What is the cheapest airline that flies from Des Moines to Mexico?

United Airlines, American Airlines, and Delta are the most popular carriers operating from Des Moines to Mexico

What airlines fly to Mexico?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Mexico from Des Moines according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Mexico. Keep in mind that there are 5 different airlines that fly to Mexico on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Mexico?

Prices for flights from Des Moines Airport to Mexico are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Mexico?

As of September 2026, there are 5 operators available to choose from for flights from Des Moines Airport to Mexico.

How old do you have to be to fly from Des Moines Airport to Mexico?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Mexico.

What documentation or ID do you need to fly to Mexico?

The travel and health documents you'll need for your trip to Mexico may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Mexico. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$146 Cheap Flights from Des Moines to Mexico in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Mexico

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:15 am - 11:57 amDSM Des Moines-GDL Guadalajara Miguel Hidal

29h 42m1 stop Boston Logan Intl

2:07 pm - 2:36 pmGDL Guadalajara Miguel Hidal-DSM Des Moines

24h 29m1 stop Nashville Intl

$357Multiple Airlines

Mon, Oct 19 - Thu, Nov 5

8:25 pm - 9:51 pmDSM Des Moines-GDL Guadalajara Miguel Hidal

26h 26m2 stops Denver Intl Nashville Intl

2:07 pm - 2:36 pmGDL Guadalajara Miguel Hidal-DSM Des Moines

24h 29m1 stop Nashville Intl

$390Multiple Airlines

Fri, Oct 23 - Thu, Nov 5

7:37 pm - 10:36 amDSM Des Moines-CUN Cancun

13h 59m2 stops Dallas/Fort Worth Austin Bergstrom

5:10 pm - 11:57 pmCUN Cancun-DSM Des Moines

7h 47m1 stop Charlotte Douglas

$543American Airlines

Fri, Nov 6 - Fri, Nov 13

10:25 am - 9:18 pmDSM Des Moines-CUN Cancun

9h 53m1 stop Dallas/Fort Worth

3:10 pm - 10:16 pmCUN Cancun-DSM Des Moines

8h 06m1 stop Dallas/Fort Worth

$570American Airlines

Sun, Jan 31 - Wed, Feb 10

8:00 am - 3:37 pmDSM Des Moines-CUN Cancun

6h 37m1 stop Houston George Bush Intcntl

2:55 pm - 11:15 pmCUN Cancun-DSM Des Moines

9h 20m1 stop Chicago O'Hare Intl

$570United Airlines

Wed, Dec 2 - Wed, Dec 9

8:00 am - 3:37 pmDSM Des Moines-CUN Cancun

6h 37m1 stop Houston George Bush Intcntl

1:16 pm - 8:10 pmCUN Cancun-DSM Des Moines

7h 54m1 stop Chicago O'Hare Intl

$570United Airlines

Wed, Feb 3 - Wed, Feb 10

5:35 am - 1:05 pmDSM Des Moines-CUN Cancun

7h 30m1 stop Atlanta Hartsfield-Jackson

8:00 am - 3:16 pmCUN Cancun-DSM Des Moines

8h 16m1 stop Atlanta Hartsfield-Jackson

$570Delta

Tue, Oct 27 - Wed, Nov 4

5:35 am - 1:05 pmDSM Des Moines-CUN Cancun

7h 30m1 stop Atlanta Hartsfield-Jackson

8:00 am - 10:33 pmCUN Cancun-DSM Des Moines

14h 33m1 stop Atlanta Hartsfield-Jackson

$570Delta

Tue, Oct 27 - Fri, Oct 30

5:30 am - 8:55 pmDSM Des Moines-CUN Cancun

14h 25m1 stop Atlanta Hartsfield-Jackson

12:13 pm - 10:35 pmCUN Cancun-DSM Des Moines

11h 22m1 stop Atlanta Hartsfield-Jackson

$570Aeromexico

Wed, Nov 11 - Fri, Nov 20

6:45 am - 3:21 pmDSM Des Moines-CUN Cancun

7h 36m1 stop Minneapolis St Paul

8:02 am - 10:35 pmCUN Cancun-DSM Des Moines

15h 33m2 stops Mexico City Benito Juarez Atlanta Hartsfield-Jackson

$570Aeromexico

Sun, Nov 15 - Thu, Nov 26

Cheap last minute flights

Enter your travel dates to find the best prices.

