What airlines fly to South America?

American Airlines, Spirit Airlines and Delta are the top three most popular airlines that fly to South America from Greenville according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 6 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Greenville to South America?

Avianca, United Airlines, and American Airlines are the most popular carriers operating from Greenville to South America

When did momondo last update prices for flights from Greenville Airport to South America?

Prices for flights from Greenville Airport to South America were last updated today.

How many operators does momondo search for flights from Greenville Airport to South America?

The number of operators available for flights from Greenville Airport to South America is 3 as of February 2026.

How old do you have to be to fly from Greenville Airport to South America?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$170 Cheap Flights from Greenville to South America in 2026

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Greenville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:43 pm - 12:21 am

GSP

MDE

7h 38m

1 stop

1:11 am - 4:53 pm

MDE

GSP

14h 42m

1 stop

$311Multiple Airlines

Fri, Apr 10 - Thu, Apr 16

9:46 pm - 12:21 am

GSP

MDE

27h 35m

1 stop

2:06 pm - 4:53 pm

MDE

GSP

25h 47m

1 stop

$348Multiple Airlines

Thu, Mar 26 - Thu, Apr 23

5:32 pm - 4:35 pm

GSP

PEI

24h 03m

2 stops

5:15 am - 9:46 am

PEI

GSP

27h 31m

2 stops

$489Avianca

Tue, Mar 10 - Mon, Apr 13

5:32 pm - 9:45 pm

GSP

PEI

29h 13m

2 stops

7:00 am - 9:56 am

PEI

GSP

25h 56m

2 stops

$553Avianca

Tue, Mar 10 - Mon, Apr 13

5:20 am - 7:57 pm

GSP

UIO

15h 37m

2 stops

11:40 pm - 6:15 pm

UIO

GSP

17h 35m

1 stop

$612American Airlines

Thu, Apr 23 - Thu, May 7

6:00 am - 10:24 pm

GSP

UIO

17h 24m

1 stop

7:05 am - 6:15 pm

UIO

GSP

10h 10m

1 stop

$616American Airlines

Thu, Apr 23 - Fri, May 8

5:42 am - 6:59 pm

GSP

UIO

14h 17m

1 stop

12:59 am - 10:45 am

UIO

GSP

8h 46m

1 stop

$647Delta

Thu, Apr 23 - Wed, May 6

6:45 am - 9:35 pm

GSP

LIM

15h 50m

2 stops

12:05 am - 8:13 pm

LIM

GSP

19h 08m

1 stop

$649Delta

Mon, May 25 - Thu, May 28

3:42 pm - 5:00 am

GSP

LIM

14h 18m

2 stops

12:05 am - 6:52 pm

LIM

GSP

17h 47m

2 stops

$674LATAM Airlines

Fri, Jul 3 - Thu, Jul 9

6:45 am - 7:47 am

GSP

PEI

26h 02m

2 stops

7:55 am - 10:13 pm

PEI

GSP

13h 18m

3 stops

$722LATAM Airlines

Tue, Mar 10 - Mon, Apr 13

Delta flights from Greenville to South America

Our best Delta deals on Greenville to South America flight tickets

Delta

Apr 16

GSP7:59 pmGreenville

17h 06m

2 stops

BOG12:05 pmBogotá El Dorado

Apr 27

BOG9:00 amBogotá El Dorado

10h 02m

1 stop

GSP8:02 pmGreenville

$515

Delta

Apr 16

GSP6:51 amGreenville

13h 24m

1 stop

BOG7:15 pmBogotá El Dorado

Apr 25

BOG2:55 pmBogotá El Dorado

8h 01m

1 stop

GSP11:56 pmGreenville

$525

Delta

May 9

GSP5:05 pmGreenville

20h 00m

2 stops

BOG12:05 pmBogotá El Dorado

May 23

BOG2:55 pmBogotá El Dorado

7h 53m

1 stop

GSP11:48 pmGreenville

$535

LATAM Airlines flights from Greenville to South America

Our best LATAM Airlines deals on Greenville to South America flight tickets

LATAM Airlines

Apr 17

GSP6:51 amGreenville

11h 59m

2 stops

BOG5:50 pmBogotá El Dorado

Apr 27

BOG11:00 amBogotá El Dorado

11h 56m

2 stops

GSP11:56 pmGreenville

$530

LATAM Airlines

Jun 26

GSP12:00 pmGreenville

9h 10m

2 stops

BOG8:10 pmBogotá El Dorado

Jun 30

BOG10:40 amBogotá El Dorado

21h 47m

2 stops

GSP9:27 amGreenville

$569

LATAM Airlines

Mar 25

GSP8:30 amGreenville

12h 50m

2 stops

BOG8:20 pmBogotá El Dorado

Apr 5

BOG10:35 amBogotá El Dorado

12h 19m

2 stops

GSP11:54 pmGreenville

$573

momondo Fare Finder

Use the filters below to find and compare flights from Greenville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 4/10

