What is the cheapest airline that flies from Charleston to South America?

Spirit Airlines, American Airlines, and United Airlines are the most popular carriers operating from Charleston to South America

What airlines fly to South America?

American Airlines, Delta and LATAM Airlines are the top three most popular airlines that fly to South America from Charleston according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 4 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Charleston Airport to South America?

Prices for flights from Charleston Airport to South America are refreshed on a daily basis.

How many operators does momondo search for flights from Charleston Airport to South America?

The number of operators available for flights from Charleston Airport to South America is 3 as of November 2025.

How old do you have to be to fly from Charleston Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$100 Cheap Flights from Charleston to South America in 2025/26

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Cheap round-trip flights

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9:49 pm - 1:09 amCHS-MDE

27h 20m1 stop

3:10 pm - 9:23 pmMDE-CHS

30h 13m1 stop

$266Spirit Airlines

Find Deal

Thu, Dec 11 - Wed, Dec 17

6:50 am - 12:56 amCHS-MDE

18h 06m1 stop

3:10 pm - 8:54 pmMDE-CHS

29h 44m1 stop

$293Spirit Airlines

Find Deal

Mon, Dec 1 - Thu, Dec 4

6:50 am - 9:40 pmCHS-MDE

14h 50m1 stop

1:00 pm - 8:54 pmMDE-CHS

7h 54m1 stop

$299Multiple Airlines

Find Deal

Mon, Dec 1 - Sun, Dec 7

9:49 pm - 1:57 pmCHS-MDE

16h 08m2 stops

2:54 pm - 8:37 amMDE-CHS

17h 43m1 stop

$306Multiple Airlines

Find Deal

Thu, Dec 11 - Mon, Dec 15

9:27 am - 3:30 pmCHS-CTG

6h 03m1 stop

4:30 pm - 11:55 pmCTG-CHS

7h 25m1 stop

$505American Airlines

Find Deal

Thu, Jan 22 - Mon, Jan 26

6:10 am - 3:30 pmCHS-CTG

9h 20m2 stops

4:30 pm - 11:39 amCTG-CHS

19h 09m2 stops

$510American Airlines

Find Deal

Thu, Jan 22 - Mon, Jan 26

6:30 am - 2:33 pmCHS-BOG

9h 03m1 stop

6:15 am - 11:38 pmBOG-CHS

16h 23m2 stops

$523Delta

Find Deal

Tue, Mar 10 - Wed, Mar 18

7:45 am - 1:15 pmCHS-CTG

6h 30m1 stop

2:30 pm - 8:42 amCTG-CHS

17h 12m1 stop

$537Delta

Find Deal

Mon, Mar 9 - Wed, Mar 11

7:45 am - 8:15 pmCHS-LIM

13h 30m2 stops

12:15 pm - 11:38 pmLIM-CHS

10h 23m1 stop

$577LATAM Airlines

Find Deal

Tue, Mar 17 - Tue, Mar 24

7:45 am - 8:55 pmCHS-LIM

14h 10m2 stops

8:25 am - 11:38 pmLIM-CHS

14h 13m2 stops

$582LATAM Airlines

Find Deal

Tue, Mar 17 - Tue, Mar 24

Delta flights from Charleston to South America

Our best Delta deals on Charleston to South America flight tickets

Delta

Mar 10

CHS6:30 amCharleston

9h 03m

1 stop

BOG2:33 pmBogotá El Dorado

Mar 18

BOG6:15 amBogotá El Dorado

16h 23m

2 stops

CHS11:38 pmCharleston

$523

Find similar

Delta

Mar 9

CHS7:45 amCharleston

6h 30m

1 stop

CTG1:15 pmCartagena Rafael Nunez

Mar 11

CTG2:30 pmCartagena Rafael Nunez

17h 12m

1 stop

CHS8:42 amCharleston

$537

Find similar

Delta

Mar 9

CHS7:45 amCharleston

6h 30m

1 stop

CTG1:15 pmCartagena Rafael Nunez

Mar 11

CTG5:05 amCartagena Rafael Nunez

26h 37m

2 stops

CHS8:42 amCharleston

$540

Find similar

American Airlines flights from Charleston to South America

Our best American Airlines deals on Charleston to South America flight tickets

American Airlines

Jan 22

CHS9:27 amCharleston

6h 03m

1 stop

CTG3:30 pmCartagena Rafael Nunez

Jan 26

CTG4:30 pmCartagena Rafael Nunez

7h 25m

1 stop

CHS11:55 pmCharleston

$505

Find similar

American Airlines

Jan 22

CHS6:10 amCharleston

9h 20m

2 stops

CTG3:30 pmCartagena Rafael Nunez

Jan 26

CTG4:30 pmCartagena Rafael Nunez

19h 09m

2 stops

CHS11:39 amCharleston

$510

Find similar

American Airlines

Mar 10

CHS5:51 amCharleston

17h 19m

1 stop

BOG10:10 pmBogotá El Dorado

Mar 17

BOG12:48 amBogotá El Dorado

11h 32m

1 stop

CHS1:20 pmCharleston

$542

Find similar

Fly from

Fly to

Route

Depart

Return

Price

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 12/11

9:49 pm-1:09 am

1 stop27h 20m

Medellín Jose Maria Cordova Intl

Wed 12/17

3:10 pm-9:23 pm

1 stop30h 13m

$266

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Mon 12/1

6:50 am-12:56 am

1 stop18h 06m

Medellín Jose Maria Cordova Intl

Thu 12/4

3:10 pm-8:54 pm

1 stop29h 44m

$293

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Mon 12/1

6:50 am-9:40 pm

1 stop14h 50m

Medellín Jose Maria Cordova Intl

Sun 12/7

1:00 pm-8:54 pm

1 stop7h 54m

$299

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 12/11

9:49 pm-1:57 pm

2 stops16h 08m

Medellín Jose Maria Cordova Intl

Mon 12/15

2:54 pm-8:37 am

1 stop17h 43m

$306

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 1/22

9:27 am-3:30 pm

1 stop6h 03m

Cartagena Rafael Nunez

Mon 1/26

4:30 pm-11:55 pm

1 stop7h 25m

$505

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 1/22

6:10 am-3:30 pm

2 stops9h 20m

Cartagena Rafael Nunez

Mon 1/26

4:30 pm-11:39 am

2 stops19h 09m

$510

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Tue 3/10

6:30 am-2:33 pm

1 stop9h 03m

Bogotá El Dorado

Wed 3/18

6:15 am-11:38 pm

2 stops16h 23m

$523

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 3/9

7:45 am-1:15 pm

1 stop6h 30m

Cartagena Rafael Nunez

Wed 3/11

2:30 pm-8:42 am

1 stop17h 12m

$537

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Tue 3/17

7:45 am-8:15 pm

2 stops13h 30m

Lima J Chavez Intl

Tue 3/24

12:15 pm-11:38 pm

1 stop10h 23m

$577

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Tue 3/17

7:45 am-8:55 pm

2 stops14h 10m

Lima J Chavez Intl

Tue 3/24

