What is the cheapest airline that flies from Charleston to South America?

United Airlines, Delta, and Azul are the most popular carriers operating from Charleston to South America

What airlines fly to South America?

American Airlines, Delta and LATAM Airlines are the top three most popular airlines that fly to South America from Charleston according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Charleston Airport to South America?

Prices for flights from Charleston Airport to South America are refreshed on a daily basis.

How many operators does momondo search for flights from Charleston Airport to South America?

The number of operators available for flights from Charleston Airport to South America is 3 as of September 2026.

How old do you have to be to fly from Charleston Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$245 Cheap Flights from Charleston to South America in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:57 pm - 9:15 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

29h 18m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:40 am - 9:59 pmMDE Medellín Jose Maria Cordova Intl-CHS Charleston

11h 19m1 stop Houston George Bush Intcntl

$472United Airlines

Sat, Oct 24 - Wed, Nov 4

4:45 pm - 10:15 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

29h 30m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:45 am - 9:55 amMDE Medellín Jose Maria Cordova Intl-CHS Charleston

23h 10m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$487United Airlines

Sat, Feb 27 - Wed, Mar 3

6:30 am - 9:10 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

39h 40m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

9:45 am - 2:04 pmMDE Medellín Jose Maria Cordova Intl-CHS Charleston

27h 19m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$489United Airlines

Mon, Oct 19 - Fri, Oct 23

7:15 am - 1:35 pmCHS Charleston-CTG Cartagena Rafael Nunez

6h 20m1 stop Miami

4:41 pm - 11:58 pmCTG Cartagena Rafael Nunez-CHS Charleston

7h 17m1 stop Miami

$533American Airlines

Sat, Jan 30 - Sat, Feb 6

7:15 am - 3:41 pmCHS Charleston-CTG Cartagena Rafael Nunez

8h 26m1 stop Miami

4:41 pm - 10:48 amCTG Cartagena Rafael Nunez-CHS Charleston

18h 07m2 stops Miami Washington, D.C. Reagan-National

$538American Airlines

Sat, Jan 30 - Sat, Feb 6

5:38 pm - 3:41 pmCHS Charleston-CTG Cartagena Rafael Nunez

22h 03m2 stops Charlotte Douglas Miami

4:41 pm - 11:50 amCTG Cartagena Rafael Nunez-CHS Charleston

19h 09m2 stops Miami Charlotte Douglas

$538American Airlines

Sat, Jan 30 - Sat, Feb 6

6:00 am - 5:55 pmCHS Charleston-BOG Bogotá El Dorado

11h 55m2 stops Atlanta Hartsfield-Jackson Miami

3:55 pm - 9:42 amBOG Bogotá El Dorado-CHS Charleston

17h 47m1 stop Atlanta Hartsfield-Jackson

$642Delta

Sat, Dec 5 - Sat, Jan 30

7:00 am - 5:55 pmCHS Charleston-BOG Bogotá El Dorado

10h 55m2 stops Atlanta Hartsfield-Jackson Miami

4:50 am - 11:56 pmBOG Bogotá El Dorado-CHS Charleston

19h 06m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$642Delta

Sat, Dec 5 - Fri, Jan 29

2:18 pm - 5:00 amCHS Charleston-LIM Lima J Chavez Intl

14h 42m1 stop Atlanta Hartsfield-Jackson

12:10 pm - 11:59 pmLIM Lima J Chavez Intl-CHS Charleston

11h 49m1 stop Atlanta Hartsfield-Jackson

$785LATAM Airlines

Thu, Nov 5 - Wed, Nov 11

7:05 am - 6:30 pmCHS Charleston-LIM Lima J Chavez Intl

11h 25m2 stops Atlanta Hartsfield-Jackson Miami

12:15 am - 7:18 pmLIM Lima J Chavez Intl-CHS Charleston

19h 03m2 stops Miami Atlanta Hartsfield-Jackson

$805LATAM Airlines

Thu, Nov 5 - Tue, Nov 10

Cheap last minute flights

Enter your travel dates to find the best prices.

