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Cheap flights from San Francisco to Santiago from $307

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago departing on 4/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
1:12 am - 11:26 pm
SFO
-
SCL
19h 14m
1 stop
Copa Airlines Logo
11:17 am - 11:40 pm
SCL
-
SFO
15h 23m
1 stop
$578Copa Airlines
mar., may. 12 - mar., may. 19
Copa Airlines Logo
1:12 am - 5:03 am
SFO
-
SCL
24h 51m
1 stop
Copa Airlines Logo
12:38 am - 11:40 pm
SCL
-
SFO
26h 02m
1 stop
$618Copa Airlines
mié., may. 6 - dom., may. 10
Delta Logo
6:00 am - 6:55 am
SFO
-
SCL
21h 55m
2 stops
Delta Logo
10:55 pm - 11:07 pm
SCL
-
SFO
27h 12m
1 stop
$620Delta
jue., abr. 30 - lun., may. 18
Multiple Airlines Logo
2:15 pm - 4:25 am
SFO
-
SCL
34h 10m
3 stops
Multiple Airlines Logo
6:10 am - 11:55 pm
SCL
-
SFO
20h 45m
2 stops
$642Multiple Airlines
jue., abr. 2 - jue., abr. 16
LATAM Airlines Logo
6:00 am - 5:35 am
SFO
-
SCL
20h 35m
1 stop
LATAM Airlines Logo
11:25 pm - 11:59 am
SCL
-
SFO
15h 34m
1 stop
$644LATAM Airlines
sáb., abr. 11 - mié., abr. 22
Copa Airlines Logo
1:12 am - 5:03 am
SFO
-
SCL
24h 51m
1 stop
Copa Airlines Logo
4:09 am - 11:40 pm
SCL
-
SFO
22h 31m
1 stop
$646Copa Airlines
jue., may. 21 - mar., may. 26
LATAM Airlines Logo
11:05 am - 5:35 am
SFO
-
SCL
15h 30m
1 stop
LATAM Airlines Logo
11:00 pm - 5:10 pm
SCL
-
SFO
21h 10m
2 stops
$648LATAM Airlines
jue., may. 7 - lun., may. 11
Multiple Airlines Logo
2:15 pm - 5:16 am
SFO
-
SCL
35h 01m
3 stops
Multiple Airlines Logo
6:10 am - 11:55 pm
SCL
-
SFO
20h 45m
2 stops
$654Multiple Airlines
mar., mar. 31 - mar., abr. 14
LATAM Airlines Logo
8:55 am - 5:35 am
SFO
-
SCL
16h 40m
1 stop
LATAM Airlines Logo
7:15 am - 11:00 pm
SCL
-
SFO
18h 45m
1 stop
$657LATAM Airlines
mar., mar. 24 - mié., abr. 8
LATAM Airlines Logo
11:00 am - 5:35 am
SFO
-
SCL
14h 35m
1 stop
LATAM Airlines Logo
11:00 pm - 5:36 pm
SCL
-
SFO
22h 36m
2 stops
$662LATAM Airlines
mié., mar. 18 - mar., mar. 31

Copa Airlines flights from San Francisco to Santiago

Our best Copa Airlines deals on San Francisco to Santiago flight tickets
Copa Airlines
May 12
SFO1:12 amSan Francisco
19h 14m
1 stop
SCL11:26 pmSantiago Arturo Merino Benitez
May 19
SCL11:17 amSantiago Arturo Merino Benitez
15h 23m
1 stop
SFO11:40 pmSan Francisco
$578
Copa Airlines
May 6
SFO1:12 amSan Francisco
24h 51m
1 stop
SCL5:03 amSantiago Arturo Merino Benitez
May 10
SCL12:38 amSantiago Arturo Merino Benitez
26h 02m
1 stop
SFO11:40 pmSan Francisco
$618
Copa Airlines
May 21
SFO1:12 amSan Francisco
24h 51m
1 stop
SCL5:03 amSantiago Arturo Merino Benitez
May 26
SCL4:09 amSantiago Arturo Merino Benitez
22h 31m
1 stop
SFO11:40 pmSan Francisco
$646

