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Cheap flights from Des Moines to Rome from $221

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Rome departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Scandinavian Airlines Logo
10:52 am - 11:05 amDSM-FCO
42h 13m2 stops
Scandinavian Airlines Logo
11:55 am - 10:43 pmFCO-DSM
41h 48m2 stops
$619Scandinavian Airlines
Find Deal
Wed, Oct 29 - Wed, Nov 5
Finnair Logo
11:30 am - 5:55 pmDSM-FCO
23h 25m2 stops
Finnair Logo
6:40 pm - 10:59 pmFCO-DSM
35h 19m2 stops
$631Finnair
Find Deal
Mon, Nov 10 - Mon, Nov 17
United Airlines Logo
1:05 pm - 7:45 amDSM-FCO
11h 40m1 stop
United Airlines Logo
7:05 am - 5:25 pmFCO-DSM
17h 20m2 stops
$658United Airlines
Find Deal
Fri, Nov 14 - Tue, Nov 18
American Airlines Logo
5:45 am - 9:00 amDSM-FCO
20h 15m2 stops
American Airlines Logo
11:35 am - 10:59 pmFCO-DSM
18h 24m1 stop
$659American Airlines
Find Deal
Mon, Nov 10 - Mon, Nov 17
United Airlines Logo
11:26 am - 10:55 amDSM-FCO
16h 29m2 stops
United Airlines Logo
7:05 am - 9:32 pmFCO-DSM
21h 27m2 stops
$663United Airlines
Find Deal
Fri, Nov 14 - Tue, Nov 18
American Airlines Logo
1:24 pm - 1:55 pmDSM-FCO
17h 31m2 stops
American Airlines Logo
11:35 am - 10:59 pmFCO-DSM
18h 24m1 stop
$668American Airlines
Find Deal
Mon, Nov 10 - Mon, Nov 17
Logo
11:26 am - 8:55 amDSM-FCO
38h 29m2 stops
Logo
6:25 pm - 5:25 pmFCO-DSM
30h 00m2 stops
$669
Find Deal
Thu, Nov 6 - Mon, Nov 10
Scandinavian Airlines Logo
2:13 pm - 6:45 pmDSM-FCO
21h 32m2 stops
Scandinavian Airlines Logo
11:55 am - 10:43 pmFCO-DSM
41h 48m2 stops
$680Scandinavian Airlines
Find Deal
Mon, Oct 6 - Mon, Oct 13
KLM Logo
2:14 pm - 10:30 amDSM-FCO
13h 16m1 stop
KLM Logo
10:05 am - 10:23 pmFCO-DSM
19h 18m1 stop
$755KLM
Find Deal
Mon, Nov 10 - Mon, Nov 17
Delta Logo
10:52 am - 8:45 amDSM-FCO
15h 53m2 stops
Delta Logo
12:40 pm - 10:43 pmFCO-DSM
17h 03m1 stop
$764Delta
Find Deal
Wed, Oct 29 - Wed, Nov 5

KLM flights from Des Moines to Rome

Our best KLM deals on Des Moines to Rome flight tickets
KLM
Nov 10
DSM2:14 pmDes Moines
13h 16m
1 stop
FCO10:30 amRome Fiumicino
Nov 17
FCO10:05 amRome Fiumicino
19h 18m
1 stop
DSM10:23 pmDes Moines
$755
Find similar
KLM
Aug 6
DSM11:24 amDes Moines
13h 11m
1 stop
FCO7:35 amRome Fiumicino
Aug 13
FCO11:35 amRome Fiumicino
18h 04m
1 stop
DSM10:39 pmDes Moines
$1,463
Find similar
KLM
Aug 1
DSM11:24 amDes Moines
13h 11m
1 stop
FCO7:35 amRome Fiumicino
Aug 2
FCO9:45 amRome Fiumicino
19h 48m
1 stop
DSM10:33 pmDes Moines
$5,084
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British Airways flights from Des Moines to Rome

Our best British Airways deals on Des Moines to Rome flight tickets
British Airways
Sep 30
DSM4:25 pmDes Moines
15h 35m
2 stops
FCO3:00 pmRome Fiumicino
Oct 6
FCO8:30 pmRome Fiumicino
28h 07m
2 stops
DSM5:37 pmDes Moines
$792
Find similar
British Airways
Oct 11
DSM6:07 pmDes Moines
32h 03m
1 stop
FCO9:10 amRome Fiumicino
Oct 21
FCO11:05 amRome Fiumicino
16h 06m
2 stops
DSM8:11 pmDes Moines
$793
Find similar
British Airways
Oct 1
DSM4:20 pmDes Moines
23h 45m
2 stops
FCO11:05 pmRome Fiumicino
Oct 6
FCO8:30 pmRome Fiumicino
28h 07m
2 stops
DSM5:37 pmDes Moines
$797
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to Rome that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 10/29

