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Cheap flights from San Francisco to Santiago from $233

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Santiago

Cheap round-trip flights

Avianca Logo
2:20 pm - 2:25 pmSFO-SCL
20h 05m2 stops
Avianca Logo
3:30 pm - 12:35 pmSCL-SFO
25h 05m2 stops
$477Avianca
Find Deal
Sun, Sep 7 - Mon, Sep 29
Avianca Logo
12:05 am - 11:30 pmSFO-SCL
19h 25m2 stops
Avianca Logo
4:25 pm - 12:00 pmSCL-SFO
24h 35m2 stops
$487Avianca
Find Deal
Sun, Sep 7 - Wed, Nov 19
Copa Airlines Logo
12:42 am - 12:32 amSFO-SCL
18h 50m1 stop
Copa Airlines Logo
1:38 am - 11:40 pmSCL-SFO
26h 02m1 stop
$502Copa Airlines
Find Deal
Mon, Jan 12 - Wed, Mar 11
LATAM Airlines Logo
11:30 am - 7:00 amSFO-SCL
14h 30m1 stop
LATAM Airlines Logo
8:10 am - 11:51 pmSCL-SFO
20h 41m2 stops
$507LATAM Airlines
Find Deal
Tue, Jan 20 - Thu, Feb 19
LATAM Airlines Logo
4:15 pm - 6:10 amSFO-SCL
32h 55m2 stops
LATAM Airlines Logo
8:10 am - 11:51 pmSCL-SFO
20h 41m2 stops
$511LATAM Airlines
Find Deal
Tue, Jan 20 - Thu, Feb 19
United Airlines Logo
1:00 pm - 8:50 amSFO-SCL
14h 50m1 stop
United Airlines Logo
9:45 pm - 2:50 pmSCL-SFO
21h 05m1 stop
$514United Airlines
Find Deal
Tue, Jan 13 - Thu, Mar 12
Copa Airlines Logo
12:42 am - 4:14 amSFO-SCL
22h 32m1 stop
Copa Airlines Logo
12:28 pm - 11:16 pmSCL-SFO
15h 48m1 stop
$520Copa Airlines
Find Deal
Sat, Jan 3 - Tue, Mar 3
United Airlines Logo
5:15 am - 8:50 amSFO-SCL
22h 35m1 stop
United Airlines Logo
10:45 pm - 5:05 pmSCL-SFO
23h 20m1 stop
$554United Airlines
Find Deal
Sun, Jan 4 - Tue, Mar 3
Delta Logo
6:00 am - 7:00 amSFO-SCL
20h 00m1 stop
Delta Logo
10:35 am - 11:57 pmSCL-SFO
18h 22m2 stops
$558Delta
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Mon, Jan 5 - Fri, Jan 16
Delta Logo
6:00 am - 7:00 amSFO-SCL
20h 00m1 stop
Delta Logo
10:35 am - 11:57 pmSCL-SFO
18h 22m2 stops
$598Delta
Find Deal
Sun, Jan 4 - Fri, Jan 16

Avianca flights from San Francisco to Santiago

Our best Avianca deals on San Francisco to Santiago flight tickets
Avianca
Aug 26
SFO12:05 amSan Francisco
25h 10m
2 stops
SCL4:15 amSantiago Arturo Merino Benitez
Sep 2
SCL2:30 pmSantiago Arturo Merino Benitez
25h 05m
2 stops
SFO12:35 pmSan Francisco
$477
Find similar
Avianca
Sep 7
SFO12:05 amSan Francisco
19h 25m
2 stops
SCL11:30 pmSantiago Arturo Merino Benitez
Nov 19
SCL4:25 pmSantiago Arturo Merino Benitez
24h 35m
2 stops
SFO12:00 pmSan Francisco
$487
Find similar
Avianca
Aug 31
SFO12:05 amSan Francisco
25h 10m
2 stops
SCL4:15 amSantiago Arturo Merino Benitez
Oct 31
SCL4:25 pmSantiago Arturo Merino Benitez
34h 25m
2 stops
SFO10:50 pmSan Francisco
$492
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Delta flights from San Francisco to Santiago

