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Cheap flights from Greenville to Panama from $392

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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United Airlines Logo
6:40 am - 7:38 pmGSP-PTY
12h 58m1 stop
United Airlines Logo
8:55 am - 9:57 pmPTY-GSP
13h 02m1 stop
$392United Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
7:42 pm - 3:38 pmGSP-PTY
19h 56m2 stops
American Airlines Logo
2:27 pm - 12:07 pmPTY-GSP
21h 40m2 stops
$396American Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
United Airlines Logo
6:50 am - 5:07 pmGSP-PTY
10h 17m1 stop
United Airlines Logo
8:55 am - 9:59 pmPTY-GSP
13h 04m1 stop
$410United Airlines
Find Deal
Thu, Feb 12 - Fri, Feb 20
United Airlines Logo
6:50 am - 2:45 pmGSP-PTY
7h 55m1 stop
United Airlines Logo
11:35 am - 9:59 pmPTY-GSP
10h 24m1 stop
$435United Airlines
Find Deal
Thu, Feb 12 - Fri, Feb 20
American Airlines Logo
11:34 am - 1:43 pmGSP-PTY
26h 09m1 stop
American Airlines Logo
2:43 pm - 11:59 pmPTY-GSP
9h 16m1 stop
$460American Airlines
Find Deal
Wed, Nov 19 - Wed, Nov 26
American Airlines Logo
8:41 pm - 3:00 pmGSP-PTY
18h 19m2 stops
American Airlines Logo
2:30 pm - 12:10 amPTY-GSP
9h 40m1 stop
$496American Airlines
Find Deal
Thu, Feb 12 - Fri, Feb 20
American Airlines Logo
4:37 pm - 1:49 pmGSP-PTY
21h 12m2 stops
American Airlines Logo
2:49 pm - 10:58 amPTY-GSP
20h 09m2 stops
$500American Airlines
Find Deal
Sat, Nov 8 - Sat, Nov 15
American Airlines Logo
6:11 pm - 1:49 pmGSP-PTY
19h 38m1 stop
American Airlines Logo
2:49 pm - 11:33 amPTY-GSP
20h 44m2 stops
$509American Airlines
Find Deal
Sat, Nov 8 - Sat, Nov 15
United Airlines Logo
6:50 am - 7:38 pmGSP-PTY
12h 48m1 stop
United Airlines Logo
8:55 am - 9:58 pmPTY-GSP
13h 03m1 stop
$540United Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
Multiple Airlines Logo
7:25 pm - 8:19 pmGSP-PTY
24h 54m1 stop
Multiple Airlines Logo
12:03 pm - 8:08 pmPTY-GSP
8h 05m1 stop
$842Multiple Airlines
Find Deal
Mon, Dec 29 - Fri, Jan 2

United Airlines flights from Greenville to Panama

Our best United Airlines deals on Greenville to Panama flight tickets
United Airlines
Jan 21
GSP6:40 amGreenville
12h 58m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 4
PTY8:55 amPanama City Tocumen Intl
13h 02m
1 stop
GSP9:57 pmGreenville
$392
Find similar
United Airlines
Feb 12
GSP6:50 amGreenville
10h 17m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 20
PTY8:55 amPanama City Tocumen Intl
13h 04m
1 stop
GSP9:59 pmGreenville
$410
Find similar
United Airlines
Feb 12
GSP6:50 amGreenville
7h 55m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Feb 20
PTY11:35 amPanama City Tocumen Intl
10h 24m
1 stop
GSP9:59 pmGreenville
$435
Find similar

American Airlines flights from Greenville to Panama

Our best American Airlines deals on Greenville to Panama flight tickets
American Airlines
Jan 21
GSP7:42 pmGreenville
19h 56m
2 stops
PTY3:38 pmPanama City Tocumen Intl
Feb 4
PTY2:27 pmPanama City Tocumen Intl
21h 40m
2 stops
GSP12:07 pmGreenville
$396
Find similar
American Airlines
Nov 19
GSP11:34 amGreenville
26h 09m
1 stop
PTY1:43 pmPanama City Tocumen Intl
Nov 26
PTY2:43 pmPanama City Tocumen Intl
9h 16m
1 stop
GSP11:59 pmGreenville
$460
Find similar
American Airlines
Feb 12
GSP8:41 pmGreenville
18h 19m
2 stops
PTY3:00 pmPanama City Tocumen Intl
Feb 20
PTY2:30 pmPanama City Tocumen Intl
9h 40m
1 stop
GSP12:10 amGreenville
$496
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:40 am-7:38 pm

1 stop12h 58m

Panama City Tocumen Intl

Wed 2/4

8:55 am-9:57 pm

1 stop13h 02m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:42 pm-3:38 pm

2 stops19h 56m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-12:07 pm

2 stops21h 40m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 2/12

6:50 am-5:07 pm

1 stop10h 17m

Panama City Tocumen Intl

Fri 2/20

8:55 am-9:59 pm

1 stop13h 04m

$410

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 2/12

6:50 am-2:45 pm

1 stop7h 55m

Panama City Tocumen Intl

Fri 2/20

11:35 am-9:59 pm

1 stop10h 24m

$435

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 11/19

11:34 am-1:43 pm

1 stop26h 09m

Panama City Tocumen Intl

Wed 11/26

2:43 pm-11:59 pm

1 stop9h 16m

$460

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 2/12

8:41 pm-3:00 pm

2 stops18h 19m

Panama City Tocumen Intl

Fri 2/20

2:30 pm-12:10 am

1 stop9h 40m

$496

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 11/8

4:37 pm-1:49 pm

2 stops21h 12m

Panama City Tocumen Intl

Sat 11/15

2:49 pm-10:58 am

2 stops20h 09m

$500

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 11/8

6:11 pm-1:49 pm

1 stop19h 38m

Panama City Tocumen Intl

Sat 11/15

2:49 pm-11:33 am

2 stops20h 44m

$509

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 12/3

6:50 am-7:38 pm

1 stop12h 48m

Panama City Tocumen Intl

Wed 12/10

8:55 am-9:58 pm

1 stop13h 03m

$540

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 12/29

7:25 pm-8:19 pm

1 stop24h 54m

Panama City Tocumen Intl

Fri 1/2

12:03 pm-8:08 pm

1 stop8h 05m

$842

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama from

How to get the cheapest flight ticket from Greenville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Greenville, with most prices found around $371. If you don’t want to visit Panama in August, then you should wait until October to fly from Greenville, when ticket prices are also cheap, with an average price of $391.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Greenville. The lowest ticket price found for a Wednesday departure recently was $371. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Greenville to Panama for around $681.

What is the cheapest time of day to depart on your flight to Panama?

In the morning is the cheapest time of day to fly from Greenville to Panama when you can find flight prices for as low as $441. Flying to Panama in the morning is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Panama, so prices are often more expensive at around $677 per ticket.

Cheap Greenville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama

Direct flights

None
There are no direct flights from Greenville to Panama. There are no popular flight routes from Greenville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Greenville Airport to Panama?

    Prices for flights from Greenville Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama?

  • How old do you have to be to fly from Greenville Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Greenville to Panama

Compare and see reviews for airlines that fly from Greenville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $352Free CancellationRating
7.4
8,994 reviews
Search United Airlines flights
DeltaPriceFrom $371Free CancellationRating
7.9
7,976 reviews
Search Delta flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,026 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama?

It is quick and easy to find Greenville to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Greenville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Panama?

Once all potential Greenville to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Greenville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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