What is the cheapest airline that flies from Charleston to South America?

Spirit Airlines, American Airlines, and LATAM Airlines are the most popular carriers operating from Charleston to South America

What airlines fly to South America?

American Airlines, Delta and LATAM Airlines are the top three most popular airlines that fly to South America from Charleston according to our data. American Airlines is the first choice among our users, with 57% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 4 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Charleston Airport to South America?

Prices for flights from Charleston Airport to South America are refreshed on a daily basis.

How many operators does momondo search for flights from Charleston Airport to South America?

The number of operators available for flights from Charleston Airport to South America is 3 as of April 2026.

How old do you have to be to fly from Charleston Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$161 Cheap Flights from Charleston to South America in 2026

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Find the cheapest flights from Charleston to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:34 pm - 1:00 pm

CHS

MDE

21h 26m

1 stop

1:55 pm - 9:38 am

MDE

CHS

18h 43m

1 stop

$350Multiple Airlines

Wed, May 6 - Tue, May 19

2:53 pm - 1:00 pm

CHS

MDE

23h 07m

1 stop

1:55 pm - 9:38 am

MDE

CHS

18h 43m

1 stop

$367Multiple Airlines

Thu, May 7 - Tue, May 19

8:12 pm - 1:00 pm

CHS

CTG

17h 48m

1 stop

2:05 pm - 7:17 pm

CTG

CHS

28h 12m

1 stop

$448JetBlue

Thu, May 7 - Mon, May 11

8:12 pm - 1:00 pm

CHS

CTG

17h 48m

1 stop

2:05 pm - 3:38 pm

CTG

CHS

24h 33m

2 stops

$522JetBlue

Thu, May 7 - Mon, May 11

6:20 pm - 2:13 pm

CHS

CTG

20h 53m

2 stops

3:15 pm - 12:08 pm

CTG

CHS

19h 53m

2 stops

$535American Airlines

Wed, May 20 - Wed, May 27

11:14 am - 2:13 pm

CHS

CTG

27h 59m

1 stop

1:35 pm - 11:59 pm

CTG

CHS

9h 24m

1 stop

$540American Airlines

Wed, May 20 - Wed, May 27

11:18 am - 12:05 pm

CHS

BOG

25h 47m

2 stops

2:55 pm - 12:26 am

BOG

CHS

8h 31m

1 stop

$557LATAM Airlines

Thu, Jul 16 - Thu, Jul 23

5:15 am - 1:40 pm

CHS

BOG

9h 25m

1 stop

11:00 am - 10:56 pm

BOG

CHS

10h 56m

2 stops

$560Delta

Thu, May 28 - Thu, Jun 4

5:10 am - 7:15 pm

CHS

BOG

15h 05m

1 stop

11:00 am - 10:18 am

BOG

CHS

22h 18m

2 stops

$572Delta

Mon, Jun 8 - Mon, Jun 29

7:20 am - 8:10 pm

CHS

BOG

13h 50m

2 stops

2:55 pm - 12:26 am

BOG

CHS

8h 31m

1 stop

$574LATAM Airlines

Mon, Jul 20 - Mon, Jul 27

Spirit Airlines flights from Charleston to South America

Our best Spirit Airlines deals on Charleston to South America flight tickets

Spirit Airlines

May 8

CHS2:39 pmCharleston

23h 24m

2 stops

BOG1:03 pmBogotá El Dorado

May 10

BOG2:08 pmBogotá El Dorado

22h 36m

2 stops

CHS1:44 pmCharleston

$487

Spirit Airlines

May 8

CHS2:39 pmCharleston

23h 24m

3 stops

BOG1:03 pmBogotá El Dorado

May 10

BOG2:08 pmBogotá El Dorado

22h 36m

2 stops

CHS1:44 pmCharleston

$564

Spirit Airlines

May 7

CHS2:39 pmCharleston

22h 47m

3 stops

CTG12:26 pmCartagena Rafael Nunez

May 11

CTG1:31 pmCartagena Rafael Nunez

23h 13m

2 stops

CHS1:44 pmCharleston

$608

United Airlines flights from Charleston to South America

Our best United Airlines deals on Charleston to South America flight tickets

United Airlines

Jun 8

CHS11:18 amCharleston

11h 42m

1 stop

BOG10:00 pmBogotá El Dorado

Jun 29

BOG8:30 amBogotá El Dorado

12h 45m

1 stop

CHS10:15 pmCharleston

$555

United Airlines

Jun 8

CHS11:18 amCharleston

11h 42m

1 stop

BOG10:00 pmBogotá El Dorado

Jun 29

BOG8:30 amBogotá El Dorado

12h 45m

1 stop

CHS10:15 pmCharleston

$612

United Airlines

Jul 15

CHS6:40 pmCharleston

25h 40m

2 stops

BOG7:20 pmBogotá El Dorado

Jul 22

BOG8:30 amBogotá El Dorado

24h 41m

2 stops

CHS10:11 amCharleston

$617

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Wed 5/6

