Which airport is the most popular layover for flights between San Francisco and Santiago?

Houston (IAH) was the most common stop: 38% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from San Francisco to Santiago?

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 14h 44m.

What airlines fly to Santiago?

LATAM Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Santiago from San Francisco according to our data. LATAM Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 7 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport offers the lowest fares from San Francisco to Santiago?

Flights via Houston (IAH) offer the lowest average round-trip price of $668.

Which layover airport has the shortest connection time from San Francisco to Santiago?

Atlanta (ATL) has the shortest average layover time for this route: 1h 53m.

When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

As of May 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$391 Cheap Flights from San Francisco to Santiago in 2026

Q: What is the typical price of a round-trip flight between San Francisco and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $1,066 to $651. The lowest price recently found on this route was $703.

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Find the cheapest flights from San Francisco to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:00 am - 5:35 am

SFO

SCL

19h 35m

1 stop

11:25 pm - 3:11 pm

SCL

SFO

19h 46m

1 stop

$703LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

6:00 am - 5:35 am

SFO

SCL

20h 35m

2 stops

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$724LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

7:00 am - 5:35 am

SFO

SCL

19h 35m

1 stop

11:25 pm - 11:59 am

SCL

SFO

15h 34m

1 stop

$726LATAM Airlines

Fri, Aug 14 - Sat, Aug 22

1:12 am - 10:43 pm

SFO

SCL

18h 31m

1 stop

11:22 am - 5:59 pm

SCL

SFO

33h 37m

1 stop

$729Copa Airlines

Sat, Aug 8 - Mon, Aug 24

8:21 pm - 11:22 pm

SFO

SCL

24h 01m

1 stop

12:22 pm - 11:40 pm

SCL

SFO

15h 18m

1 stop

$740Copa Airlines

Wed, Sep 2 - Wed, Sep 30

10:59 pm - 7:45 pm

SFO

SCL

17h 46m

2 stops

11:25 pm - 11:59 am

SCL

SFO

15h 34m

1 stop

$741LATAM Airlines

Sun, Aug 9 - Sun, Aug 30

7:00 am - 4:50 am

SFO

SCL

17h 50m

2 stops

8:40 pm - 11:45 am

SCL

SFO

19h 05m

1 stop

$752LATAM Airlines

Tue, Sep 8 - Tue, Sep 22

10:59 pm - 7:45 pm

SFO

SCL

17h 46m

2 stops

12:40 am - 7:24 pm

SCL

SFO

21h 44m

2 stops

$756LATAM Airlines

Tue, Aug 4 - Tue, Aug 11

10:30 pm - 7:45 pm

SFO

SCL

18h 15m

2 stops

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$757LATAM Airlines

Wed, Sep 2 - Wed, Sep 30

6:00 am - 7:15 am

SFO

SCL

22h 15m

1 stop

11:25 pm - 3:11 pm

SCL

SFO

19h 46m

1 stop

$760LATAM Airlines

Wed, Sep 2 - Wed, Sep 30

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Copa Airlines flights from San Francisco to Santiago

