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Cheap flights from Cleveland to Panama from $286

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Cleveland to Panama departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Cleveland to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
7:05 am - 12:58 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
6h 53m1 stop Atlanta Hartsfield-Jackson
JetBlue Logo
2:23 pm - 12:39 amPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
9h 16m1 stop Atlanta Hartsfield-Jackson
$638JetBlue
Sat, Sep 12 - Sat, Sep 19
Delta Logo
7:05 am - 2:05 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
7h 00m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:25 pm - 12:35 amPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
9h 10m1 stop Atlanta Hartsfield-Jackson
$681Delta
Thu, Dec 10 - Thu, Mar 18
United Airlines Logo
6:15 am - 5:12 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
10h 57m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 9:51 pmPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
12h 56m1 stop Houston George Bush Intcntl
$681United Airlines
Wed, Dec 9 - Fri, Dec 11
United Airlines Logo
6:15 am - 5:12 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
10h 57m1 stop Houston George Bush Intcntl
United Airlines Logo
9:30 am - 9:57 pmPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
11h 27m1 stop Newark
$681United Airlines
Wed, Dec 9 - Wed, Mar 17
Delta Logo
6:00 am - 2:05 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
8h 05m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 12:58 amPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
9h 28m1 stop Atlanta Hartsfield-Jackson
$681Delta
Thu, Dec 10 - Fri, Dec 11
American Airlines Logo
6:50 pm - 2:13 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
19h 23m2 stops Philadelphia Miami
American Airlines Logo
3:13 pm - 9:32 amPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
18h 19m2 stops Miami Chicago O'Hare Intl
$685American Airlines
Tue, Dec 8 - Fri, Dec 11
American Airlines Logo
7:12 pm - 3:33 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
20h 21m2 stops New York LaGuardia Miami
American Airlines Logo
2:39 pm - 9:02 amPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
18h 23m2 stops Miami Charlotte Douglas
$685American Airlines
Mon, Jan 4 - Tue, Feb 16
Multiple Airlines Logo
8:00 am - 10:30 amCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
26h 30m2 stops Miami San Salvador El Salvador Intl
Multiple Airlines Logo
5:50 pm - 1:29 pmPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
19h 39m3 stops Bogotá El Dorado Miami Atlanta Hartsfield-Jackson
$704Multiple Airlines
Fri, Nov 13 - Sun, Nov 15
Copa Airlines Logo
10:52 am - 8:41 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
10h 49m1 stop Chicago O'Hare Intl
Copa Airlines Logo
6:41 pm - 9:41 amPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
14h 00m1 stop Washington, D.C. Dulles Intl
$923Copa Airlines
Sat, Aug 29 - Sun, Aug 30
Copa Airlines Logo
7:45 pm - 1:31 pmCLE  Cleveland Hopkins Intl-PTY Panama City Tocumen Intl
17h 46m1 stop Washington, D.C. Dulles Intl
Copa Airlines Logo
8:16 am - 9:25 pmPTY  Panama City Tocumen Intl-CLE Cleveland Hopkins Intl
13h 09m1 stop Orlando
$1,533Copa Airlines
Sat, Dec 26 - Sat, Jan 2

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JetBlue flights from Cleveland to Panama

Our best JetBlue deals on Cleveland to Panama flight tickets
JetBlue
Sep 12
CLE7:05 amCleveland Hopkins Intl
6h 53m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 19
PTY2:23 pmPanama City Tocumen Intl
9h 16m
1 stop
CLE12:39 amCleveland Hopkins Intl
$638
JetBlue
Aug 18
CLE5:26 amCleveland Hopkins Intl
8h 29m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Aug 25
PTY2:20 pmPanama City Tocumen Intl
17h 50m
1 stop
CLE9:10 amCleveland Hopkins Intl
$670

Avianca flights from Cleveland to Panama

Our best Avianca deals on Cleveland to Panama flight tickets
Avianca
Sep 12
CLE10:37 amCleveland Hopkins Intl
16h 18m
2 stops
PTY1:55 amPanama City Tocumen Intl
Sep 19
PTY3:50 pmPanama City Tocumen Intl
16h 45m
2 stops
CLE9:35 amCleveland Hopkins Intl
$758
Avianca
Sep 12
CLE10:37 amCleveland Hopkins Intl
29h 18m
3 stops
PTY2:55 pmPanama City Tocumen Intl
Sep 19
PTY11:25 amPanama City Tocumen Intl
21h 10m
3 stops
CLE9:35 amCleveland Hopkins Intl
$845

momondo Fare Finder

 
Customize your flight search to find flights from Cleveland to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Cleveland to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Sat 9/12