American Airlines flights from San Francisco to Santiago

Our best American Airlines deals on San Francisco to Santiago flight tickets
American Airlines
Apr 20
SFO6:15 amSan Francisco
21h 35m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
May 4
SCL8:30 pmSantiago Arturo Merino Benitez
27h 19m
1 stop
SFO8:49 pmSan Francisco
$663
American Airlines
Apr 20
SFO5:34 amSan Francisco
22h 16m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
May 4
SCL8:30 pmSantiago Arturo Merino Benitez
27h 19m
1 stop
SFO8:49 pmSan Francisco
$667
American Airlines
Mar 18
SFO1:20 pmSan Francisco
15h 45m
1 stop
SCL9:05 amSantiago Arturo Merino Benitez
Mar 31
SCL9:25 pmSantiago Arturo Merino Benitez
30h 34m
1 stop
SFO11:59 pmSan Francisco
$699

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 27, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 5/12

1:12 am-11:26 pm

1 stop19h 14m

Santiago Arturo Merino Benitez

mar. 5/19

11:17 am-11:40 pm

1 stop15h 23m

$578

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 5/6

1:12 am-5:03 am

1 stop24h 51m

Santiago Arturo Merino Benitez

dom. 5/10

12:38 am-11:40 pm

1 stop26h 02m

$618

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

jue. 4/30

6:00 am-6:55 am

2 stops21h 55m

Santiago Arturo Merino Benitez

lun. 5/18

10:55 pm-11:07 pm

1 stop27h 12m

$620

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

jue. 4/2

2:15 pm-4:25 am

3 stops34h 10m

Santiago Arturo Merino Benitez

jue. 4/16

6:10 am-11:55 pm

2 stops20h 45m

$642

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

sáb. 4/11

6:00 am-5:35 am

1 stop20h 35m

Santiago Arturo Merino Benitez

mié. 4/22

11:25 pm-11:59 am

1 stop15h 34m

$644

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

jue. 5/21

1:12 am-5:03 am

1 stop24h 51m

Santiago Arturo Merino Benitez

mar. 5/26

4:09 am-11:40 pm

1 stop22h 31m

$646

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

jue. 5/7

11:05 am-5:35 am

1 stop15h 30m

Santiago Arturo Merino Benitez

lun. 5/11

11:00 pm-5:10 pm

2 stops21h 10m

$648

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 3/31

2:15 pm-5:16 am

3 stops35h 01m

Santiago Arturo Merino Benitez

mar. 4/14

6:10 am-11:55 pm

2 stops20h 45m

$654

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 3/24

8:55 am-5:35 am

1 stop16h 40m

Santiago Arturo Merino Benitez

mié. 4/8

7:15 am-11:00 pm

1 stop18h 45m

$657

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 3/18

11:00 am-5:35 am

1 stop14h 35m

Santiago Arturo Merino Benitez

mar. 3/31

11:00 pm-5:36 pm

2 stops22h 36m

$662

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Santiago?

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $683. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $779 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $540 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 9% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of January 2026, prices for San Francisco to Santiago flights are approximately 15% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time

18h 50m

Direct flights

None
The fastest flight from San Francisco to Santiago takes 18h 50m
There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.
Search flight deals

  • How far is San Francisco to Santiago Arturo Merino Benitez by plane?

    A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 18h 50m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago?

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $366Free CancellationRating
6.6
2,487 reviews
Search Avianca flights
United AirlinesPriceFrom $494Free CancellationRating
7.4
9,207 reviews
Search United Airlines flights
American AirlinesPriceFrom $498Free CancellationRating
7.2
11,198 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $501Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights
DeltaPriceFrom $569Free CancellationRating
7.9
8,119 reviews
Search Delta flights
LATAM AirlinesPriceFrom $589Free CancellationRating
7.5
1,912 reviews
Search LATAM Airlines flights
AeromexicoPriceFrom $765Free CancellationRating
7.4
1,587 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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