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Cheap flights from Greenville to Panama from $174

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama departing on 4/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Greenville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:40 am - 1:03 pm
GSP
-
PTY
8h 23m
1 stop
Delta Logo
2:20 pm - 11:56 pm
PTY
-
GSP
8h 36m
1 stop
$413Delta
Wed, Apr 8 - Wed, Apr 29
American Airlines Logo
8:21 pm - 3:15 pm
GSP
-
PTY
18h 54m
2 stops
American Airlines Logo
1:40 pm - 12:21 am
PTY
-
GSP
9h 41m
1 stop
$417American Airlines
Thu, Mar 5 - Thu, Mar 12
American Airlines Logo
7:00 pm - 1:27 pm
GSP
-
PTY
18h 27m
2 stops
American Airlines Logo
1:49 pm - 10:35 am
PTY
-
GSP
19h 46m
2 stops
$423American Airlines
Mon, Feb 2 - Thu, Apr 30
American Airlines Logo
7:26 pm - 2:20 pm
GSP
-
PTY
19h 54m
1 stop
American Airlines Logo
3:10 pm - 10:15 am
PTY
-
GSP
18h 05m
2 stops
$426American Airlines
Mon, Mar 9 - Tue, Mar 17
Copa Airlines Logo
6:12 am - 8:02 pm
GSP
-
PTY
13h 50m
1 stop
Copa Airlines Logo
3:41 pm - 9:58 pm
PTY
-
GSP
29h 17m
1 stop
$428Copa Airlines
Thu, Feb 26 - Mon, Mar 9
American Airlines Logo
7:00 pm - 1:27 pm
GSP
-
PTY
18h 27m
2 stops
American Airlines Logo
4:50 pm - 11:24 am
PTY
-
GSP
18h 34m
2 stops
$429American Airlines
Mon, Feb 2 - Thu, Feb 5
American Airlines Logo
3:58 pm - 12:40 pm
GSP
-
PTY
21h 42m
2 stops
American Airlines Logo
1:40 pm - 10:41 am
PTY
-
GSP
20h 01m
2 stops
$435American Airlines
Sun, Mar 8 - Tue, Mar 17
American Airlines Logo
7:26 pm - 2:20 pm
GSP
-
PTY
19h 54m
1 stop
American Airlines Logo
3:10 pm - 12:21 am
PTY
-
GSP
8h 11m
1 stop
$440American Airlines
Sun, Mar 8 - Wed, Mar 18
American Airlines Logo
7:26 pm - 2:20 pm
GSP
-
PTY
19h 54m
1 stop
American Airlines Logo
3:10 pm - 12:15 pm
PTY
-
GSP
20h 05m
2 stops
$445American Airlines
Sun, Mar 8 - Tue, Mar 17
United Airlines Logo
4:41 pm - 6:37 pm
GSP
-
PTY
26h 56m
1 stop
United Airlines Logo
10:00 am - 9:59 pm
PTY
-
GSP
10h 59m
1 stop
$446United Airlines
Wed, Apr 1 - Wed, Apr 15

American Airlines flights from Greenville to Panama

Our best American Airlines deals on Greenville to Panama flight tickets
American Airlines
Mar 31
GSP6:40 amGreenville
7h 00m
1 stop
PTY12:40 pmPanama City Tocumen Intl
Apr 15
PTY1:49 pmPanama City Tocumen Intl
9h 08m
1 stop
GSP11:57 pmGreenville
$413
American Airlines
Mar 31
GSP5:29 pmGreenville
22h 32m
2 stops
PTY3:01 pmPanama City Tocumen Intl
Apr 15
PTY1:49 pmPanama City Tocumen Intl
9h 08m
1 stop
GSP11:57 pmGreenville
$417
American Airlines
Feb 2
GSP7:00 pmGreenville
18h 27m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Apr 30
PTY1:49 pmPanama City Tocumen Intl
19h 46m
2 stops
GSP10:35 amGreenville
$423

United Airlines flights from Greenville to Panama

Our best United Airlines deals on Greenville to Panama flight tickets
United Airlines
Apr 18
GSP7:00 amGreenville
10h 12m
1 stop
PTY4:12 pmPanama City Tocumen Intl
Apr 28
PTY10:00 amPanama City Tocumen Intl
10h 59m
1 stop
GSP9:59 pmGreenville
$422
United Airlines
Apr 21
GSP7:00 amGreenville
10h 12m
1 stop
PTY4:12 pmPanama City Tocumen Intl
Apr 27
PTY10:00 amPanama City Tocumen Intl
10h 59m
1 stop
GSP9:59 pmGreenville
$429
United Airlines
Apr 18
GSP7:00 amGreenville
8h 14m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Apr 24
PTY3:30 pmPanama City Tocumen Intl
23h 24m
1 stop
GSP3:54 pmGreenville
$440

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 4/8

5:40 am-1:03 pm

1 stop8h 23m

Panama City Tocumen Intl

Wed 4/29

2:20 pm-11:56 pm

1 stop8h 36m

$413

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 3/5

8:21 pm-3:15 pm

2 stops18h 54m

Panama City Tocumen Intl

Thu 3/12

1:40 pm-12:21 am

1 stop9h 41m

$417

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/2

7:00 pm-1:27 pm

2 stops18h 27m

Panama City Tocumen Intl

Thu 4/30

1:49 pm-10:35 am

2 stops19h 46m

$423

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 3/9

7:26 pm-2:20 pm

1 stop19h 54m

Panama City Tocumen Intl

Tue 3/17

3:10 pm-10:15 am

2 stops18h 05m

$426

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 2/26

6:12 am-8:02 pm

1 stop13h 50m

Panama City Tocumen Intl

Mon 3/9

3:41 pm-9:58 pm

1 stop29h 17m

$428

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/2

7:00 pm-1:27 pm

2 stops18h 27m

Panama City Tocumen Intl

Thu 2/5

4:50 pm-11:24 am

2 stops18h 34m

$429

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 3/8

3:58 pm-12:40 pm

2 stops21h 42m

Panama City Tocumen Intl

Tue 3/17

1:40 pm-10:41 am

2 stops20h 01m

$435

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 3/8

7:26 pm-2:20 pm

1 stop19h 54m

Panama City Tocumen Intl

Wed 3/18

3:10 pm-12:21 am

1 stop8h 11m

$440

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 3/8

7:26 pm-2:20 pm

1 stop19h 54m

Panama City Tocumen Intl

Tue 3/17

3:10 pm-12:15 pm

2 stops20h 05m

$445

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 4/1

4:41 pm-6:37 pm

1 stop26h 56m

Panama City Tocumen Intl

Wed 4/15

10:00 am-9:59 pm

1 stop10h 59m

$446

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Greenville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Greenville, with most prices found around $371. If you don’t want to visit Panama in August, then you should wait until October to fly from Greenville, when ticket prices are also cheap, with an average price of $391.

Cheap Greenville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama

Fastest flight time

8h 23m

Direct flights

None
The fastest flight from Greenville to Panama takes 8h 23m
There are no direct flights from Greenville to Panama. There are no popular flight routes from Greenville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Greenville Airport to Panama?

    Prices for flights from Greenville Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama?

  • How old do you have to be to fly from Greenville Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Greenville to Panama

Compare and see reviews for airlines that fly from Greenville to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $371Free CancellationRating
7.9
8,088 reviews
Search Delta flights
United AirlinesPriceFrom $383Free CancellationRating
7.4
9,191 reviews
Search United Airlines flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,174 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama?

It is quick and easy to find Greenville to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Greenville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Panama?

Once all potential Greenville to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Greenville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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