12:43 pm - 6:59 pmCHS Charleston-UIO Quito Mariscal Sucr

7h 16m1 stop Atlanta Hartsfield-Jackson

12:59 am - 10:08 amUIO Quito Mariscal Sucr-CHS Charleston

8h 09m1 stop Atlanta Hartsfield-Jackson

$825LATAM Airlines

Thu, Sep 10 - Wed, Sep 16

6:30 am - 11:25 pmCHS Charleston-UIO Quito Mariscal Sucr

17h 55m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

12:35 am - 10:11 pmUIO Quito Mariscal Sucr-CHS Charleston

20h 36m1 stop Houston George Bush Intcntl

$842United Airlines

Thu, Sep 10 - Wed, Sep 16

11:37 am - 11:25 pmCHS Charleston-UIO Quito Mariscal Sucr

12h 48m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

12:35 am - 10:37 amUIO Quito Mariscal Sucr-CHS Charleston

57h 02m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$851United Airlines

Thu, Sep 10 - Wed, Sep 16

11:13 am - 8:15 amCHS Charleston-SCL Santiago Arturo Merino Benitez

20h 02m1 stop Atlanta Hartsfield-Jackson

11:55 pm - 9:24 pmSCL Santiago Arturo Merino Benitez-CHS Charleston

22h 29m1 stop New York John F Kennedy Intl

$1,015Delta

Tue, Sep 15 - Wed, Sep 23

12:43 pm - 6:25 amCHS Charleston-SCL Santiago Arturo Merino Benitez

16h 42m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

6:40 am - 11:59 pmSCL Santiago Arturo Merino Benitez-CHS Charleston

18h 19m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,015LATAM Airlines

Tue, Sep 15 - Wed, Sep 23

4:12 pm - 8:15 amCHS Charleston-SCL Santiago Arturo Merino Benitez

15h 03m1 stop Atlanta Hartsfield-Jackson

6:40 am - 11:59 pmSCL Santiago Arturo Merino Benitez-CHS Charleston

18h 19m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,015LATAM Airlines

Tue, Sep 15 - Wed, Sep 23

7:00 am - 11:00 pmCHS Charleston-CTG Cartagena Rafael Nunez

17h 00m2 stops Houston George Bush Intcntl Panama City Tocumen Intl

3:05 pm - 10:11 pmCTG Cartagena Rafael Nunez-CHS Charleston

54h 06m2 stops Panama City Tocumen Intl Houston George Bush Intcntl

$1,019United Airlines

Fri, Sep 11 - Mon, Sep 14

7:50 am - 5:40 amCHS Charleston-SCL Santiago Arturo Merino Benitez

20h 50m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

9:30 am - 5:47 pmSCL Santiago Arturo Merino Benitez-CHS Charleston

33h 17m3 stops Buenos Aires Ministro Pistarini Miami Atlanta Hartsfield-Jackson

$1,072LATAM Airlines

Tue, Sep 15 - Wed, Sep 23

6:20 pm - 12:35 pmCHS Charleston-CTG Cartagena Rafael Nunez

19h 15m1 stop Miami

1:35 pm - 12:49 pmCTG Cartagena Rafael Nunez-CHS Charleston

22h 14m2 stops Miami Philadelphia

$1,143American Airlines

Fri, Sep 11 - Mon, Sep 14

6:20 pm - 12:35 pmCHS Charleston-CTG Cartagena Rafael Nunez

19h 15m1 stop Miami

1:35 pm - 11:43 pmCTG Cartagena Rafael Nunez-CHS Charleston

9h 08m1 stop Miami

$1,471GOL

Fri, Sep 11 - Mon, Sep 14

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American Airlines flights from Charleston to South America

