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Cheap flights from Knoxville to Chicago from $102

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 1/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:00 am - 7:55 am
TYS
-
ORD
1h 55mnonstop
United Airlines Logo
6:00 pm - 8:45 pm
ORD
-
TYS
1h 45mnonstop
$189United Airlines
Fri, May 1 - Mon, May 4
Multiple Airlines Logo
3:53 pm - 3:28 pm
TYS
-
ORD
24h 35m1 stop
Multiple Airlines Logo
12:44 pm - 10:10 am
ORD
-
TYS
20h 26m1 stop
$196Multiple Airlines
Wed, Jan 7 - Sun, Jan 11
Multiple Airlines Logo
10:00 am - 7:36 pm
TYS
-
ORD
10h 36m1 stop
Multiple Airlines Logo
5:32 pm - 3:57 pm
ORD
-
TYS
21h 25m1 stop
$206Multiple Airlines
Sun, Jan 18 - Tue, Jan 20
Multiple Airlines Logo
3:53 pm - 2:22 pm
TYS
-
ORD
23h 29m2 stops
Multiple Airlines Logo
8:27 pm - 10:10 am
ORD
-
TYS
12h 43m1 stop
$207Multiple Airlines
Wed, Jan 7 - Sun, Jan 11
Delta Logo
7:30 am - 1:08 pm
TYS
-
ORD
6h 38m1 stop
Delta Logo
5:59 pm - 11:45 pm
ORD
-
TYS
4h 46m1 stop
$209Delta
Fri, Jan 9 - Mon, Jan 12
Multiple Airlines Logo
1:39 pm - 12:08 pm
TYS
-
ORD
23h 29m2 stops
Multiple Airlines Logo
5:32 pm - 3:57 pm
ORD
-
TYS
21h 25m1 stop
$216Multiple Airlines
Sun, Jan 18 - Tue, Jan 20
United Airlines Logo
6:45 am - 7:52 am
TYS
-
ORD
2h 07mnonstop
United Airlines Logo
7:25 am - 10:15 am
ORD
-
TYS
1h 50mnonstop
$219United Airlines
Tue, Dec 30 - Sun, Jan 4
United Airlines Logo
7:00 am - 7:55 am
TYS
-
ORD
1h 55mnonstop
United Airlines Logo
6:01 pm - 8:46 pm
ORD
-
TYS
1h 45mnonstop
$223United Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
5:17 am - 6:10 am
TYS
-
ORD
1h 53mnonstop
American Airlines Logo
1:30 pm - 7:01 pm
ORD
-
TYS
4h 31m1 stop
$224American Airlines
Fri, May 1 - Sat, May 9
American Airlines Logo
7:54 am - 9:02 am
TYS
-
ORD
2h 08mnonstop
American Airlines Logo
7:29 pm - 10:09 pm
ORD
-
TYS
1h 40mnonstop
$233American Airlines
Sat, Jan 10 - Thu, Jan 15

United Airlines flights from Knoxville to Chicago O'Hare Intl Airport

Our best United Airlines deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
United Airlines
May 1
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
May 4
ORD6:00 pmChicago O'Hare Intl
1h 45m
TYS8:45 pmKnoxville McGhee Tyson
$189
Find similar
United Airlines
Dec 30
TYS6:45 amKnoxville McGhee Tyson
2h 07m
ORD7:52 amChicago O'Hare Intl
Jan 4
ORD7:25 amChicago O'Hare Intl
1h 50m
TYS10:15 amKnoxville McGhee Tyson
$219
Find similar
United Airlines
Apr 7
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
Apr 11
ORD6:01 pmChicago O'Hare Intl
1h 45m
TYS8:46 pmKnoxville McGhee Tyson
$223
Find similar

Delta flights from Knoxville to Chicago O'Hare Intl Airport

Our best Delta deals on Knoxville to Chicago O'Hare Intl Airport flight tickets
Delta
Jan 9
TYS7:30 amKnoxville McGhee Tyson
6h 38m
1 stop
ORD1:08 pmChicago O'Hare Intl
Jan 12
ORD5:59 pmChicago O'Hare Intl
4h 46m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
$209
Find similar
Delta
Apr 10
TYS10:51 amKnoxville McGhee Tyson
6h 52m
1 stop
ORD4:43 pmChicago O'Hare Intl
Apr 15
ORD7:10 amChicago O'Hare Intl
5h 15m
1 stop
TYS1:25 pmKnoxville McGhee Tyson
$234
Find similar
Delta
Feb 13
TYS4:03 pmKnoxville McGhee Tyson
3h 46m
1 stop
ORD6:49 pmChicago O'Hare Intl
Feb 15
ORD5:25 amChicago O'Hare Intl
4h 43m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$253
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 5/1

