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Cheap flights from Knoxville to Chicago from $91

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 11/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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American Airlines Logo
6:29 pm - 7:33 pmTYS-ORD
2h 04mnonstop
American Airlines Logo
11:42 am - 2:27 pmORD-TYS
1h 45mnonstop
$189American Airlines
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Fri, Dec 12 - Mon, Dec 15
United Airlines Logo
8:26 am - 9:30 amTYS-ORD
2h 04mnonstop
United Airlines Logo
10:35 am - 1:17 pmORD-TYS
1h 42mnonstop
$194United Airlines
Find Deal
Sat, Nov 1 - Wed, Nov 5
United Airlines Logo
5:52 pm - 6:53 pmTYS-ORD
2h 01mnonstop
United Airlines Logo
5:50 pm - 8:33 pmORD-TYS
1h 43mnonstop
$199United Airlines
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Thu, Oct 30 - Mon, Nov 3
Multiple Airlines Logo
9:54 am - 8:27 pmTYS-ORD
11h 33m1 stop
Multiple Airlines Logo
5:25 am - 10:59 pmORD-TYS
16h 34m1 stop
$204Multiple Airlines
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Thu, Nov 13 - Sun, Nov 16
Multiple Airlines Logo
7:00 am - 12:15 amTYS-ORD
18h 15m1 stop
Multiple Airlines Logo
7:15 am - 1:44 pmORD-TYS
29h 29m1 stop
$206Multiple Airlines
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Thu, Nov 6 - Sat, Nov 8
Multiple Airlines Logo
1:41 pm - 11:59 pmTYS-ORD
11h 18m1 stop
Multiple Airlines Logo
5:15 pm - 7:14 pmORD-TYS
24h 59m1 stop
$208Multiple Airlines
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Fri, Dec 12 - Sun, Dec 14
Delta Logo
7:59 pm - 12:02 amTYS-ORD
5h 03m1 stop
Delta Logo
6:45 am - 11:47 amORD-TYS
4h 02m1 stop
$209Delta
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Thu, Dec 11 - Sun, Dec 14
Multiple Airlines Logo
6:09 pm - 2:16 pmTYS-ORD
21h 07m1 stop
Multiple Airlines Logo
4:01 pm - 9:56 pmORD-TYS
28h 55m2 stops
$211Multiple Airlines
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Wed, Dec 10 - Wed, Dec 17
Delta Logo
5:19 pm - 10:26 pmTYS-ORD
6h 07m1 stop
Delta Logo
6:45 am - 11:45 amORD-TYS
4h 00m1 stop
$214Delta
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Tue, Nov 4 - Sun, Nov 16
American Airlines Logo
1:14 pm - 2:17 pmTYS-ORD
2h 03mnonstop
American Airlines Logo
9:50 am - 12:43 pmORD-TYS
1h 53mnonstop
$219American Airlines
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Thu, Dec 11 - Sun, Dec 14

United Airlines flights from Knoxville to Chicago O'Hare Intl Airport

Our best United Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
United Airlines
Nov 1
TYS8:26 amKnoxville McGhee Tyson
2h 04m
ORD9:30 amChicago O'Hare Intl
Nov 5
ORD10:35 amChicago O'Hare Intl
1h 42m
TYS1:17 pmKnoxville McGhee Tyson
$194
Find similar
United Airlines
Oct 30
TYS5:52 pmKnoxville McGhee Tyson
2h 01m
ORD6:53 pmChicago O'Hare Intl
Nov 3
ORD5:50 pmChicago O'Hare Intl
1h 43m
TYS8:33 pmKnoxville McGhee Tyson
$199
Find similar
United Airlines
Jan 19
TYS6:45 amKnoxville McGhee Tyson
2h 03m
ORD7:48 amChicago O'Hare Intl
Jan 26
ORD7:42 amChicago O'Hare Intl
1h 50m
TYS10:32 amKnoxville McGhee Tyson
$212
Find similar

American Airlines flights from Knoxville to Chicago O'Hare Intl Airport

Our best American Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
American Airlines
Dec 12
TYS6:29 pmKnoxville McGhee Tyson
2h 04m
ORD7:33 pmChicago O'Hare Intl
Dec 15
ORD11:42 amChicago O'Hare Intl
1h 45m
TYS2:27 pmKnoxville McGhee Tyson
$189
Find similar
American Airlines
Dec 11
TYS1:14 pmKnoxville McGhee Tyson
2h 03m
ORD2:17 pmChicago O'Hare Intl
Dec 14
ORD9:50 amChicago O'Hare Intl
1h 53m
TYS12:43 pmKnoxville McGhee Tyson
$219
Find similar
American Airlines
Dec 6
TYS4:22 pmKnoxville McGhee Tyson
6h 56m
1 stop
ORD10:18 pmChicago O'Hare Intl
Dec 7
ORD9:50 amChicago O'Hare Intl
1h 53m
TYS12:43 pmKnoxville McGhee Tyson
$224
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 12/12

