Which layover airport offers the lowest fares from San Francisco to Santiago?

Flights via Houston (IAH) offer the lowest average round-trip price of $696.

Which layover airport has the shortest connection time from San Francisco to Santiago?

Miami (MIA) has the shortest average layover time for this route: 1h 51m.

What airlines fly to Santiago?

LATAM Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Santiago from San Francisco according to our data. LATAM Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 8 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest travel time from San Francisco to Santiago?

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 14h 38m.

Which airport is the most popular layover for flights between San Francisco and Santiago?

Los Angeles (LAX) was the most common stop: 40% of momondo users choosing 1-stop flights on this route connected there.

What is the cheapest airline that flies from San Francisco to Santiago Arturo Merino Benitez?

LATAM Airlines is the most popular carrier operating from San Francisco to Santiago Arturo Merino Benitez

When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

As of September 2026, there are 8 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$386 Cheap Flights from San Francisco to Santiago in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:15 pm - 3:00 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

17h 45m2 stops Los Angeles Lima J Chavez Intl

9:55 pm - 11:04 amSCL Santiago Arturo Merino Benitez-SFO San Francisco

17h 09m2 stops Lima J Chavez Intl Los Angeles

$786LATAM Airlines

Mon, Mar 1 - Mon, Mar 15

7:00 am - 5:20 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

17h 20m2 stops Los Angeles Lima J Chavez Intl

9:55 pm - 11:04 amSCL Santiago Arturo Merino Benitez-SFO San Francisco

18h 09m2 stops Lima J Chavez Intl Los Angeles

$786LATAM Airlines

Thu, Feb 4 - Sun, Feb 21

5:00 am - 8:50 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

22h 50m1 stop Houston George Bush Intcntl

10:45 pm - 7:20 amSCL Santiago Arturo Merino Benitez-SFO San Francisco

37h 35m1 stop Houston George Bush Intcntl

$840United Airlines

Sun, Jan 3 - Fri, Feb 12

5:00 am - 8:50 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

22h 50m1 stop Houston George Bush Intcntl

10:45 pm - 7:20 amSCL Santiago Arturo Merino Benitez-SFO San Francisco

37h 35m1 stop Houston George Bush Intcntl

$841United Airlines

Sun, Jan 3 - Fri, Feb 12

7:36 pm - 2:53 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

26h 17m1 stop Panama City Tocumen Intl

3:29 am - 11:17 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

24h 48m1 stop Panama City Tocumen Intl

$843Copa Airlines

Sun, Jan 10 - Tue, Feb 9

7:36 pm - 11:40 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

23h 04m1 stop Panama City Tocumen Intl

5:13 am - 5:25 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

17h 12m1 stop Panama City Tocumen Intl

$843Copa Airlines

Wed, Jan 6 - Sat, Jan 16

7:30 am - 7:40 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

19h 10m1 stop Atlanta Hartsfield-Jackson

11:55 pm - 10:25 amSCL Santiago Arturo Merino Benitez-SFO San Francisco

15h 30m1 stop Los Angeles

$845Multiple Airlines

Tue, Jan 12 - Wed, Jan 20

7:30 am - 7:40 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

19h 10m1 stop Atlanta Hartsfield-Jackson

7:40 am - 9:49 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

19h 09m2 stops Lima J Chavez Intl Los Angeles

$850Multiple Airlines

Tue, Jan 12 - Tue, Jan 26

11:12 am - 7:45 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

15h 33m1 stop Dallas/Fort Worth

11:45 pm - 8:34 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

25h 49m1 stop Dallas/Fort Worth

$855American Airlines

Sun, Jan 17 - Sun, Jan 31

6:45 am - 7:45 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

20h 00m1 stop Dallas/Fort Worth

11:45 pm - 9:10 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

25h 25m1 stop Dallas/Fort Worth

$855American Airlines

Fri, Mar 5 - Sun, Mar 14

Cheap last minute flights

Enter your travel dates to find the best prices.

