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Cheap flights from San Francisco to Santiago de los Caballeros from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago de los Caballeros departing on 12/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
8:00 am - 11:02 amSFO-STI
23h 02m1 stop
JetBlue Logo
6:01 am - 2:12 pmSTI-SFO
12h 11m1 stop
$446JetBlue
Find Deal
Tue, Jan 20 - Sun, Feb 1
JetBlue Logo
7:00 am - 3:44 amSFO-STI
16h 44m1 stop
JetBlue Logo
11:06 pm - 12:46 pmSTI-SFO
17h 40m1 stop
$452JetBlue
Find Deal
Sun, Mar 1 - Thu, Mar 5
JetBlue Logo
7:00 am - 9:53 pmSFO-STI
10h 53m1 stop
JetBlue Logo
4:10 am - 2:12 pmSTI-SFO
14h 02m1 stop
$455JetBlue
Find Deal
Tue, Jan 20 - Sat, Jan 31
JetBlue Logo
10:51 am - 4:22 amSFO-STI
13h 31m1 stop
JetBlue Logo
10:11 am - 11:58 pmSTI-SFO
17h 47m1 stop
$461JetBlue
Find Deal
Thu, Feb 5 - Thu, Feb 12
JetBlue Logo
11:30 pm - 3:15 pmSFO-STI
11h 45m1 stop
JetBlue Logo
4:35 am - 7:28 pmSTI-SFO
18h 53m1 stop
$491JetBlue
Find Deal
Sun, Mar 1 - Wed, Mar 4
JetBlue Logo
12:59 pm - 4:49 amSFO-STI
11h 50m1 stop
JetBlue Logo
4:35 am - 4:42 pmSTI-SFO
16h 07m1 stop
$502JetBlue
Find Deal
Sun, Mar 1 - Wed, Mar 4
JetBlue Logo
10:30 pm - 11:59 amSFO-STI
10h 29m1 stop
JetBlue Logo
6:00 am - 5:49 pmSTI-SFO
14h 49m1 stop
$514JetBlue
Find Deal
Thu, Apr 2 - Mon, Apr 6
Copa Airlines Logo
12:42 am - 2:56 pmSFO-STI
10h 14m1 stop
Copa Airlines Logo
3:51 pm - 11:20 pmSTI-SFO
11h 29m1 stop
$524Copa Airlines
Find Deal
Wed, Feb 4 - Thu, Feb 12
JetBlue Logo
10:51 am - 4:22 amSFO-STI
13h 31m1 stop
JetBlue Logo
4:35 am - 12:46 pmSTI-SFO
12h 11m1 stop
$542JetBlue
Find Deal
Thu, Feb 5 - Wed, Feb 11
JetBlue Logo
7:00 am - 9:40 pmSFO-STI
10h 40m1 stop
JetBlue Logo
11:06 pm - 12:46 pmSTI-SFO
17h 40m1 stop
$591JetBlue
Find Deal
Fri, Feb 27 - Sat, Feb 28

American Airlines flights from San Francisco to Santiago de los Caballeros

Our best American Airlines deals on San Francisco to Santiago de los Caballeros flight tickets
American Airlines
Feb 4
SFO12:17 amSan Francisco
11h 15m
2 stops
STI3:32 pmSantiago de los Caballeros
Feb 12
STI8:00 amSantiago de los Caballeros
18h 04m
2 stops
SFO10:04 pmSan Francisco
$622
Find similar
American Airlines
Jan 19
SFO12:17 amSan Francisco
17h 29m
2 stops
STI9:46 pmSantiago de los Caballeros
Feb 1
STI6:00 amSantiago de los Caballeros
19h 26m
1 stop
SFO9:26 pmSan Francisco
$647
Find similar
American Airlines
May 8
SFO11:56 pmSan Francisco
11h 24m
1 stop
STI2:20 pmSantiago de los Caballeros
May 11
STI3:35 pmSantiago de los Caballeros
23h 15m
2 stops
SFO11:50 amSan Francisco
$662
Find similar

