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Cheap flights from Des Moines to Central America from $166

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Central America departing on 2/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Central America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:30 pm - 12:29 pm
DSM
-
GUA
43h 59m2 stops
Multiple Airlines Logo
1:29 pm - 11:12 pm
GUA
-
DSM
9h 43m1 stop
$347Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
Multiple Airlines Logo
4:30 pm - 12:29 pm
DSM
-
GUA
43h 59m2 stops
Multiple Airlines Logo
1:29 pm - 11:12 pm
GUA
-
DSM
9h 43m1 stop
$354Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
Multiple Airlines Logo
4:30 pm - 12:29 pm
DSM
-
GUA
43h 59m2 stops
Multiple Airlines Logo
1:29 pm - 11:12 pm
GUA
-
DSM
9h 43m1 stop
$356Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
Frontier Logo
7:59 pm - 1:36 pm
DSM
-
SAL
17h 37m2 stops
Frontier Logo
2:54 pm - 8:45 am
SAL
-
DSM
17h 51m2 stops
$367Frontier
Fri, Feb 27 - Sat, Mar 7
American Airlines Logo
11:42 am - 10:30 pm
DSM
-
SJO
10h 48m1 stop
American Airlines Logo
6:00 am - 5:06 pm
SJO
-
DSM
11h 06m2 stops
$389American Airlines
Tue, Feb 3 - Tue, Feb 10
United Airlines Logo
6:48 pm - 12:56 pm
DSM
-
SJO
18h 08m1 stop
United Airlines Logo
2:20 pm - 10:30 pm
SJO
-
DSM
8h 10m1 stop
$398United Airlines
Sun, Feb 1 - Wed, Feb 11
American Airlines Logo
10:09 am - 10:43 pm
DSM
-
SJO
12h 34m2 stops
American Airlines Logo
3:55 pm - 10:47 am
SJO
-
DSM
18h 52m2 stops
$403American Airlines
Wed, Feb 25 - Wed, Mar 4
United Airlines Logo
6:55 pm - 12:56 pm
DSM
-
SJO
18h 01m1 stop
United Airlines Logo
12:35 pm - 10:20 pm
SJO
-
DSM
9h 45m1 stop
$408United Airlines
Wed, Feb 25 - Wed, Mar 4
Delta Logo
6:54 am - 12:50 pm
DSM
-
LIR
29h 56m2 stops
Delta Logo
3:05 pm - 9:41 am
LIR
-
DSM
18h 36m2 stops
$579Delta
Sun, Jan 18 - Thu, Jan 29
Delta Logo
5:16 pm - 11:20 am
DSM
-
LIR
18h 04m1 stop
Delta Logo
2:05 pm - 9:41 am
LIR
-
DSM
19h 36m2 stops
$599Delta
Fri, Jan 16 - Wed, Jan 28

American Airlines flights from Des Moines to Central America

Our best American Airlines deals on Des Moines to Central America flight tickets
American Airlines
Feb 3
DSM11:42 amDes Moines
10h 48m
1 stop
SJO10:30 pmSan José Juan Santamaria Intl
Feb 10
SJO6:00 amSan José Juan Santamaria Intl
11h 06m
2 stops
DSM5:06 pmDes Moines
$389
Find similar
American Airlines
Feb 25
DSM10:09 amDes Moines
12h 34m
2 stops
SJO10:43 pmSan José Juan Santamaria Intl
Mar 4
SJO3:55 pmSan José Juan Santamaria Intl
21h 22m
2 stops
DSM1:17 pmDes Moines
$403
Find similar
American Airlines
Apr 29
DSM5:19 amDes Moines
17h 36m
1 stop
SJO9:55 pmSan José Juan Santamaria Intl
May 6
SJO2:25 pmSan José Juan Santamaria Intl
20h 49m
2 stops
DSM12:14 pmDes Moines
$414
Find similar

United Airlines flights from Des Moines to Central America

Our best United Airlines deals on Des Moines to Central America flight tickets
United Airlines
Feb 1
DSM6:48 pmDes Moines
18h 08m
1 stop
SJO12:56 pmSan José Juan Santamaria Intl
Feb 11
SJO2:20 pmSan José Juan Santamaria Intl
8h 10m
1 stop
DSM10:30 pmDes Moines
$398
Find similar
United Airlines
Feb 25
DSM6:55 pmDes Moines
18h 01m
1 stop
SJO12:56 pmSan José Juan Santamaria Intl
Mar 4
SJO12:35 pmSan José Juan Santamaria Intl
9h 45m
1 stop
DSM10:20 pmDes Moines
$408
Find similar
United Airlines
Apr 14
DSM8:20 amDes Moines
12h 17m
1 stop
SJO7:37 pmSan José Juan Santamaria Intl
Apr 21
SJO11:13 amSan José Juan Santamaria Intl
10h 30m
1 stop
DSM10:43 pmDes Moines
$409
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Des Moines to Central America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuatemala City