6:29 pm-7:33 pm

Nonstop2h 04m

Chicago O'Hare Intl

Mon 12/15

11:42 am-2:27 pm

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 11/1

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Wed 11/5

10:35 am-1:17 pm

Nonstop1h 42m

$194

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 10/30

5:52 pm-6:53 pm

Nonstop2h 01m

Chicago O'Hare Intl

Mon 11/3

5:50 pm-8:33 pm

Nonstop1h 43m

$199

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 11/13

9:54 am-8:27 pm

1 stop11h 33m

Chicago O'Hare Intl

Sun 11/16

5:25 am-10:59 pm

1 stop16h 34m

$204

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 11/6

7:00 am-12:15 am

1 stop18h 15m

Chicago O'Hare Intl

Sat 11/8

7:15 am-1:44 pm

1 stop29h 29m

$206

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 12/12

1:41 pm-11:59 pm

1 stop11h 18m

Chicago O'Hare Intl

Sun 12/14

5:15 pm-7:14 pm

1 stop24h 59m

$208

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 12/11

7:59 pm-12:02 am

1 stop5h 03m

Chicago O'Hare Intl

Sun 12/14

6:45 am-11:47 am

1 stop4h 02m

$209

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 12/10

6:09 pm-2:16 pm

1 stop21h 07m

Chicago O'Hare Intl

Wed 12/17

4:01 pm-9:56 pm

2 stops28h 55m

$211

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 11/4

5:19 pm-10:26 pm

1 stop6h 07m

Chicago O'Hare Intl

Sun 11/16

6:45 am-11:45 am

1 stop4h 00m

$214

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 12/11

1:14 pm-2:17 pm

Nonstop2h 03m

Chicago O'Hare Intl

Sun 12/14

9:50 am-12:43 pm

Nonstop1h 53m

$219

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of February is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Knoxville averaging around $246.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $411. This is often the case because there is less demand to fly during this day of the week. On the other hand, Monday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $760.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $492 when looking at flights departing in the morning. Try not to purchase tickets in the evening because they tend to be around $851. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago O'Hare Intl flight route?

Fly from Knoxville McGhee Tyson to Chicago O'Hare Intl for the best Knoxville McGhee Tyson - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $283 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Knoxville for as low as $205 on momondo.

What cabin class options are available on Knoxville McGhee Tyson to Chicago O'Hare Intl flights?

There are 4 cabin classes available to choose from on Knoxville McGhee Tyson to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Knoxville to Chicago O'Hare Intl Airport flight prices changed over time?

As of October 2025, prices for Knoxville to Chicago O'Hare Intl Airport flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago O'Hare Intl Airport (TYS to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago O'Hare Intl Airport

Best Price Found

$218

Fastest flight time

1h 55m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Knoxville in the past 72 hours is $218. The best round-trip flight deal from Knoxville to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $336.
The fastest flight from Knoxville to Chicago O'Hare Intl Airport takes 1h 55m
Direct flights go from Knoxville to Chicago O'Hare Intl Airport every day.
Search flight deals

  • How far is Knoxville McGhee Tyson to Chicago O'Hare Intl by plane?

    The straight-line distance from Knoxville McGhee Tyson to Chicago O'Hare Intl is 467.2 mi. 1h 57m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Knoxville to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Knoxville to Chicago O'Hare Intl Airport?

Best airlines flying from Knoxville to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $189Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
United AirlinesPriceFrom $192Free CancellationRating
7.4
8,982 reviews
Search United Airlines flights

  • United Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    United Airlines is one of the most popular airlines flying from Knoxville to Chicago O'Hare Intl Airport, operating 30 flights/week on average for this route. A good United Airlines flight deal for Knoxville to Chicago O'Hare Intl Airport starts from $192 round-trip, up to an average price of $315. Our users have rated United Airlines at 7.4/10.

  • American Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    American Airlines is also a popular choice for this route. American Airlines flight deals for Knoxville to Chicago O'Hare Intl Airport start from as low as $189 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $269. American Airlines operates 27 flights to Chicago O'Hare Intl Airport from Knoxville in an average week. Users have rated it 7.2/10 across 11,043 reviews.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
South Haven
Schaumburg
Rockford
Merrillville
Gurnee
Naperville
Rosemont
Kenosha
New Buffalo
Joliet
Oak Brook
Racine
Orland Park
Hammond
Tinley Park
Janesville
Elgin
Aurora
Benton Harbor

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Chicago for you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

All flight searches from Knoxville to Chicago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Knoxville.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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