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Cheap flights from Des Moines to Rome from $326

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Rome departing on 2/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Rome

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
8:00 am - 9:25 am
DSM
-
FCO
42h 25m2 stops
Air Canada Logo
12:50 pm - 2:27 pm
FCO
-
DSM
32h 37m2 stops
$434Air Canada
Thu, Feb 5 - Thu, Feb 12
Lufthansa Logo
6:48 pm - 6:15 pm
DSM
-
FCO
16h 27m2 stops
Lufthansa Logo
7:05 am - 9:50 pm
FCO
-
DSM
21h 45m2 stops
$474Lufthansa
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
8:00 am - 6:45 am
DSM
-
FCO
15h 45m2 stops
Multiple Airlines Logo
9:45 am - 9:50 pm
FCO
-
DSM
19h 05m2 stops
$475Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
Air France Logo
12:06 pm - 11:45 am
DSM
-
FCO
16h 39m2 stops
Air France Logo
12:40 pm - 4:28 pm
FCO
-
DSM
34h 48m1 stop
$476Air France
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
8:00 am - 11:05 am
DSM
-
FCO
20h 05m2 stops
Multiple Airlines Logo
8:25 am - 5:47 pm
FCO
-
DSM
16h 22m2 stops
$478Multiple Airlines
Wed, Feb 4 - Wed, Feb 11
Air France Logo
10:21 am - 10:30 am
DSM
-
FCO
17h 09m2 stops
Air France Logo
12:40 pm - 4:27 pm
FCO
-
DSM
34h 47m1 stop
$479Air France
Thu, Feb 5 - Thu, Feb 12
Multiple Airlines Logo
3:35 pm - 1:25 pm
DSM
-
FCO
14h 50m2 stops
Multiple Airlines Logo
9:45 am - 9:50 pm
FCO
-
DSM
19h 05m2 stops
$483Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
KLM Logo
5:16 pm - 10:30 am
DSM
-
FCO
34h 14m1 stop
KLM Logo
6:10 am - 4:28 pm
FCO
-
DSM
17h 18m2 stops
$485KLM
Wed, Feb 4 - Wed, Feb 11
Air Canada Logo
6:48 pm - 11:05 am
DSM
-
FCO
33h 17m2 stops
Air Canada Logo
7:05 am - 9:50 pm
FCO
-
DSM
21h 45m3 stops
$490Air Canada
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
6:48 pm - 6:15 pm
DSM
-
FCO
16h 27m2 stops
Lufthansa Logo
7:05 am - 9:50 pm
FCO
-
DSM
21h 45m2 stops
$491Lufthansa
Mon, Jan 19 - Mon, Jan 26

Air Canada flights from Des Moines to Rome

Our best Air Canada deals on Des Moines to Rome flight tickets
Air Canada
Feb 5
DSM8:00 amDes Moines
42h 25m
2 stops
FCO9:25 amRome Fiumicino
Feb 12
FCO12:50 pmRome Fiumicino
32h 37m
2 stops
DSM2:27 pmDes Moines
$434
Find similar
Air Canada
Feb 3
DSM6:48 pmDes Moines
33h 17m
2 stops
FCO11:05 amRome Fiumicino
Feb 10
FCO7:05 amRome Fiumicino
21h 45m
3 stops
DSM9:50 pmDes Moines
$490
Find similar
Air Canada
Dec 30
DSM6:46 pmDes Moines
31h 34m
2 stops
FCO9:20 amRome Fiumicino
Jan 22
FCO12:50 pmRome Fiumicino
40h 00m
2 stops
DSM9:50 pmDes Moines
$1,373
Find similar

Lufthansa flights from Des Moines to Rome

Our best Lufthansa deals on Des Moines to Rome flight tickets
Lufthansa
Feb 3
DSM6:48 pmDes Moines
16h 27m
2 stops
FCO6:15 pmRome Fiumicino
Feb 10
FCO7:05 amRome Fiumicino
21h 45m
2 stops
DSM9:50 pmDes Moines
$474
Find similar
Lufthansa
Jan 19
DSM6:48 pmDes Moines
16h 27m
2 stops
FCO6:15 pmRome Fiumicino
Jan 26
FCO7:05 amRome Fiumicino
21h 45m
2 stops
DSM9:50 pmDes Moines
$491
Find similar
Lufthansa
Jan 4
DSM6:46 pmDes Moines
39h 54m
2 stops
FCO5:40 pmRome Fiumicino
Jan 22
FCO7:05 amRome Fiumicino
21h 45m
2 stops
DSM9:50 pmDes Moines
$900
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Des Moines to Rome that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Thu 2/5

