Which airport is the most popular layover for flights between Des Moines and Rome?

Chicago (ORD) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from Des Moines to Rome?

Flights connecting via Minneapolis (MSP) have the shortest average one-way travel time: 11h 44m.

Which layover airport offers the lowest fares from Des Moines to Rome?

Flights via Minneapolis (MSP) offer the lowest average round-trip price of $960.

What is the cheapest airline that flies from Des Moines to Rome?

KLM, United Airlines, and Air Canada are the most popular carriers operating from Des Moines to Rome

Which layover airport has the shortest connection time from Des Moines to Rome?

Minneapolis (MSP) has the shortest average layover time for this route: 1h 13m.

When did momondo last update prices for flights from Des Moines Airport to Rome?

Prices for flights from Des Moines Airport to Rome are updated daily.

How many operators does momondo search for flights from Des Moines Airport to Rome?

The number of operators available for flights from Des Moines Airport to Rome is 2 as of August 2026.

How old do you have to be to fly from Des Moines Airport to Rome?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Rome.

What documentation or ID do you need to fly to Rome?

The necessary travel and health documents for your Rome trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$392 Cheap Flights from Des Moines to Rome in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Rome

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:15 am - 7:55 amDSM Des Moines-FCO Rome Fiumicino

18h 40m2 stops Chicago O'Hare Intl Newark

1:15 pm - 2:11 pmFCO Rome Fiumicino-DSM Des Moines

31h 56m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl

$776United Airlines

Mon, Feb 1 - Fri, Feb 5

8:00 am - 7:55 amDSM Des Moines-FCO Rome Fiumicino

16h 55m3 stops Chicago O'Hare Intl Washington, D.C. Reagan-National Newark

7:05 am - 9:17 pmFCO Rome Fiumicino-DSM Des Moines

21h 12m2 stops Frankfurt am Main Chicago O'Hare Intl

$799United Airlines

Mon, Feb 1 - Fri, Feb 5

8:00 am - 8:55 amDSM Des Moines-FCO Rome Fiumicino

17h 55m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl

7:05 am - 9:17 pmFCO Rome Fiumicino-DSM Des Moines

21h 12m2 stops Frankfurt am Main Chicago O'Hare Intl

$823Multiple Airlines

Sun, Jan 31 - Sat, Feb 6

8:00 am - 8:55 amDSM Des Moines-FCO Rome Fiumicino

17h 55m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl

11:15 am - 7:25 pmFCO Rome Fiumicino-DSM Des Moines

39h 10m2 stops Toronto Pearson Intl Chicago O'Hare Intl

$829Air Canada

Wed, Nov 25 - Sat, Dec 12

8:00 am - 10:55 amDSM Des Moines-FCO Rome Fiumicino

19h 55m3 stops Chicago O'Hare Intl Washington, D.C. Reagan-National Newark

11:15 am - 7:25 pmFCO Rome Fiumicino-DSM Des Moines

39h 10m2 stops Toronto Pearson Intl Chicago O'Hare Intl

$830Multiple Airlines

Wed, Nov 25 - Sat, Dec 12

5:45 am - 11:20 amDSM Des Moines-FCO Rome Fiumicino

22h 35m1 stop Atlanta Hartsfield-Jackson

10:25 am - 10:29 pmFCO Rome Fiumicino-DSM Des Moines

19h 04m1 stop Atlanta Hartsfield-Jackson

$846Delta

Wed, Jan 27 - Sat, Feb 6

11:04 am - 11:20 amDSM Des Moines-FCO Rome Fiumicino

17h 16m1 stop Atlanta Hartsfield-Jackson

1:30 pm - 10:29 pmFCO Rome Fiumicino-DSM Des Moines

15h 59m1 stop Atlanta Hartsfield-Jackson

$846Air France

Sun, Jan 31 - Sat, Feb 6

6:20 am - 9:35 amDSM Des Moines-FCO Rome Fiumicino

20h 15m1 stop Detroit Metropolitan Wayne County

6:10 am - 8:14 pmFCO Rome Fiumicino-DSM Des Moines

21h 04m2 stops Amsterdam Schiphol Minneapolis St Paul

$905Delta

Wed, Dec 23 - Tue, Dec 29

6:20 am - 9:35 amDSM Des Moines-FCO Rome Fiumicino

20h 15m1 stop Detroit Metropolitan Wayne County

6:10 am - 8:14 pmFCO Rome Fiumicino-DSM Des Moines

21h 04m2 stops Amsterdam Schiphol Minneapolis St Paul

$905Delta

Wed, Dec 23 - Tue, Dec 29

2:48 pm - 4:20 pmDSM Des Moines-FCO Rome Fiumicino

18h 32m2 stops Minneapolis St Paul Amsterdam Schiphol

10:10 am - 9:13 pmFCO Rome Fiumicino-DSM Des Moines

18h 03m2 stops Amsterdam Schiphol Minneapolis St Paul

$905Delta

Fri, Nov 20 - Fri, Nov 27

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American Airlines flights from Des Moines to Rome

Our best American Airlines deals on Des Moines to Rome flight tickets

American Airlines

Oct 14

DSM6:05 amDes Moines

18h 00m

1 stop

FCO7:05 amRome Fiumicino

Oct 21

FCO2:10 pmRome Fiumicino

15h 33m

1 stop

DSM10:43 pmDes Moines

$903

American Airlines

Oct 14

DSM1:15 pmDes Moines

15h 50m

1 stop

FCO12:05 pmRome Fiumicino

Oct 21

FCO12:15 pmRome Fiumicino

18h 59m

2 stops

DSM12:14 amDes Moines

$907

American Airlines

Oct 7

DSM2:01 pmDes Moines

15h 04m

2 stops

FCO12:05 pmRome Fiumicino

Oct 14

FCO2:10 pmRome Fiumicino

15h 33m

1 stop

DSM10:43 pmDes Moines

$972

Lufthansa flights from Des Moines to Rome

Our best Lufthansa deals on Des Moines to Rome flight tickets

Lufthansa

Nov 2

DSM6:45 pmDes Moines

16h 15m

2 stops

FCO6:00 pmRome Fiumicino

Nov 16

FCO6:50 pmRome Fiumicino

34h 05m

2 stops

DSM9:55 pmDes Moines

$906

Lufthansa

Oct 7

DSM1:24 pmDes Moines

13h 36m

2 stops

FCO10:00 amRome Fiumicino

Oct 14

FCO1:20 pmRome Fiumicino

17h 15m

2 stops

DSM11:35 pmDes Moines

$923

Lufthansa

Oct 7

DSM1:24 pmDes Moines

11h 31m

1 stop

FCO7:55 amRome Fiumicino

Oct 14

FCO9:45 amRome Fiumicino

18h 38m

1 stop

DSM9:23 pmDes Moines

$954

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Mon 2/1

6:15 am-7:55 am

2 stops18h 40m

Rome Fiumicino

Fri 2/5

1:15 pm-2:11 pm

2 stops31h 56m

$776

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Mon 2/1

8:00 am-7:55 am

3 stops16h 55m

Rome Fiumicino

Fri 2/5

7:05 am-9:17 pm

2 stops21h 12m

$799

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Sun 1/31

8:00 am-8:55 am

2 stops17h 55m

Rome Fiumicino

Sat 2/6

7:05 am-9:17 pm

2 stops21h 12m

$823

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Wed 11/25

8:00 am-8:55 am

2 stops17h 55m

Rome Fiumicino

Sat 12/12

11:15 am-7:25 pm

2 stops39h 10m

$829

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Wed 11/25

8:00 am-10:55 am

3 stops19h 55m

Rome Fiumicino

Sat 12/12

11:15 am-7:25 pm

2 stops39h 10m

$830

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Wed 1/27

5:45 am-11:20 am

1 stop22h 35m

Rome Fiumicino

Sat 2/6

10:25 am-10:29 pm

1 stop19h 04m

$846

Quickest round-trip

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Sun 1/31

11:04 am-11:20 am

1 stop17h 16m

Rome Fiumicino

Sat 2/6

1:30 pm-10:29 pm

1 stop15h 59m

$846

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Wed 12/23

6:20 am-9:35 am

1 stop20h 15m

Rome Fiumicino

Tue 12/29

6:10 am-8:14 pm

2 stops21h 04m

$905

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Wed 12/23

6:20 am-9:35 am

1 stop20h 15m

Rome Fiumicino

Tue 12/29

6:10 am-8:14 pm

2 stops21h 04m

$905

Des MoinesRome

DSM Des Moines - FCO Rome Fiumicino

DSMFCO

Des Moines

Fri 11/20

2:48 pm-4:20 pm

2 stops18h 32m

Rome Fiumicino

Fri 11/27

10:10 am-9:13 pm

2 stops18h 03m

$905

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Rome

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between Des Moines and Rome?

