What airlines fly to Mexico?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Mexico from Des Moines according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Mexico. Keep in mind that there are 5 different airlines that fly to Mexico on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Mexico?

United Airlines, American Airlines, and Delta are the most popular carriers operating from Des Moines to Mexico

When did momondo last update prices for flights from Des Moines Airport to Mexico?

Prices for flights from Des Moines Airport to Mexico are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Mexico?

As of November 2026, there are 5 operators available to choose from for flights from Des Moines Airport to Mexico.

How old do you have to be to fly from Des Moines Airport to Mexico?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Mexico.

What documentation or ID do you need to fly to Mexico?

The travel and health documents you'll need for your trip to Mexico may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Mexico. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$225 Cheap Flights from Des Moines to Mexico in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Mexico

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

9:59 pm - 10:51 pmDSM Des Moines-GDL Guadalajara Miguel Hidal

24h 52m1 stop Nashville Intl

6:16 am - 5:04 pmGDL Guadalajara Miguel Hidal-DSM Des Moines

34h 48m2 stops Phoenix Sky Harbor Intl Las Vegas Harry Reid Intl

$398Multiple Airlines

Mon, Jan 18 - Wed, Jan 27

9:59 pm - 10:51 pmDSM Des Moines-GDL Guadalajara Miguel Hidal

24h 52m1 stop Nashville Intl

5:03 pm - 2:34 pmGDL Guadalajara Miguel Hidal-DSM Des Moines

21h 31m2 stops Phoenix Sky Harbor Intl Las Vegas Harry Reid Intl

$410Multiple Airlines

Mon, Jan 18 - Thu, Jan 28

3:31 pm - 2:10 pmDSM Des Moines-CZM Cozumel Intl

21h 39m1 stop Dallas/Fort Worth

3:00 pm - 10:16 pmCZM Cozumel Intl-DSM Des Moines

8h 16m1 stop Dallas/Fort Worth

$596American Airlines

Sat, Jan 23 - Thu, Jan 28

6:14 pm - 12:14 pmDSM Des Moines-CUN Cancun

17h 00m1 stop Dallas/Fort Worth

7:00 am - 2:33 pmCUN Cancun-DSM Des Moines

8h 33m1 stop Dallas/Fort Worth

$607American Airlines

Sat, Jan 23 - Thu, Jan 28

8:00 am - 3:37 pmDSM Des Moines-CUN Cancun

6h 37m1 stop Houston George Bush Intcntl

1:35 pm - 8:38 pmCUN Cancun-DSM Des Moines

8h 03m1 stop Denver Intl

$615United Airlines

Wed, Jan 20 - Tue, Jan 26

8:00 am - 3:37 pmDSM Des Moines-CUN Cancun

6h 37m1 stop Houston George Bush Intcntl

4:42 pm - 11:17 pmCUN Cancun-DSM Des Moines

7h 35m1 stop Chicago O'Hare Intl

$615United Airlines

Tue, Dec 15 - Tue, Dec 22

5:20 am - 1:50 pmDSM Des Moines-CUN Cancun

7h 30m1 stop Atlanta Hartsfield-Jackson

9:24 am - 10:38 pmCUN Cancun-DSM Des Moines

14h 14m2 stops Mexico City Benito Juarez Atlanta Hartsfield-Jackson

$615Delta

Tue, Dec 1 - Tue, Dec 8

5:20 am - 3:10 pmDSM Des Moines-CUN Cancun

8h 50m1 stop Atlanta Hartsfield-Jackson

8:05 am - 6:06 pmCUN Cancun-DSM Des Moines

11h 01m1 stop Atlanta Hartsfield-Jackson

$615Delta

Tue, Dec 1 - Thu, Dec 10

8:00 am - 7:45 pmDSM Des Moines-CUN Cancun

10h 45m2 stops Nashville Intl Houston Hobby

9:40 am - 9:35 pmCUN Cancun-DSM Des Moines

12h 55m2 stops Houston Hobby Chicago Midway

$620Southwest

Wed, Feb 24 - Tue, Mar 2

6:30 am - 5:25 pmDSM Des Moines-CUN Cancun

9h 55m2 stops Denver Intl Houston Hobby

2:55 pm - 9:35 pmCUN Cancun-DSM Des Moines

7h 40m1 stop Chicago Midway

$620Southwest

Sun, Feb 28 - Wed, Mar 3

Cheap last minute flights

Enter your travel dates to find the best prices.

