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Cheap flights from Des Moines to Rome from $289

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Rome departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
6:48 pm - 9:25 amDSM-FCO
55h 37m2 stops
Air Canada Logo
11:15 am - 9:51 pmFCO-DSM
41h 36m2 stops
$488Air Canada
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Fri, Feb 6 - Mon, Feb 16
Delta Logo
10:54 am - 11:45 amDSM-FCO
17h 51m2 stops
Delta Logo
12:40 pm - 10:31 pmFCO-DSM
16h 51m1 stop
$510Delta
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Fri, Feb 6 - Mon, Feb 16
Multiple Airlines Logo
6:40 am - 2:30 pmDSM-FCO
24h 50m1 stop
Multiple Airlines Logo
7:10 pm - 12:55 pmFCO-DSM
24h 45m1 stop
$539Multiple Airlines
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Mon, Nov 24 - Thu, Dec 11
Multiple Airlines Logo
2:00 pm - 2:30 pmDSM-FCO
41h 30m2 stops
Multiple Airlines Logo
7:10 pm - 12:55 pmFCO-DSM
24h 45m1 stop
$556Multiple Airlines
Find Deal
Wed, Nov 26 - Thu, Dec 11
Multiple Airlines Logo
6:40 am - 2:30 pmDSM-FCO
24h 50m1 stop
Multiple Airlines Logo
7:10 pm - 12:55 pmFCO-DSM
24h 45m1 stop
$581Multiple Airlines
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Mon, Nov 24 - Thu, Dec 11
United Airlines Logo
1:05 pm - 7:45 amDSM-FCO
11h 40m1 stop
United Airlines Logo
1:10 pm - 2:34 pmFCO-DSM
32h 24m2 stops
$582United Airlines
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Wed, Nov 26 - Fri, Dec 12
United Airlines Logo
6:50 pm - 7:45 amDSM-FCO
29h 55m1 stop
United Airlines Logo
1:10 pm - 2:34 pmFCO-DSM
32h 24m2 stops
$587United Airlines
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Tue, Nov 25 - Fri, Dec 12
Lufthansa Logo
6:50 pm - 11:00 pmDSM-FCO
21h 10m2 stops
Lufthansa Logo
7:05 pm - 9:50 pmFCO-DSM
33h 45m2 stops
$619Lufthansa
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Tue, Nov 25 - Mon, Dec 15
Air France Logo
11:00 am - 8:40 amDSM-FCO
14h 40m2 stops
Air France Logo
10:05 am - 10:34 pmFCO-DSM
19h 29m1 stop
$660Air France
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Mon, Nov 24 - Sun, Dec 14
Lufthansa Logo
6:45 pm - 6:15 pmDSM-FCO
17h 30m2 stops
Lufthansa Logo
6:50 am - 9:36 pmFCO-DSM
21h 46m2 stops
$691Lufthansa
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Mon, Mar 23 - Wed, Apr 1

Air Canada flights from Des Moines to Rome

Our best Air Canada deals on Des Moines to Rome flight tickets
Air Canada
Feb 6
DSM6:48 pmDes Moines
55h 37m
2 stops
FCO9:25 amRome Fiumicino
Feb 16
FCO11:15 amRome Fiumicino
41h 36m
2 stops
DSM9:51 pmDes Moines
$488
Find similar
Air Canada
Nov 26
DSM8:02 amDes Moines
17h 53m
2 stops
FCO8:55 amRome Fiumicino
Dec 11
FCO10:55 amRome Fiumicino
43h 49m
2 stops
DSM11:44 pmDes Moines
$589
Find similar
Air Canada
Nov 25
DSM3:15 pmDes Moines
34h 40m
2 stops
FCO8:55 amRome Fiumicino
Dec 16
FCO1:10 pmRome Fiumicino
41h 34m
2 stops
DSM11:44 pmDes Moines
$594
Find similar

Delta flights from Des Moines to Rome

Our best Delta deals on Des Moines to Rome flight tickets
Delta
Feb 6
DSM10:54 amDes Moines
17h 51m
2 stops
FCO11:45 amRome Fiumicino
Feb 16
FCO12:40 pmRome Fiumicino
16h 51m
1 stop
DSM10:31 pmDes Moines
$510
Find similar
Delta
Nov 26
DSM6:32 pmDes Moines
18h 13m
2 stops
FCO7:45 pmRome Fiumicino
Dec 17
FCO9:20 amRome Fiumicino
17h 23m
1 stop
DSM7:43 pmDes Moines
$609
Find similar
Delta
Nov 27
DSM1:10 pmDes Moines
21h 15m
2 stops
FCO5:25 pmRome Fiumicino
Dec 5
FCO6:10 amRome Fiumicino
23h 24m
2 stops
DSM10:34 pmDes Moines
$659
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Des Moines to Rome that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 2/6

