Cheap flights from St. Louis to Santiago de los Caballeros from $485

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santiago de los Caballeros departing on 8/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Spirit Airlines Logo
5:26 pm - 9:15 amSTL-STI
14h 49m1 stop
Spirit Airlines Logo
10:20 am - 9:40 amSTI-STL
24h 20m1 stop
$485Spirit Airlines
Find Deal
Tue, Aug 12 - Sat, Aug 16
Spirit Airlines Logo
5:26 pm - 9:15 amSTL-STI
14h 49m1 stop
Spirit Airlines Logo
10:20 am - 1:32 pmSTI-STL
28h 12m2 stops
$535Spirit Airlines
Find Deal
Tue, Aug 12 - Sat, Aug 16
Spirit Airlines Logo
5:26 pm - 9:15 amSTL-STI
14h 49m1 stop
Spirit Airlines Logo
10:20 am - 1:32 pmSTI-STL
28h 12m3 stops
$550Spirit Airlines
Find Deal
Tue, Aug 12 - Sat, Aug 16
American Airlines Logo
5:26 am - 12:31 pmSTL-STI
6h 05m1 stop
American Airlines Logo
1:29 pm - 11:59 pmSTI-STL
11h 30m1 stop
$560American Airlines
Find Deal
Tue, Aug 19 - Tue, Sep 16
American Airlines Logo
6:00 am - 8:48 pmSTL-STI
13h 48m2 stops
American Airlines Logo
1:29 pm - 11:59 pmSTI-STL
11h 30m1 stop
$564American Airlines
Find Deal
Tue, Aug 19 - Tue, Sep 16
Frontier Logo
5:40 pm - 12:51 pmSTL-STI
18h 11m2 stops
Frontier Logo
2:06 pm - 11:47 pmSTI-STL
10h 41m2 stops
$567Frontier
Find Deal
Tue, Aug 12 - Mon, Aug 18
Spirit Airlines Logo
5:26 pm - 9:15 amSTL-STI
14h 49m1 stop
Spirit Airlines Logo
10:20 am - 1:32 pmSTI-STL
28h 12m2 stops
$575Spirit Airlines
Find Deal
Tue, Aug 12 - Sun, Aug 17
 Logo
9:50 am - 9:15 amSTL-STI
22h 25m3 stops
 Logo
10:20 am - 1:32 pmSTI-STL
28h 12m3 stops
Tue, Aug 12 - Sat, Aug 16
 Logo
9:50 am - 9:15 amSTL-STI
22h 25m3 stops
 Logo
10:20 am - 1:32 pmSTI-STL
28h 12m3 stops
Tue, Aug 12 - Sun, Aug 17
United Airlines Logo
6:00 am - 3:12 pmSTL-STI
8h 12m1 stop
United Airlines Logo
2:07 pm - 11:43 pmSTI-STL
10h 36m1 stop
$968United Airlines
Find Deal
Mon, Aug 11 - Sun, Aug 17

American Airlines flights from St. Louis to Santiago de los Caballeros

Our best American Airlines deals on St. Louis to Santiago de los Caballeros flight tickets
American Airlines
Aug 19
STL5:26 amLambert-St Louis
6h 05m
1 stop
STI12:31 pmSantiago de los Caballeros
Sep 16
STI1:29 pmSantiago de los Caballeros
11h 30m
1 stop
STL11:59 pmLambert-St Louis
American Airlines
Aug 19
STL6:00 amLambert-St Louis
13h 48m
2 stops
STI8:48 pmSantiago de los Caballeros
Sep 16
STI1:29 pmSantiago de los Caballeros
11h 30m
1 stop
STL11:59 pmLambert-St Louis
American Airlines
Aug 12
STL5:26 amLambert-St Louis
6h 05m
1 stop
STI12:31 pmSantiago de los Caballeros
Aug 18
STI7:00 amSantiago de los Caballeros
14h 47m
2 stops
STL8:47 pmLambert-St Louis

Spirit Airlines flights from St. Louis to Santiago de los Caballeros

Our best Spirit Airlines deals on St. Louis to Santiago de los Caballeros flight tickets
Spirit Airlines
Aug 12
STL5:26 pmLambert-St Louis
14h 49m
1 stop
STI9:15 amSantiago de los Caballeros
Aug 16
STI10:20 amSantiago de los Caballeros
24h 20m
1 stop
STL9:40 amLambert-St Louis
Spirit Airlines
Aug 12
STL5:26 pmLambert-St Louis
14h 49m
1 stop
STI9:15 amSantiago de los Caballeros
Aug 16
STI10:20 amSantiago de los Caballeros
28h 12m
2 stops
STL1:32 pmLambert-St Louis
Spirit Airlines
Aug 12
STL5:26 pmLambert-St Louis
14h 49m
1 stop
STI9:15 amSantiago de los Caballeros
Aug 16
STI10:20 amSantiago de los Caballeros
28h 12m
3 stops
STL1:32 pmLambert-St Louis

