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Cheap flights from Des Moines to Mexico from $151

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Mexico departing on 10/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Mexico

Cheap round-trip flights

American Airlines Logo
7:31 pm - 9:15 amDSM-SJD
15h 44m1 stop
American Airlines Logo
2:50 pm - 3:03 pmSJD-DSM
22h 13m1 stop
$351American Airlines
Find Deal
Fri, Oct 17 - Fri, Oct 24
American Airlines Logo
9:22 am - 2:24 pmDSM-SJD
6h 02m1 stop
American Airlines Logo
1:25 pm - 10:40 pmSJD-DSM
8h 15m1 stop
$356American Airlines
Find Deal
Sun, Jan 18 - Fri, Jan 23
Logo
3:30 pm - 9:10 pmDSM-MEX
30h 40m1 stop
Logo
8:10 am - 1:40 pmMEX-DSM
28h 30m1 stop
$361
Find Deal
Mon, Sep 29 - Sun, Oct 5
Logo
8:25 am - 12:59 pmDSM-CUN
28h 34m2 stops
Logo
9:16 am - 8:29 amCUN-DSM
23h 13m1 stop
$364
Find Deal
Mon, Sep 29 - Fri, Oct 3
United Airlines Logo
6:36 pm - 10:07 amDSM-SJD
17h 31m1 stop
United Airlines Logo
11:52 am - 9:50 pmSJD-DSM
7h 58m1 stop
$391United Airlines
Find Deal
Fri, Oct 17 - Fri, Oct 24
Aeromexico Logo
5:47 am - 11:42 amDSM-SJD
7h 55m1 stop
Aeromexico Logo
7:00 pm - 10:30 pmSJD-DSM
25h 30m2 stops
$393Aeromexico
Find Deal
Thu, Oct 23 - Mon, Oct 27
Aeromexico Logo
5:47 am - 2:55 pmDSM-SJD
11h 08m2 stops
Aeromexico Logo
12:47 pm - 10:30 pmSJD-DSM
7h 43m1 stop
$403Aeromexico
Find Deal
Fri, Oct 17 - Fri, Oct 24
Delta Logo
7:00 am - 7:12 pmDSM-PVR
13h 12m2 stops
Delta Logo
1:32 pm - 10:37 pmPVR-DSM
8h 05m1 stop
$417Delta
Find Deal
Tue, Sep 23 - Tue, Sep 30
United Airlines Logo
6:15 am - 2:37 pmDSM-CUN
8h 22m1 stop
United Airlines Logo
12:20 pm - 9:50 pmCUN-DSM
9h 30m1 stop
$422United Airlines
Find Deal
Tue, Oct 14 - Tue, Oct 21
Delta Logo
5:44 am - 2:20 pmDSM-CUN
8h 36m1 stop
Delta Logo
8:00 am - 8:35 pmCUN-DSM
12h 35m2 stops
$426Delta
Find Deal
Tue, Sep 30 - Thu, Oct 23

American Airlines flights from Des Moines to Mexico

Our best American Airlines deals on Des Moines to Mexico flight tickets
American Airlines
Oct 17
DSM7:31 pmDes Moines
15h 44m
1 stop
SJD9:15 amSan José del Cabo Los Cabos
Oct 24
SJD2:50 pmSan José del Cabo Los Cabos
22h 13m
1 stop
DSM3:03 pmDes Moines
$351
Find similar
American Airlines
Jan 18
DSM9:22 amDes Moines
6h 02m
1 stop
SJD2:24 pmSan José del Cabo Los Cabos
Jan 23
SJD1:25 pmSan José del Cabo Los Cabos
8h 15m
1 stop
DSM10:40 pmDes Moines
$356
Find similar
American Airlines
Nov 8
DSM6:40 pmDes Moines
20h 19m
1 stop
SJD1:59 pmSan José del Cabo Los Cabos
Nov 13
SJD2:14 pmSan José del Cabo Los Cabos
8h 45m
1 stop
DSM11:59 pmDes Moines
$357
Find similar

Aeromexico flights from Des Moines to Mexico

Our best Aeromexico deals on Des Moines to Mexico flight tickets
Aeromexico
Oct 23
DSM5:47 amDes Moines
7h 55m
1 stop
SJD11:42 amSan José del Cabo Los Cabos
Oct 27
SJD7:00 pmSan José del Cabo Los Cabos
25h 30m
2 stops
DSM10:30 pmDes Moines
$393
Find similar
Aeromexico
Oct 17
DSM5:47 amDes Moines
11h 08m
2 stops
SJD2:55 pmSan José del Cabo Los Cabos
Oct 24
SJD12:47 pmSan José del Cabo Los Cabos
7h 43m
1 stop
DSM10:30 pmDes Moines
$403
Find similar
Aeromexico
Oct 23
DSM5:47 amDes Moines
7h 55m
1 stop
SJD11:42 amSan José del Cabo Los Cabos
Oct 27
SJD12:47 pmSan José del Cabo Los Cabos
7h 43m
1 stop
DSM10:30 pmDes Moines
$431
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Fri 10/17