10:52 am-11:05 am

2 stops42h 13m

Rome Fiumicino

Wed 11/5

11:55 am-10:43 pm

2 stops41h 48m

$619

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/10

11:30 am-5:55 pm

2 stops23h 25m

Rome Fiumicino

Mon 11/17

6:40 pm-10:59 pm

2 stops35h 19m

$631

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 11/14

1:05 pm-7:45 am

1 stop11h 40m

Rome Fiumicino

Tue 11/18

7:05 am-5:25 pm

2 stops17h 20m

$658

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/10

5:45 am-9:00 am

2 stops20h 15m

Rome Fiumicino

Mon 11/17

11:35 am-10:59 pm

1 stop18h 24m

$659

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 11/14

11:26 am-10:55 am

2 stops16h 29m

Rome Fiumicino

Tue 11/18

7:05 am-9:32 pm

2 stops21h 27m

$663

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/10

1:24 pm-1:55 pm

2 stops17h 31m

Rome Fiumicino

Mon 11/17

11:35 am-10:59 pm

1 stop18h 24m

$668

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Thu 11/6

11:26 am-8:55 am

2 stops38h 29m

Rome Fiumicino

Mon 11/10

6:25 pm-5:25 pm

2 stops30h 00m

$669

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 10/6

2:13 pm-6:45 pm

2 stops21h 32m

Rome Fiumicino

Mon 10/13

11:55 am-10:43 pm

2 stops41h 48m

$680

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/10

2:14 pm-10:30 am

1 stop13h 16m

Rome Fiumicino

Mon 11/17

10:05 am-10:23 pm

1 stop19h 18m

$755

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 10/29

10:52 am-8:45 am

2 stops15h 53m

Rome Fiumicino

Wed 11/5

12:40 pm-10:43 pm

1 stop17h 03m

$764

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Rome from

How to get the cheapest flight ticket from Des Moines to Rome

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Rome?

What is the cheapest month to fly to Rome?

The cheapest month to fly to Rome from Des Moines is in November. Flight prices, which tend to average around $771, are often lower during this time because this is during the off-season. If you aren’t able to travel to Rome during the month of November, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $800.

What is the cheapest day to depart on your flight to Rome?

The cheapest day to depart on your flight to Rome is on a Tuesday when prices can be found for as low as $1,012. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Rome on Sunday is $1,591.

What is the cheapest time of day to depart on your flight to Rome?

In the afternoon is the cheapest time of day to fly from Des Moines to Rome when you can find flight prices for as low as $1,222. Flying to Rome in the afternoon is an ideal time because this is during off-peak travel hours. Flights to Rome are more costly at noon, with an average ticket price of $1,332. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Des Moines to Rome flights?

You could potentially save up to 3% on your flight if you consider stops on a Des Moines to Rome flight.

When to book flights from Des Moines to Rome

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Rome according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Rome (DSM to ROM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Rome

Best Price Found

$221

Fastest flight time

11h 40m

Direct flights

None

Airports in Rome

1 airport
The best one-way flight to Rome from Des Moines in the past 72 hours is $221. The best round-trip flight deal from Des Moines to Rome found on momondo in the last 72 hours is $619.
The fastest flight from Des Moines to Rome takes 11h 40m
There are no direct flights from Des Moines to Rome. Popular non-direct route for this connection is Des Moines Airport - Rome Fiumicino Airport.
There is 1 airport near Rome: Rome Fiumicino (FCO)
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  • How far is Des Moines to Rome by plane?

    The straight-line distance from Des Moines to Rome is 5055.2 mi. In terms of flight time, this usually takes a little over 11h 40m.

  • When did momondo last update prices for flights from Des Moines Airport to Rome?

    Prices for flights from Des Moines Airport to Rome are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Rome?

  • How old do you have to be to fly from Des Moines Airport to Rome?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Rome.

  • What documentation or ID do you need to fly to Rome?

    The necessary travel and health documents for your Rome trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Rome?

Best airlines flying from Des Moines to Rome

Compare and see reviews for airlines that fly from Des Moines to Rome with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
8.0
7,981 reviews
Search Delta flights
KLMPriceFrom $680Free CancellationRating
7.8
1,383 reviews
Search KLM flights
United AirlinesPriceFrom $703Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
American AirlinesPriceFrom $789Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Civitavecchia
Cassino
Ponza
Pienza
Ciampino
Montepulciano
Tivoli
Gaeta
Sperlonga
Santa Marinella
Cortona
Grosseto
Orvieto
Saturnia
Anzio
Sabaudia
Terracina
Ascoli Piceno
Foligno

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Rome?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Rome. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Rome with flexible booking policies on momondo?

Flights from Des Moines to Rome with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Rome?

momondo helps you find the best flight between Des Moines and Rome by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Rome right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Rome flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to Italy

Fly into one of these airports located in Rome

Airports listed have a maximum distance of 14.7 mi from Rome
Rome Ciampino Airport
Rome Fiumicino Airport