Our best Copa Airlines deals on San Francisco to Santiago flight tickets

Copa Airlines

Aug 8

SFO1:12 amSan Francisco

18h 31m

1 stop

SCL10:43 pmSantiago Arturo Merino Benitez

Aug 24

SCL11:22 amSantiago Arturo Merino Benitez

33h 37m

1 stop

SFO5:59 pmSan Francisco

$729

Copa Airlines

Sep 2

SFO8:21 pmSan Francisco

24h 01m

1 stop

SCL11:22 pmSantiago Arturo Merino Benitez

Sep 30

SCL12:22 pmSantiago Arturo Merino Benitez

15h 18m

1 stop

SFO11:40 pmSan Francisco

$740

Copa Airlines

Jul 29

SFO1:12 amSan Francisco

22h 48m

1 stop

SCL3:00 amSantiago Arturo Merino Benitez

Aug 25

SCL2:27 amSantiago Arturo Merino Benitez

24h 13m

1 stop

SFO11:40 pmSan Francisco

$763

Delta flights from San Francisco to Santiago

Our best Delta deals on San Francisco to Santiago flight tickets

Delta

Oct 3

SFO7:30 amSan Francisco

20h 45m

1 stop

SCL8:15 amSantiago Arturo Merino Benitez

Oct 16

SCL8:40 pmSantiago Arturo Merino Benitez

24h 31m

1 stop

SFO5:11 pmSan Francisco

$785

Delta

Sep 1

SFO7:00 amSan Francisco

19h 35m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Sep 30

SCL11:00 pmSantiago Arturo Merino Benitez

21h 55m

2 stops

SFO4:55 pmSan Francisco

$790

Delta

Jun 24

SFO11:38 amSan Francisco

16h 37m

1 stop

SCL7:15 amSantiago Arturo Merino Benitez

Aug 3

SCL11:25 pmSantiago Arturo Merino Benitez

17h 01m

1 stop

SFO1:26 pmSan Francisco

$846

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

7:00 am-5:35 am

1 stop19h 35m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-3:11 pm

1 stop19h 46m

$703

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

6:00 am-5:35 am

2 stops20h 35m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$724

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 8/14

7:00 am-5:35 am

1 stop19h 35m

Santiago Arturo Merino Benitez

Sat 8/22

11:25 pm-11:59 am

1 stop15h 34m

$726

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 8/8

1:12 am-10:43 pm

1 stop18h 31m

Santiago Arturo Merino Benitez

Mon 8/24

11:22 am-5:59 pm

1 stop33h 37m

$729

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 9/2

8:21 pm-11:22 pm

1 stop24h 01m

Santiago Arturo Merino Benitez

Wed 9/30

12:22 pm-11:40 pm

1 stop15h 18m

$740

Quickest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 8/9

10:59 pm-7:45 pm

2 stops17h 46m

Santiago Arturo Merino Benitez

Sun 8/30

11:25 pm-11:59 am

1 stop15h 34m

$741

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/8

7:00 am-4:50 am

2 stops17h 50m

Santiago Arturo Merino Benitez

Tue 9/22

8:40 pm-11:45 am

1 stop19h 05m

$752

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 8/4

10:59 pm-7:45 pm

2 stops17h 46m

Santiago Arturo Merino Benitez

Tue 8/11

12:40 am-7:24 pm

2 stops21h 44m

$756

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 9/2

10:30 pm-7:45 pm

2 stops18h 15m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$757

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 9/2

6:00 am-7:15 am

1 stop22h 15m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-3:11 pm

1 stop19h 46m

$760

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between San Francisco and Santiago?

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $666. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight from San Francisco to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $799 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $580 on momondo.

How have San Francisco to Santiago flight prices changed over time?

As of May 2026, prices for San Francisco to Santiago flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time	16h 55m
Direct flights	None

The fastest flight from San Francisco to Santiago takes 16h 55m

There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.

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Frequently asked questions about flying from San Francisco to Santiago

How far is San Francisco to Santiago Arturo Merino Benitez by plane?
A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5934.4 mi. In terms of flight time, this usually takes a little over 16h 55m.
When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.
How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
As of May 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from San Francisco to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Francisco to Santiago is LATAM Airlines (30% of total bookings). The next most popular airlines are American Airlines (19%), United Airlines (19%), and Delta (15%).

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Avianca	PriceFrom $290	Free Cancellation	Rating 6.5 2,520 reviews	Search Avianca flights
United Airlines	PriceFrom $494	Free Cancellation	Rating 7.4 9,682 reviews	Search United Airlines flights
American Airlines	PriceFrom $494	Free Cancellation	Rating 7.1 11,672 reviews	Search American Airlines flights
Copa Airlines	PriceFrom $501	Free Cancellation	Rating 7.5 1,578 reviews	Search Copa Airlines flights
LATAM Airlines	PriceFrom $593	Free Cancellation	Rating 7.4 1,913 reviews	Search LATAM Airlines flights
Delta	PriceFrom $594	Free Cancellation	Rating 7.9 8,460 reviews	Search Delta flights
Aeromexico	PriceFrom $758	Free Cancellation	Rating 7.4 1,520 reviews	Search Aeromexico flights

Viña del Mar

Valparaíso

Santa Cruz

Valle Nevado

Pichilemu

San Fernando

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.