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

5:26 pm-9:15 am

1 stop14h 49m

Santiago de los Caballeros

Sat 8/16

10:20 am-9:40 am

1 stop24h 20m

$485

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

5:26 pm-9:15 am

1 stop14h 49m

Santiago de los Caballeros

Sat 8/16

10:20 am-1:32 pm

2 stops28h 12m

$535

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

5:26 pm-9:15 am

1 stop14h 49m

Santiago de los Caballeros

Sat 8/16

10:20 am-1:32 pm

3 stops28h 12m

$550

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/19

5:26 am-12:31 pm

1 stop6h 05m

Santiago de los Caballeros

Tue 9/16

1:29 pm-11:59 pm

1 stop11h 30m

$560

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/19

6:00 am-8:48 pm

2 stops13h 48m

Santiago de los Caballeros

Tue 9/16

1:29 pm-11:59 pm

1 stop11h 30m

$564

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

5:40 pm-12:51 pm

2 stops18h 11m

Santiago de los Caballeros

Mon 8/18

2:06 pm-11:47 pm

2 stops10h 41m

$567

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

5:26 pm-9:15 am

1 stop14h 49m

Santiago de los Caballeros

Sun 8/17

10:20 am-1:32 pm

2 stops28h 12m

$575

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

9:50 am-9:15 am

3 stops22h 25m

Santiago de los Caballeros

Sat 8/16

10:20 am-1:32 pm

3 stops28h 12m

$742

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Tue 8/12

9:50 am-9:15 am

3 stops22h 25m

Santiago de los Caballeros

Sun 8/17

10:20 am-1:32 pm

3 stops28h 12m

$773

St. LouisSantiago de los Caballeros

STL - STI

STLSTI

Lambert-St Louis

Mon 8/11

6:00 am-3:12 pm

1 stop8h 12m

Santiago de los Caballeros

Sun 8/17

2:07 pm-11:43 pm

1 stop10h 36m

$968

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from St. Louis to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from St. Louis to Santiago de los Caballeros is on a Tuesday when prices can be found for as low as $582. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Santiago de los Caballeros for around $887.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest St. Louis to Santiago de los Caballeros flights are usually those with departure times in the morning. Our users have found flights to Santiago de los Caballeros in the morning for as low as $685. In the afternoon is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $887 per ticket.

When to book flights from St. Louis to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santiago de los Caballeros (STL to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santiago de los Caballeros

Best Price Found

$485

Fastest flight time

6h 05m

Direct flights

None

Airports in Santiago de los Caballeros

1 airport
The best flight deal from St. Louis to Santiago de los Caballeros found on momondo in the last 72 hours is $485
The fastest flight from St. Louis to Santiago de los Caballeros takes 6h 05m
There are no direct flights from St. Louis to Santiago de los Caballeros. Popular non-direct route for this connection is Lambert-St Louis Airport - Santiago de los Caballeros Airport.
There is 1 airport near Santiago de los Caballeros: Santiago de los Caballeros (STI)

  • How far is Lambert-St Louis to Santiago de los Caballeros by plane?

    The distance between Lambert-St Louis and Santiago de los Caballeros is about 1763.6 mi. Typically, this will take 6h 05m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santiago de los Caballeros Airport?

    Prices for flights from Lambert-St Louis Airport to Santiago de los Caballeros Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The travel and health documents you'll need for your trip to Santiago de los Caballeros Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago de los Caballeros Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Santiago de los Caballeros?


Best airlines flying from St. Louis to Santiago de los Caballeros

Compare and see reviews for airlines that fly from St. Louis to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $633Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Santiago de los Caballeros?

Finding the right flight to Santiago de los Caballeros from St. Louis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago de los Caballeros quick and easy, saving you time and money.

Can I find flights from St. Louis to Santiago de los Caballeros with flexible booking policies on momondo?

Flights from St. Louis to Santiago de los Caballeros with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from St. Louis.

I’m not ready to book a flight from St. Louis to Santiago de los Caballeros right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Santiago de los Caballeros now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago de los Caballeros and let you know when they change.


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1 adult
Tue 8/5
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