What airlines fly to South America?

American Airlines, LATAM Airlines and Delta are the top three most popular airlines that fly to South America from Charleston according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Charleston to South America?

United Airlines, Delta, and American Airlines are the most popular carriers operating from Charleston to South America

When did momondo last update prices for flights from Charleston Airport to South America?

Prices for flights from Charleston Airport to South America are refreshed on a daily basis.

How many operators does momondo search for flights from Charleston Airport to South America?

The number of operators available for flights from Charleston Airport to South America is 3 as of October 2026.

How old do you have to be to fly from Charleston Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$280 Cheap Flights from Charleston to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:05 am - 10:10 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

16h 05m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:40 am - 9:55 amMDE Medellín Jose Maria Cordova Intl-CHS Charleston

23h 15m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$493United Airlines

Sat, Feb 27 - Wed, Mar 3

4:50 pm - 10:10 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

29h 20m1 stop Houston George Bush Intcntl

10:40 am - 9:59 pmMDE Medellín Jose Maria Cordova Intl-CHS Charleston

11h 19m1 stop Houston George Bush Intcntl

$498United Airlines

Wed, Jan 20 - Wed, Jan 27

4:50 pm - 10:10 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

29h 20m1 stop Houston George Bush Intcntl

10:40 am - 9:55 amMDE Medellín Jose Maria Cordova Intl-CHS Charleston

23h 15m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$502United Airlines

Sat, Feb 27 - Wed, Mar 3

7:44 pm - 3:37 pmCHS Charleston-CTG Cartagena Rafael Nunez

19h 53m2 stops Charlotte Douglas Miami

2:36 pm - 10:30 amCTG Cartagena Rafael Nunez-CHS Charleston

19h 54m2 stops Miami Charlotte Douglas

$609American Airlines

Sat, Dec 5 - Sat, Dec 12

7:26 pm - 1:35 pmCHS Charleston-CTG Cartagena Rafael Nunez

18h 09m2 stops Charlotte Douglas Miami

2:35 pm - 10:02 pmCTG Cartagena Rafael Nunez-CHS Charleston

7h 27m1 stop Miami

$609American Airlines

Sat, Nov 14 - Wed, Nov 18

5:27 pm - 1:36 pmCHS Charleston-CTG Cartagena Rafael Nunez

20h 09m2 stops Charlotte Douglas Miami

2:36 pm - 12:31 amCTG Cartagena Rafael Nunez-CHS Charleston

9h 55m1 stop Miami

$609American Airlines

Sat, Dec 5 - Sat, Dec 12

5:55 pm - 4:20 pmCHS Charleston-BOG Bogotá El Dorado

22h 25m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

4:10 pm - 9:42 amBOG Bogotá El Dorado-CHS Charleston

17h 32m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$623Delta

Tue, Jan 26 - Wed, Feb 10

5:30 am - 7:30 pmCHS Charleston-BOG Bogotá El Dorado

14h 00m1 stop Atlanta Hartsfield-Jackson

4:10 pm - 9:42 amBOG Bogotá El Dorado-CHS Charleston

17h 32m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$623Delta

Tue, Jan 26 - Wed, Feb 10

6:34 am - 7:30 pmCHS Charleston-BOG Bogotá El Dorado

12h 56m1 stop Atlanta Hartsfield-Jackson

3:55 pm - 11:59 pmBOG Bogotá El Dorado-CHS Charleston

8h 04m1 stop Atlanta Hartsfield-Jackson

$623LATAM Airlines

Tue, Nov 10 - Tue, Nov 17

6:34 am - 7:30 pmCHS Charleston-BOG Bogotá El Dorado

12h 56m1 stop Atlanta Hartsfield-Jackson

3:55 pm - 11:59 pmBOG Bogotá El Dorado-CHS Charleston

8h 04m1 stop Atlanta Hartsfield-Jackson

$623LATAM Airlines

Tue, Nov 10 - Tue, Nov 17

Cheap last minute flights

Enter your travel dates to find the best prices.