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Mon 5/4

6:00 pm-8:45 pm

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-3:28 pm

1 stop24h 35m

Chicago O'Hare Intl

Sun 1/11

12:44 pm-10:10 am

1 stop20h 26m

$196

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sun 1/18

10:00 am-7:36 pm

1 stop10h 36m

Chicago O'Hare Intl

Tue 1/20

5:32 pm-3:57 pm

1 stop21h 25m

$206

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-2:22 pm

2 stops23h 29m

Chicago O'Hare Intl

Sun 1/11

8:27 pm-10:10 am

1 stop12h 43m

$207

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 1/9

7:30 am-1:08 pm

1 stop6h 38m

Chicago O'Hare Intl

Mon 1/12

5:59 pm-11:45 pm

1 stop4h 46m

$209

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sun 1/18

1:39 pm-12:08 pm

2 stops23h 29m

Chicago O'Hare Intl

Tue 1/20

5:32 pm-3:57 pm

1 stop21h 25m

$216

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 12/30

6:45 am-7:52 am

Nonstop2h 07m

Chicago O'Hare Intl

Sun 1/4

7:25 am-10:15 am

Nonstop1h 50m

$219

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 4/7

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Sat 4/11

6:01 pm-8:46 pm

Nonstop1h 45m

$223

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 5/1

5:17 am-6:10 am

Nonstop1h 53m

Chicago O'Hare Intl

Sat 5/9

1:30 pm-7:01 pm

1 stop4h 31m

$224

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 1/10

7:54 am-9:02 am

Nonstop2h 08m

Chicago O'Hare Intl

Thu 1/15

7:29 pm-10:09 pm

Nonstop1h 40m

$233

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Knoxville to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of February is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Knoxville averaging around $244.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $395. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $788.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $486 when looking at flights departing in the morning. Try not to purchase tickets in the evening because they tend to be around $836. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Knoxville McGhee Tyson to Chicago O'Hare Intl flight route?

Fly from Knoxville McGhee Tyson to Chicago O'Hare Intl for the best Knoxville McGhee Tyson - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $289 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Knoxville for as low as $214 on momondo.

What cabin class options are available on Knoxville McGhee Tyson to Chicago O'Hare Intl flights?

There are 4 cabin classes available to choose from on Knoxville McGhee Tyson to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Knoxville to Chicago O'Hare Intl Airport flight prices changed over time?

As of December 2025, prices for Knoxville to Chicago O'Hare Intl Airport flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Chicago O'Hare Intl Airport (TYS to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago O'Hare Intl Airport

Best Price Found

$267

Fastest flight time

1h 55m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Knoxville in the past 72 hours is $267. The best round-trip flight deal from Knoxville to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $337.
The fastest flight from Knoxville to Chicago O'Hare Intl Airport takes 1h 55m
Direct flights go from Knoxville to Chicago O'Hare Intl Airport every day.
Search flight deals

  • How far is Knoxville McGhee Tyson to Chicago O'Hare Intl by plane?

    The straight-line distance from Knoxville McGhee Tyson to Chicago O'Hare Intl is 467.2 mi. 1h 55m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Knoxville to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Knoxville to Chicago O'Hare Intl Airport?

Best airlines flying from Knoxville to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Knoxville to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $189Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights
American AirlinesPriceFrom $189Free CancellationRating
7.2
11,049 reviews
Search American Airlines flights

  • United Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    United Airlines is one of the most popular airlines flying from Knoxville to Chicago O'Hare Intl Airport, operating 10 flights/week on average for this route. A good United Airlines flight deal for Knoxville to Chicago O'Hare Intl Airport starts from $189 round-trip, up to an average price of $318. Our users have rated United Airlines at 7.4/10.

  • American Airlines Flights From Knoxville to Chicago O'Hare Intl Airport

    American Airlines is also a popular choice for this route. American Airlines flight deals for Knoxville to Chicago O'Hare Intl Airport start from as low as $189 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $269. American Airlines operates 7 flights to Chicago O'Hare Intl Airport from Knoxville in an average week. Users have rated it 7.2/10 across 11,049 reviews.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
South Haven
Rockford
Merrillville
Gurnee
Naperville
Rosemont
Kenosha
New Buffalo
Joliet
Oak Brook
Orland Park
Racine
Hammond
Janesville
Tinley Park
Aurora
Elgin
Benton Harbor

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Chicago for you.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

All flight searches from Knoxville to Chicago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Chicago?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Chicago from Knoxville.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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