Our best Delta deals on San Francisco to Santiago flight tickets
Delta
Jan 5
SFO6:00 amSan Francisco
20h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Jan 16
SCL10:35 amSantiago Arturo Merino Benitez
18h 22m
2 stops
SFO11:57 pmSan Francisco
$558
Find similar
Delta
Jan 4
SFO6:00 amSan Francisco
20h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Jan 16
SCL10:35 amSantiago Arturo Merino Benitez
18h 22m
2 stops
SFO11:57 pmSan Francisco
$598
Find similar
Delta
Nov 19
SFO6:00 amSan Francisco
19h 35m
2 stops
SCL6:35 amSantiago Arturo Merino Benitez
Nov 27
SCL11:55 pmSantiago Arturo Merino Benitez
17h 05m
1 stop
SFO12:00 pmSan Francisco
$614
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momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 9/7

2:20 pm-2:25 pm

2 stops20h 05m

Santiago Arturo Merino Benitez

Mon 9/29

3:30 pm-12:35 pm

2 stops25h 05m

$477

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 9/7

12:05 am-11:30 pm

2 stops19h 25m

Santiago Arturo Merino Benitez

Wed 11/19

4:25 pm-12:00 pm

2 stops24h 35m

$487

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 1/12

12:42 am-12:32 am

1 stop18h 50m

Santiago Arturo Merino Benitez

Wed 3/11

1:38 am-11:40 pm

1 stop26h 02m

$502

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 1/20

11:30 am-7:00 am

1 stop14h 30m

Santiago Arturo Merino Benitez

Thu 2/19

8:10 am-11:51 pm

2 stops20h 41m

$507

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 1/20

4:15 pm-6:10 am

2 stops32h 55m

Santiago Arturo Merino Benitez

Thu 2/19

8:10 am-11:51 pm

2 stops20h 41m

$511

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 1/13

1:00 pm-8:50 am

1 stop14h 50m

Santiago Arturo Merino Benitez

Thu 3/12

9:45 pm-2:50 pm

1 stop21h 05m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 1/3

12:42 am-4:14 am

1 stop22h 32m

Santiago Arturo Merino Benitez

Tue 3/3

12:28 pm-11:16 pm

1 stop15h 48m

$520

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 1/4

5:15 am-8:50 am

1 stop22h 35m

Santiago Arturo Merino Benitez

Tue 3/3

10:45 pm-5:05 pm

1 stop23h 20m

$554

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 1/5

6:00 am-7:00 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Fri 1/16

10:35 am-11:57 pm

2 stops18h 22m

$558

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 1/4

6:00 am-7:00 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Fri 1/16

10:35 am-11:57 pm

2 stops18h 22m

$598

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, August is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $707. If you don’t want to visit Santiago in August, then you should wait until May to fly from San Francisco, when ticket prices are also cheap, with an average price of $710.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $812. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,066.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from San Francisco to Santiago when you can find flight prices for as low as $831. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,007 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking week ahead of your departure date. In general, you can expect to find flights to Santiago for around $832 when searching week out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $750 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 15% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of August 2025, prices for San Francisco to Santiago flights are approximately 12% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Direct flights

None
There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.
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  • How far is San Francisco to Santiago Arturo Merino Benitez by plane?

    A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 14h 20m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago?

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $534Free CancellationRating
7.5
1,512 reviews
Search Copa Airlines flights
AviancaPriceFrom $591Free CancellationRating
6.7
2,411 reviews
Search Avianca flights
United AirlinesPriceFrom $622Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
DeltaPriceFrom $642Free CancellationRating
7.9
7,981 reviews
Search Delta flights
LATAM AirlinesPriceFrom $657Free CancellationRating
7.5
1,844 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $657Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
AeromexicoPriceFrom $758Free CancellationRating
7.4
1,716 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Santiago trip

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