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Cheap flights from Knoxville to Chicago from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 11/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:55 pm - 12:50 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
18h 55m1 stop Fort Lauderdale
Multiple Airlines Logo
7:11 am - 10:04 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
25h 53m1 stop Fort Lauderdale
$236Multiple Airlines
Sat, Sep 5 - Sat, Sep 12
Multiple Airlines Logo
6:56 pm - 12:50 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
18h 54m1 stop Fort Lauderdale
Multiple Airlines Logo
8:05 am - 10:04 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
24h 59m1 stop Fort Lauderdale
$236Multiple Airlines
Sat, Aug 29 - Tue, Sep 1
Multiple Airlines Logo
5:40 pm - 3:20 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
22h 40m1 stop Fort Lauderdale
Multiple Airlines Logo
7:11 am - 4:31 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
8h 20m1 stop Fort Lauderdale
$237Multiple Airlines
Mon, Sep 14 - Thu, Sep 17
Multiple Airlines Logo
2:51 pm - 11:08 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
9h 17m1 stop Orlando
Multiple Airlines Logo
8:05 am - 10:04 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
24h 59m1 stop Fort Lauderdale
$241Multiple Airlines
Mon, Aug 24 - Sat, Aug 29
American Airlines Logo
7:59 am - 9:10 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
2h 11mnonstop
American Airlines Logo
8:18 am - 11:10 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 52mnonstop
$259American Airlines
Sat, Sep 5 - Mon, Sep 7
American Airlines Logo
11:20 am - 12:18 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 58mnonstop
American Airlines Logo
8:15 am - 11:05 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 50mnonstop
$259American Airlines
Sat, Sep 19 - Sun, Sep 20
United Airlines Logo
7:00 am - 7:56 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 56mnonstop
United Airlines Logo
6:59 am - 9:59 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
2h 00mnonstop
$259United Airlines
Fri, Sep 4 - Mon, Sep 7
United Airlines Logo
6:00 am - 6:55 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 55mnonstop
United Airlines Logo
8:02 pm - 10:49 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 47mnonstop
$259United Airlines
Sun, Sep 13 - Sun, Sep 20
American Airlines Logo
8:00 am - 9:10 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
2h 10mnonstop
American Airlines Logo
7:51 pm - 10:42 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 51mnonstop
$259American Airlines
Fri, Sep 18 - Tue, Sep 22
United Airlines Logo
7:00 am - 7:56 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 56mnonstop
United Airlines Logo
9:30 pm - 12:23 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 53mnonstop
$259United Airlines
Fri, Sep 4 - Tue, Sep 8

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American Airlines flights from Knoxville to Chicago O'Hare Intl Airport

Our best American Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
American Airlines
Sep 3
TYS7:34 amKnoxville McGhee Tyson
2h 11m
ORD8:45 amChicago O'Hare Intl
Sep 7
ORD8:18 amChicago O'Hare Intl
1h 52m
TYS11:10 amKnoxville McGhee Tyson
$259
American Airlines
Sep 3
TYS6:05 pmKnoxville McGhee Tyson
6h 47m
1 stop
ORD11:52 pmChicago O'Hare Intl
Sep 7
ORD8:18 amChicago O'Hare Intl
1h 52m
TYS11:10 amKnoxville McGhee Tyson
$269
American Airlines
Aug 25
TYS1:21 pmKnoxville McGhee Tyson
2h 02m
ORD2:23 pmChicago O'Hare Intl
Sep 1
ORD10:00 amChicago O'Hare Intl
1h 46m
TYS12:46 pmKnoxville McGhee Tyson
$274

United Airlines flights from Knoxville to Chicago O'Hare Intl Airport

Our best United Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
United Airlines
Aug 28
TYS10:40 amKnoxville McGhee Tyson
2h 04m
ORD11:44 amChicago O'Hare Intl
Sep 13
ORD7:00 amChicago O'Hare Intl
1h 54m
TYS9:54 amKnoxville McGhee Tyson
$274
United Airlines
Aug 20
TYS6:02 pmKnoxville McGhee Tyson
1h 57m
ORD6:59 pmChicago O'Hare Intl
Aug 23
ORD2:10 pmChicago O'Hare Intl
1h 48m
TYS4:58 pmKnoxville McGhee Tyson
$319