Our best American Airlines deals on Charleston to South America flight tickets

American Airlines

Jan 30

CHS7:15 amCharleston

6h 20m

1 stop

CTG1:35 pmCartagena Rafael Nunez

Feb 6

CTG4:41 pmCartagena Rafael Nunez

7h 17m

1 stop

CHS11:58 pmCharleston

$533

American Airlines

Jan 30

CHS5:38 pmCharleston

22h 03m

2 stops

CTG3:41 pmCartagena Rafael Nunez

Feb 6

CTG4:41 pmCartagena Rafael Nunez

19h 09m

2 stops

CHS11:50 amCharleston

$538

American Airlines

Sep 18

CHS6:00 amCharleston

16h 17m

1 stop

BOG9:17 pmBogotá El Dorado

Sep 26

BOG2:10 pmBogotá El Dorado

8h 33m

1 stop

CHS11:43 pmCharleston

$561

Delta flights from Charleston to South America

Our best Delta deals on Charleston to South America flight tickets

Delta

Dec 5

CHS7:00 amCharleston

10h 55m

2 stops

BOG5:55 pmBogotá El Dorado

Jan 29

BOG4:50 amBogotá El Dorado

19h 06m

2 stops

CHS11:56 pmCharleston

$642

Delta

Jan 31

CHS7:59 pmCharleston

18h 11m

1 stop

CTG2:10 pmCartagena Rafael Nunez

Feb 7

CTG3:25 pmCartagena Rafael Nunez

18h 17m

1 stop

CHS9:42 amCharleston

$649

Delta

Sep 18

CHS5:25 amCharleston

15h 45m

2 stops

BOG8:10 pmBogotá El Dorado

Sep 26

BOG5:00 amBogotá El Dorado

17h 59m

2 stops

CHS11:59 pmCharleston

$652

momondo Fare Finder

Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonMedellín

CHS Charleston - MDE Medellín Jose Maria Cordova Intl

CHSMDE

Charleston

Sat 10/24

4:57 pm-9:15 pm

2 stops29h 18m

Medellín Jose Maria Cordova Intl

Wed 11/4

10:40 am-9:59 pm

1 stop11h 19m

$472

CharlestonMedellín

CHS Charleston - MDE Medellín Jose Maria Cordova Intl

CHSMDE

Charleston

Sat 2/27

4:45 pm-10:15 pm

2 stops29h 30m

Medellín Jose Maria Cordova Intl

Wed 3/3

10:45 am-9:55 am

2 stops23h 10m

$487

CharlestonMedellín

CHS Charleston - MDE Medellín Jose Maria Cordova Intl

CHSMDE

Charleston

Mon 10/19

6:30 am-9:10 pm

2 stops39h 40m

Medellín Jose Maria Cordova Intl

Fri 10/23

9:45 am-2:04 pm

2 stops27h 19m

$489

Quickest round-trip

CharlestonCartagena

CHS Charleston - CTG Cartagena Rafael Nunez

CHSCTG

Charleston

Sat 1/30

7:15 am-1:35 pm

1 stop6h 20m

Cartagena Rafael Nunez

Sat 2/6

4:41 pm-11:58 pm

1 stop7h 17m

$533

CharlestonCartagena

CHS Charleston - CTG Cartagena Rafael Nunez

CHSCTG

Charleston

Sat 1/30

7:15 am-3:41 pm

1 stop8h 26m

Cartagena Rafael Nunez

Sat 2/6

4:41 pm-10:48 am

2 stops18h 07m

$538

CharlestonCartagena

CHS Charleston - CTG Cartagena Rafael Nunez

CHSCTG

Charleston

Sat 1/30

5:38 pm-3:41 pm

2 stops22h 03m

Cartagena Rafael Nunez

Sat 2/6

4:41 pm-11:50 am

2 stops19h 09m

$538

CharlestonBogotá

CHS Charleston - BOG Bogotá El Dorado

CHSBOG

Charleston

Sat 12/5

6:00 am-5:55 pm

2 stops11h 55m

Bogotá El Dorado

Sat 1/30

3:55 pm-9:42 am

1 stop17h 47m

$642

CharlestonBogotá

CHS Charleston - BOG Bogotá El Dorado

CHSBOG

Charleston

Sat 12/5

7:00 am-5:55 pm

2 stops10h 55m

Bogotá El Dorado

Fri 1/29

4:50 am-11:56 pm

2 stops19h 06m

$642

CharlestonLima

CHS Charleston - LIM Lima J Chavez Intl

CHSLIM

Charleston

Thu 11/5

2:18 pm-5:00 am

1 stop14h 42m

Lima J Chavez Intl

Wed 11/11

12:10 pm-11:59 pm

1 stop11h 49m

$785

CharlestonLima

CHS Charleston - LIM Lima J Chavez Intl

CHSLIM

Charleston

Thu 11/5

7:05 am-6:30 pm

2 stops11h 25m

Lima J Chavez Intl

Tue 11/10

12:15 am-7:18 pm

2 stops19h 03m

$805

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, March is the cheapest month to fly from Charleston to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $587. If you aren’t able to travel during the month of March, then book flights to South America from Charleston during October instead. Flights to South America in October, while not as cheap as those in March, still average around $672.

Can stopping save me money on Charleston to South America flights?

You could potentially save up to 9% on your flight if you consider stops on a Charleston to South America flight.

Cheap Charleston to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to South America

Best Price Found	$245
Fastest flight time	6h 50m
Direct flights	None

The best one-way flight to South America from Charleston in the past 72 hours is $245. The best round-trip flight deal from Charleston to South America found on momondo in the last 72 hours is $472.

The fastest flight from Charleston to South America takes 6h 50m

There are no direct flights from Charleston to South America. There are no popular flight routes from Charleston to South America.

Search flight deals

Frequently asked questions about flying from Charleston to South America

When did momondo last update prices for flights from Charleston Airport to South America?
Prices for flights from Charleston Airport to South America are refreshed on a daily basis.
How many operators does momondo search for flights from Charleston Airport to South America?
The number of operators available for flights from Charleston Airport to South America is 3 as of September 2026.
How old do you have to be to fly from Charleston Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to South America

Compare and see reviews for airlines that fly from Charleston to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $301	Free Cancellation	Rating 7.8 8,554 reviews	Search Delta flights
American Airlines	PriceFrom $523	Free Cancellation	Rating 7.1 12,049 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $650	Free Cancellation	Rating 7.4 1,987 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from Charleston.

Can I find flights from Charleston to South America with flexible booking policies on momondo?

Flights from Charleston to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to South America?

Once all potential Charleston to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Charleston to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.