6:41 am - 11:26 amDSM Des Moines-SJD San José del Cabo Los Cabos

6h 45m1 stop Dallas/Fort Worth

2:11 pm - 9:17 amSJD San José del Cabo Los Cabos-DSM Des Moines

17h 06m1 stop Dallas/Fort Worth

$719American Airlines

Tue, Sep 29 - Fri, Oct 2

5:30 am - 12:24 pmDSM Des Moines-SJD San José del Cabo Los Cabos

8h 54m1 stop Phoenix Sky Harbor Intl

2:11 pm - 11:12 pmSJD San José del Cabo Los Cabos-DSM Des Moines

7h 01m1 stop Dallas/Fort Worth

$719American Airlines

Tue, Sep 29 - Fri, Oct 2

5:45 am - 12:58 pmDSM Des Moines-CUN Cancun

7h 13m1 stop Denver Intl

3:43 pm - 11:48 pmCUN Cancun-DSM Des Moines

8h 05m1 stop Denver Intl

$730United Airlines

Thu, Oct 1 - Thu, Oct 8

7:15 am - 7:50 pmDSM Des Moines-CUN Cancun

12h 35m2 stops New York LaGuardia Atlanta Hartsfield-Jackson

12:35 pm - 10:33 pmCUN Cancun-DSM Des Moines

9h 58m1 stop Atlanta Hartsfield-Jackson

$735Delta

Fri, Oct 2 - Wed, Oct 7

7:15 am - 7:50 pmDSM Des Moines-CUN Cancun

12h 35m2 stops New York LaGuardia Atlanta Hartsfield-Jackson

8:00 am - 8:40 pmCUN Cancun-DSM Des Moines

12h 40m2 stops Atlanta Hartsfield-Jackson Detroit Metropolitan Wayne County

$735Delta

Fri, Oct 2 - Wed, Oct 7

11:29 am - 12:02 amDSM Des Moines-GDL Guadalajara Miguel Hidal

13h 33m2 stops Denver Intl Los Angeles

10:28 pm - 1:59 pmGDL Guadalajara Miguel Hidal-DSM Des Moines

14h 31m1 stop Boston Logan Intl

$738Multiple Airlines

Thu, Oct 1 - Sun, Oct 18

7:15 am - 12:50 pmDSM Des Moines-SJD San José del Cabo Los Cabos

7h 35m2 stops Denver Intl Phoenix Sky Harbor Intl

10:45 am - 10:10 pmSJD San José del Cabo Los Cabos-DSM Des Moines

9h 25m2 stops Houston Hobby Denver Intl

$753Southwest

Tue, Sep 29 - Thu, Oct 1

11:47 am - 7:54 pmDSM Des Moines-GDL Guadalajara Miguel Hidal

9h 07m1 stop Las Vegas Harry Reid Intl

8:21 pm - 1:52 pmGDL Guadalajara Miguel Hidal-DSM Des Moines

40h 31m2 stops Mexico City Benito Juarez Las Vegas Harry Reid Intl

$753Multiple Airlines

Fri, Oct 2 - Mon, Oct 5

6:00 am - 2:37 pmDSM Des Moines-CUN Cancun

8h 37m1 stop Houston George Bush Intcntl

3:43 pm - 11:48 pmCUN Cancun-DSM Des Moines

8h 05m1 stop Denver Intl

$825United Airlines

Wed, Sep 30 - Sun, Oct 4

5:40 am - 1:30 pmDSM Des Moines-CUN Cancun

7h 50m2 stops Chicago Midway Lambert-St Louis

12:50 pm - 10:00 pmCUN Cancun-DSM Des Moines

9h 10m2 stops Houston Hobby Chicago Midway

$855Southwest

Mon, Sep 28 - Wed, Sep 30

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Frontier flights from Des Moines to Mexico