7:00 am - 9:05 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

15h 05m1 stop Houston George Bush Intcntl

9:45 am - 9:59 pmMDE Medellín Jose Maria Cordova Intl-CHS Charleston

11h 14m1 stop Houston George Bush Intcntl

$559United Airlines

Sat, Oct 24 - Sat, Oct 31

7:00 am - 9:05 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

15h 05m1 stop Houston George Bush Intcntl

9:45 am - 2:56 pmMDE Medellín Jose Maria Cordova Intl-CHS Charleston

28h 11m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$563United Airlines

Sat, Oct 24 - Sat, Oct 31

4:57 pm - 9:15 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

29h 18m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

9:45 am - 11:06 amMDE Medellín Jose Maria Cordova Intl-CHS Charleston

24h 21m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$563United Airlines

Sat, Oct 24 - Sat, Oct 31

6:00 am - 9:17 pmCHS Charleston-BOG Bogotá El Dorado

16h 17m1 stop Miami

6:40 am - 6:58 pmBOG Bogotá El Dorado-CHS Charleston

11h 18m1 stop Miami

$638American Airlines

Fri, Oct 23 - Mon, Oct 26

6:00 am - 9:17 pmCHS Charleston-BOG Bogotá El Dorado

16h 17m1 stop Miami

6:40 am - 6:58 pmBOG Bogotá El Dorado-CHS Charleston

11h 18m1 stop Miami

$638American Airlines

Fri, Oct 23 - Mon, Oct 26

12:40 pm - 7:15 pmCHS Charleston-BOG Bogotá El Dorado

7h 35m1 stop Atlanta Hartsfield-Jackson

8:35 am - 11:59 pmBOG Bogotá El Dorado-CHS Charleston

14h 24m2 stops Miami Atlanta Hartsfield-Jackson

$642Delta

Fri, Oct 23 - Mon, Oct 26

12:40 pm - 7:15 pmCHS Charleston-BOG Bogotá El Dorado

7h 35m1 stop Atlanta Hartsfield-Jackson

8:35 am - 11:59 pmBOG Bogotá El Dorado-CHS Charleston

14h 24m2 stops Miami Atlanta Hartsfield-Jackson

$642Delta

Fri, Oct 23 - Mon, Oct 26

6:00 am - 9:17 pmCHS Charleston-BOG Bogotá El Dorado

16h 17m1 stop Miami

6:40 am - 9:50 pmBOG Bogotá El Dorado-CHS Charleston

14h 10m2 stops Miami Charlotte Douglas

$642American Airlines

Fri, Oct 23 - Mon, Oct 26

12:40 pm - 10:05 pmCHS Charleston-MDE Medellín Jose Maria Cordova Intl

10h 25m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

11:25 pm - 5:59 pmMDE Medellín Jose Maria Cordova Intl-CHS Charleston

18h 34m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$694LATAM Airlines

Mon, Oct 26 - Sat, Nov 14

12:40 pm - 9:20 pmCHS Charleston-LIM Lima J Chavez Intl

9h 40m1 stop Atlanta Hartsfield-Jackson

12:10 pm - 11:59 pmLIM Lima J Chavez Intl-CHS Charleston

11h 49m1 stop Atlanta Hartsfield-Jackson

$902LATAM Airlines

Tue, Oct 27 - Tue, Nov 17

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GOL flights from Charleston to South America