5:43 pm-12:21 am

1 stop7h 38m

Medellín Jose Maria Cordova Intl

Thu 4/16

1:11 am-4:53 pm

1 stop14h 42m

$311

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 3/26

9:46 pm-12:21 am

1 stop27h 35m

Medellín Jose Maria Cordova Intl

Thu 4/23

2:06 pm-4:53 pm

1 stop25h 47m

$348

GreenvillePereira

GSP - PEI

GSPPEI

Greenville

Tue 3/10

5:32 pm-4:35 pm

2 stops24h 03m

Pereira Matecana

Mon 4/13

5:15 am-9:46 am

2 stops27h 31m

$489

GreenvillePereira

GSP - PEI

GSPPEI

Greenville

Tue 3/10

5:32 pm-9:45 pm

2 stops29h 13m

Pereira Matecana

Mon 4/13

7:00 am-9:56 am

2 stops25h 56m

$553

GreenvilleQuito

GSP - UIO

GSPUIO

Greenville

Thu 4/23

5:20 am-7:57 pm

2 stops15h 37m

Quito Mariscal Sucr

Thu 5/7

11:40 pm-6:15 pm

1 stop17h 35m

$612

GreenvilleQuito

GSP - UIO

GSPUIO

Greenville

Thu 4/23

6:00 am-10:24 pm

1 stop17h 24m

Quito Mariscal Sucr

Fri 5/8

7:05 am-6:15 pm

1 stop10h 10m

$616

GreenvilleQuito

GSP - UIO

GSPUIO

Greenville

Thu 4/23

5:42 am-6:59 pm

1 stop14h 17m

Quito Mariscal Sucr

Wed 5/6

12:59 am-10:45 am

1 stop8h 46m

$647

GreenvilleLima

GSP - LIM

GSPLIM

Greenville

Mon 5/25

6:45 am-9:35 pm

2 stops15h 50m

Lima J Chavez Intl

Thu 5/28

12:05 am-8:13 pm

1 stop19h 08m

$649

GreenvilleLima

GSP - LIM

GSPLIM

Greenville

Fri 7/3

3:42 pm-5:00 am

2 stops14h 18m

Lima J Chavez Intl

Thu 7/9

12:05 am-6:52 pm

2 stops17h 47m

$674

GreenvillePereira

GSP - PEI

GSPPEI

Greenville

Tue 3/10

6:45 am-7:47 am

2 stops26h 02m

Pereira Matecana

Mon 4/13

7:55 am-10:13 pm

3 stops13h 18m

$722

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Greenville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Can stopping save me money on Greenville to South America flights?

You could potentially save up to 34% on your flight if you consider stops on a Greenville to South America flight.

Cheap Greenville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to South America

Fastest flight time	7h 38m
Direct flights	None

The fastest flight from Greenville to South America takes 7h 38m

There are no direct flights from Greenville to South America. There are no popular flight routes from Greenville to South America.

Search flight deals

When did momondo last update prices for flights from Greenville Airport to South America?
Prices for flights from Greenville Airport to South America were last updated today.
How many operators does momondo search for flights from Greenville Airport to South America?
The number of operators available for flights from Greenville Airport to South America is 3 as of February 2026.
How old do you have to be to fly from Greenville Airport to South America?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Greenville to South America

Compare and see reviews for airlines that fly from Greenville to South America with momondo

Airline	Rating	Free Cancellation	Price
LATAM Airlines	PriceFrom $494	Free Cancellation	Rating 7.5 1,922 reviews	Search LATAM Airlines flights
American Airlines	PriceFrom $502	Free Cancellation	Rating 7.2 11,357 reviews	Search American Airlines flights
Delta	PriceFrom $532	Free Cancellation	Rating 7.9 8,242 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to South America?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Greenville to South America for you.

Can I find flights from Greenville to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Greenville with this policy.

How can momondo help me find flights from Greenville to South America?

momondo provides multiple filters to help you find the best flight to South America from Greenville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Greenville to South America right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South America, momondo offers a useful price alert feature which will track prices for flights to South America from Greenville and alert you when they change.