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Cheap flights from Knoxville to Panama from $216

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:05 am - 4:12 pm
TYS
-
PTY
10h 07m
1 stop
United Airlines Logo
7:55 am - 11:41 pm
PTY
-
TYS
14h 46m
1 stop
$477United Airlines
Sun, Mar 29 - Wed, Apr 8
American Airlines Logo
5:47 pm - 3:01 pm
TYS
-
PTY
22h 14m
2 stops
American Airlines Logo
1:49 pm - 12:30 pm
PTY
-
TYS
21h 41m
2 stops
$501American Airlines
Sun, Mar 29 - Wed, Apr 8
United Airlines Logo
9:10 am - 7:38 pm
TYS
-
PTY
10h 28m
1 stop
United Airlines Logo
4:41 pm - 1:46 pm
PTY
-
TYS
21h 05m
1 stop
$546United Airlines
Fri, Feb 27 - Tue, Mar 3
United Airlines Logo
7:05 am - 7:38 pm
TYS
-
PTY
12h 33m
1 stop
United Airlines Logo
4:41 pm - 1:46 pm
PTY
-
TYS
21h 05m
1 stop
$547United Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
4:15 pm - 12:41 pm
TYS
-
PTY
21h 26m
2 stops
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
TYS
9h 10m
1 stop
$551American Airlines
Sun, Mar 29 - Wed, Apr 8
United Airlines Logo
9:10 am - 7:38 pm
TYS
-
PTY
10h 28m
1 stop
United Airlines Logo
8:55 am - 7:55 pm
PTY
-
TYS
11h 00m
1 stop
$557United Airlines
Fri, Feb 27 - Tue, Mar 3
American Airlines Logo
6:38 pm - 3:15 pm
TYS
-
PTY
20h 37m
2 stops
American Airlines Logo
2:40 pm - 11:57 am
PTY
-
TYS
21h 17m
2 stops
$561American Airlines
Thu, Feb 26 - Mon, Mar 2
United Airlines Logo
11:41 am - 7:38 pm
TYS
-
PTY
7h 57m
1 stop
United Airlines Logo
4:41 pm - 6:10 pm
PTY
-
TYS
25h 29m
1 stop
$567United Airlines
Fri, Feb 27 - Tue, Mar 3
American Airlines Logo
6:15 am - 12:46 pm
TYS
-
PTY
7h 31m
1 stop
American Airlines Logo
1:49 pm - 11:18 am
PTY
-
TYS
20h 29m
2 stops
$571American Airlines
Tue, Apr 14 - Sat, Apr 18
American Airlines Logo
5:47 pm - 12:40 pm
TYS
-
PTY
19h 53m
2 stops
American Airlines Logo
1:40 pm - 10:10 am
PTY
-
TYS
19h 30m
2 stops
$611American Airlines
Thu, Mar 12 - Mon, Mar 16

Avianca flights from Knoxville to Panama

Our best Avianca deals on Knoxville to Panama flight tickets
Avianca
Feb 20
TYS7:25 pmKnoxville McGhee Tyson
15h 05m
2 stops
PTY10:30 amPanama City Tocumen Intl
Feb 23
PTY7:50 pmPanama City Tocumen Intl
14h 59m
2 stops
TYS10:49 amKnoxville McGhee Tyson
$696
Avianca
Feb 20
TYS7:25 pmKnoxville McGhee Tyson
23h 30m
2 stops
PTY6:55 pmPanama City Tocumen Intl
Feb 23
PTY11:25 amPanama City Tocumen Intl
23h 24m
3 stops
TYS10:49 amKnoxville McGhee Tyson
$919
Avianca
Feb 26
TYS9:40 amKnoxville McGhee Tyson
29h 15m
3 stops
PTY2:55 pmPanama City Tocumen Intl
Mar 2
PTY7:50 pmPanama City Tocumen Intl
14h 59m
2 stops
TYS10:49 amKnoxville McGhee Tyson
$1,015

United Airlines flights from Knoxville to Panama

Our best United Airlines deals on Knoxville to Panama flight tickets
United Airlines
Mar 29
TYS7:05 amKnoxville McGhee Tyson
10h 07m
1 stop
PTY4:12 pmPanama City Tocumen Intl
Apr 8
PTY7:55 amPanama City Tocumen Intl
14h 46m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$477
United Airlines
Feb 26
TYS9:10 amKnoxville McGhee Tyson
10h 28m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Mar 2
PTY11:35 amPanama City Tocumen Intl
26h 11m
1 stop
TYS1:46 pmKnoxville McGhee Tyson
$547
United Airlines
Feb 27
TYS11:41 amKnoxville McGhee Tyson
7h 57m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Mar 3
PTY8:55 amPanama City Tocumen Intl
11h 00m
1 stop
TYS7:55 pmKnoxville McGhee Tyson
$557

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 3/29

7:05 am-4:12 pm

1 stop10h 07m

Panama City Tocumen Intl

Wed 4/8

7:55 am-11:41 pm

1 stop14h 46m

$477

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 3/29

5:47 pm-3:01 pm

2 stops22h 14m

Panama City Tocumen Intl

Wed 4/8

1:49 pm-12:30 pm

2 stops21h 41m

$501

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/27

9:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-1:46 pm

1 stop21h 05m

$546

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 2/26

7:05 am-7:38 pm

1 stop12h 33m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-1:46 pm

1 stop21h 05m

$547

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 3/29

4:15 pm-12:41 pm

2 stops21h 26m

Panama City Tocumen Intl

Wed 4/8

1:49 pm-11:59 pm

1 stop9h 10m

$551

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/27

9:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Tue 3/3

8:55 am-7:55 pm

1 stop11h 00m

$557

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 2/26

6:38 pm-3:15 pm

2 stops20h 37m

Panama City Tocumen Intl

Mon 3/2

2:40 pm-11:57 am

2 stops21h 17m

$561

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/27

11:41 am-7:38 pm

1 stop7h 57m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-6:10 pm

1 stop25h 29m

$567

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 4/14

6:15 am-12:46 pm

1 stop7h 31m

Panama City Tocumen Intl

Sat 4/18

1:49 pm-11:18 am

2 stops20h 29m

$571

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 3/12

5:47 pm-12:40 pm

2 stops19h 53m

Panama City Tocumen Intl

Mon 3/16

1:40 pm-10:10 am

2 stops19h 30m

$611

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of September is, on average, the cheapest month to fly to Panama from Knoxville, with most prices found around $471. If you don’t want to visit Panama in September, then you should wait until May to fly from Knoxville, when ticket prices are also cheap, with an average price of $504.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Fastest flight time

8h 12m

Direct flights

None
The fastest flight from Knoxville to Panama takes 8h 12m
There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $312Free CancellationRating
7.4
9,249 reviews
Search United Airlines flights
American AirlinesPriceFrom $475Free CancellationRating
7.2
11,248 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to Panama

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