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Cheap flights from Knoxville to Chicago from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 8/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:20 pm - 11:10 pm
TYS
-
ORD
28h 50m
1 stop
Multiple Airlines Logo
8:05 am - 10:26 am
ORD
-
TYS
25h 21m
1 stop
$222Multiple Airlines
Mon, Aug 3 - Fri, Aug 7
Multiple Airlines Logo
4:52 pm - 12:25 pm
TYS
-
ORD
20h 33m
1 stop
Multiple Airlines Logo
7:55 am - 10:04 am
ORD
-
TYS
25h 09m
1 stop
$230Multiple Airlines
Thu, Aug 20 - Tue, Aug 25
Multiple Airlines Logo
3:49 pm - 12:25 pm
TYS
-
ORD
21h 36m
1 stop
Multiple Airlines Logo
7:55 am - 10:04 am
ORD
-
TYS
25h 09m
1 stop
$231Multiple Airlines
Wed, Aug 26 - Sat, Aug 29
Multiple Airlines Logo
7:20 pm - 11:10 pm
TYS
-
ORD
28h 50m
1 stop
Multiple Airlines Logo
5:30 pm - 11:12 pm
ORD
-
TYS
28h 42m
1 stop
$236Multiple Airlines
Mon, Aug 3 - Thu, Aug 6
Multiple Airlines Logo
6:54 pm - 12:25 pm
TYS
-
ORD
18h 31m
1 stop
Multiple Airlines Logo
7:55 am - 4:02 pm
ORD
-
TYS
7h 07m
1 stop
$243Multiple Airlines
Mon, Aug 24 - Thu, Aug 27
American Airlines Logo
1:00 pm - 1:59 pm
TYS
-
ORD
1h 59mnonstop
American Airlines Logo
3:13 pm - 6:02 pm
ORD
-
TYS
1h 49mnonstop
$249American Airlines
Wed, Jul 8 - Wed, Jul 15
American Airlines Logo
7:02 am - 8:10 am
TYS
-
ORD
2h 08mnonstop
American Airlines Logo
7:09 pm - 9:58 pm
ORD
-
TYS
1h 49mnonstop
$250American Airlines
Mon, Jul 27 - Mon, Aug 3
American Airlines Logo
7:02 am - 8:10 am
TYS
-
ORD
2h 08mnonstop
American Airlines Logo
2:55 pm - 9:33 pm
ORD
-
TYS
5h 38m
1 stop
$259American Airlines
Wed, Jul 8 - Wed, Jul 15
United Airlines Logo
6:00 am - 6:59 am
TYS
-
ORD
1h 59mnonstop
United Airlines Logo
5:55 pm - 8:44 pm
ORD
-
TYS
1h 49mnonstop
$260United Airlines
Thu, Jul 9 - Thu, Jul 16
Frontier Logo
8:32 pm - 8:43 pm
TYS
-
ORD
25h 11m
1 stop
Frontier Logo
9:57 pm - 7:24 pm
ORD
-
TYS
20h 27m
1 stop
$262Frontier
Fri, Jul 3 - Tue, Jul 7

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American Airlines flights from Knoxville to Chicago O'Hare Intl Airport

Our best American Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
American Airlines
Jul 8
TYS1:00 pmKnoxville McGhee Tyson
1h 59m
ORD1:59 pmChicago O'Hare Intl
Jul 15
ORD3:13 pmChicago O'Hare Intl
1h 49m
TYS6:02 pmKnoxville McGhee Tyson
$249
American Airlines
Jul 27
TYS7:02 amKnoxville McGhee Tyson
2h 08m
ORD8:10 amChicago O'Hare Intl
Aug 3
ORD7:09 pmChicago O'Hare Intl
1h 49m
TYS9:58 pmKnoxville McGhee Tyson
$250
American Airlines
Jul 8
TYS7:02 amKnoxville McGhee Tyson
2h 08m
ORD8:10 amChicago O'Hare Intl
Jul 15
ORD2:55 pmChicago O'Hare Intl
5h 38m
1 stop
TYS9:33 pmKnoxville McGhee Tyson
$259

Frontier flights from Knoxville to Chicago O'Hare Intl Airport

Our best Frontier deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
Frontier
Jul 3
TYS8:32 pmKnoxville McGhee Tyson
25h 11m
1 stop
ORD8:43 pmChicago O'Hare Intl
Jul 7
ORD9:57 pmChicago O'Hare Intl
20h 27m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
$262
Frontier
Aug 12
TYS8:19 pmKnoxville McGhee Tyson
25h 33m
1 stop
ORD8:52 pmChicago O'Hare Intl
Aug 16
ORD9:57 pmChicago O'Hare Intl
20h 27m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
$272

