Which layover airport has the shortest connection time from San Francisco to Santiago?

Miami (MIA) has the shortest average layover time for this route: 1h 55m.

Which layover airport offers the lowest fares from San Francisco to Santiago?

Flights via Houston (IAH) offer the lowest average round-trip price of $668.

Which airport is the most popular layover for flights between San Francisco and Santiago?

Houston (IAH) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Santiago?

LATAM Airlines, American Airlines and Delta are the top three most popular airlines that fly to Santiago from San Francisco according to our data. LATAM Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 7 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from San Francisco to Santiago?

Flights connecting via Los Angeles (LAX) have the shortest average one-way travel time: 14h 46m.

When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

As of February 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$290 Cheap Flights from San Francisco to Santiago in 2026

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Find the cheapest flights from San Francisco to Santiago

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One-way

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6:00 am - 5:35 am

SFO

SCL

20h 35m

1 stop

11:25 pm - 11:59 am

SCL

SFO

15h 34m

1 stop

$633LATAM Airlines

Sat, Apr 11 - Wed, Apr 22

11:45 pm - 6:00 am

SFO

SCL

27h 15m

2 stops

11:25 pm - 3:11 pm

SCL

SFO

18h 46m

1 stop

$635Delta

Sat, Aug 15 - Sun, Aug 23

1:45 pm - 7:45 pm

SFO

SCL

27h 00m

2 stops

11:25 pm - 11:59 am

SCL

SFO

15h 34m

1 stop

$640LATAM Airlines

Sun, Jul 26 - Sun, Aug 9

9:30 pm - 6:00 am

SFO

SCL

29h 30m

2 stops

10:30 am - 11:45 am

SCL

SFO

28h 15m

2 stops

$642LATAM Airlines

Mon, Jun 8 - Tue, Jun 23

6:00 am - 5:35 am

SFO

SCL

20h 35m

1 stop

11:25 pm - 11:59 am

SCL

SFO

15h 34m

1 stop

$648LATAM Airlines

Sat, Apr 11 - Wed, Apr 22

8:00 am - 5:35 am

SFO

SCL

18h 35m

2 stops

11:25 pm - 10:53 am

SCL

SFO

14h 28m

1 stop

$652LATAM Airlines

Wed, Apr 15 - Wed, May 6

11:00 am - 5:35 am

SFO

SCL

15h 35m

1 stop

11:00 pm - 4:57 pm

SCL

SFO

20h 57m

2 stops

$657LATAM Airlines

Mon, Apr 27 - Mon, May 4

11:28 am - 7:15 am

SFO

SCL

16h 47m

1 stop

11:25 pm - 3:56 pm

SCL

SFO

19h 31m

1 stop

$658LATAM Airlines

Tue, May 12 - Sun, May 24

1:05 pm - 1:45 pm

SFO

SCL

21h 40m

1 stop

11:25 pm - 3:21 pm

SCL

SFO

18h 56m

1 stop

$661LATAM Airlines

Fri, Apr 10 - Wed, Apr 22

4:03 pm - 1:45 pm

SFO

SCL

18h 42m

2 stops

11:25 pm - 3:21 pm

SCL

SFO

18h 56m

1 stop

$662LATAM Airlines

Fri, Apr 10 - Wed, Apr 22

Delta flights from San Francisco to Santiago

Our best Delta deals on San Francisco to Santiago flight tickets

Delta

Aug 15

SFO11:45 pmSan Francisco

27h 15m

2 stops

SCL6:00 amSantiago Arturo Merino Benitez

Aug 23

SCL11:25 pmSantiago Arturo Merino Benitez

18h 46m

1 stop

SFO3:11 pmSan Francisco

$635

Delta

Jul 21

SFO8:55 amSan Francisco

17h 40m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Aug 20

SCL8:40 pmSantiago Arturo Merino Benitez

19h 41m

1 stop

SFO1:21 pmSan Francisco

$670

Delta

Jul 28

SFO11:05 amSan Francisco

29h 40m

2 stops

SCL7:45 pmSantiago Arturo Merino Benitez

Aug 12

SCL11:25 pmSantiago Arturo Merino Benitez

21h 25m

1 stop

SFO5:50 pmSan Francisco

$675

LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets

LATAM Airlines

Apr 11

SFO6:00 amSan Francisco

20h 35m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Apr 22

SCL11:25 pmSantiago Arturo Merino Benitez

15h 34m

1 stop

SFO11:59 amSan Francisco

$633

LATAM Airlines

Jul 26

SFO1:45 pmSan Francisco

27h 00m

2 stops

SCL7:45 pmSantiago Arturo Merino Benitez

Aug 9

SCL11:25 pmSantiago Arturo Merino Benitez

15h 34m

1 stop

SFO11:59 amSan Francisco

$640

LATAM Airlines

Jun 8

SFO9:30 pmSan Francisco

29h 30m

2 stops