JetBlue flights from San Francisco to Santiago de los Caballeros

Our best JetBlue deals on San Francisco to Santiago de los Caballeros flight tickets
JetBlue
Jan 20
SFO8:00 amSan Francisco
23h 02m
1 stop
STI11:02 amSantiago de los Caballeros
Feb 1
STI6:01 amSantiago de los Caballeros
12h 11m
1 stop
SFO2:12 pmSan Francisco
$446
Find similar
JetBlue
Mar 1
SFO7:00 amSan Francisco
16h 44m
1 stop
STI3:44 amSantiago de los Caballeros
Mar 5
STI11:06 pmSantiago de los Caballeros
17h 40m
1 stop
SFO12:46 pmSan Francisco
$452
Find similar
JetBlue
Jan 20
SFO7:00 amSan Francisco
10h 53m
1 stop
STI9:53 pmSantiago de los Caballeros
Jan 31
STI4:10 amSantiago de los Caballeros
14h 02m
1 stop
SFO2:12 pmSan Francisco
$455
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 1/20

8:00 am-11:02 am

1 stop23h 02m

Santiago de los Caballeros

Sun 2/1

6:01 am-2:12 pm

1 stop12h 11m

$446

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 3/1

7:00 am-3:44 am

1 stop16h 44m

Santiago de los Caballeros

Thu 3/5

11:06 pm-12:46 pm

1 stop17h 40m

$452

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 1/20

7:00 am-9:53 pm

1 stop10h 53m

Santiago de los Caballeros

Sat 1/31

4:10 am-2:12 pm

1 stop14h 02m

$455

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 2/5

10:51 am-4:22 am

1 stop13h 31m

Santiago de los Caballeros

Thu 2/12

10:11 am-11:58 pm

1 stop17h 47m

$461

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 3/1

11:30 pm-3:15 pm

1 stop11h 45m

Santiago de los Caballeros

Wed 3/4

4:35 am-7:28 pm

1 stop18h 53m

$491

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Sun 3/1

12:59 pm-4:49 am

1 stop11h 50m

Santiago de los Caballeros

Wed 3/4

4:35 am-4:42 pm

1 stop16h 07m

$502

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 4/2

10:30 pm-11:59 am

1 stop10h 29m

Santiago de los Caballeros

Mon 4/6

6:00 am-5:49 pm

1 stop14h 49m

$514

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Wed 2/4

12:42 am-2:56 pm

1 stop10h 14m

Santiago de los Caballeros

Thu 2/12

3:51 pm-11:20 pm

1 stop11h 29m

$524

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 2/5

10:51 am-4:22 am

1 stop13h 31m

Santiago de los Caballeros

Wed 2/11

4:35 am-12:46 pm

1 stop12h 11m

$542

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Fri 2/27

7:00 am-9:40 pm

1 stop10h 40m

Santiago de los Caballeros

Sat 2/28

11:06 pm-12:46 pm

1 stop17h 40m

$591

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from San Francisco to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from San Francisco to Santiago de los Caballeros is on a Monday when prices can be found for as low as $496. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Santiago de los Caballeros for around $880.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest San Francisco to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $496. In the evening is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $735 per ticket.

Can stopping save me money on San Francisco to Santiago de los Caballeros flights?

You could potentially save up to 39% on your flight if you consider stops on a San Francisco to Santiago de los Caballeros flight.

When to book flights from San Francisco to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago de los Caballeros (SFO to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago de los Caballeros

Direct flights

None
There are no direct flights from San Francisco to Santiago de los Caballeros. There are no popular flight routes from San Francisco to Santiago de los Caballeros.
Search flight deals

  • How far is San Francisco to Santiago de los Caballeros by plane?

    A flight from San Francisco to Santiago de los Caballeros will travel around 3332.2 mi. A reasonable flight in good conditions will take 8h 47m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago de los Caballeros Airport?

    Prices for flights from San Francisco Airport to Santiago de los Caballeros Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago de los Caballeros Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The travel and health documents you'll need for your trip to Santiago de los Caballeros Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santiago de los Caballeros Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago de los Caballeros?

Best airlines flying from San Francisco to Santiago de los Caballeros

Compare and see reviews for airlines that fly from San Francisco to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $463Free CancellationRating
7.2
2,907 reviews
Search JetBlue flights
American AirlinesPriceFrom $614Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago de los Caballeros?

Finding the right flight to Santiago de los Caballeros from San Francisco is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago de los Caballeros quick and easy, saving you time and money.

Can I find flights from San Francisco to Santiago de los Caballeros with flexible booking policies on momondo?

Flights from San Francisco to Santiago de los Caballeros with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago de los Caballeros?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Santiago de los Caballeros.

I’m not ready to book a flight from San Francisco to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Santiago de los Caballeros flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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