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Cheap flights from St. Louis to Santiago de los Caballeros from $539

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago de los Caballeros departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from St. Louis to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:15 am - 9:13 pm
STL
-
STI
14h 58m
1 stop
American Airlines Logo
9:06 am - 10:58 pm
STI
-
STL
14h 52m
1 stop
$539American Airlines
Thu, May 28 - Tue, Jun 2
American Airlines Logo
6:55 pm - 12:23 pm
STL
-
STI
16h 28m
2 stops
American Airlines Logo
1:32 pm - 8:24 am
STI
-
STL
19h 52m
2 stops
$543American Airlines
Thu, Apr 16 - Tue, Apr 21
American Airlines Logo
11:22 am - 8:29 pm
STL
-
STI
8h 07m
1 stop
American Airlines Logo
7:00 am - 11:58 pm
STI
-
STL
17h 58m
1 stop
$548American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
5:15 am - 9:13 pm
STL
-
STI
14h 58m
1 stop
American Airlines Logo
9:06 am - 10:58 pm
STI
-
STL
14h 52m
1 stop
$549American Airlines
Thu, May 28 - Tue, Jun 2
American Airlines Logo
5:15 am - 9:13 pm
STL
-
STI
14h 58m
1 stop
American Airlines Logo
9:06 am - 8:52 pm
STI
-
STL
12h 46m
2 stops
$553American Airlines
Thu, May 28 - Tue, Jun 2
American Airlines Logo
5:15 am - 8:29 pm
STL
-
STI
14h 14m
1 stop
American Airlines Logo
1:30 pm - 11:58 pm
STI
-
STL
11h 28m
1 stop
$561American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
5:15 am - 12:30 pm
STL
-
STI
6h 15m
1 stop
American Airlines Logo
7:00 am - 11:58 pm
STI
-
STL
17h 58m
1 stop
$562American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
6:00 am - 8:29 pm
STL
-
STI
13h 29m
2 stops
American Airlines Logo
7:00 am - 5:40 pm
STI
-
STL
11h 40m
1 stop
$566American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
5:12 am - 8:29 pm
STL
-
STI
14h 17m
2 stops
American Airlines Logo
7:00 am - 5:40 pm
STI
-
STL
11h 40m
1 stop
$567American Airlines
Tue, Mar 17 - Wed, Mar 25
American Airlines Logo
5:15 am - 9:13 pm
STL
-
STI
14h 58m
1 stop
American Airlines Logo
3:38 pm - 10:58 pm
STI
-
STL
8h 20m
1 stop
$575American Airlines
Thu, May 28 - Tue, Jun 2

American Airlines flights from St. Louis to Santiago de los Caballeros

Our best American Airlines deals on St. Louis to Santiago de los Caballeros flight tickets
American Airlines
May 28
STL5:15 amLambert-St Louis
14h 58m
1 stop
STI9:13 pmSantiago de los Caballeros
Jun 2
STI9:06 amSantiago de los Caballeros
14h 52m
1 stop
STL10:58 pmLambert-St Louis
$539
American Airlines
Apr 16
STL6:55 pmLambert-St Louis
16h 28m
2 stops
STI12:23 pmSantiago de los Caballeros
Apr 21
STI1:32 pmSantiago de los Caballeros
9h 52m
1 stop
STL10:24 pmLambert-St Louis
$543
American Airlines
Mar 17
STL11:22 amLambert-St Louis
8h 07m
1 stop
STI8:29 pmSantiago de los Caballeros
Mar 25
STI7:00 amSantiago de los Caballeros
17h 58m
1 stop
STL11:58 pmLambert-St Louis
$548

United Airlines flights from St. Louis to Santiago de los Caballeros

Our best United Airlines deals on St. Louis to Santiago de los Caballeros flight tickets
United Airlines
Feb 21
STL1:11 pmLambert-St Louis
23h 42m
2 stops
STI2:53 pmSantiago de los Caballeros
Feb 25
STI6:00 amSantiago de los Caballeros
17h 05m
2 stops
STL9:05 pmLambert-St Louis
$797
United Airlines
Feb 21
STL9:55 amLambert-St Louis
11h 56m
2 stops
STI11:51 pmSantiago de los Caballeros
Feb 25
STI6:00 amSantiago de los Caballeros
17h 05m
2 stops
STL9:05 pmLambert-St Louis
$811
United Airlines
Feb 21
STL8:17 amLambert-St Louis
13h 34m
2 stops
STI11:51 pmSantiago de los Caballeros
Feb 25
STI4:00 pmSantiago de los Caballeros
9h 59m
1 stop
STL11:59 pmLambert-St Louis
$821

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Thu 5/28

5:15 am-9:13 pm

1 stop14h 58m

Santiago de los Caballeros

Tue 6/2

9:06 am-10:58 pm

1 stop14h 52m

$539

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Thu 4/16

6:55 pm-12:23 pm

2 stops16h 28m

Santiago de los Caballeros

Tue 4/21

1:32 pm-8:24 am

2 stops19h 52m

$543

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 3/17

11:22 am-8:29 pm

1 stop8h 07m

Santiago de los Caballeros

Wed 3/25

7:00 am-11:58 pm

1 stop17h 58m

$548

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Thu 5/28

5:15 am-9:13 pm

1 stop14h 58m

Santiago de los Caballeros

Tue 6/2

9:06 am-10:58 pm

1 stop14h 52m

$549

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Thu 5/28

5:15 am-9:13 pm

1 stop14h 58m

Santiago de los Caballeros

Tue 6/2

9:06 am-8:52 pm

2 stops12h 46m

$553

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 3/17

5:15 am-8:29 pm

1 stop14h 14m

Santiago de los Caballeros

Wed 3/25

1:30 pm-11:58 pm

1 stop11h 28m

$561

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 3/17

5:15 am-12:30 pm

1 stop6h 15m

Santiago de los Caballeros

Wed 3/25

7:00 am-11:58 pm

1 stop17h 58m

$562

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 3/17

6:00 am-8:29 pm

2 stops13h 29m

Santiago de los Caballeros

Wed 3/25

7:00 am-5:40 pm

1 stop11h 40m

$566

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 3/17

5:12 am-8:29 pm

2 stops14h 17m

Santiago de los Caballeros

Wed 3/25

7:00 am-5:40 pm

1 stop11h 40m

$567

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Thu 5/28

5:15 am-9:13 pm

1 stop14h 58m

Santiago de los Caballeros

Tue 6/2

3:38 pm-10:58 pm

1 stop8h 20m

$575

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from St. Louis to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Santiago de los Caballeros?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Santiago de los Caballeros from St. Louis according to our data. American Airlines is the first choice among our users, with 65% of people opting to fly with this airline when traveling to Santiago de los Caballeros. Keep in mind that there are 3 different airlines that fly to Santiago de los Caballeros on a routine basis, so you have a few additional options to choose from.

When to book flights from St. Louis to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago de los Caballeros (STL to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago de los Caballeros

Fastest flight time

14h 07m

Direct flights

None
The fastest flight from St. Louis to Santiago de los Caballeros takes 14h 07m
There are no direct flights from St. Louis to Santiago de los Caballeros. There are no popular flight routes from St. Louis to Santiago de los Caballeros.
Search flight deals

  • How far is Lambert-St Louis to Santiago de los Caballeros by plane?

    The distance between Lambert-St Louis and Santiago de los Caballeros is about 1763.6 mi. Typically, this will take 14h 07m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago de los Caballeros Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago de los Caballeros Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The travel and health documents you'll need for your trip to Santiago de los Caballeros Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago de los Caballeros Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Santiago de los Caballeros?

Best airlines flying from St. Louis to Santiago de los Caballeros

Compare and see reviews for airlines that fly from St. Louis to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $524Free CancellationRating
7.2
11,271 reviews
Search American Airlines flights
United AirlinesPriceFrom $538Free CancellationRating
7.4
9,279 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago de los Caballeros?

Finding the right flight to Santiago de los Caballeros from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago de los Caballeros quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago de los Caballeros with flexible booking policies on momondo?

Flights from St. Louis to Santiago de los Caballeros with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from St. Louis.

I’m not ready to book a flight from St. Louis to Santiago de los Caballeros right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago de los Caballeros now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago de los Caballeros and let you know when they change.

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