Cheap flights from Knoxville to Chicago from $95
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 12/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Not ready to book? to track prices.American Airlines flights from Knoxville to Chicago O'Hare Intl Airport
Our best American Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
Delta flights from Knoxville to Chicago O'Hare Intl Airport
Our best Delta deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
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Fly from
Fly to
Route
Depart
Return
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Wed 11/18
4:59 pm-6:15 pm
Nonstop2h 16m
Chicago O'Hare Intl
Sat 11/21
6:49 pm-11:59 pm
1 stop4h 10m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Wed 11/18
8:13 am-2:19 pm
1 stop7h 06m
Chicago O'Hare Intl
Wed 11/25
8:55 pm-11:47 pm
Nonstop1h 52m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Fri 11/6
6:48 am-11:34 am
1 stop5h 46m
Chicago O'Hare Intl
Fri 11/13
8:55 pm-11:47 pm
Nonstop1h 52m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Sat 12/12
7:16 am-12:19 pm
1 stop6h 03m
Chicago O'Hare Intl
Fri 1/1
8:11 am-11:02 am
Nonstop1h 51m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Fri 11/6
1:17 pm-10:43 pm
1 stop10h 26m
Chicago O'Hare Intl
Fri 11/13
7:50 pm-11:23 am
2 stops38h 33m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Thu 12/10
11:00 am-7:20 am
2 stops21h 20m
Chicago O'Hare Intl
Sun 12/13
9:34 pm-6:42 pm
1 stop20h 08m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Thu 10/22
9:05 am-3:30 pm
1 stop7h 25m
Chicago O'Hare Intl
Tue 10/27
7:50 pm-11:29 am
2 stops38h 39m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Sat 12/12
6:25 am-7:31 am
Nonstop2h 06m
Chicago O'Hare Intl
Sun 12/13
7:18 am-10:14 am
Nonstop1h 56m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Fri 11/6
6:45 am-7:54 am
Nonstop2h 09m
Chicago O'Hare Intl
Sun 11/8
2:07 pm-4:59 pm
Nonstop1h 52m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Fri 11/6
6:45 am-7:54 am
Nonstop2h 09m
Chicago O'Hare Intl
Sun 11/8
2:07 pm-4:59 pm
Nonstop1h 52m
See travel insights to Chicago from
How to get the cheapest flight ticket from Knoxville to Chicago O'Hare Intl Airport
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the typical price of a round-trip flight between Knoxville and Chicago O'Hare Intl Airport?
Prices are currently typical for flights on this route.
Typical prices usually range from $259 to $540.The lowest price recently found on this route was $259.
What is the cheapest month to fly to Chicago O'Hare Intl Airport?
The month of January is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Knoxville averaging around $293.
What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?
The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $421. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $796.
What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?
Flying to Chicago O'Hare Intl Airport from Knoxville in the evening is the least expensive time of day to depart. momondo users have found prices as low as $395 when looking at flights departing in the evening. Try not to purchase tickets at noon because they tend to be around $833. Of course, these prices can vary depending on the time of year and what airport you fly to.
What is the cheapest Knoxville McGhee Tyson to Chicago O'Hare Intl flight route?
Fly from Knoxville McGhee Tyson to Chicago O'Hare Intl for the best Knoxville McGhee Tyson - Chicago O'Hare Intl flight prices
How far in advance should I book a flight from Knoxville to Chicago O'Hare Intl Airport?
You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $328 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Knoxville for as low as $236 on momondo.
What cabin class options are available on Knoxville to Chicago O'Hare Intl Airport flights?
There are 4 cabin classes available to choose from on Knoxville to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.
Can stopping save me money on Knoxville to Chicago O'Hare Intl Airport flights?
You could potentially save up to 21% on your flight if you consider stops on a Knoxville to Chicago O'Hare Intl Airport flight.
How have Knoxville to Chicago O'Hare Intl Airport flight prices changed over time?
