Cheap flights from Knoxville to Chicago from $121

The month of November is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Knoxville averaging around $279.

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $402. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $795.

Flying to Chicago O'Hare Intl Airport from Knoxville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $491 when looking at flights departing in the morning. Try not to purchase tickets at noon because they tend to be around $817. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Knoxville McGhee Tyson to Chicago O'Hare Intl for the best Knoxville McGhee Tyson - Chicago O'Hare Intl flight prices

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $318 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Knoxville for as low as $236 on momondo.

There are 4 cabin classes available to choose from on Knoxville to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 3% on your flight if you consider stops on a Knoxville to Chicago O'Hare Intl Airport flight.

As of September 2026, prices for Knoxville to Chicago O'Hare Intl Airport flights are approximately 121% more expensive when compared to flights at the same time last year.

Delta is the most popular carrier operating from Knoxville McGhee Tyson to Chicago O'Hare Intl

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Chicago O'Hare Intl Airport from Knoxville according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Chicago O'Hare Intl Airport. Keep in mind that there are 3 different airlines that fly to Chicago O'Hare Intl Airport on a routine basis, so you have a few additional options to choose from.

As of September 2026, 20 flights take off from Knoxville and land in Chicago O'Hare Intl Airport each day. The most common flight departure time for this route is 1:00PM, with 38% of daily flights taking off in the afternoon.

As of September 2026, there are 141 flights per week flying from Knoxville to Chicago O'Hare Intl Airport. The most common day of the week flights depart is Wed, with 23% of flights taking off on this day.