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Knoxville to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-11:10 pm

1 stop28h 50m

Chicago O'Hare Intl

Fri 8/7

8:05 am-10:26 am

1 stop25h 21m

$222

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 8/20

4:52 pm-12:25 pm

1 stop20h 33m

Chicago O'Hare Intl

Tue 8/25

7:55 am-10:04 am

1 stop25h 09m

$230

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 8/26

3:49 pm-12:25 pm

1 stop21h 36m

Chicago O'Hare Intl

Sat 8/29

7:55 am-10:04 am

1 stop25h 09m

$231

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-11:10 pm

1 stop28h 50m

Chicago O'Hare Intl

Thu 8/6

5:30 pm-11:12 pm

1 stop28h 42m

$236

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 8/24

6:54 pm-12:25 pm

1 stop18h 31m

Chicago O'Hare Intl

Thu 8/27

7:55 am-4:02 pm

1 stop7h 07m

$243
Quickest round-trip

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 7/8

1:00 pm-1:59 pm

Nonstop1h 59m

Chicago O'Hare Intl

Wed 7/15

3:13 pm-6:02 pm

Nonstop1h 49m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 7/27

7:02 am-8:10 am

Nonstop2h 08m

Chicago O'Hare Intl

Mon 8/3

7:09 pm-9:58 pm

Nonstop1h 49m

$250

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 7/8

7:02 am-8:10 am

Nonstop2h 08m

Chicago O'Hare Intl

Wed 7/15

2:55 pm-9:33 pm

1 stop5h 38m

$259

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 7/9

6:00 am-6:59 am

Nonstop1h 59m

Chicago O'Hare Intl

Thu 7/16

5:55 pm-8:44 pm

Nonstop1h 49m

$260

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 7/3

8:32 pm-8:43 pm

1 stop25h 11m

Chicago O'Hare Intl

Tue 7/7

9:57 pm-7:24 pm

1 stop20h 27m

$262

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Chicago O'Hare Intl Airport?

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of April is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Knoxville averaging around $264.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $388. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $788.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $497 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $738. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago O'Hare Intl flight route?

Fly from Knoxville McGhee Tyson to Chicago O'Hare Intl for the best Knoxville McGhee Tyson - Chicago O'Hare Intl flight prices

How far in advance should I book a flight from Knoxville to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $305 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Knoxville for as low as $193 on momondo.

What cabin class options are available on Knoxville to Chicago O'Hare Intl Airport flights?

There are 4 cabin classes available to choose from on Knoxville to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Knoxville to Chicago O'Hare Intl Airport flight prices changed over time?

As of June 2026, prices for Knoxville to Chicago O'Hare Intl Airport flights are approximately 34% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago O'Hare Intl Airport (TYS to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago O'Hare Intl Airport

Best Price Found

$255

Fastest flight time

1h 55m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Knoxville in the past 72 hours is $255. The best round-trip flight deal from Knoxville to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $397.
The fastest flight from Knoxville to Chicago O'Hare Intl Airport takes 1h 55m
Direct flights go from Knoxville to Chicago O'Hare Intl Airport every day.
Search flight deals

Frequently asked questions about flying from Knoxville to Chicago O'Hare Intl Airport

  • How far is Knoxville McGhee Tyson to Chicago O'Hare Intl by plane?

    The straight-line distance from Knoxville McGhee Tyson to Chicago O'Hare Intl is 467.2 mi. 1h 55m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Knoxville to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Knoxville to Chicago O'Hare Intl Airport?

Best airlines flying from Knoxville to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $189Free CancellationRating
7.4
9,830 reviews
Search United Airlines flights
American AirlinesPriceFrom $189Free CancellationRating
7.1
11,660 reviews
Search American Airlines flights

  • United Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    United Airlines is one of the most popular airlines flying from Knoxville to Chicago O'Hare Intl Airport, operating 29 flights/week on average for this route. A good United Airlines flight deal for Knoxville to Chicago O'Hare Intl Airport starts from $189 round-trip, up to an average price of $316. Our users have rated United Airlines at 7.4/10.

  • American Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    American Airlines is also a popular choice for this route. American Airlines flight deals for Knoxville to Chicago O'Hare Intl Airport start from as low as $189 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $304. American Airlines operates 18 flights to Chicago O'Hare Intl Airport from Knoxville in an average week. Users have rated it 7.1/10 across 11,660 reviews.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
South Haven
Rockford
Merrillville
Gurnee
Rosemont
Naperville
Orland Park
Oak Brook
New Buffalo
Joliet
Kenosha
Aurora
Hammond
Racine
Janesville
Evanston
Elgin
South Holland

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Chicago for you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

All flight searches from Knoxville to Chicago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Knoxville.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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