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Cheap flights from Knoxville to Panama from $221

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Panama

Cheap round-trip flights

United Airlines Logo
7:00 am - 7:38 pmTYS-PTY
12h 38m1 stop
United Airlines Logo
4:41 pm - 8:09 pmPTY-TYS
27h 28m1 stop
$497United Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
American Airlines Logo
5:07 pm - 1:36 pmTYS-PTY
20h 29m1 stop
American Airlines Logo
2:43 pm - 12:43 pmPTY-TYS
22h 00m2 stops
$507American Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
American Airlines Logo
6:03 am - 2:03 pmTYS-PTY
9h 00m2 stops
American Airlines Logo
3:15 pm - 1:36 pmPTY-TYS
21h 21m2 stops
$512American Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 18
United Airlines Logo
9:30 am - 6:37 pmTYS-PTY
10h 07m1 stop
United Airlines Logo
3:30 pm - 7:52 pmPTY-TYS
27h 22m1 stop
$517United Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 18
American Airlines Logo
7:45 pm - 2:31 pmTYS-PTY
19h 46m2 stops
American Airlines Logo
3:15 pm - 9:32 amPTY-TYS
17h 17m2 stops
$532American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 11
Delta Logo
5:30 am - 1:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
8:05 am - 3:06 pmPTY-TYS
7h 01m1 stop
$557Delta
Find Deal
Mon, Jan 5 - Sun, Jan 18
American Airlines Logo
7:51 pm - 3:35 pmTYS-PTY
19h 44m2 stops
American Airlines Logo
4:40 pm - 11:23 amPTY-TYS
18h 43m2 stops
$567American Airlines
Find Deal
Mon, Jan 5 - Sun, Jan 18
Logo
7:02 pm - 4:30 pmTYS-PTY
22h 28m3 stops
Logo
5:25 pm - 8:11 pmPTY-TYS
25h 46m2 stops
$577
Find Deal
Fri, Oct 10 - Sat, Oct 18
Avianca Logo
7:23 pm - 12:50 pmTYS-PTY
17h 27m3 stops
Avianca Logo
2:55 am - 6:42 pmPTY-TYS
15h 47m2 stops
$2,204Avianca
Find Deal
Mon, Jan 5 - Sat, Jan 17
Avianca Logo
7:23 pm - 10:20 amTYS-PTY
14h 57m2 stops
Avianca Logo
2:55 am - 6:42 pmPTY-TYS
15h 47m2 stops
$2,278Avianca
Find Deal
Mon, Jan 5 - Sat, Jan 17

American Airlines flights from Knoxville to Panama

Our best American Airlines deals on Knoxville to Panama flight tickets
American Airlines
Nov 13
TYS5:07 pmKnoxville McGhee Tyson
20h 29m
1 stop
PTY1:36 pmPanama City Tocumen Intl
Nov 16
PTY2:43 pmPanama City Tocumen Intl
22h 00m
2 stops
TYS12:43 pmKnoxville McGhee Tyson
$507
Find similar
American Airlines
Oct 11
TYS6:03 amKnoxville McGhee Tyson
9h 00m
2 stops
PTY2:03 pmPanama City Tocumen Intl
Oct 18
PTY3:15 pmPanama City Tocumen Intl
21h 21m
2 stops
TYS1:36 pmKnoxville McGhee Tyson
$512
Find similar
American Airlines
Oct 4
TYS7:45 pmKnoxville McGhee Tyson
19h 46m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Oct 11
PTY3:15 pmPanama City Tocumen Intl
17h 17m
2 stops
TYS9:32 amKnoxville McGhee Tyson
$532
Find similar

Avianca flights from Knoxville to Panama

Our best Avianca deals on Knoxville to Panama flight tickets
Avianca
Jan 5
TYS7:23 pmKnoxville McGhee Tyson
17h 27m
3 stops
PTY12:50 pmPanama City Tocumen Intl
Jan 17
PTY2:55 amPanama City Tocumen Intl
15h 47m
2 stops
TYS6:42 pmKnoxville McGhee Tyson
$2,204
Find similar
Avianca
Jan 5
TYS7:23 pmKnoxville McGhee Tyson
14h 57m
2 stops
PTY10:20 amPanama City Tocumen Intl
Jan 17
PTY2:55 amPanama City Tocumen Intl
15h 47m
2 stops
TYS6:42 pmKnoxville McGhee Tyson
$2,278
Find similar
Avianca
Nov 13
TYS9:50 amKnoxville McGhee Tyson
15h 10m
2 stops
PTY1:00 amPanama City Tocumen Intl
Nov 15
PTY2:55 amPanama City Tocumen Intl
17h 25m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
$2,475
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 11/13

7:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Sun 11/16

4:41 pm-8:09 pm

1 stop27h 28m

$497

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 11/13

5:07 pm-1:36 pm

1 stop20h 29m

Panama City Tocumen Intl

Sun 11/16

2:43 pm-12:43 pm

2 stops22h 00m

$507

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 10/11

6:03 am-2:03 pm

2 stops9h 00m

Panama City Tocumen Intl

Sat 10/18

3:15 pm-1:36 pm

2 stops21h 21m

$512

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 10/11

9:30 am-6:37 pm

1 stop10h 07m

Panama City Tocumen Intl

Sat 10/18

3:30 pm-7:52 pm

1 stop27h 22m

$517

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 10/4

7:45 pm-2:31 pm

2 stops19h 46m

Panama City Tocumen Intl

Sat 10/11

3:15 pm-9:32 am

2 stops17h 17m

$532

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/5

5:30 am-1:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Sun 1/18

8:05 am-3:06 pm

1 stop7h 01m

$557

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/5

7:51 pm-3:35 pm

2 stops19h 44m

Panama City Tocumen Intl

Sun 1/18

4:40 pm-11:23 am

2 stops18h 43m

$567

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 10/10

7:02 pm-4:30 pm

3 stops22h 28m

Panama City Tocumen Intl

Sat 10/18

5:25 pm-8:11 pm

2 stops25h 46m

$577

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/5

7:23 pm-12:50 pm

3 stops17h 27m

Panama City Tocumen Intl

Sat 1/17

2:55 am-6:42 pm

2 stops15h 47m

$2,204

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/5

7:23 pm-10:20 am

2 stops14h 57m

Panama City Tocumen Intl

Sat 1/17

2:55 am-6:42 pm

2 stops15h 47m

$2,278

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Knoxville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama?

According to our data, Friday is the cheapest day to fly to Panama from Knoxville. The lowest ticket price found for a Friday departure recently was $517. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Panama for around $818.

Cheap Knoxville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama

Direct flights

None
There are no direct flights from Knoxville to Panama. There are no popular flight routes from Knoxville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Panama

Compare and see reviews for airlines that fly from Knoxville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $387Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
DeltaPriceFrom $427Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $440Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Panama?

momondo helps you find the best flight between Knoxville and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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