As of October 2026, prices for Knoxville to Chicago O'Hare Intl Airport flights are approximately 20% cheaper when compared to flights at the same time last year.
What is the cheapest airline that flies from Knoxville McGhee Tyson to Chicago O'Hare Intl?
Delta is the most popular carrier operating from Knoxville McGhee Tyson to Chicago O'Hare Intl
What airlines fly to Chicago O'Hare Intl Airport?
American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Chicago O'Hare Intl Airport from Knoxville according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Chicago O'Hare Intl Airport. Keep in mind that there are 3 different airlines that fly to Chicago O'Hare Intl Airport on a routine basis, so you have a few additional options to choose from.
How many flights depart from Knoxville to Chicago O'Hare Intl Airport on average per day?
As of October 2026, 32 flights take off from Knoxville and land in Chicago O'Hare Intl Airport each day. The most common flight departure time for this route is 1:00PM, with 44% of daily flights taking off at noon.
How many flights depart from Knoxville to Chicago O'Hare Intl Airport on average per week?
As of October 2026, there are 227 flights per week flying from Knoxville to Chicago O'Hare Intl Airport. The most common day of the week flights depart is Fri, with 15% of flights taking off on this day.
When to book flights from Knoxville to Chicago O'Hare Intl Airport
Cheap Knoxville to Chicago O'Hare Intl Airport (TYS to ORD) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago O'Hare Intl Airport
Frequently asked questions about flying from Knoxville to Chicago O'Hare Intl Airport
How far is Knoxville McGhee Tyson to Chicago O'Hare Intl by plane?
The straight-line distance from Knoxville McGhee Tyson to Chicago O'Hare Intl is 467.2 mi. 1h 55m is a normal flight duration for this route.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport are updated daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?
As of October 2026, there are 2 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport.
What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?
The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Knoxville to Chicago O'Hare Intl Airport?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Knoxville to Chicago O'Hare Intl Airport is Canadair (Bombardier) Regional Jet CRJ-550 (18.86% of total bookings). The next most popular plane models are Canadair (Bombardier) Regional Jet 700 (15.88%), Embraer 170 (14.23%), and Embraer 175 (11.25%).
What is the most popular airline from Knoxville to Chicago O'Hare Intl Airport?
Based on momondo bookings for flights between Knoxville and Chicago O'Hare Intl Airport, the leading airline is American Airlines, making up 55% of the total bookings. Other popular airlines include United Airlines with 45%.
Best airlines flying from Knoxville to Chicago O'Hare Intl Airport
Compare and see reviews for airlines that fly from Knoxville to Chicago O'Hare Intl Airport with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $189 | Free Cancellation | Rating 7.4 10,350 reviews | |||
| PriceFrom $189 | Free Cancellation | Rating 7.0 12,152 reviews |
United Airlines Flights From Knoxville to Chicago O'Hare Intl Airport
United Airlines is one of the most popular airlines flying from Knoxville to Chicago O'Hare Intl Airport, operating 23 flights/week on average for this route. A good United Airlines flight deal for Knoxville to Chicago O'Hare Intl Airport starts from $189 round-trip, up to an average price of $329. Our users have rated United Airlines at 7.4/10.
American Airlines Flights From Knoxville to Chicago O'Hare Intl Airport
American Airlines is also a popular choice for this route. American Airlines flight deals for Knoxville to Chicago O'Hare Intl Airport start from as low as $189 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $310. American Airlines operates 26 flights to Chicago O'Hare Intl Airport from Knoxville in an average week. Users have rated it 7.0/10 across 12,152 reviews.
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Book flights to Chicago if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Knoxville to Chicago?
We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Chicago for you.
Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?
All flight searches from Knoxville to Chicago on momondo can be filtered to show those which offer flexible booking policies.
How can momondo help me find flights from Knoxville to Chicago?
Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Knoxville.
I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?
Yes. momondo can track prices for Knoxville to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.