Prices are currently low for flights on this route.

Typical prices usually range from $960 to $1,123.
The lowest price recently found on this route was $776.

What is the cheapest month to fly to Rome?

The cheapest month to fly to Rome from Des Moines is in January. Flight prices, which tend to average around $718, are often lower during this time because this is during the off-season. If you aren’t able to travel to Rome during the month of January, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $767.

Can stopping save me money on Des Moines to Rome flights?

You could potentially save up to 7% on your flight if you consider stops on a Des Moines to Rome flight.

When to book flights from Des Moines to Rome

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Rome according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Rome (DSM to ROM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Rome

Best Price Found	$392
Fastest flight time	14h 50m
Direct flights	None

The best one-way flight to Rome from Des Moines in the past 72 hours is $392. The best round-trip flight deal from Des Moines to Rome found on momondo in the last 72 hours is $776.

The fastest flight from Des Moines to Rome takes 14h 50m

There are no direct flights from Des Moines to Rome. There are no popular flight routes from Des Moines to Rome.

Search flight deals

Frequently asked questions about flying from Des Moines to Rome

How far is Des Moines to Rome by plane?
The straight-line distance from Des Moines to Rome is 5055.2 mi. In terms of flight time, this usually takes a little over 14h 50m.
When did momondo last update prices for flights from Des Moines Airport to Rome?
Prices for flights from Des Moines Airport to Rome are updated daily.
How many operators does momondo search for flights from Des Moines Airport to Rome?
The number of operators available for flights from Des Moines Airport to Rome is 2 as of August 2026.
How old do you have to be to fly from Des Moines Airport to Rome?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Rome.
What documentation or ID do you need to fly to Rome?
The necessary travel and health documents for your Rome trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Rome?
Based on momondo bookings for flights between Des Moines and Rome, the leading airline is Delta, making up 32% of the total bookings. Other popular airlines include United Airlines with 24%, American Airlines with 15%, and Air France with 15%.

Best airlines flying from Des Moines to Rome

Compare and see reviews for airlines that fly from Des Moines to Rome with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $491	Free Cancellation	Rating 7.4 10,127 reviews		Search United Airlines flights
Delta	PriceFrom $655	Free Cancellation	Rating 7.8 8,531 reviews		Search Delta flights

Fiumicino

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Gaeta

Orvieto

Montepulciano

Ladispoli

Pienza

Tivoli

Chianciano Terme

Orbetello

Ponza

Cassino

Ciampino

Porto Ercole

Sperlonga

Terracina

Saturnia

Ascoli Piceno

Foligno

Santa Marinella

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Rome?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Rome. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Rome with flexible booking policies on momondo?

Flights from Des Moines to Rome with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Rome?

momondo helps you find the best flight between Des Moines and Rome by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Rome right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Rome flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from Des Moines to Rome from $392

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Rome departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Des Moines to Rome

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How to get the cheapest flight ticket from Des Moines to Rome

What is the typical price of a round-trip flight between Des Moines and Rome?

What is the cheapest month to fly to Rome?

Can stopping save me money on Des Moines to Rome flights?

What is the cheapest airline that flies from Des Moines to Rome?

Which airport is the most popular layover for flights between Des Moines and Rome?

Which layover airport offers the lowest fares from Des Moines to Rome?

Which layover airport has the shortest travel time from Des Moines to Rome?

Which layover airport has the shortest connection time from Des Moines to Rome?

When to book flights from Des Moines to Rome

Cheap Des Moines to Rome (DSM to ROM) flight deals and tips

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Fastest flight time

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Frequently asked questions about flying from Des Moines to Rome

Best airlines flying from Des Moines to Rome

Compare and see reviews for airlines that fly from Des Moines to Rome with momondo

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Why use momondo?

An easier way to manage your Rome trip

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Airports listed have a maximum distance of 14.7 mi from Rome

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List of cabin classes available on flights landing in Rome. Availability may vary depending on flight origin and airline.

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