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Cheap flights from San Francisco to Santiago from $359

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
11:00 am - 5:35 am
SFO
-
SCL
15h 35m
1 stop
LATAM Airlines Logo
11:00 pm - 5:10 pm
SCL
-
SFO
21h 10m
2 stops
$595LATAM Airlines
Thu, Apr 30 - Mon, May 11
American Airlines Logo
7:00 am - 6:50 am
SFO
-
SCL
20h 50m
2 stops
American Airlines Logo
8:30 pm - 1:10 pm
SCL
-
SFO
19h 40m
2 stops
$605American Airlines
Mon, Apr 20 - Mon, May 11
LATAM Airlines Logo
8:00 am - 7:15 am
SFO
-
SCL
20h 15m
1 stop
LATAM Airlines Logo
11:00 pm - 4:57 pm
SCL
-
SFO
20h 57m
2 stops
$608LATAM Airlines
Mon, Apr 20 - Mon, May 4
LATAM Airlines Logo
6:00 am - 1:35 pm
SFO
-
SCL
28h 35m
2 stops
LATAM Airlines Logo
4:30 pm - 7:12 pm
SCL
-
SFO
29h 42m
2 stops
$615LATAM Airlines
Mon, Apr 20 - Mon, May 4
Delta Logo
8:55 am - 5:35 am
SFO
-
SCL
17h 40m
1 stop
Delta Logo
11:00 pm - 5:10 pm
SCL
-
SFO
21h 10m
2 stops
$620Delta
Thu, Apr 30 - Mon, May 11
Copa Airlines Logo
1:23 am - 2:20 am
SFO
-
SCL
21h 57m
1 stop
Copa Airlines Logo
2:22 am - 11:40 pm
SCL
-
SFO
24h 18m
1 stop
$623Copa Airlines
Sun, Apr 19 - Sun, May 3
LATAM Airlines Logo
6:00 am - 5:35 am
SFO
-
SCL
20h 35m
1 stop
LATAM Airlines Logo
11:25 pm - 3:18 pm
SCL
-
SFO
18h 53m
1 stop
$629LATAM Airlines
Sat, Apr 11 - Wed, Apr 22
Multiple Airlines Logo
8:45 pm - 5:35 am
SFO
-
SCL
29h 50m
1 stop
Multiple Airlines Logo
4:50 pm - 12:21 pm
SCL
-
SFO
22h 31m
2 stops
$639Multiple Airlines
Sat, May 9 - Tue, May 19
Copa Airlines Logo
1:23 am - 5:03 am
SFO
-
SCL
24h 40m
1 stop
Copa Airlines Logo
2:30 am - 11:40 pm
SCL
-
SFO
24h 10m
1 stop
$643Copa Airlines
Fri, Apr 17 - Fri, Apr 24
LATAM Airlines Logo
11:00 am - 5:35 am
SFO
-
SCL
15h 35m
1 stop
LATAM Airlines Logo
7:45 am - 11:16 pm
SCL
-
SFO
18h 31m
2 stops
$644LATAM Airlines
Sat, Apr 11 - Wed, Apr 22

LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets
LATAM Airlines
Apr 30
SFO11:00 amSan Francisco
15h 35m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
May 11
SCL11:00 pmSantiago Arturo Merino Benitez
21h 10m
2 stops
SFO5:10 pmSan Francisco
$595
LATAM Airlines
Apr 20
SFO8:00 amSan Francisco
20h 15m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
May 4
SCL11:00 pmSantiago Arturo Merino Benitez
20h 57m
2 stops
SFO4:57 pmSan Francisco
$608
LATAM Airlines
Apr 20
SFO6:00 amSan Francisco
28h 35m
2 stops
SCL1:35 pmSantiago Arturo Merino Benitez
May 4
SCL4:30 pmSantiago Arturo Merino Benitez
29h 42m
2 stops
SFO7:12 pmSan Francisco
$615

Delta flights from San Francisco to Santiago

Our best Delta deals on San Francisco to Santiago flight tickets
Delta
Apr 30
SFO8:55 amSan Francisco
17h 40m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
May 11
SCL11:00 pmSantiago Arturo Merino Benitez
21h 10m
2 stops
SFO5:10 pmSan Francisco
$620
Delta
Apr 30
SFO11:00 amSan Francisco
15h 35m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
May 11
SCL10:55 pmSantiago Arturo Merino Benitez
25h 19m
1 stop
SFO9:14 pmSan Francisco
$650
Delta
Mar 9
SFO7:00 amSan Francisco
20h 40m
2 stops
SCL7:40 amSantiago Arturo Merino Benitez
Mar 18
SCL10:30 pmSantiago Arturo Merino Benitez
20h 16m
1 stop
SFO2:46 pmSan Francisco
$690

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 4/30

11:00 am-5:35 am

1 stop15h 35m

Santiago Arturo Merino Benitez

Mon 5/11

11:00 pm-5:10 pm

2 stops21h 10m

$595

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

7:00 am-6:50 am

2 stops20h 50m

Santiago Arturo Merino Benitez

Mon 5/11

8:30 pm-1:10 pm

2 stops19h 40m

$605

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

8:00 am-7:15 am

1 stop20h 15m

Santiago Arturo Merino Benitez

Mon 5/4

11:00 pm-4:57 pm

2 stops20h 57m

$608

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

6:00 am-1:35 pm

2 stops28h 35m

Santiago Arturo Merino Benitez

Mon 5/4

4:30 pm-7:12 pm

2 stops29h 42m

$615

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 4/30

8:55 am-5:35 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Mon 5/11

11:00 pm-5:10 pm

2 stops21h 10m

$620

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 4/19

1:23 am-2:20 am

1 stop21h 57m

Santiago Arturo Merino Benitez

Sun 5/3

2:22 am-11:40 pm

1 stop24h 18m

$623

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 4/11

6:00 am-5:35 am

1 stop20h 35m

Santiago Arturo Merino Benitez

Wed 4/22

11:25 pm-3:18 pm

1 stop18h 53m

$629

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 5/9

8:45 pm-5:35 am

1 stop29h 50m

Santiago Arturo Merino Benitez

Tue 5/19

4:50 pm-12:21 pm

2 stops22h 31m

$639

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 4/17

1:23 am-5:03 am

1 stop24h 40m

Santiago Arturo Merino Benitez

Fri 4/24

2:30 am-11:40 pm

1 stop24h 10m

$643

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 4/11

11:00 am-5:35 am

1 stop15h 35m

Santiago Arturo Merino Benitez

Wed 4/22

7:45 am-11:16 pm

2 stops18h 31m

$644

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $680. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $776 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $540 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 9% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of January 2026, prices for San Francisco to Santiago flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time

15h 00m

Direct flights

None
The fastest flight from San Francisco to Santiago takes 15h 00m
There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.
Search flight deals

  • How far is San Francisco to Santiago Arturo Merino Benitez by plane?

    A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 15h 00m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago?

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $492Free CancellationRating
6.6
2,496 reviews
Search Avianca flights
United AirlinesPriceFrom $494Free CancellationRating
7.4
9,188 reviews
Search United Airlines flights
American AirlinesPriceFrom $498Free CancellationRating
7.2
11,169 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $502Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
DeltaPriceFrom $569Free CancellationRating
7.9
8,081 reviews
Search Delta flights
LATAM AirlinesPriceFrom $589Free CancellationRating
7.5
1,913 reviews
Search LATAM Airlines flights
AeromexicoPriceFrom $765Free CancellationRating
7.4
1,596 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Santiago trip

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