8:25 am-11:38 pm

2 stops14h 13m

$582

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, April is the cheapest month to fly from Charleston to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $625. If you aren’t able to travel during the month of April, then book flights to South America from Charleston during September instead. Flights to South America in September, while not as cheap as those in April, still average around $633.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Charleston to South America is on a Monday when prices can be found for as low as $530. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to South America for around $871.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Charleston to South America flights are usually those with departure times in the afternoon. Our users have found flights to South America in the afternoon for as low as $659. If you have a flexible travel schedule, then try to avoid flying in the evening when prices are $833 on average. Flights to South America from Charleston in the evening are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Charleston to South America flights?

You could potentially save up to 64% on your flight if you consider stops on a Charleston to South America flight.

Cheap Charleston to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to South America

Direct flights	None

There are no direct flights from Charleston to South America. There are no popular flight routes from Charleston to South America.

Search flight deals

When did momondo last update prices for flights from Charleston Airport to South America?
Prices for flights from Charleston Airport to South America are refreshed on a daily basis.
How many operators does momondo search for flights from Charleston Airport to South America?
The number of operators available for flights from Charleston Airport to South America is 3 as of November 2025.
How old do you have to be to fly from Charleston Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to South America

Compare and see reviews for airlines that fly from Charleston to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $301	Free Cancellation	Rating 7.9 8,004 reviews	Search Delta flights
American Airlines	PriceFrom $458	Free Cancellation	Rating 7.2 11,039 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $542	Free Cancellation	Rating 7.5 1,874 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from Charleston.

Can I find flights from Charleston to South America with flexible booking policies on momondo?

Flights from Charleston to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to South America?

Once all potential Charleston to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Charleston to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Find better results for your trip to South America

Popular cities in South America

Flights to Limafrom $273

Flights to Buenos Airesfrom $466

Flights to Bogotáfrom $182

Flights to Sao Paulofrom $381

Flights to Rio de Janeirofrom $424

Flights to Medellínfrom $166

Flights to Santiagofrom $343

Flights to Cartagenafrom $183

Flights to Quitofrom $315

Flights to Cuscofrom $367

Flights to Guayaquilfrom $233

Flights to Califrom $187

Cheap flights from Charleston to South America from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to South America departing on 1/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Charleston to South America

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Delta flights from Charleston to South America

Our best Delta deals on Charleston to South America flight tickets

American Airlines flights from Charleston to South America

Our best American Airlines deals on Charleston to South America flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Charleston to South America that are best for you.

How to get the cheapest flight ticket from Charleston to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Charleston to South America is on a Monday when prices can be found for as low as $530. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to South America for around $871.

What is the cheapest time of day to depart on your flight to South America?

Can stopping save me money on Charleston to South America flights?

You could potentially save up to 64% on your flight if you consider stops on a Charleston to South America flight.

What is the cheapest airline that flies from Charleston to South America?

Spirit Airlines, American Airlines, and United Airlines are the most popular carriers operating from Charleston to South America

What airlines fly to South America?

Cheap Charleston to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to South America

Direct flights

When did momondo last update prices for flights from Charleston Airport to South America?

How many operators does momondo search for flights from Charleston Airport to South America?

How old do you have to be to fly from Charleston Airport to South America?

What documentation or ID do you need to fly to South America?

Best airlines flying from Charleston to South America

Compare and see reviews for airlines that fly from Charleston to South America with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to South America?

Can I find flights from Charleston to South America with flexible booking policies on momondo?

How can momondo help me find flights from Charleston to South America?

I’m not ready to book a flight from Charleston to South America right now. Can momondo alert me if prices change?

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo