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Cheap flights from San Francisco to Santiago de los Caballeros from $420

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago de los Caballeros departing on 5/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
11:59 pm - 3:56 pm
SFO
-
STI
12h 57m1 stop
JetBlue Logo
4:15 am - 5:35 pm
STI
-
SFO
16h 20m1 stop
$420JetBlue
Sun, May 3 - Wed, May 6
JetBlue Logo
8:00 am - 11:02 am
SFO
-
STI
23h 02m1 stop
JetBlue Logo
2:06 pm - 10:59 pm
STI
-
SFO
12h 53m1 stop
$437JetBlue
Tue, Jan 20 - Sun, Feb 1
JetBlue Logo
7:00 am - 9:53 pm
SFO
-
STI
10h 53m1 stop
JetBlue Logo
6:01 am - 2:12 pm
STI
-
SFO
12h 11m1 stop
$454JetBlue
Tue, Jan 20 - Sun, Feb 1
JetBlue Logo
11:59 pm - 10:37 am
SFO
-
STI
30h 38m1 stop
JetBlue Logo
7:01 am - 5:09 pm
STI
-
SFO
14h 08m1 stop
$471JetBlue
Tue, Jan 20 - Sun, Feb 1
American Airlines Logo
6:00 pm - 3:32 pm
SFO
-
STI
17h 32m2 stops
American Airlines Logo
6:00 am - 5:24 pm
STI
-
SFO
15h 24m2 stops
$642American Airlines
Thu, Jan 15 - Mon, Jan 26
American Airlines Logo
12:17 am - 9:46 pm
SFO
-
STI
17h 29m2 stops
American Airlines Logo
6:00 am - 9:37 pm
STI
-
SFO
19h 37m2 stops
$647American Airlines
Mon, Jan 19 - Sun, Feb 1
JetBlue Logo
12:55 pm - 1:45 am
SFO
-
STI
32h 50m1 stop
JetBlue Logo
10:11 am - 9:59 am
STI
-
SFO
27h 48m1 stop
$651JetBlue
Thu, Feb 12 - Sun, Feb 22
JetBlue Logo
12:40 pm - 9:39 am
SFO
-
STI
16h 59m1 stop
JetBlue Logo
5:10 am - 6:55 pm
STI
-
SFO
17h 45m1 stop
$680JetBlue
Thu, Jan 15 - Mon, Jan 26
American Airlines Logo
8:00 am - 9:46 pm
SFO
-
STI
9h 46m1 stop
American Airlines Logo
6:00 am - 9:26 pm
STI
-
SFO
19h 26m1 stop
$683American Airlines
Thu, Jan 15 - Mon, Jan 26
JetBlue Logo
9:00 am - 1:15 am
SFO
-
STI
13h 15m1 stop
JetBlue Logo
10:09 pm - 10:34 am
STI
-
SFO
15h 25m1 stop
$685JetBlue
Sun, Apr 12 - Sat, Apr 18

American Airlines flights from San Francisco to Santiago de los Caballeros

Our best American Airlines deals on San Francisco to Santiago de los Caballeros flight tickets
American Airlines
Jan 15
SFO6:00 pmSan Francisco
17h 32m
2 stops
STI3:32 pmSantiago de los Caballeros
Jan 26
STI6:00 amSantiago de los Caballeros
15h 24m
2 stops
SFO5:24 pmSan Francisco
$642
Find similar
American Airlines
Jan 19
SFO12:17 amSan Francisco
17h 29m
2 stops
STI9:46 pmSantiago de los Caballeros
Feb 1
STI6:00 amSantiago de los Caballeros
19h 37m
2 stops
SFO9:37 pmSan Francisco
$647
Find similar
American Airlines
Jan 15
SFO8:00 amSan Francisco
9h 46m
1 stop
STI9:46 pmSantiago de los Caballeros
Jan 26
STI6:00 amSantiago de los Caballeros
19h 26m
1 stop
SFO9:26 pmSan Francisco
$683
Find similar

JetBlue flights from San Francisco to Santiago de los Caballeros

Our best JetBlue deals on San Francisco to Santiago de los Caballeros flight tickets
JetBlue
May 3
SFO11:59 pmSan Francisco
12h 57m
1 stop
STI3:56 pmSantiago de los Caballeros
May 6
STI4:15 amSantiago de los Caballeros
16h 20m
1 stop
SFO5:35 pmSan Francisco
$420
Find similar
JetBlue
Jan 20
SFO8:00 amSan Francisco
23h 02m
1 stop
STI11:02 amSantiago de los Caballeros
Feb 1
STI2:06 pmSantiago de los Caballeros
12h 53m
1 stop
SFO10:59 pmSan Francisco
$437
Find similar
JetBlue
Jan 20
SFO7:00 amSan Francisco
10h 53m
1 stop
STI9:53 pmSantiago de los Caballeros
Feb 1
STI6:01 amSantiago de los Caballeros
12h 11m
1 stop
SFO2:12 pmSan Francisco
$454
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 5/3

11:59 pm-3:56 pm

1 stop12h 57m

Santiago de los Caballeros

Wed 5/6

4:15 am-5:35 pm

1 stop16h 20m

$420

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 1/20

8:00 am-11:02 am

1 stop23h 02m

Santiago de los Caballeros

Sun 2/1

2:06 pm-10:59 pm

1 stop12h 53m

$437

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 1/20

7:00 am-9:53 pm

1 stop10h 53m

Santiago de los Caballeros

Sun 2/1

6:01 am-2:12 pm

1 stop12h 11m

$454

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 1/20

11:59 pm-10:37 am

1 stop30h 38m

Santiago de los Caballeros

Sun 2/1

7:01 am-5:09 pm

1 stop14h 08m

$471

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 1/15

6:00 pm-3:32 pm

2 stops17h 32m

Santiago de los Caballeros

Mon 1/26

6:00 am-5:24 pm

2 stops15h 24m

$642

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Mon 1/19

12:17 am-9:46 pm

2 stops17h 29m

Santiago de los Caballeros

Sun 2/1

6:00 am-9:37 pm

2 stops19h 37m

$647

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 2/12

12:55 pm-1:45 am

1 stop32h 50m

Santiago de los Caballeros

Sun 2/22

10:11 am-9:59 am

1 stop27h 48m

$651

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 1/15

12:40 pm-9:39 am

1 stop16h 59m

Santiago de los Caballeros

Mon 1/26

5:10 am-6:55 pm

1 stop17h 45m

$680

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 1/15

8:00 am-9:46 pm

1 stop9h 46m

Santiago de los Caballeros

Mon 1/26

6:00 am-9:26 pm

1 stop19h 26m

$683

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 4/12

9:00 am-1:15 am

1 stop13h 15m

Santiago de los Caballeros

Sat 4/18

10:09 pm-10:34 am

1 stop15h 25m

$685

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from San Francisco to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from San Francisco to Santiago de los Caballeros is on a Monday when prices can be found for as low as $496. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Santiago de los Caballeros for around $880.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest San Francisco to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $496. In the evening is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $735 per ticket.

Can stopping save me money on San Francisco to Santiago de los Caballeros flights?

You could potentially save up to 14% on your flight if you consider stops on a San Francisco to Santiago de los Caballeros flight.

When to book flights from San Francisco to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago de los Caballeros (SFO to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago de los Caballeros

Fastest flight time

10h 30m

Direct flights

None
The fastest flight from San Francisco to Santiago de los Caballeros takes 10h 30m
There are no direct flights from San Francisco to Santiago de los Caballeros. There are no popular flight routes from San Francisco to Santiago de los Caballeros.
Search flight deals

  • How far is San Francisco to Santiago de los Caballeros by plane?

    A flight from San Francisco to Santiago de los Caballeros will travel around 3332.2 mi. A reasonable flight in good conditions will take 10h 30m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago de los Caballeros Airport?

    Prices for flights from San Francisco Airport to Santiago de los Caballeros Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago de los Caballeros Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The travel and health documents you'll need for your trip to Santiago de los Caballeros Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago de los Caballeros Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago de los Caballeros?

Best airlines flying from San Francisco to Santiago de los Caballeros

Compare and see reviews for airlines that fly from San Francisco to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $473Free CancellationRating
7.2
2,898 reviews
Search JetBlue flights
American AirlinesPriceFrom $614Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago de los Caballeros?

Finding the right flight to Santiago de los Caballeros from San Francisco is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago de los Caballeros quick and easy, saving you time and money.

Can I find flights from San Francisco to Santiago de los Caballeros with flexible booking policies on momondo?

Flights from San Francisco to Santiago de los Caballeros with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago de los Caballeros?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Santiago de los Caballeros.

I’m not ready to book a flight from San Francisco to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Santiago de los Caballeros flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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