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Cheap flights from Greenville to Panama from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama departing on 12/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:52 am - 6:37 pm
GSP
-
PTY
12h 45m1 stop
United Airlines Logo
10:00 am - 10:00 pm
PTY
-
GSP
11h 00m1 stop
$392United Airlines
Tue, Apr 14 - Wed, Apr 29
American Airlines Logo
5:40 pm - 1:27 pm
GSP
-
PTY
19h 47m2 stops
American Airlines Logo
2:27 pm - 11:57 pm
PTY
-
GSP
9h 30m1 stop
$396American Airlines
Wed, Jan 21 - Wed, Feb 4
Delta Logo
7:59 pm - 12:55 pm
GSP
-
PTY
17h 56m1 stop
Delta Logo
2:20 pm - 1:56 pm
PTY
-
GSP
22h 36m1 stop
$404Delta
Sun, Apr 12 - Wed, Apr 29
American Airlines Logo
7:00 am - 3:31 pm
GSP
-
PTY
8h 31m1 stop
American Airlines Logo
5:00 pm - 11:57 pm
PTY
-
GSP
6h 57m1 stop
$410American Airlines
Wed, Jan 7 - Sat, Jan 31
American Airlines Logo
5:40 pm - 3:31 pm
GSP
-
PTY
21h 51m2 stops
American Airlines Logo
5:00 pm - 10:27 am
PTY
-
GSP
17h 27m2 stops
$414American Airlines
Tue, Jan 6 - Sat, Jan 31
Delta Logo
7:00 am - 12:55 pm
GSP
-
PTY
6h 55m1 stop
Delta Logo
2:20 pm - 1:56 pm
PTY
-
GSP
22h 36m1 stop
$416Delta
Sat, Apr 11 - Wed, Apr 29
United Airlines Logo
6:52 am - 2:14 pm
GSP
-
PTY
8h 22m1 stop
United Airlines Logo
7:55 am - 10:00 pm
PTY
-
GSP
13h 05m1 stop
$417United Airlines
Thu, Apr 16 - Mon, Apr 27
United Airlines Logo
4:55 pm - 2:14 pm
GSP
-
PTY
22h 19m1 stop
United Airlines Logo
7:55 am - 10:00 pm
PTY
-
GSP
13h 05m1 stop
$418United Airlines
Sat, Apr 11 - Mon, Apr 27
American Airlines Logo
7:56 pm - 12:15 pm
GSP
-
PTY
17h 19m2 stops
American Airlines Logo
1:55 pm - 10:56 am
PTY
-
GSP
20h 01m2 stops
$419American Airlines
Thu, May 7 - Sun, May 10
Delta Logo
7:59 pm - 12:55 pm
GSP
-
PTY
17h 56m1 stop
Delta Logo
2:20 pm - 9:28 am
PTY
-
GSP
18h 08m1 stop
$422Delta
Sun, Apr 12 - Fri, May 1

United Airlines flights from Greenville to Panama

Our best United Airlines deals on Greenville to Panama flight tickets
United Airlines
Jan 21
GSP6:49 amGreenville
10h 18m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 4
PTY9:55 amPanama City Tocumen Intl
12h 02m
1 stop
GSP9:57 pmGreenville
$392
Find similar
United Airlines
May 7
GSP7:00 amGreenville
8h 14m
1 stop
PTY2:14 pmPanama City Tocumen Intl
May 10
PTY10:00 amPanama City Tocumen Intl
10h 46m
1 stop
GSP9:46 pmGreenville
$410
Find similar
United Airlines
Dec 8
GSP5:00 pmGreenville
21h 45m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Dec 17
PTY8:55 amPanama City Tocumen Intl
13h 03m
1 stop
GSP9:58 pmGreenville
$412
Find similar

American Airlines flights from Greenville to Panama

Our best American Airlines deals on Greenville to Panama flight tickets
American Airlines
Jan 21
GSP6:23 pmGreenville
19h 04m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Feb 4
PTY2:27 pmPanama City Tocumen Intl
20h 00m
2 stops
GSP10:27 amGreenville
$396
Find similar
American Airlines
Jan 6
GSP5:40 pmGreenville
21h 51m
2 stops
PTY3:31 pmPanama City Tocumen Intl
Jan 31
PTY5:00 pmPanama City Tocumen Intl
17h 27m
2 stops
GSP10:27 amGreenville
$414
Find similar
American Airlines
Jan 6
GSP6:56 pmGreenville
20h 35m
1 stop
PTY3:31 pmPanama City Tocumen Intl
Jan 31
PTY5:00 pmPanama City Tocumen Intl
6h 57m
1 stop
GSP11:57 pmGreenville
$418
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 4/14

6:52 am-6:37 pm

1 stop12h 45m

Panama City Tocumen Intl

Wed 4/29

10:00 am-10:00 pm

1 stop11h 00m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

5:40 pm-1:27 pm

2 stops19h 47m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 4/12

7:59 pm-12:55 pm

1 stop17h 56m

Panama City Tocumen Intl

Wed 4/29

2:20 pm-1:56 pm

1 stop22h 36m

$404

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/7

7:00 am-3:31 pm

1 stop8h 31m

Panama City Tocumen Intl

Sat 1/31

5:00 pm-11:57 pm

1 stop6h 57m

$410

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 1/6

5:40 pm-3:31 pm

2 stops21h 51m

Panama City Tocumen Intl

Sat 1/31

5:00 pm-10:27 am

2 stops17h 27m

$414

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/11

7:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 4/29

2:20 pm-1:56 pm

1 stop22h 36m

$416

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 4/16

6:52 am-2:14 pm

1 stop8h 22m

Panama City Tocumen Intl

Mon 4/27

7:55 am-10:00 pm

1 stop13h 05m

$417

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/11

4:55 pm-2:14 pm

1 stop22h 19m

Panama City Tocumen Intl

Mon 4/27

7:55 am-10:00 pm

1 stop13h 05m

$418

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 5/7

7:56 pm-12:15 pm

2 stops17h 19m

Panama City Tocumen Intl

Sun 5/10

1:55 pm-10:56 am

2 stops20h 01m

$419

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 4/12

7:59 pm-12:55 pm

1 stop17h 56m

Panama City Tocumen Intl

Fri 5/1

2:20 pm-9:28 am

1 stop18h 08m

$422

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Greenville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Greenville, with most prices found around $371. If you don’t want to visit Panama in August, then you should wait until October to fly from Greenville, when ticket prices are also cheap, with an average price of $391.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Greenville. The lowest ticket price found for a Wednesday departure recently was $371. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Greenville to Panama for around $681.

What is the cheapest time of day to depart on your flight to Panama?

In the morning is the cheapest time of day to fly from Greenville to Panama when you can find flight prices for as low as $441. Flying to Panama in the morning is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Panama, so prices are often more expensive at around $677 per ticket.

Cheap Greenville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama

Fastest flight time

7h 55m

Direct flights

None
The fastest flight from Greenville to Panama takes 7h 55m
There are no direct flights from Greenville to Panama. There are no popular flight routes from Greenville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Greenville Airport to Panama?

    Prices for flights from Greenville Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama?

  • How old do you have to be to fly from Greenville Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Greenville to Panama

Compare and see reviews for airlines that fly from Greenville to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $371Free CancellationRating
7.9
8,011 reviews
Search Delta flights
United AirlinesPriceFrom $383Free CancellationRating
7.4
9,066 reviews
Search United Airlines flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama?

It is quick and easy to find Greenville to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Greenville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Panama?

Once all potential Greenville to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Greenville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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