6:48 pm-9:25 am

2 stops55h 37m

Rome Fiumicino

Mon 2/16

11:15 am-9:51 pm

2 stops41h 36m

$488

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 2/6

10:54 am-11:45 am

2 stops17h 51m

Rome Fiumicino

Mon 2/16

12:40 pm-10:31 pm

1 stop16h 51m

$510

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/24

6:40 am-2:30 pm

1 stop24h 50m

Rome Fiumicino

Thu 12/11

7:10 pm-12:55 pm

1 stop24h 45m

$539

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 11/26

2:00 pm-2:30 pm

2 stops41h 30m

Rome Fiumicino

Thu 12/11

7:10 pm-12:55 pm

1 stop24h 45m

$556

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/24

6:40 am-2:30 pm

1 stop24h 50m

Rome Fiumicino

Thu 12/11

7:10 pm-12:55 pm

1 stop24h 45m

$581

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 11/26

1:05 pm-7:45 am

1 stop11h 40m

Rome Fiumicino

Fri 12/12

1:10 pm-2:34 pm

2 stops32h 24m

$582

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 11/25

6:50 pm-7:45 am

1 stop29h 55m

Rome Fiumicino

Fri 12/12

1:10 pm-2:34 pm

2 stops32h 24m

$587

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 11/25

6:50 pm-11:00 pm

2 stops21h 10m

Rome Fiumicino

Mon 12/15

7:05 pm-9:50 pm

2 stops33h 45m

$619

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/24

11:00 am-8:40 am

2 stops14h 40m

Rome Fiumicino

Sun 12/14

10:05 am-10:34 pm

1 stop19h 29m

$660

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 3/23

6:45 pm-6:15 pm

2 stops17h 30m

Rome Fiumicino

Wed 4/1

6:50 am-9:36 pm

2 stops21h 46m

$691

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Rome from

How to get the cheapest flight ticket from Des Moines to Rome

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Rome?

What is the cheapest month to fly to Rome?

The cheapest month to fly to Rome from Des Moines is in November. Flight prices, which tend to average around $654, are often lower during this time because this is during the off-season. If you aren’t able to travel to Rome during the month of November, then flying in December is also cheap. Prices for this month can be found on momondo for an average of $773.

What is the cheapest day to depart on your flight to Rome?

The cheapest day to depart on your flight to Rome is on a Tuesday when prices can be found for as low as $1,012. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Rome on Sunday is $1,591.

What is the cheapest time of day to depart on your flight to Rome?

In the afternoon is the cheapest time of day to fly from Des Moines to Rome when you can find flight prices for as low as $1,222. Flying to Rome in the afternoon is an ideal time because this is during off-peak travel hours. Flights to Rome are more costly at noon, with an average ticket price of $1,332. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Des Moines to Rome flights?

You could potentially save up to 28% on your flight if you consider stops on a Des Moines to Rome flight.

When to book flights from Des Moines to Rome

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Rome according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Rome (DSM to ROM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Rome

Direct flights

None
There are no direct flights from Des Moines to Rome. There are no popular flight routes from Des Moines to Rome.
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  • How far is Des Moines to Rome by plane?

    The straight-line distance from Des Moines to Rome is 5055.2 mi. In terms of flight time, this usually takes a little over 11h 40m.

  • When did momondo last update prices for flights from Des Moines Airport to Rome?

    Prices for flights from Des Moines Airport to Rome are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Rome?

  • How old do you have to be to fly from Des Moines Airport to Rome?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Rome.

  • What documentation or ID do you need to fly to Rome?

    The necessary travel and health documents for your Rome trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Rome?

Best airlines flying from Des Moines to Rome

Compare and see reviews for airlines that fly from Des Moines to Rome with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
7.9
8,004 reviews
Search Delta flights
United AirlinesPriceFrom $655Free CancellationRating
7.4
9,003 reviews
Search United Airlines flights
KLMPriceFrom $680Free CancellationRating
7.7
1,405 reviews
Search KLM flights

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Civitavecchia
Cassino
Pienza
Ponza
Montepulciano
Gaeta
Tivoli
Sperlonga
Orvieto
Ciampino
Cortona
Terracina
Ascoli Piceno
Santa Marinella
Grosseto
Chianciano Terme
Sabaudia
Saturnia
Foligno

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Rome?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Rome. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Rome with flexible booking policies on momondo?

Flights from Des Moines to Rome with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Rome?

momondo helps you find the best flight between Des Moines and Rome by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Rome right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Rome flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to Italy

Fly into one of these airports located in Rome

Airports listed have a maximum distance of 14.7 mi from Rome
Rome Ciampino Airport
Rome Fiumicino Airport