Which layover airport has the shortest travel time from San Francisco to Santiago?

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 14h 44m.

What airlines fly to Santiago?

LATAM Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Santiago from San Francisco according to our data. LATAM Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 7 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between San Francisco and Santiago?

Houston (IAH) was the most common stop: 40% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from San Francisco to Santiago?

Flights via Houston (IAH) offer the lowest average round-trip price of $668.

What is the cheapest airline that flies from San Francisco to Santiago Arturo Merino Benitez?

Avianca and LATAM Airlines are the most popular carriers operating from San Francisco to Santiago Arturo Merino Benitez

Which layover airport has the shortest connection time from San Francisco to Santiago?

Miami (MIA) has the shortest average layover time for this route: 1h 55m.

When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

As of April 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$336 Cheap Flights from San Francisco to Santiago in 2026

Q: What is the typical price of a round-trip flight between San Francisco and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $989 to $685. The lowest price recently found on this route was $657.

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Find the cheapest flights from San Francisco to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:55 pm - 3:56 am

SFO

SCL

25h 01m

3 stops

3:20 pm - 10:35 pm

SCL

SFO

34h 15m

2 stops

$657Multiple Airlines

Mon, May 18 - Sun, May 31

2:15 pm - 4:16 am

SFO

SCL

35h 01m

3 stops

3:20 pm - 12:50 pm

SCL

SFO

24h 30m

2 stops

$672Multiple Airlines

Tue, May 12 - Thu, May 28

2:30 am - 4:16 am

SFO

SCL

22h 46m

3 stops

6:40 am - 10:35 pm

SCL

SFO

18h 55m

2 stops

$684Multiple Airlines

Tue, May 5 - Wed, May 13

11:05 am - 5:35 am

SFO

SCL

15h 30m

1 stop

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$691LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

2:15 pm - 4:16 am

SFO

SCL

35h 01m

3 stops

3:20 pm - 12:50 pm

SCL

SFO

24h 30m

2 stops

$697Multiple Airlines

Tue, May 12 - Tue, May 19

2:15 pm - 4:16 am

SFO

SCL

35h 01m

3 stops

3:20 pm - 12:50 pm

SCL

SFO

24h 30m

2 stops

$698Multiple Airlines

Tue, May 12 - Tue, May 19

2:15 pm - 1:30 pm

SFO

SCL

20h 15m

2 stops

3:20 pm - 12:50 pm

SCL

SFO

24h 30m

2 stops

$706Multiple Airlines

Tue, May 12 - Tue, May 19

8:55 am - 5:35 am

SFO

SCL

17h 40m

1 stop

11:25 pm - 3:11 pm

SCL

SFO

18h 46m

1 stop

$707LATAM Airlines

Sun, Aug 16 - