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Cheap flights from Greenville to Panama from $213

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama departing on 4/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Greenville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:55 am - 2:10 pm
GSP
-
PTY
9h 15m
1 stop
American Airlines Logo
3:35 pm - 11:14 pm
PTY
-
GSP
6h 39m
1 stop
$497American Airlines
Tue, Sep 15 - Thu, Oct 15
American Airlines Logo
7:49 pm - 2:10 pm
GSP
-
PTY
19h 21m
2 stops
American Airlines Logo
3:35 pm - 11:14 pm
PTY
-
GSP
6h 39m
1 stop
$501American Airlines
Tue, Sep 15 - Thu, Oct 15
Delta Logo
6:51 am - 1:02 pm
GSP
-
PTY
7h 11m
1 stop
Delta Logo
2:27 pm - 11:56 pm
PTY
-
GSP
8h 29m
1 stop
$503Delta
Wed, Apr 29 - Wed, May 6
American Airlines Logo
6:05 pm - 12:46 pm
GSP
-
PTY
19h 41m
2 stops
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
GSP
9h 10m
1 stop
$504American Airlines
Wed, Apr 29 - Wed, May 6
United Airlines Logo
6:30 am - 7:31 pm
GSP
-
PTY
14h 01m
2 stops
United Airlines Logo
3:30 pm - 9:46 am
PTY
-
GSP
17h 16m
2 stops
$513United Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
6:45 pm - 12:46 pm
GSP
-
PTY
19h 01m
1 stop
American Airlines Logo
1:49 pm - 12:05 pm
PTY
-
GSP
21h 16m
2 stops
$514American Airlines
Thu, Apr 30 - Thu, May 7
United Airlines Logo
7:42 pm - 4:12 pm
GSP
-
PTY
21h 30m
2 stops
United Airlines Logo
3:30 pm - 9:46 am
PTY
-
GSP
17h 16m
2 stops
$519United Airlines
Wed, Apr 1 - Wed, Apr 8
American Airlines Logo
6:45 pm - 12:46 pm
GSP
-
PTY
19h 01m
1 stop
American Airlines Logo
1:49 pm - 6:15 pm
PTY
-
GSP
27h 26m
1 stop
$520American Airlines
Thu, Apr 30 - Thu, May 7
United Airlines Logo
6:36 am - 6:37 pm
GSP
-
PTY
13h 01m
2 stops
United Airlines Logo
9:45 am - 9:58 am
PTY
-
GSP
23h 13m
2 stops
$522United Airlines
Sat, May 9 - Wed, May 13
United Airlines Logo
4:41 pm - 4:12 pm
GSP
-
PTY
24h 31m
1 stop
United Airlines Logo
3:30 pm - 9:46 am
PTY
-
GSP
17h 16m
2 stops
$523United Airlines
Tue, Apr 7 - Tue, Apr 14

American Airlines flights from Greenville to Panama

Our best American Airlines deals on Greenville to Panama flight tickets
American Airlines
Sep 15
GSP5:55 amGreenville
9h 15m
1 stop
PTY2:10 pmPanama City Tocumen Intl
Oct 15
PTY3:35 pmPanama City Tocumen Intl
6h 39m
1 stop
GSP11:14 pmGreenville
$497
American Airlines
Sep 15
GSP7:49 pmGreenville
19h 21m
2 stops
PTY2:10 pmPanama City Tocumen Intl
Oct 15
PTY3:35 pmPanama City Tocumen Intl
6h 39m
1 stop
GSP11:14 pmGreenville
$501
American Airlines
Apr 29
GSP6:05 pmGreenville
19h 41m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 6
PTY1:49 pmPanama City Tocumen Intl
9h 10m
1 stop
GSP11:59 pmGreenville
$504

United Airlines flights from Greenville to Panama

Our best United Airlines deals on Greenville to Panama flight tickets
United Airlines
Apr 7
GSP6:30 amGreenville
14h 01m
2 stops
PTY7:31 pmPanama City Tocumen Intl
Apr 14
PTY3:30 pmPanama City Tocumen Intl
17h 16m
2 stops
GSP9:46 amGreenville
$513
United Airlines
Apr 1
GSP7:42 pmGreenville
21h 30m
2 stops
PTY4:12 pmPanama City Tocumen Intl
Apr 8
PTY3:30 pmPanama City Tocumen Intl
17h 16m
2 stops
GSP9:46 amGreenville
$519
United Airlines
May 9
GSP6:36 amGreenville
13h 01m
2 stops
PTY6:37 pmPanama City Tocumen Intl
May 13
PTY9:45 amPanama City Tocumen Intl
23h 13m
2 stops
GSP9:58 amGreenville
$522

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

5:55 am-2:10 pm

1 stop9h 15m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$497

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

7:49 pm-2:10 pm

2 stops19h 21m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$501
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 4/29

6:51 am-1:02 pm

1 stop7h 11m

Panama City Tocumen Intl

Wed 5/6

2:27 pm-11:56 pm

1 stop8h 29m

$503

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 4/29

6:05 pm-12:46 pm

2 stops19h 41m

Panama City Tocumen Intl

Wed 5/6

1:49 pm-11:59 pm

1 stop9h 10m

$504

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 4/7

6:30 am-7:31 pm

2 stops14h 01m

Panama City Tocumen Intl

Tue 4/14

3:30 pm-9:46 am

2 stops17h 16m

$513

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 4/30

6:45 pm-12:46 pm

1 stop19h 01m

Panama City Tocumen Intl

Thu 5/7

1:49 pm-12:05 pm

2 stops21h 16m

$514

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 4/1

7:42 pm-4:12 pm

2 stops21h 30m

Panama City Tocumen Intl

Wed 4/8

3:30 pm-9:46 am

2 stops17h 16m

$519

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 4/30

6:45 pm-12:46 pm

1 stop19h 01m

Panama City Tocumen Intl

Thu 5/7

1:49 pm-6:15 pm

1 stop27h 26m

$520

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 5/9

6:36 am-6:37 pm

2 stops13h 01m

Panama City Tocumen Intl

Wed 5/13

9:45 am-9:58 am

2 stops23h 13m

$522

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 4/7

4:41 pm-4:12 pm

1 stop24h 31m

Panama City Tocumen Intl

Tue 4/14

3:30 pm-9:46 am

2 stops17h 16m

$523

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Greenville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Greenville to Panama?

American Airlines and United Airlines are the most popular carriers operating from Greenville to Panama

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Greenville according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Cheap Greenville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama

Fastest flight time

7h 53m

Direct flights

None
The fastest flight from Greenville to Panama takes 7h 53m
There are no direct flights from Greenville to Panama. There are no popular flight routes from Greenville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Greenville Airport to Panama?

    Prices for flights from Greenville Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama?

  • How old do you have to be to fly from Greenville Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Greenville to Panama

Compare and see reviews for airlines that fly from Greenville to Panama with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $353Free CancellationRating
7.1
11,472 reviews
Search American Airlines flights
DeltaPriceFrom $371Free CancellationRating
7.9
8,292 reviews
Search Delta flights
United AirlinesPriceFrom $391Free CancellationRating
7.4
9,439 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama?

It is quick and easy to find Greenville to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Greenville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Panama?

Once all potential Greenville to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Greenville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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Sat 4/18
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