Cheap flights from Charleston to South America from $120

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to South America departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Spirit Airlines Logo
10:31 am - 12:25 amCHS-MDE
14h 54m1 stop
Spirit Airlines Logo
1:24 am - 9:26 amMDE-CHS
7h 02m1 stop
$277Spirit Airlines
Find Deal
Fri, Sep 19 - Sun, Sep 28
Spirit Airlines Logo
10:31 am - 1:00 pmCHS-MDE
27h 29m2 stops
Spirit Airlines Logo
1:24 am - 9:26 amMDE-CHS
7h 02m1 stop
$295Spirit Airlines
Find Deal
Fri, Sep 19 - Sun, Sep 28
 Logo
3:33 pm - 12:00 pmCHS-BOG
21h 27m1 stop
 Logo
12:55 pm - 8:37 amBOG-CHS
18h 42m1 stop
Fri, Sep 19 - Mon, Sep 29
 Logo
2:50 pm - 12:00 pmCHS-BOG
22h 10m1 stop
 Logo
1:54 pm - 7:12 pmBOG-CHS
28h 18m1 stop
Thu, Aug 21 - Thu, Aug 28
American Airlines Logo
4:30 pm - 12:25 pmCHS-CTG
20h 55m2 stops
American Airlines Logo
1:25 pm - 10:26 amCTG-CHS
20h 01m2 stops
$495American Airlines
Find Deal
Sun, Oct 12 - Sat, Oct 25
American Airlines Logo
7:44 pm - 12:25 pmCHS-CTG
17h 41m1 stop
American Airlines Logo
1:25 pm - 11:59 pmCTG-CHS
9h 34m1 stop
$500American Airlines
Find Deal
Sun, Oct 12 - Sat, Oct 25
Delta Logo
6:20 am - 1:16 pmCHS-CTG
7h 56m1 stop
Delta Logo
3:42 am - 9:16 amCTG-CHS
28h 34m2 stops
$504Delta
Find Deal
Sat, Sep 27 - Fri, Oct 3
Delta Logo
6:20 am - 1:16 pmCHS-CTG
7h 56m1 stop
Delta Logo
2:33 pm - 8:48 pmCTG-CHS
29h 15m1 stop
$508Delta
Find Deal
Sat, Sep 27 - Sat, Oct 4
LATAM Airlines Logo
12:15 pm - 7:30 pmCHS-BOG
7h 15m1 stop
LATAM Airlines Logo
9:00 am - 4:51 pmBOG-CHS
7h 51m1 stop
$516LATAM Airlines
Find Deal
Wed, Nov 12 - Mon, Nov 24
LATAM Airlines Logo
10:37 am - 8:20 pmCHS-BOG
9h 43m2 stops
LATAM Airlines Logo
9:00 am - 4:51 pmBOG-CHS
7h 51m1 stop
$520LATAM Airlines
Find Deal
Wed, Nov 12 - Mon, Nov 24

LATAM Airlines flights from Charleston to South America

Our best LATAM Airlines deals on Charleston to South America flight tickets
LATAM Airlines
Nov 12
CHS12:15 pmCharleston
7h 15m
1 stop
BOG7:30 pmBogotá El Dorado
Nov 24
BOG9:00 amBogotá El Dorado
7h 51m
1 stop
CHS4:51 pmCharleston
LATAM Airlines
Nov 12
CHS10:37 amCharleston
9h 43m
2 stops
BOG8:20 pmBogotá El Dorado
Nov 24
BOG9:00 amBogotá El Dorado
7h 51m
1 stop
CHS4:51 pmCharleston
LATAM Airlines
Nov 3
CHS12:59 pmCharleston
6h 31m
1 stop
BOG7:30 pmBogotá El Dorado
Nov 28
BOG3:50 pmBogotá El Dorado
17h 47m
1 stop
CHS9:37 amCharleston

United Airlines flights from Charleston to South America

Our best United Airlines deals on Charleston to South America flight tickets
United Airlines
Nov 12
CHS6:00 amCharleston
16h 35m
2 stops
BOG10:35 pmBogotá El Dorado
Nov 23
BOG1:30 amBogotá El Dorado
14h 21m
1 stop
CHS3:51 pmCharleston
United Airlines
Sep 11
CHS7:00 amCharleston
26h 41m
2 stops
CTG8:41 amCartagena Rafael Nunez
Sep 18
CTG9:39 amCartagena Rafael Nunez
35h 28m
2 stops
CHS10:07 pmCharleston
United Airlines
Nov 12
CHS5:05 pmCharleston
44h 29m
2 stops
GYE1:34 pmGuayaquil Jose Joaquin de Olmedo
Nov 24
GYE8:30 amGuayaquil Jose Joaquin de Olmedo
37h 29m
2 stops
CHS9:59 pmCharleston

