - 1:53 pm

TYS

PTY

18h 52m1 stop

2:53 pm - 12:38 am

PTY

TYS

9h 45m1 stop

$732American Airlines

Mon, Dec 22 - Mon, Dec 29

American Airlines flights from Knoxville to Panama

Our best American Airlines deals on Knoxville to Panama flight tickets

American Airlines

Jan 25

TYS5:14 pmKnoxville McGhee Tyson

20h 13m

2 stops

PTY1:27 pmPanama City Tocumen Intl

Feb 1

PTY4:50 pmPanama City Tocumen Intl

19h 56m

2 stops

TYS12:46 pmKnoxville McGhee Tyson

$505

Find similar

American Airlines

Jan 4

TYS6:25 pmKnoxville McGhee Tyson

19h 28m

2 stops

PTY1:53 pmPanama City Tocumen Intl

Jan 18

PTY4:50 pmPanama City Tocumen Intl

17h 59m

2 stops

TYS10:49 amKnoxville McGhee Tyson

$565

Find similar

American Airlines

Jan 4

TYS6:25 pmKnoxville McGhee Tyson

19h 28m

2 stops

PTY1:53 pmPanama City Tocumen Intl

Jan 18

PTY2:27 pmPanama City Tocumen Intl

21h 07m

2 stops

TYS11:34 amKnoxville McGhee Tyson

$575

Find similar

United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets

United Airlines

Jan 25

TYS9:05 amKnoxville McGhee Tyson

29h 40m

1 stop

PTY2:45 pmPanama City Tocumen Intl

Feb 1

PTY8:55 amPanama City Tocumen Intl

9h 10m

1 stop

TYS6:05 pmKnoxville McGhee Tyson

$485

Find similar

United Airlines

Dec 22

TYS9:05 amKnoxville McGhee Tyson

8h 02m

1 stop

PTY5:07 pmPanama City Tocumen Intl

Dec 29

PTY4:41 pmPanama City Tocumen Intl

18h 30m

1 stop

TYS11:11 amKnoxville McGhee Tyson

$626

Find similar

United Airlines

Jan 4

TYS7:00 amKnoxville McGhee Tyson

10h 07m

1 stop

PTY5:07 pmPanama City Tocumen Intl

Jan 18

PTY4:41 pmPanama City Tocumen Intl

25h 24m

1 stop

TYS6:05 pmKnoxville McGhee Tyson

$776

Find similar

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/25

9:05 am-2:45 pm

1 stop29h 40m

Panama City Tocumen Intl

Sun 2/1

8:55 am-6:05 pm

1 stop9h 10m

$485

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/25

5:14 pm-1:27 pm

2 stops20h 13m

Panama City Tocumen Intl

Sun 2/1

4:50 pm-12:46 pm

2 stops19h 56m

$505

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

6:25 pm-1:53 pm

2 stops19h 28m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-10:49 am

2 stops17h 59m

$565

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

6:25 pm-1:53 pm

2 stops19h 28m

Panama City Tocumen Intl

Sun 1/18

2:27 pm-11:34 am

2 stops21h 07m

$575

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 12/22

9:05 am-5:07 pm

1 stop8h 02m

Panama City Tocumen Intl

Mon 12/29

4:41 pm-11:11 am

1 stop18h 30m

$626

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/25

1:39 pm-4:55 pm

3 stops27h 16m

Panama City Tocumen Intl

Sat 1/31

2:55 am-5:53 pm

2 stops14h 58m

$650

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/25

1:39 pm-4:55 pm

3 stops27h 16m

Panama City Tocumen Intl

Sun 2/1

11:25 am-12:05 pm

3 stops24h 40m

$663

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 12/22

4:22 pm-1:53 pm

2 stops21h 31m

Panama City Tocumen Intl

Mon 12/29

2:53 pm-12:38 am

1 stop9h 45m

$720

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

5:15 am-1:53 pm

1 stop8h 38m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-11:34 am

2 stops18h 44m

$721

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 12/22

7:01 pm-1:53 pm

1 stop18h 52m

Panama City Tocumen Intl

Mon 12/29

2:53 pm-12:38 am

1 stop9h 45m

$732

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $471. If you don’t want to visit Panama in September, then you should wait until February to fly from Knoxville, when ticket prices are also cheap, with an average price of $497.

What is the cheapest day to depart on your flight to Panama?

According to our data, Friday is the cheapest day to fly to Panama from Knoxville. The lowest ticket price found for a Friday departure recently was $517. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Panama for around $818.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Fastest flight time	7h 46m
Direct flights	None

The fastest flight from Knoxville to Panama takes 7h 46m

There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.

Search flight deals

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?
Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?
As of December 2025, there are 2 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Panama.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.
What documentation or ID do you need to fly to Panama?
The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $387	Free Cancellation	Rating 7.4 9,095 reviews		Search United Airlines flights
American Airlines	PriceFrom $440	Free Cancellation	Rating 7.2 11,050 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.