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Sat 9/5

6:55 pm-12:50 pm

1 stop18h 55m

Chicago O'Hare Intl

Sat 9/12

7:11 am-10:04 am

1 stop25h 53m

$236

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Sat 8/29

6:56 pm-12:50 pm

1 stop18h 54m

Chicago O'Hare Intl

Tue 9/1

8:05 am-10:04 am

1 stop24h 59m

$236

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Mon 9/14

5:40 pm-3:20 pm

1 stop22h 40m

Chicago O'Hare Intl

Thu 9/17

7:11 am-4:31 pm

1 stop8h 20m

$237

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Mon 8/24

2:51 pm-11:08 pm

1 stop9h 17m

Chicago O'Hare Intl

Sat 8/29

8:05 am-10:04 am

1 stop24h 59m

$241

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Sat 9/5

7:59 am-9:10 am

Nonstop2h 11m

Chicago O'Hare Intl

Mon 9/7

8:18 am-11:10 am

Nonstop1h 52m

$259

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Sat 9/19

11:20 am-12:18 pm

Nonstop1h 58m

Chicago O'Hare Intl

Sun 9/20

8:15 am-11:05 am

Nonstop1h 50m

$259

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Fri 9/4

7:00 am-7:56 am

Nonstop1h 56m

Chicago O'Hare Intl

Mon 9/7

6:59 am-9:59 am

Nonstop2h 00m

$259
Quickest round-trip

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Sun 9/13

6:00 am-6:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Sun 9/20

8:02 pm-10:49 pm

Nonstop1h 47m

$259

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Fri 9/18

8:00 am-9:10 am

Nonstop2h 10m

Chicago O'Hare Intl

Tue 9/22

7:51 pm-10:42 pm

Nonstop1h 51m

$259

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Fri 9/4

7:00 am-7:56 am

Nonstop1h 56m

Chicago O'Hare Intl

Tue 9/8

9:30 pm-12:23 am

Nonstop1h 53m

$259

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Chicago O'Hare Intl Airport?

Prices are currently low for flights on this route.

Typical prices usually range from $249 to $339.
The lowest price recently found on this route was $236.

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of April is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Knoxville averaging around $264.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $401. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $795.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $500 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $844. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago O'Hare Intl flight route?

Fly from Knoxville McGhee Tyson to Chicago O'Hare Intl for the best Knoxville McGhee Tyson - Chicago O'Hare Intl flight prices

How far in advance should I book a flight from Knoxville to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $315 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Knoxville for as low as $241 on momondo.

What cabin class options are available on Knoxville to Chicago O'Hare Intl Airport flights?

There are 4 cabin classes available to choose from on Knoxville to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Knoxville to Chicago O'Hare Intl Airport flight prices changed over time?

As of August 2026, prices for Knoxville to Chicago O'Hare Intl Airport flights are approximately 69% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago O'Hare Intl Airport (TYS to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago O'Hare Intl Airport

Best Price Found

$244

Fastest flight time

1h 55m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Knoxville in the past 72 hours is $244. The best round-trip flight deal from Knoxville to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $319.
The fastest flight from Knoxville to Chicago O'Hare Intl Airport takes 1h 55m
Direct flights go from Knoxville to Chicago O'Hare Intl Airport every day.
Search flight deals

Frequently asked questions about flying from Knoxville to Chicago O'Hare Intl Airport

  • How far is Knoxville McGhee Tyson to Chicago O'Hare Intl by plane?

    The straight-line distance from Knoxville McGhee Tyson to Chicago O'Hare Intl is 467.2 mi. 1h 55m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Knoxville to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Knoxville to Chicago O'Hare Intl Airport?

Best airlines flying from Knoxville to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $189Free CancellationRating
7.4
10,101 reviews
Search United Airlines flights
American AirlinesPriceFrom $189Free CancellationRating
7.1
11,902 reviews
Search American Airlines flights

  • United Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    United Airlines is one of the most popular airlines flying from Knoxville to Chicago O'Hare Intl Airport, operating 4 flights/week on average for this route. A good United Airlines flight deal for Knoxville to Chicago O'Hare Intl Airport starts from $189 round-trip, up to an average price of $319. Our users have rated United Airlines at 7.4/10.

  • American Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    American Airlines is also a popular choice for this route. American Airlines flight deals for Knoxville to Chicago O'Hare Intl Airport start from as low as $189 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $312. American Airlines operates 18 flights to Chicago O'Hare Intl Airport from Knoxville in an average week. Users have rated it 7.1/10 across 11,902 reviews.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
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Rockford
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Gurnee
Rosemont
Oak Brook
Orland Park
Naperville
Joliet
New Buffalo
Kenosha
Hammond
Racine
Aurora
Janesville
Elgin
South Holland
Evanston

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Chicago for you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

All flight searches from Knoxville to Chicago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Knoxville.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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