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 9/19

10:31 am-12:25 am

1 stop14h 54m

Medellín Jose Maria Cordova Intl

Sun 9/28

1:24 am-9:26 am

1 stop7h 02m

$277

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 9/19

10:31 am-1:00 pm

2 stops27h 29m

Medellín Jose Maria Cordova Intl

Sun 9/28

1:24 am-9:26 am

1 stop7h 02m

$295

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 9/19

3:33 pm-12:00 pm

1 stop21h 27m

Bogotá El Dorado

Mon 9/29

12:55 pm-8:37 am

1 stop18h 42m

$338

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 8/21

2:50 pm-12:00 pm

1 stop22h 10m

Bogotá El Dorado

Thu 8/28

1:54 pm-7:12 pm

1 stop28h 18m

$366

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sun 10/12

4:30 pm-12:25 pm

2 stops20h 55m

Cartagena Rafael Nunez

Sat 10/25

1:25 pm-10:26 am

2 stops20h 01m

$495

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sun 10/12

7:44 pm-12:25 pm

1 stop17h 41m

Cartagena Rafael Nunez

Sat 10/25

1:25 pm-11:59 pm

1 stop9h 34m

$500

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sat 9/27

6:20 am-1:16 pm

1 stop7h 56m

Cartagena Rafael Nunez

Fri 10/3

3:42 am-9:16 am

2 stops28h 34m

$504

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sat 9/27

6:20 am-1:16 pm

1 stop7h 56m

Cartagena Rafael Nunez

Sat 10/4

2:33 pm-8:48 pm

1 stop29h 15m

$508

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Wed 11/12

12:15 pm-7:30 pm

1 stop7h 15m

Bogotá El Dorado

Mon 11/24

9:00 am-4:51 pm

1 stop7h 51m

$516

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Wed 11/12

10:37 am-8:20 pm

2 stops9h 43m

Bogotá El Dorado

Mon 11/24

9:00 am-4:51 pm

1 stop7h 51m

$520

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Charleston to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, January is the cheapest month to fly from Charleston to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $585. If you aren’t able to travel during the month of January, then book flights to South America from Charleston during April instead. Flights to South America in April, while not as cheap as those in January, still average around $625.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Charleston to South America is on a Monday when prices can be found for as low as $530. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to South America for around $871.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Charleston to South America flights are usually those with departure times in the afternoon. Our users have found flights to South America in the afternoon for as low as $659. If you have a flexible travel schedule, then try to avoid flying in the evening when prices are $833 on average. Flights to South America from Charleston in the evening are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Charleston to South America flights?

You could potentially save up to 56% on your flight if you consider stops on a Charleston to South America flight.

Cheap Charleston to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to South America

Best Price Found

$120

Fastest flight time

6h 05m

Direct flights

None

Airports in South America

8 airports
The best one-way flight to South America from Charleston in the past 72 hours is $120. The best round-trip flight deal from Charleston to South America found on momondo in the last 72 hours is $277.
The fastest flight from Charleston to South America takes 6h 05m
There are no direct flights from Charleston to South America. Popular non-direct routes for this connection are Charleston Airport - Cartagena Rafael Nunez Airport, Charleston Airport - Bogotá El Dorado Airport and Charleston Airport - Medellín Jose Maria Cordova Intl Airport.
There are 8 airports near South America: Buenos Aires Ministro Pistarini (EZE), Lima J Chavez Intl (LIM), Guayaquil Jose Joaquin de Olmedo (GYE), Cartagena Rafael Nunez (CTG), Bogotá El Dorado (BOG), Sao Paulo Guarulhos Intl (GRU), Buenos Aires Jorge Newbery (AEP), Medellín Jose Maria Cordova Intl (MDE)

  • When did momondo last update prices for flights from Charleston Airport to South America?

    Prices for flights from Charleston Airport to South America are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to South America?

  • How old do you have to be to fly from Charleston Airport to South America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.


Best airlines flying from Charleston to South America

Compare and see reviews for airlines that fly from Charleston to South America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $436Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $458Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $571Free CancellationRating
7.5
1,822 reviews
Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from Charleston.

Can I find flights from Charleston to South America with flexible booking policies on momondo?

Flights from Charleston to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to South America?

Once all potential Charleston to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Charleston to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Charleston. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.


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1 adult
Tue 8/5
Tue 8/12

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