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Cheap flights from San Francisco to Santiago de los Caballeros from $219

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago de los Caballeros departing on 10/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santiago de los Caballeros

Cheap round-trip flights

JetBlue Logo
9:35 pm - 12:07 pmSFO-STI
10h 32m1 stop
JetBlue Logo
1:35 pm - 10:49 pmSTI-SFO
13h 14m1 stop
$451JetBlue
Find Deal
Sun, Mar 1 - Thu, Mar 5
American Airlines Logo
12:27 am - 8:51 pmSFO-STI
16h 24m2 stops
American Airlines Logo
4:33 pm - 10:59 pmSTI-SFO
10h 26m1 stop
$762American Airlines
Find Deal
Sat, Nov 8 - Thu, Nov 13
Delta Logo
6:15 am - 11:54 pmSFO-STI
13h 39m2 stops
Delta Logo
6:35 am - 3:18 pmSTI-SFO
12h 43m1 stop
$828Delta
Find Deal
Sun, Mar 1 - Thu, Mar 5
Delta Logo
6:45 am - 12:34 amSFO-STI
14h 49m1 stop
Delta Logo
2:40 pm - 1:21 amSTI-SFO
13h 41m1 stop
$4,607Delta
Find Deal
Thu, Sep 25 - Mon, Sep 29

Delta flights from San Francisco to Santiago de los Caballeros

Our best Delta deals on San Francisco to Santiago de los Caballeros flight tickets
Delta
Mar 1
SFO6:15 amSan Francisco
13h 39m
2 stops
STI11:54 pmSantiago de los Caballeros
Mar 5
STI6:35 amSantiago de los Caballeros
12h 43m
1 stop
SFO3:18 pmSan Francisco
$828
Find similar
Delta
Sep 25
SFO6:45 amSan Francisco
14h 49m
1 stop
STI12:34 amSantiago de los Caballeros
Sep 29
STI2:40 pmSantiago de los Caballeros
13h 41m
1 stop
SFO1:21 amSan Francisco
$4,607
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 2, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 3/1

9:35 pm-12:07 pm

1 stop10h 32m

Santiago de los Caballeros

Thu 3/5

1:35 pm-10:49 pm

1 stop13h 14m

$451

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sat 11/8

12:27 am-8:51 pm

2 stops16h 24m

Santiago de los Caballeros

Thu 11/13

4:33 pm-10:59 pm

1 stop10h 26m

$762

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 3/1

6:15 am-11:54 pm

2 stops13h 39m

Santiago de los Caballeros

Thu 3/5

6:35 am-3:18 pm

1 stop12h 43m

$828

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 9/25

6:45 am-12:34 am

1 stop14h 49m

Santiago de los Caballeros

Mon 9/29

2:40 pm-1:21 am

1 stop13h 41m

$4,607

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 10/2

10:37 pm-10:38 am

3 stops57h 01m

$219

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Fri 12/5

8:43 am-5:06 pm

2 stops28h 23m

$248

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 10/2

10:37 pm-11:03 am

2 stops33h 26m

$250

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Wed 12/3

6:00 am-5:06 pm

2 stops31h 06m

$265

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Wed 10/1

6:15 am-2:21 am

1 stop17h 06m

$269

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Wed 12/3

11:41 am-2:28 am

1 stop10h 47m

$270

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from San Francisco to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from San Francisco to Santiago de los Caballeros is on a Monday when prices can be found for as low as $496. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Santiago de los Caballeros for around $880.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest San Francisco to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $496. In the evening is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $735 per ticket.

Can stopping save me money on San Francisco to Santiago de los Caballeros flights?

You could potentially save up to 2% on your flight if you consider stops on a San Francisco to Santiago de los Caballeros flight.

When to book flights from San Francisco to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago de los Caballeros (SFO to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago de los Caballeros

Direct flights

None
There are no direct flights from San Francisco to Santiago de los Caballeros. There are no popular flight routes from San Francisco to Santiago de los Caballeros.
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  • How far is San Francisco to Santiago de los Caballeros by plane?

    A flight from San Francisco to Santiago de los Caballeros will travel around 3332.2 mi. A reasonable flight in good conditions will take 10h 32m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago de los Caballeros Airport?

    Prices for flights from San Francisco Airport to Santiago de los Caballeros Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago de los Caballeros Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The travel and health documents you'll need for your trip to Santiago de los Caballeros Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago de los Caballeros Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago de los Caballeros?

Best airlines flying from San Francisco to Santiago de los Caballeros

Compare and see reviews for airlines that fly from San Francisco to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $463Free CancellationRating
7.2
2,918 reviews
Search JetBlue flights
American AirlinesPriceFrom $614Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago de los Caballeros?

Finding the right flight to Santiago de los Caballeros from San Francisco is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago de los Caballeros quick and easy, saving you time and money.

Can I find flights from San Francisco to Santiago de los Caballeros with flexible booking policies on momondo?

Flights from San Francisco to Santiago de los Caballeros with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago de los Caballeros?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Santiago de los Caballeros.

I’m not ready to book a flight from San Francisco to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Santiago de los Caballeros flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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