10:25 pm - 9:10 pmDSM Des Moines-MEX Mexico City Benito Juarez

22h 45m1 stop Las Vegas Harry Reid Intl

11:10 am - 7:33 pmMEX Mexico City Benito Juarez-DSM Des Moines

32h 23m2 stops Orlando Denver Intl

$611Multiple Airlines

Fri, Nov 13 - Sat, Nov 21

9:37 am - 10:27 pmDSM Des Moines-BJX León Del Bajio

12h 50m1 stop Dallas/Fort Worth

3:52 pm - 5:29 pmBJX León Del Bajio-DSM Des Moines

25h 37m1 stop Dallas/Fort Worth

$750American Airlines

Thu, Nov 12 - Sun, Jan 17

6:45 am - 3:21 pmDSM Des Moines-CUN Cancun

7h 36m1 stop Minneapolis St Paul

12:13 pm - 6:07 pmCUN Cancun-DSM Des Moines

6h 54m1 stop Atlanta Hartsfield-Jackson

$755Delta

Sun, Nov 15 - Wed, Nov 25

5:30 am - 3:06 pmDSM Des Moines-CUN Cancun

8h 36m1 stop Atlanta Hartsfield-Jackson

3:15 pm - 9:13 pmCUN Cancun-DSM Des Moines

6h 58m1 stop Minneapolis St Paul

$755Delta

Sun, Nov 15 - Tue, Nov 24

5:25 am - 1:40 pmDSM Des Moines-CUN Cancun

7h 15m1 stop Chicago Midway

11:55 am - 9:50 pmCUN Cancun-DSM Des Moines

10h 55m1 stop Denver Intl

$775Southwest

Sun, Nov 15 - Sat, Nov 21

7:06 am - 4:10 pmDSM Des Moines-CUN Cancun

8h 04m1 stop Charlotte Douglas

2:21 pm - 12:19 amCUN Cancun-DSM Des Moines

10h 58m1 stop Chicago O'Hare Intl

$775American Airlines

Sun, Nov 15 - Mon, Nov 23

5:25 am - 1:40 pmDSM Des Moines-CUN Cancun

7h 15m1 stop Chicago Midway

11:50 am - 11:00 pmCUN Cancun-DSM Des Moines

12h 10m2 stops Orlando Chicago Midway

$780Southwest

Sun, Nov 15 - Sat, Nov 21

8:30 pm - 10:55 pmDSM Des Moines-MEX Mexico City Benito Juarez

26h 25m2 stops Denver Intl Houston George Bush Intcntl

7:00 am - 7:33 pmMEX Mexico City Benito Juarez-DSM Des Moines

36h 33m2 stops Dallas/Fort Worth Denver Intl

$782Frontier

Fri, Nov 13 - Sat, Nov 21

5:30 am - 2:15 pmDSM Des Moines-MEX Mexico City Benito Juarez

8h 45m1 stop Denver Intl

3:30 pm - 10:21 pmMEX Mexico City Benito Juarez-DSM Des Moines

6h 51m1 stop Houston George Bush Intcntl

$791United Airlines

Sat, Nov 14 - Mon, Dec 14

1:27 pm - 12:10 amDSM Des Moines-MEX Mexico City Benito Juarez

10h 43m2 stops Denver Intl Houston George Bush Intcntl

7:50 am - 2:15 pmMEX Mexico City Benito Juarez-DSM Des Moines

6h 25m1 stop Houston George Bush Intcntl

$791United Airlines

Sat, Nov 14 - Mon, Dec 14

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Frontier flights from Des Moines to Mexico