Our best GOL deals on Charleston to South America flight tickets

GOL

Nov 2

CHS7:26 pmCharleston

18h 49m

2 stops

BOG2:15 pmBogotá El Dorado

Nov 12

BOG3:15 pmBogotá El Dorado

8h 44m

1 stop

CHS11:59 pmCharleston

$649

GOL

Nov 3

CHS3:29 pmCharleston

15h 06m

1 stop

GRU8:35 amSao Paulo Guarulhos Intl

Nov 10

GRU11:15 pmSao Paulo Guarulhos Intl

20h 17m

1 stop

CHS5:32 pmCharleston

$5,520

GOL

Feb 25

CHS7:41 pmCharleston

11h 19m

1 stop

SCL9:00 amSantiago Arturo Merino Benitez

Mar 10

SCL10:15 pmSantiago Arturo Merino Benitez

14h 05m

1 stop

CHS10:20 amCharleston

$5,897

United Airlines flights from Charleston to South America

Our best United Airlines deals on Charleston to South America flight tickets

United Airlines

Feb 27

CHS6:05 amCharleston

16h 05m

2 stops

MDE10:10 pmMedellín Jose Maria Cordova Intl

Mar 3

MDE10:40 amMedellín Jose Maria Cordova Intl

23h 15m

2 stops

CHS9:55 amCharleston

$493

United Airlines

Jan 20

CHS4:50 pmCharleston

29h 20m

1 stop

MDE10:10 pmMedellín Jose Maria Cordova Intl

Jan 27

MDE10:40 amMedellín Jose Maria Cordova Intl

11h 19m

1 stop

CHS9:59 pmCharleston

$498

United Airlines

Jan 20

CHS4:50 pmCharleston

29h 20m

1 stop

MDE10:10 pmMedellín Jose Maria Cordova Intl

Jan 28

MDE10:40 amMedellín Jose Maria Cordova Intl

27h 06m

2 stops

CHS1:46 pmCharleston

$502

momondo Fare Finder

Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonMedellín

CHS Charleston - MDE Medellín Jose Maria Cordova Intl

CHSMDE

Charleston

Sat 2/27

6:05 am-10:10 pm

2 stops16h 05m

Medellín Jose Maria Cordova Intl

Wed 3/3

10:40 am-9:55 am

2 stops23h 15m

$493

CharlestonMedellín

CHS Charleston - MDE Medellín Jose Maria Cordova Intl

CHSMDE

Charleston

Wed 1/20

4:50 pm-10:10 pm

1 stop29h 20m

Medellín Jose Maria Cordova Intl

Wed 1/27

10:40 am-9:59 pm

1 stop11h 19m

$498

CharlestonMedellín

CHS Charleston - MDE Medellín Jose Maria Cordova Intl

CHSMDE

Charleston

Sat 2/27

4:50 pm-10:10 pm

1 stop29h 20m

Medellín Jose Maria Cordova Intl

Wed 3/3

10:40 am-9:55 am

2 stops23h 15m

$502

CharlestonCartagena

CHS Charleston - CTG Cartagena Rafael Nunez

CHSCTG

Charleston

Sat 12/5

7:44 pm-3:37 pm

2 stops19h 53m

Cartagena Rafael Nunez

Sat 12/12

2:36 pm-10:30 am

2 stops19h 54m

$609

CharlestonCartagena

CHS Charleston - CTG Cartagena Rafael Nunez

CHSCTG

Charleston

Sat 11/14

7:26 pm-1:35 pm

2 stops18h 09m

Cartagena Rafael Nunez

Wed 11/18

2:35 pm-10:02 pm

1 stop7h 27m

$609

CharlestonCartagena

CHS Charleston - CTG Cartagena Rafael Nunez

CHSCTG

Charleston

Sat 12/5

5:27 pm-1:36 pm

2 stops20h 09m

Cartagena Rafael Nunez

Sat 12/12

2:36 pm-12:31 am

1 stop9h 55m

$609

CharlestonBogotá

CHS Charleston - BOG Bogotá El Dorado

CHSBOG

Charleston

Tue 1/26

5:55 pm-4:20 pm

2 stops22h 25m

Bogotá El Dorado

Wed 2/10

4:10 pm-9:42 am

2 stops17h 32m

$623

CharlestonBogotá

CHS Charleston - BOG Bogotá El Dorado

CHSBOG

Charleston

Tue 1/26

5:30 am-7:30 pm

1 stop14h 00m

Bogotá El Dorado

Wed 2/10

4:10 pm-9:42 am

2 stops17h 32m

$623

Quickest round-trip

CharlestonBogotá

CHS Charleston - BOG Bogotá El Dorado

CHSBOG

Charleston

Tue 11/10

6:34 am-7:30 pm

1 stop12h 56m

Bogotá El Dorado

Tue 11/17

3:55 pm-11:59 pm

1 stop8h 04m

$623

CharlestonBogotá

CHS Charleston - BOG Bogotá El Dorado

CHSBOG

Charleston

Tue 11/10

6:34 am-7:30 pm

1 stop12h 56m

Bogotá El Dorado

Tue 11/17

3:55 pm-11:59 pm

1 stop8h 04m

$623

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, March is the cheapest month to fly from Charleston to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $661. If you aren’t able to travel during the month of March, then book flights to South America from Charleston during June instead. Flights to South America in June, while not as cheap as those in March, still average around $699.

Can stopping save me money on Charleston to South America flights?

You could potentially save up to 9% on your flight if you consider stops on a Charleston to South America flight.

Cheap Charleston to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to South America

Best Price Found	$280
Fastest flight time	7h 15m
Direct flights	None

The best one-way flight to South America from Charleston in the past 72 hours is $280. The best round-trip flight deal from Charleston to South America found on momondo in the last 72 hours is $493.

The fastest flight from Charleston to South America takes 7h 15m

There are no direct flights from Charleston to South America. There are no popular flight routes from Charleston to South America.

Search flight deals

Frequently asked questions about flying from Charleston to South America

When did momondo last update prices for flights from Charleston Airport to South America?
Prices for flights from Charleston Airport to South America are refreshed on a daily basis.
How many operators does momondo search for flights from Charleston Airport to South America?
The number of operators available for flights from Charleston Airport to South America is 3 as of October 2026.
How old do you have to be to fly from Charleston Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to South America

Compare and see reviews for airlines that fly from Charleston to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $318	Free Cancellation	Rating 7.8 8,654 reviews	Search Delta flights
American Airlines	PriceFrom $523	Free Cancellation	Rating 7.0 12,179 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $664	Free Cancellation	Rating 7.4 1,970 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from Charleston.

Can I find flights from Charleston to South America with flexible booking policies on momondo?

Flights from Charleston to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to South America?

Once all potential Charleston to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Charleston to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.