Our best Frontier deals on Des Moines to Mexico flight tickets

Frontier

Mar 4

DSM8:26 pmDes Moines

26h 29m

2 stops

MEX10:55 pmMexico City Benito Juarez

Mar 8

MEX11:10 amMexico City Benito Juarez

21h 21m

1 stop

DSM8:31 amDes Moines

$589

Frontier

Nov 6

DSM8:30 pmDes Moines

26h 25m

2 stops

MEX10:55 pmMexico City Benito Juarez

Nov 13

MEX5:50 amMexico City Benito Juarez

13h 45m

2 stops

DSM7:35 pmDes Moines

$606

Frontier

Oct 1

DSM11:29 amDes Moines

26h 56m

2 stops

GDL1:25 pmGuadalajara Miguel Hidal

Oct 18

GDL7:59 amGuadalajara Miguel Hidal

34h 31m

2 stops

DSM7:30 pmDes Moines

$840

American Airlines flights from Des Moines to Mexico

Our best American Airlines deals on Des Moines to Mexico flight tickets

American Airlines

Nov 6

DSM7:37 pmDes Moines

13h 59m

2 stops

CUN10:36 amCancun

Nov 13

CUN5:10 pmCancun

7h 47m

1 stop

DSM11:57 pmDes Moines

$543

American Airlines

Nov 8

DSM7:26 pmDes Moines

15h 37m

1 stop

CUN12:03 pmCancun

Nov 20

CUN4:39 pmCancun

7h 44m

1 stop

DSM11:23 pmDes Moines

$570

American Airlines

Nov 9

DSM8:10 amDes Moines

7h 46m

1 stop

SJD2:56 pmSan José del Cabo Los Cabos

Nov 12

SJD3:51 pmSan José del Cabo Los Cabos

6h 45m

1 stop

DSM11:36 pmDes Moines

$575

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGuadalajara

DSM Des Moines - GDL Guadalajara Miguel Hidal

DSMGDL

Des Moines

Mon 10/19

7:15 am-11:57 am

1 stop29h 42m

Guadalajara Miguel Hidal

Thu 11/5

2:07 pm-2:36 pm

1 stop24h 29m

$357

Des MoinesGuadalajara

DSM Des Moines - GDL Guadalajara Miguel Hidal

DSMGDL

Des Moines

Fri 10/23

8:25 pm-9:51 pm

2 stops26h 26m

Guadalajara Miguel Hidal

Thu 11/5

2:07 pm-2:36 pm

1 stop24h 29m

$390

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Fri 11/6

7:37 pm-10:36 am

2 stops13h 59m

Cancun

Fri 11/13

5:10 pm-11:57 pm

1 stop7h 47m

$543

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Sun 1/31

10:25 am-9:18 pm

1 stop9h 53m

Cancun

Wed 2/10

3:10 pm-10:16 pm

1 stop8h 06m

$570

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Wed 12/2

8:00 am-3:37 pm

1 stop6h 37m

Cancun

Wed 12/9

2:55 pm-11:15 pm

1 stop9h 20m

$570

Quickest round-trip

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Wed 2/3

8:00 am-3:37 pm

1 stop6h 37m

Cancun

Wed 2/10

1:16 pm-8:10 pm

1 stop7h 54m

$570

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Tue 10/27

5:35 am-1:05 pm

1 stop7h 30m

Cancun

Wed 11/4

8:00 am-3:16 pm

1 stop8h 16m

$570

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Tue 10/27

5:35 am-1:05 pm

1 stop7h 30m

Cancun

Fri 10/30

8:00 am-10:33 pm

1 stop14h 33m

$570

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Wed 11/11

5:30 am-8:55 pm

1 stop14h 25m

Cancun

Fri 11/20

12:13 pm-10:35 pm

1 stop11h 22m

$570

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Sun 11/15

6:45 am-3:21 pm

1 stop7h 36m

Cancun

Thu 11/26

8:02 am-10:35 pm

2 stops15h 33m

$570

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Mexico

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Mexico?

If you’re not able to fly to Mexico in January, then February is your next best option. Flight prices from Des Moines to Mexico during February average around $647.

Can stopping save me money on Des Moines to Mexico flights?

You could potentially save up to 7% on your flight if you consider stops on a Des Moines to Mexico flight.

Cheap Des Moines to Mexico flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Mexico

Best Price Found	$146
Fastest flight time	5h 29m
Direct flights	None

The best one-way flight to Mexico from Des Moines in the past 72 hours is $146. The best round-trip flight deal from Des Moines to Mexico found on momondo in the last 72 hours is $357.

The fastest flight from Des Moines to Mexico takes 5h 29m

There are no direct flights from Des Moines to Mexico. There are no popular flight routes from Des Moines to Mexico.

Search flight deals

Frequently asked questions about flying from Des Moines to Mexico

When did momondo last update prices for flights from Des Moines Airport to Mexico?
Prices for flights from Des Moines Airport to Mexico are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Mexico?
As of September 2026, there are 5 operators available to choose from for flights from Des Moines Airport to Mexico.
How old do you have to be to fly from Des Moines Airport to Mexico?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Mexico.
What documentation or ID do you need to fly to Mexico?
The travel and health documents you'll need for your trip to Mexico may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Mexico. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Mexico

Compare and see reviews for airlines that fly from Des Moines to Mexico with momondo

Airline	Rating	Free Cancellation	Price
Aeromexico	PriceFrom $229	Free Cancellation	Rating 7.5 1,459 reviews	Search Aeromexico flights
United Airlines	PriceFrom $459	Free Cancellation	Rating 7.4 10,243 reviews	Search United Airlines flights
American Airlines	PriceFrom $459	Free Cancellation	Rating 7.0 12,099 reviews	Search American Airlines flights
Delta	PriceFrom $467	Free Cancellation	Rating 7.8 8,610 reviews	Search Delta flights
Southwest	PriceFrom $569	Free Cancellation	Rating 8.0 4,201 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Mexico?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Mexico from Des Moines.

Can I find flights from Des Moines to Mexico with flexible booking policies on momondo?

momondo does allow users to show only those flights to Mexico from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Mexico?

momondo helps you find the best flight between Des Moines and Mexico by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Mexico right now. Can momondo alert me if prices change?

Price alerts on flights to Mexico from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.