4:34 pm-1:00 pm

1 stop21h 26m

Medellín Jose Maria Cordova Intl

Tue 5/19

1:55 pm-9:38 am

1 stop18h 43m

$350

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 5/7

2:53 pm-1:00 pm

1 stop23h 07m

Medellín Jose Maria Cordova Intl

Tue 5/19

1:55 pm-9:38 am

1 stop18h 43m

$367

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 5/7

8:12 pm-1:00 pm

1 stop17h 48m

Cartagena Rafael Nunez

Mon 5/11

2:05 pm-7:17 pm

1 stop28h 12m

$448

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 5/7

8:12 pm-1:00 pm

1 stop17h 48m

Cartagena Rafael Nunez

Mon 5/11

2:05 pm-3:38 pm

2 stops24h 33m

$522

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Wed 5/20

6:20 pm-2:13 pm

2 stops20h 53m

Cartagena Rafael Nunez

Wed 5/27

3:15 pm-12:08 pm

2 stops19h 53m

$535

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Wed 5/20

11:14 am-2:13 pm

1 stop27h 59m

Cartagena Rafael Nunez

Wed 5/27

1:35 pm-11:59 pm

1 stop9h 24m

$540

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 7/16

11:18 am-12:05 pm

2 stops25h 47m

Bogotá El Dorado

Thu 7/23

2:55 pm-12:26 am

1 stop8h 31m

$557

Quickest round-trip

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 5/28

5:15 am-1:40 pm

1 stop9h 25m

Bogotá El Dorado

Thu 6/4

11:00 am-10:56 pm

2 stops10h 56m

$560

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Mon 6/8

5:10 am-7:15 pm

1 stop15h 05m

Bogotá El Dorado

Mon 6/29

11:00 am-10:18 am

2 stops22h 18m

$572

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Mon 7/20

7:20 am-8:10 pm

2 stops13h 50m

Bogotá El Dorado

Mon 7/27

2:55 pm-12:26 am

1 stop8h 31m

$574

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Charleston to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, October is the cheapest month to fly from Charleston to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $650. If you aren’t able to travel during the month of October, then book flights to South America from Charleston during March instead. Flights to South America in March, while not as cheap as those in October, still average around $701.

Can stopping save me money on Charleston to South America flights?

You could potentially save up to 37% on your flight if you consider stops on a Charleston to South America flight.

Cheap Charleston to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to South America

Fastest flight time	11h 36m
Direct flights	None

The fastest flight from Charleston to South America takes 11h 36m

There are no direct flights from Charleston to South America. There are no popular flight routes from Charleston to South America.

Search flight deals

Frequently asked questions about flying from Charleston to South America

When did momondo last update prices for flights from Charleston Airport to South America?
Prices for flights from Charleston Airport to South America are refreshed on a daily basis.
How many operators does momondo search for flights from Charleston Airport to South America?
The number of operators available for flights from Charleston Airport to South America is 3 as of April 2026.
How old do you have to be to fly from Charleston Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Charleston to South America

Compare and see reviews for airlines that fly from Charleston to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $301	Free Cancellation	Rating 7.9 8,390 reviews	Search Delta flights
American Airlines	PriceFrom $465	Free Cancellation	Rating 7.1 11,559 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $542	Free Cancellation	Rating 7.4 1,909 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from Charleston.

Can I find flights from Charleston to South America with flexible booking policies on momondo?

Flights from Charleston to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to South America?

Once all potential Charleston to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Charleston to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.