SCL6:00 amSantiago Arturo Merino Benitez

Jun 23

SCL10:30 amSantiago Arturo Merino Benitez

28h 15m

2 stops

SFO11:45 amSan Francisco

$642

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 4/11

6:00 am-5:35 am

1 stop20h 35m

Santiago Arturo Merino Benitez

Wed 4/22

11:25 pm-11:59 am

1 stop15h 34m

$633

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 8/15

11:45 pm-6:00 am

2 stops27h 15m

Santiago Arturo Merino Benitez

Sun 8/23

11:25 pm-3:11 pm

1 stop18h 46m

$635

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 7/26

1:45 pm-7:45 pm

2 stops27h 00m

Santiago Arturo Merino Benitez

Sun 8/9

11:25 pm-11:59 am

1 stop15h 34m

$640

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 6/8

9:30 pm-6:00 am

2 stops29h 30m

Santiago Arturo Merino Benitez

Tue 6/23

10:30 am-11:45 am

2 stops28h 15m

$642

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 4/11

6:00 am-5:35 am

1 stop20h 35m

Santiago Arturo Merino Benitez

Wed 4/22

11:25 pm-11:59 am

1 stop15h 34m

$648

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 4/15

8:00 am-5:35 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Wed 5/6

11:25 pm-10:53 am

1 stop14h 28m

$652

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/27

11:00 am-5:35 am

1 stop15h 35m

Santiago Arturo Merino Benitez

Mon 5/4

11:00 pm-4:57 pm

2 stops20h 57m

$657

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/12

11:28 am-7:15 am

1 stop16h 47m

Santiago Arturo Merino Benitez

Sun 5/24

11:25 pm-3:56 pm

1 stop19h 31m

$658

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 4/10

1:05 pm-1:45 pm

1 stop21h 40m

Santiago Arturo Merino Benitez

Wed 4/22

11:25 pm-3:21 pm

1 stop18h 56m

$661

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 4/10

4:03 pm-1:45 pm

2 stops18h 42m

Santiago Arturo Merino Benitez

Wed 4/22

11:25 pm-3:21 pm

1 stop18h 56m

$662

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $666. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $782 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $540 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 25% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of February 2026, prices for San Francisco to Santiago flights are approximately 16% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time	16h 40m
Direct flights	None

The fastest flight from San Francisco to Santiago takes 16h 40m

There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.

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How far is San Francisco to Santiago Arturo Merino Benitez by plane?
A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 16h 40m.
When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.
How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
As of February 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from San Francisco to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Francisco to Santiago is LATAM Airlines (29% of total bookings). The next most popular airlines are American Airlines (19%), United Airlines (18%), and Delta (17%).

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Avianca	PriceFrom $366	Free Cancellation	Rating 6.6 2,497 reviews	Search Avianca flights
United Airlines	PriceFrom $494	Free Cancellation	Rating 7.4 9,308 reviews	Search United Airlines flights
American Airlines	PriceFrom $498	Free Cancellation	Rating 7.2 11,294 reviews	Search American Airlines flights
Copa Airlines	PriceFrom $501	Free Cancellation	Rating 7.5 1,556 reviews	Search Copa Airlines flights
Delta	PriceFrom $569	Free Cancellation	Rating 7.9 8,208 reviews	Search Delta flights
LATAM Airlines	PriceFrom $594	Free Cancellation	Rating 7.5 1,921 reviews	Search LATAM Airlines flights
Aeromexico	PriceFrom $765	Free Cancellation	Rating 7.4 1,575 reviews	Search Aeromexico flights

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Santa Cruz

Valle Nevado

San Fernando

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.