8:00 am-9:25 am

2 stops42h 25m

Rome Fiumicino

Thu 2/12

12:50 pm-2:27 pm

2 stops32h 37m

$434

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 2/3

6:48 pm-6:15 pm

2 stops16h 27m

Rome Fiumicino

Tue 2/10

7:05 am-9:50 pm

2 stops21h 45m

$474

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 2/3

8:00 am-6:45 am

2 stops15h 45m

Rome Fiumicino

Tue 2/10

9:45 am-9:50 pm

2 stops19h 05m

$475

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 2/3

12:06 pm-11:45 am

2 stops16h 39m

Rome Fiumicino

Tue 2/10

12:40 pm-4:28 pm

1 stop34h 48m

$476

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 2/4

8:00 am-11:05 am

2 stops20h 05m

Rome Fiumicino

Wed 2/11

8:25 am-5:47 pm

2 stops16h 22m

$478

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Thu 2/5

10:21 am-10:30 am

2 stops17h 09m

Rome Fiumicino

Thu 2/12

12:40 pm-4:27 pm

1 stop34h 47m

$479

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 2/3

3:35 pm-1:25 pm

2 stops14h 50m

Rome Fiumicino

Tue 2/10

9:45 am-9:50 pm

2 stops19h 05m

$483

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 2/4

5:16 pm-10:30 am

1 stop34h 14m

Rome Fiumicino

Wed 2/11

6:10 am-4:28 pm

2 stops17h 18m

$485

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Tue 2/3

6:48 pm-11:05 am

2 stops33h 17m

Rome Fiumicino

Tue 2/10

7:05 am-9:50 pm

3 stops21h 45m

$490

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 1/19

6:48 pm-6:15 pm

2 stops16h 27m

Rome Fiumicino

Mon 1/26

7:05 am-9:50 pm

2 stops21h 45m

$491

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Rome from

How to get the cheapest flight ticket from Des Moines to Rome

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Rome?

What is the cheapest month to fly to Rome?

The cheapest month to fly to Rome from Des Moines is in November. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel to Rome during the month of November, then flying in December is also cheap. Prices for this month can be found on momondo for an average of $773.

What is the cheapest day to depart on your flight to Rome?

The cheapest day to depart on your flight to Rome is on a Tuesday when prices can be found for as low as $1,012. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Rome on Sunday is $1,591.

What is the cheapest time of day to depart on your flight to Rome?

In the afternoon is the cheapest time of day to fly from Des Moines to Rome when you can find flight prices for as low as $1,222. Flying to Rome in the afternoon is an ideal time because this is during off-peak travel hours. Flights to Rome are more costly at noon, with an average ticket price of $1,332. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Des Moines to Rome flights?

You could potentially save up to 54% on your flight if you consider stops on a Des Moines to Rome flight.

When to book flights from Des Moines to Rome

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Rome according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Rome (DSM to ROM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Rome

Fastest flight time

11h 45m

Direct flights

None
The fastest flight from Des Moines to Rome takes 11h 45m
There are no direct flights from Des Moines to Rome. There are no popular flight routes from Des Moines to Rome.
Search flight deals

  • How far is Des Moines to Rome by plane?

    The straight-line distance from Des Moines to Rome is 5055.2 mi. In terms of flight time, this usually takes a little over 11h 45m.

  • When did momondo last update prices for flights from Des Moines Airport to Rome?

    Prices for flights from Des Moines Airport to Rome are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Rome?

  • How old do you have to be to fly from Des Moines Airport to Rome?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Rome.

  • What documentation or ID do you need to fly to Rome?

    The necessary travel and health documents for your Rome trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Rome?

Best airlines flying from Des Moines to Rome

Compare and see reviews for airlines that fly from Des Moines to Rome with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $641Free CancellationRating
7.9
8,014 reviews
Search Delta flights
United AirlinesPriceFrom $655Free CancellationRating
7.4
9,103 reviews
Search United Airlines flights
KLMPriceFrom $680Free CancellationRating
7.7
1,434 reviews
Search KLM flights

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Civitavecchia
Cassino
Pienza
Ponza
Montepulciano
Tivoli
Sperlonga
Gaeta
Orvieto
Ciampino
Cortona
Terracina
Chianciano Terme
Santa Marinella
Grosseto
Sabaudia
Ascoli Piceno
Saturnia
Foligno

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Rome?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Rome. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Rome with flexible booking policies on momondo?

Flights from Des Moines to Rome with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Rome?

momondo helps you find the best flight between Des Moines and Rome by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Rome right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Rome flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to Italy

Fly into one of these airports located in Rome

Airports listed have a maximum distance of 14.7 mi from Rome
Rome Ciampino Airport
Rome Fiumicino Airport