Our best Frontier deals on Des Moines to Mexico flight tickets

Frontier

Jan 28

DSM8:26 pmDes Moines

21h 02m

1 stop

GDL5:28 pmGuadalajara Miguel Hidal

Feb 13

GDL6:16 amGuadalajara Miguel Hidal

37h 15m

2 stops

DSM7:31 pmDes Moines

$556

Frontier

Nov 16

DSM8:30 pmDes Moines

26h 25m

2 stops

MEX10:55 pmMexico City Benito Juarez

Nov 21

MEX7:00 amMexico City Benito Juarez

36h 33m

2 stops

DSM7:33 pmDes Moines

$762

Frontier

Nov 13

DSM8:30 pmDes Moines

26h 25m

2 stops

MEX10:55 pmMexico City Benito Juarez

Nov 21

MEX7:00 amMexico City Benito Juarez

36h 33m

2 stops

DSM7:33 pmDes Moines

$782

Delta flights from Des Moines to Mexico

Our best Delta deals on Des Moines to Mexico flight tickets

Delta

Dec 1

DSM6:53 pmDes Moines

16h 49m

1 stop

CUN12:42 pmCancun

Dec 9

CUN2:55 pmCancun

8h 43m

1 stop

DSM10:38 pmDes Moines

$615

Delta

Jan 31

DSM6:45 amDes Moines

11h 58m

2 stops

CUN7:43 pmCancun

Feb 10

CUN2:58 pmCancun

8h 40m

1 stop

DSM10:38 pmDes Moines

$625

Delta

Feb 9

DSM5:22 pmDes Moines

16h 43m

1 stop

CUN11:05 amCancun

Feb 19

CUN3:40 pmCancun

19h 10m

2 stops

DSM9:50 amDes Moines

$630

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGuadalajara

DSM Des Moines - GDL Guadalajara Miguel Hidal

DSMGDL

Des Moines

Mon 1/18

9:59 pm-10:51 pm

1 stop24h 52m

Guadalajara Miguel Hidal

Wed 1/27

6:16 am-5:04 pm

2 stops34h 48m

$398

Des MoinesGuadalajara

DSM Des Moines - GDL Guadalajara Miguel Hidal

DSMGDL

Des Moines

Mon 1/18

9:59 pm-10:51 pm

1 stop24h 52m

Guadalajara Miguel Hidal

Thu 1/28

5:03 pm-2:34 pm

2 stops21h 31m

$410

Des MoinesCozumel

DSM Des Moines - CZM Cozumel Intl

DSMCZM

Des Moines

Sat 1/23

3:31 pm-2:10 pm

1 stop21h 39m

Cozumel Intl

Thu 1/28

3:00 pm-10:16 pm

1 stop8h 16m

$596

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Sat 1/23

6:14 pm-12:14 pm

1 stop17h 00m

Cancun

Thu 1/28

7:00 am-2:33 pm

1 stop8h 33m

$607

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Wed 1/20

8:00 am-3:37 pm

1 stop6h 37m

Cancun

Tue 1/26

1:35 pm-8:38 pm

1 stop8h 03m

$615

Quickest round-trip

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Tue 12/15

8:00 am-3:37 pm

1 stop6h 37m

Cancun

Tue 12/22

4:42 pm-11:17 pm

1 stop7h 35m

$615

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Tue 12/1

5:20 am-1:50 pm

1 stop7h 30m

Cancun

Tue 12/8

9:24 am-10:38 pm

2 stops14h 14m

$615

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Tue 12/1

5:20 am-3:10 pm

1 stop8h 50m

Cancun

Thu 12/10

8:05 am-6:06 pm

1 stop11h 01m

$615

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Wed 2/24

8:00 am-7:45 pm

2 stops10h 45m

Cancun

Tue 3/2

9:40 am-9:35 pm

2 stops12h 55m

$620

Des MoinesCancún

DSM Des Moines - CUN Cancun

DSMCUN

Des Moines

Sun 2/28

6:30 am-5:25 pm

2 stops9h 55m

Cancun

Wed 3/3

2:55 pm-9:35 pm

1 stop7h 40m

$620

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Mexico

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Mexico?

If you’re not able to fly to Mexico in January, then February is your next best option. Flight prices from Des Moines to Mexico during February average around $655.

Can stopping save me money on Des Moines to Mexico flights?

You could potentially save up to 14% on your flight if you consider stops on a Des Moines to Mexico flight.

Cheap Des Moines to Mexico flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Mexico

Best Price Found	$225
Fastest flight time	5h 58m
Direct flights	None

The best one-way flight to Mexico from Des Moines in the past 72 hours is $225. The best round-trip flight deal from Des Moines to Mexico found on momondo in the last 72 hours is $398.

The fastest flight from Des Moines to Mexico takes 5h 58m

There are no direct flights from Des Moines to Mexico. There are no popular flight routes from Des Moines to Mexico.

Search flight deals

Frequently asked questions about flying from Des Moines to Mexico

When did momondo last update prices for flights from Des Moines Airport to Mexico?
Prices for flights from Des Moines Airport to Mexico are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Mexico?
As of November 2026, there are 5 operators available to choose from for flights from Des Moines Airport to Mexico.
How old do you have to be to fly from Des Moines Airport to Mexico?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Mexico.
What documentation or ID do you need to fly to Mexico?
The travel and health documents you'll need for your trip to Mexico may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Mexico. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Mexico

Compare and see reviews for airlines that fly from Des Moines to Mexico with momondo

Airline	Rating	Free Cancellation	Price
Aeromexico	PriceFrom $288	Free Cancellation	Rating 7.5 1,422 reviews	Search Aeromexico flights
American Airlines	PriceFrom $459	Free Cancellation	Rating 7.0 12,227 reviews	Search American Airlines flights
Delta	PriceFrom $464	Free Cancellation	Rating 7.8 8,699 reviews	Search Delta flights
United Airlines	PriceFrom $473	Free Cancellation	Rating 7.3 10,472 reviews	Search United Airlines flights
Southwest	PriceFrom $569	Free Cancellation	Rating 8.0 4,216 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Mexico?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Mexico from Des Moines.

Can I find flights from Des Moines to Mexico with flexible booking policies on momondo?

momondo does allow users to show only those flights to Mexico from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Mexico?

momondo helps you find the best flight between Des Moines and Mexico by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Mexico right now. Can momondo alert me if prices change?

Price alerts on flights to Mexico from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.