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Cheap flights from Greenville to Panama from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville to Panama

Cheap round-trip flights

Delta Logo
6:45 am - 2:02 pmGSP-PTY
7h 17m1 stop
Delta Logo
3:27 pm - 11:36 pmPTY-GSP
8h 09m1 stop
$391Delta
Find Deal
mié., ene. 21 - mié., feb. 4
American Airlines Logo
5:21 am - 3:35 pmGSP-PTY
10h 14m2 stops
American Airlines Logo
2:45 pm - 10:33 amPTY-GSP
19h 48m2 stops
$396American Airlines
Find Deal
mié., ene. 21 - mié., feb. 4
American Airlines Logo
6:00 am - 12:55 pmGSP-PTY
7h 55m1 stop
American Airlines Logo
3:31 pm - 11:56 pmPTY-GSP
7h 25m1 stop
$414American Airlines
Find Deal
mié., oct. 1 - dom., oct. 5
American Airlines Logo
6:00 am - 12:55 pmGSP-PTY
7h 55m1 stop
American Airlines Logo
3:31 pm - 12:40 pmPTY-GSP
20h 09m2 stops
$419American Airlines
Find Deal
mié., oct. 1 - dom., oct. 5
American Airlines Logo
8:01 pm - 2:03 pmGSP-PTY
19h 02m2 stops
American Airlines Logo
3:15 pm - 9:43 amPTY-GSP
17h 28m2 stops
$432American Airlines
Find Deal
vie., oct. 10 - lun., oct. 20
American Airlines Logo
8:41 pm - 3:00 pmGSP-PTY
18h 19m2 stops
American Airlines Logo
4:40 pm - 12:08 pmPTY-GSP
19h 28m2 stops
$496American Airlines
Find Deal
jue., feb. 12 - vie., feb. 20
American Airlines Logo
8:12 pm - 2:31 pmGSP-PTY
19h 19m2 stops
American Airlines Logo
3:31 pm - 12:28 pmPTY-GSP
19h 57m2 stops
$497American Airlines
Find Deal
dom., sep. 21 - dom., sep. 28
American Airlines Logo
4:46 pm - 2:03 pmGSP-PTY
22h 17m1 stop
American Airlines Logo
3:15 pm - 11:21 pmPTY-GSP
7h 06m1 stop
$498American Airlines
Find Deal
vie., oct. 10 - lun., oct. 20
United Airlines Logo
7:00 am - 6:37 pmGSP-PTY
12h 37m1 stop
United Airlines Logo
3:30 pm - 10:39 pmPTY-GSP
30h 09m1 stop
$579United Airlines
Find Deal
dom., sep. 21 - dom., sep. 28
United Airlines Logo
6:00 am - 1:55 pmGSP-PTY
8h 55m1 stop
United Airlines Logo
4:41 pm - 9:59 pmPTY-GSP
29h 18m1 stop
$740United Airlines
Find Deal
jue., oct. 30 - dom., nov. 2

American Airlines flights from Greenville to Panama

Our best American Airlines deals on Greenville to Panama flight tickets
American Airlines
Jan 21
GSP5:21 amGreenville
10h 14m
2 stops
PTY3:35 pmPanama City Tocumen Intl
Feb 4
PTY2:45 pmPanama City Tocumen Intl
19h 48m
2 stops
GSP10:33 amGreenville
$396
Find similar
American Airlines
Oct 1
GSP6:00 amGreenville
7h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Oct 5
PTY3:31 pmPanama City Tocumen Intl
7h 25m
1 stop
GSP11:56 pmGreenville
$414
Find similar
American Airlines
Oct 1
GSP6:00 amGreenville
7h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Oct 5
PTY3:31 pmPanama City Tocumen Intl
20h 09m
2 stops
GSP12:40 pmGreenville
$419
Find similar

United Airlines flights from Greenville to Panama

Our best United Airlines deals on Greenville to Panama flight tickets
United Airlines
Sep 21
GSP7:00 amGreenville
12h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Sep 28
PTY3:30 pmPanama City Tocumen Intl
30h 09m
1 stop
GSP10:39 pmGreenville
$579
Find similar
United Airlines
Sep 1
GSP6:08 amGreenville
8h 42m
1 stop
PTY1:50 pmPanama City Tocumen Intl
Sep 7
PTY3:30 pmPanama City Tocumen Intl
29h 30m
1 stop
GSP10:00 pmGreenville
$608
Find similar
United Airlines
Oct 30
GSP6:00 amGreenville
8h 55m
1 stop
PTY1:55 pmPanama City Tocumen Intl
Nov 2
PTY4:41 pmPanama City Tocumen Intl
29h 18m
1 stop
GSP9:59 pmGreenville
$740
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated agosto 25, 2025.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

6:45 am-2:02 pm

1 stop7h 17m

Panama City Tocumen Intl

mié. 2/4

3:27 pm-11:36 pm

1 stop8h 09m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

5:21 am-3:35 pm

2 stops10h 14m

Panama City Tocumen Intl

mié. 2/4

2:45 pm-10:33 am

2 stops19h 48m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 10/1

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

dom. 10/5

3:31 pm-11:56 pm

1 stop7h 25m

$414

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 10/1

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

dom. 10/5

3:31 pm-12:40 pm

2 stops20h 09m

$419

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

vie. 10/10

8:01 pm-2:03 pm

2 stops19h 02m

Panama City Tocumen Intl

lun. 10/20

3:15 pm-9:43 am

2 stops17h 28m

$432

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

jue. 2/12

8:41 pm-3:00 pm

2 stops18h 19m

Panama City Tocumen Intl

vie. 2/20

4:40 pm-12:08 pm

2 stops19h 28m

$496

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

dom. 9/21

8:12 pm-2:31 pm

2 stops19h 19m

Panama City Tocumen Intl

dom. 9/28

3:31 pm-12:28 pm

2 stops19h 57m

$497

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

vie. 10/10

4:46 pm-2:03 pm

1 stop22h 17m

Panama City Tocumen Intl

lun. 10/20

3:15 pm-11:21 pm

1 stop7h 06m

$498

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

dom. 9/21

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

dom. 9/28

3:30 pm-10:39 pm

1 stop30h 09m

$579

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

jue. 10/30

6:00 am-1:55 pm

1 stop8h 55m

Panama City Tocumen Intl

dom. 11/2

4:41 pm-9:59 pm

1 stop29h 18m

$740

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Greenville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of August is, on average, the cheapest month to fly to Panama from Greenville, with most prices found around $371. If you don’t want to visit Panama in August, then you should wait until October to fly from Greenville, when ticket prices are also cheap, with an average price of $376.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Greenville. The lowest ticket price found for a Wednesday departure recently was $371. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Greenville to Panama for around $681.

What is the cheapest time of day to depart on your flight to Panama?

In the morning is the cheapest time of day to fly from Greenville to Panama when you can find flight prices for as low as $441. Flying to Panama in the morning is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Panama, so prices are often more expensive at around $677 per ticket.

Cheap Greenville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama

Direct flights

None
There are no direct flights from Greenville to Panama. There are no popular flight routes from Greenville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Greenville Airport to Panama?

    Prices for flights from Greenville Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama?

  • How old do you have to be to fly from Greenville Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Greenville to Panama

Compare and see reviews for airlines that fly from Greenville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $352Free CancellationRating
7.4
8,940 reviews
Search United Airlines flights
DeltaPriceFrom $371Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $376Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama?

It is quick and easy to find Greenville to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Greenville to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Panama?

Once all potential Greenville to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Greenville to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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