DSM - GUA

DSMGUA

Des Moines

Thu 2/5

4:30 pm-12:29 pm

2 stops43h 59m

Guatemala City La Aurora

Thu 2/12

1:29 pm-11:12 pm

1 stop9h 43m

$347

Des MoinesGuatemala City

DSM - GUA

DSMGUA

Des Moines

Thu 2/5

4:30 pm-12:29 pm

2 stops43h 59m

Guatemala City La Aurora

Thu 2/12

1:29 pm-11:12 pm

1 stop9h 43m

$354

Des MoinesGuatemala City

DSM - GUA

DSMGUA

Des Moines

Thu 2/5

4:30 pm-12:29 pm

2 stops43h 59m

Guatemala City La Aurora

Thu 2/12

1:29 pm-11:12 pm

1 stop9h 43m

$356

Des MoinesSan Salvador

DSM - SAL

DSMSAL

Des Moines

Fri 2/27

7:59 pm-1:36 pm

2 stops17h 37m

San Salvador El Salvador Intl

Sat 3/7

2:54 pm-8:45 am

2 stops17h 51m

$367

Des MoinesSan José

DSM - SJO

DSMSJO

Des Moines

Tue 2/3

11:42 am-10:30 pm

1 stop10h 48m

San José Juan Santamaria Intl

Tue 2/10

6:00 am-5:06 pm

2 stops11h 06m

$389

Des MoinesSan José

DSM - SJO

DSMSJO

Des Moines

Sun 2/1

6:48 pm-12:56 pm

1 stop18h 08m

San José Juan Santamaria Intl

Wed 2/11

2:20 pm-10:30 pm

1 stop8h 10m

$398

Des MoinesSan José

DSM - SJO

DSMSJO

Des Moines

Wed 2/25

10:09 am-10:43 pm

2 stops12h 34m

San José Juan Santamaria Intl

Wed 3/4

3:55 pm-10:47 am

2 stops18h 52m

$403

Des MoinesSan José

DSM - SJO

DSMSJO

Des Moines

Wed 2/25

6:55 pm-12:56 pm

1 stop18h 01m

San José Juan Santamaria Intl

Wed 3/4

12:35 pm-10:20 pm

1 stop9h 45m

$408

Des MoinesLiberia

DSM - LIR

DSMLIR

Des Moines

Sun 1/18

6:54 am-12:50 pm

2 stops29h 56m

Liberia

Thu 1/29

3:05 pm-9:41 am

2 stops18h 36m

$579

Des MoinesLiberia

DSM - LIR

DSMLIR

Des Moines

Fri 1/16

5:16 pm-11:20 am

1 stop18h 04m

Liberia

Wed 1/28

2:05 pm-9:41 am

2 stops19h 36m

$599

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Central America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Central America?

In general, August is the cheapest month to fly from Des Moines to Central America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $572. If you don’t want to visit Central America in August, then you should wait until November to fly from Des Moines, when ticket prices are also cheap, with an average price of $601.

What is the cheapest day to depart on your flight to Central America?

The cheapest day to depart from Des Moines to Central America is on a Tuesday. Travelers who choose to depart for Central America on a Tuesday will often find tickets for as low as $517. On the other hand, Saturday is the most expensive day to depart from Des Moines because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $762.

What is the cheapest time of day to depart on your flight to Central America?

Our data shows that the cheapest Des Moines to Central America flights are usually those with departure times in the afternoon. Our users have found flights to Central America in the afternoon for as low as $589. Try not to purchase tickets at noon because they tend to be around $736. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Central America?

You are more likely to see cheaper flights to Central America from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Central America for around $686 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Central America from Des Moines for as low as $497 on momondo.

Can stopping save me money on Des Moines to Central America flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Central America flight.

Cheap Des Moines to Central America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Central America

Fastest flight time

6h 13m

Direct flights

None
The fastest flight from Des Moines to Central America takes 6h 13m
There are no direct flights from Des Moines to Central America. There are no popular flight routes from Des Moines to Central America.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Central America?

    Prices for flights from Des Moines Airport to Central America are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Central America?

  • How old do you have to be to fly from Des Moines Airport to Central America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Central America.

  • What documentation or ID do you need to fly to Central America?

    The travel and health documents you'll need for your trip to Central America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Central America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to Central America

Compare and see reviews for airlines that fly from Des Moines to Central America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $289Free CancellationRating
7.9
8,014 reviews
Search Delta flights
United AirlinesPriceFrom $420Free CancellationRating
7.4
9,105 reviews
Search United Airlines flights
American AirlinesPriceFrom $468Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Central America?

Finding the right flight to Central America from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Central America quick and easy, saving you time and money.

Can I find flights from Des Moines to Central America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Central America from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Central America?

momondo provides multiple filters to help you find the best flight to Central America from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Central America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Central America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Central America trip

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Find better results for your trip to Central America

Popular cities in Central America

Popular flights according to clicks in the last 7 days on momondo
Flights to San Joséfrom $144
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Flights to Liberiafrom $200
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Flights to Belize Cityfrom $245
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Flights to Davidfrom $359
Flights to Bocas del Torofrom $663