7:31 pm-9:15 am

1 stop15h 44m

San José del Cabo Los Cabos

Fri 10/24

2:50 pm-3:03 pm

1 stop22h 13m

$351

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Sun 1/18

9:22 am-2:24 pm

1 stop6h 02m

San José del Cabo Los Cabos

Fri 1/23

1:25 pm-10:40 pm

1 stop8h 15m

$356

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

Mon 9/29

3:30 pm-9:10 pm

1 stop30h 40m

Mexico City Benito Juarez

Sun 10/5

8:10 am-1:40 pm

1 stop28h 30m

$361

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Mon 9/29

8:25 am-12:59 pm

2 stops28h 34m

Cancun

Fri 10/3

9:16 am-8:29 am

1 stop23h 13m

$364

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Fri 10/17

6:36 pm-10:07 am

1 stop17h 31m

San José del Cabo Los Cabos

Fri 10/24

11:52 am-9:50 pm

1 stop7h 58m

$391

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Thu 10/23

5:47 am-11:42 am

1 stop7h 55m

San José del Cabo Los Cabos

Mon 10/27

7:00 pm-10:30 pm

2 stops25h 30m

$393

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Fri 10/17

5:47 am-2:55 pm

2 stops11h 08m

San José del Cabo Los Cabos

Fri 10/24

12:47 pm-10:30 pm

1 stop7h 43m

$403

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Tue 9/23

7:00 am-7:12 pm

2 stops13h 12m

Puerto Vallarta Ordaz

Tue 9/30

1:32 pm-10:37 pm

1 stop8h 05m

$417

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Tue 10/14

6:15 am-2:37 pm

1 stop8h 22m

Cancun

Tue 10/21

12:20 pm-9:50 pm

1 stop9h 30m

$422

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Tue 9/30

5:44 am-2:20 pm

1 stop8h 36m

Cancun

Thu 10/23

8:00 am-8:35 pm

2 stops12h 35m

$426

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Mexico from

How to get the cheapest flight ticket from Des Moines to Mexico

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Mexico?

If you’re not able to fly to Mexico in January, then May is your next best option. Flight prices from Des Moines to Mexico during May average around $537.

What is the cheapest day to depart on your flight to Mexico?

The cheapest day to depart on your flight to Mexico is on a Tuesday when prices can be found for as low as $514. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $631. These prices are subject to change though, so be sure to set up a Price Alert for flights to Mexico.

What is the cheapest time of day to depart on your flight to Mexico?

Our data shows that the cheapest Des Moines to Mexico flights are usually those with departure times in the evening. Our users have found flights to Mexico in the evening for as low as $535. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $596 on average. Flights to Mexico from Des Moines at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to Mexico?

You are more likely to see cheaper flights to Mexico from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico for around $583 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico from Des Moines for as low as $506 on momondo.

Can stopping save me money on Des Moines to Mexico flights?

You could potentially save up to 22% on your flight if you consider stops on a Des Moines to Mexico flight.

Cheap Des Moines to Mexico flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Mexico

Direct flights

None
There are no direct flights from Des Moines to Mexico. There are no popular flight routes from Des Moines to Mexico.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Mexico?

    Prices for flights from Des Moines Airport to Mexico are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Mexico?

  • How old do you have to be to fly from Des Moines Airport to Mexico?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Mexico.

  • What documentation or ID do you need to fly to Mexico?

    The travel and health documents you'll need for your trip to Mexico may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Mexico. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Mexico

Compare and see reviews for airlines that fly from Des Moines to Mexico with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $250Free CancellationRating
7.9
7,977 reviews
Search Delta flights
AeromexicoPriceFrom $350Free CancellationRating
7.4
1,706 reviews
Search Aeromexico flights
United AirlinesPriceFrom $423Free CancellationRating
7.4
8,939 reviews
Search United Airlines flights
American AirlinesPriceFrom $423Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $460Free CancellationRating
8.0
4,241 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Mexico?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Mexico from Des Moines.

Can I find flights from Des Moines to Mexico with flexible booking policies on momondo?

momondo does allow users to show only those flights to Mexico from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Mexico?

momondo helps you find the best flight between Des Moines and Mexico by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Mexico right now. Can momondo alert me if prices change?

Price alerts on flights to Mexico from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Find better results for your trip to Mexico

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