Cheap flights from Tampa to Panama from $340

The month of April is, on average, the cheapest month to fly to Panama from Tampa, with most prices found around $513. If you don’t want to visit Panama in April, then you should wait until March to fly from Tampa, when ticket prices are also cheap, with an average price of $514.

According to our data, Wednesday is the cheapest day to fly to Panama from Tampa. The lowest ticket price found for a Wednesday departure recently was $469. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Tampa to Panama for around $505.

In the evening is the cheapest time of day to fly from Tampa to Panama when you can find flight prices for as low as $453. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $502 per ticket.

Fly from Tampa to Panama City Tocumen Intl for the best Tampa - Panama flight prices

You are more likely to see cheaper flights to Panama from Tampa when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $570 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Tampa for as low as $469 on momondo.

There are 3 cabin classes available to choose from on Tampa to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

American Airlines, Copa Airlines, and United Airlines are the most popular carriers operating from Tampa to Panama

Copa Airlines, Avianca and American Airlines are the top three most popular airlines that fly to Panama from Tampa according to our data. Copa Airlines is the first choice among our users, with 88% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

As of August 2026, there are 2 flights per day flying from Tampa to Panama. The most common time of day flights depart is 3:00PM, with 66% of flights taking off in the afternoon.

As of August 2026, there are 20 flights per week flying from Tampa to Panama. The most common day of the week flights depart is Mon, with 15% of flights taking off on this day.