7:05 am-12:58 pm

1 stop6h 53m

Panama City Tocumen Intl

Sat 9/19

2:23 pm-12:39 am

1 stop9h 16m

$638

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Thu 12/10

7:05 am-2:05 pm

1 stop7h 00m

Panama City Tocumen Intl

Thu 3/18

2:25 pm-12:35 am

1 stop9h 10m

$681

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Wed 12/9

6:15 am-5:12 pm

1 stop10h 57m

Panama City Tocumen Intl

Fri 12/11

8:55 am-9:51 pm

1 stop12h 56m

$681

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Wed 12/9

6:15 am-5:12 pm

1 stop10h 57m

Panama City Tocumen Intl

Wed 3/17

9:30 am-9:57 pm

1 stop11h 27m

$681

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Thu 12/10

6:00 am-2:05 pm

1 stop8h 05m

Panama City Tocumen Intl

Fri 12/11

3:30 pm-12:58 am

1 stop9h 28m

$681

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Tue 12/8

6:50 pm-2:13 pm

2 stops19h 23m

Panama City Tocumen Intl

Fri 12/11

3:13 pm-9:32 am

2 stops18h 19m

$685

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Mon 1/4

7:12 pm-3:33 pm

2 stops20h 21m

Panama City Tocumen Intl

Tue 2/16

2:39 pm-9:02 am

2 stops18h 23m

$685

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Fri 11/13

8:00 am-10:30 am

2 stops26h 30m

Panama City Tocumen Intl

Sun 11/15

5:50 pm-1:29 pm

3 stops19h 39m

$704

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Sat 8/29

10:52 am-8:41 pm

1 stop10h 49m

Panama City Tocumen Intl

Sun 8/30

6:41 pm-9:41 am

1 stop14h 00m

$923

ClevelandPanama City

CLE Cleveland Hopkins Intl - PTY Panama City Tocumen Intl

CLEPTY

Cleveland Hopkins Intl

Sat 12/26

7:45 pm-1:31 pm

1 stop17h 46m

Panama City Tocumen Intl

Sat 1/2

8:16 am-9:25 pm

1 stop13h 09m

$1,533

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Cleveland to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of October is, on average, the cheapest month to fly to Panama from Cleveland, with most prices found around $570. If you don’t want to visit Panama in October, then you should wait until November to fly from Cleveland, when ticket prices are also cheap, with an average price of $615.

Cheap Cleveland to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cleveland to Panama

Best Price Found

$286

Fastest flight time

8h 00m

Direct flights

None
The best one-way flight to Panama from Cleveland in the past 72 hours is $286. The best round-trip flight deal from Cleveland to Panama found on momondo in the last 72 hours is $638.
The fastest flight from Cleveland to Panama takes 8h 00m
There are no direct flights from Cleveland to Panama. There are no popular flight routes from Cleveland to Panama.
Search flight deals

Frequently asked questions about flying from Cleveland to Panama

  • When did momondo last update prices for flights from Cleveland Hopkins Intl Airport to Panama?

    Prices for flights from Cleveland Hopkins Intl Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Cleveland Hopkins Intl Airport to Panama?

  • How old do you have to be to fly from Cleveland Hopkins Intl Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Cleveland Hopkins Intl Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Cleveland to Panama

Compare and see reviews for airlines that fly from Cleveland to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $489Free CancellationRating
7.4
10,107 reviews
Search United Airlines flights
DeltaPriceFrom $530Free CancellationRating
7.8
8,504 reviews
Search Delta flights
American AirlinesPriceFrom $544Free CancellationRating
7.1
11,948 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $640Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Cleveland to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Cleveland to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Cleveland to Panama with flexible booking policies on momondo?

All flight searches from Cleveland to Panama on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Cleveland to Panama?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Cleveland to Panama.

I’m not ready to book a flight from Cleveland to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Cleveland to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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