2:15 pm - 3:15 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

21h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado

7:40 am - 10:35 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

18h 55m2 stops Bogotá El Dorado San Salvador El Salvador Intl

$962Avianca

Sat, Sep 26 - Sat, Oct 10

2:15 pm - 3:15 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

21h 00m2 stops San Salvador El Salvador Intl Bogotá El Dorado

7:30 am - 9:40 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

19h 10m2 stops Bogotá El Dorado San Salvador El Salvador Intl

$962Avianca

Sat, Sep 26 - Wed, Nov 4

8:21 pm - 8:32 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

20h 11m1 stop Panama City Tocumen Intl

5:22 am - 11:40 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

22h 18m1 stop Panama City Tocumen Intl

$1,028Copa Airlines

Thu, Sep 24 - Sun, Oct 4

10:46 pm - 8:00 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

29h 14m2 stops Chicago O'Hare Intl Miami

10:30 pm - 10:53 amSCL Santiago Arturo Merino Benitez-SFO San Francisco

17h 23m1 stop Miami

$1,030GOL

Sat, Sep 26 - Wed, Nov 4

2:50 pm - 10:10 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

27h 20m2 stops Mexico City Benito Juarez Cancun

8:55 pm - 2:22 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

21h 27m2 stops Lima J Chavez Intl Los Angeles

$1,038Multiple Airlines

Sat, Sep 26 - Sat, Oct 3

6:00 am - 8:15 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

22h 15m1 stop Atlanta Hartsfield-Jackson

8:40 pm - 3:49 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

23h 09m1 stop Atlanta Hartsfield-Jackson

$1,075Delta

Mon, Sep 21 - Fri, Sep 25

6:00 am - 8:15 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

22h 15m1 stop Atlanta Hartsfield-Jackson

8:40 pm - 3:49 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

23h 09m1 stop Atlanta Hartsfield-Jackson

$1,076LATAM Airlines

Mon, Sep 21 - Fri, Sep 25

7:00 am - 8:15 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

21h 15m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson

8:55 pm - 3:49 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

22h 54m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,080Delta

Mon, Sep 21 - Fri, Sep 25

2:00 pm - 10:15 pmSFO San Francisco-SCL Santiago Arturo Merino Benitez

28h 15m3 stops Atlanta Hartsfield-Jackson Miami Punta Cana

8:20 am - 11:40 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

19h 20m2 stops Lima J Chavez Intl Los Angeles

$1,085LATAM Airlines

Thu, Sep 24 - Sun, Oct 4

1:12 am - 6:10 amSFO San Francisco-SCL Santiago Arturo Merino Benitez

24h 58m1 stop Panama City Tocumen Intl

1:06 am - 11:40 pmSCL Santiago Arturo Merino Benitez-SFO San Francisco

26h 34m1 stop Panama City Tocumen Intl

$1,109Copa Airlines

Sun, Sep 20 - Thu, Sep 24

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LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets

LATAM Airlines

Feb 4

SFO7:00 amSan Francisco

17h 20m

2 stops

SCL5:20 amSantiago Arturo Merino Benitez

Feb 21

SCL9:55 pmSantiago Arturo Merino Benitez

18h 09m

2 stops

SFO11:04 amSan Francisco

$786

LATAM Airlines

Mar 12

SFO7:00 amSan Francisco

17h 20m

2 stops

SCL5:20 amSantiago Arturo Merino Benitez

Apr 12

SCL6:40 amSantiago Arturo Merino Benitez

19h 31m

2 stops

SFO11:11 pmSan Francisco

$788

LATAM Airlines

Mar 2

SFO7:00 amSan Francisco

17h 20m

2 stops

SCL5:20 amSantiago Arturo Merino Benitez

Mar 14

SCL11:55 pmSantiago Arturo Merino Benitez

17h 34m

1 stop

SFO1:29 pmSan Francisco

$804

Avianca flights from San Francisco to Santiago

Our best Avianca deals on San Francisco to Santiago flight tickets

Avianca

Sep 26

SFO2:15 pmSan Francisco

21h 00m

2 stops

SCL3:15 pmSantiago Arturo Merino Benitez

Oct 10

SCL7:40 amSantiago Arturo Merino Benitez

18h 55m

2 stops

SFO10:35 pmSan Francisco

$962

Avianca

Sep 21

SFO2:15 pmSan Francisco

21h 00m

2 stops

SCL3:15 pmSantiago Arturo Merino Benitez

Sep 25

SCL7:40 amSantiago Arturo Merino Benitez

18h 55m

2 stops

SFO10:35 pmSan Francisco

$1,011

Avianca

Sep 26

SFO2:15 pmSan Francisco

35h 30m

2 stops

SCL5:45 amSantiago Arturo Merino Benitez

Oct 10

SCL4:20 pmSantiago Arturo Merino Benitez

24h 30m

2 stops

SFO12:50 pmSan Francisco

$1,017

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Mon 3/1

4:15 pm-3:00 pm

2 stops17h 45m

Santiago Arturo Merino Benitez

Mon 3/15

9:55 pm-11:04 am

2 stops17h 09m

$786

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Thu 2/4

7:00 am-5:20 am

2 stops17h 20m

Santiago Arturo Merino Benitez

Sun 2/21

9:55 pm-11:04 am

2 stops18h 09m

$786

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Sun 1/3

5:00 am-8:50 am

1 stop22h 50m

Santiago Arturo Merino Benitez

Fri 2/12

10:45 pm-7:20 am

1 stop37h 35m

$840

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Sun 1/3

5:00 am-8:50 am

1 stop22h 50m

Santiago Arturo Merino Benitez

Fri 2/12

10:45 pm-7:20 am

1 stop37h 35m

$841

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Sun 1/10

7:36 pm-2:53 am

1 stop26h 17m

Santiago Arturo Merino Benitez

Tue 2/9

3:29 am-11:17 pm

1 stop24h 48m

$843

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Wed 1/6

7:36 pm-11:40 pm

1 stop23h 04m

Santiago Arturo Merino Benitez

Sat 1/16

5:13 am-5:25 pm

1 stop17h 12m

$843

Quickest round-trip

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Tue 1/12

7:30 am-7:40 am

1 stop19h 10m

Santiago Arturo Merino Benitez

Wed 1/20

11:55 pm-10:25 am

1 stop15h 30m

$845

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Tue 1/12

7:30 am-7:40 am

1 stop19h 10m

Santiago Arturo Merino Benitez

Tue 1/26

7:40 am-9:49 pm

2 stops19h 09m

$850

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Sun 1/17

11:12 am-7:45 am

1 stop15h 33m

Santiago Arturo Merino Benitez

Sun 1/31

11:45 pm-8:34 pm

1 stop25h 49m

$855

San FranciscoSantiago

SFO San Francisco - SCL Santiago Arturo Merino Benitez

SFOSCL

San Francisco

Fri 3/5

6:45 am-7:45 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Sun 3/14

11:45 pm-9:10 pm

1 stop25h 25m

$855

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between San Francisco and Santiago?

Prices are currently typical for flights on this route.

Typical prices usually range from $652 to $930.
The lowest price recently found on this route was $786.

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $667. If you don’t want to visit Santiago in January, then you should wait until July to fly from San Francisco, when ticket prices are also cheap, with an average price of $772.

How far in advance should I book a flight from San Francisco to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $870 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $697 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of September 2026, prices for San Francisco to Santiago flights are approximately 40% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Best Price Found	$386
Fastest flight time	14h 36m
Direct flights	None

The best one-way flight to Santiago from San Francisco in the past 72 hours is $386. The best round-trip flight deal from San Francisco to Santiago found on momondo in the last 72 hours is $786.

The fastest flight from San Francisco to Santiago takes 14h 36m

There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.

Search flight deals

Frequently asked questions about flying from San Francisco to Santiago

How far is San Francisco to Santiago Arturo Merino Benitez by plane?
A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5934.4 mi. In terms of flight time, this usually takes a little over 14h 36m.
When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.
How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
As of September 2026, there are 8 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from San Francisco to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Francisco to Santiago is LATAM Airlines (31% of total bookings). The next most popular airlines are United Airlines (18%), American Airlines (17%), and Delta (15%).

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Avianca	PriceFrom $290	Free Cancellation	Rating 6.5 2,547 reviews	Search Avianca flights
Copa Airlines	PriceFrom $470	Free Cancellation	Rating 7.6 1,539 reviews	Search Copa Airlines flights
Air Canada	PriceFrom $482	Free Cancellation	Rating 7.1 11,655 reviews	Search Air Canada flights
American Airlines	PriceFrom $494	Free Cancellation	Rating 7.0 12,075 reviews	Search American Airlines flights
United Airlines	PriceFrom $494	Free Cancellation	Rating 7.4 10,226 reviews	Search United Airlines flights
Delta	PriceFrom $593	Free Cancellation	Rating 7.8 8,591 reviews	Search Delta flights
LATAM Airlines	PriceFrom $594	Free Cancellation	Rating 7.4 1,981 reviews	Search LATAM Airlines flights
Aeromexico	PriceFrom $919	Free Cancellation	Rating 7.5 1,462 reviews	Search Aeromexico flights

Viña del Mar

Valparaíso

Santa Cruz

San Fernando

Valle Nevado

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.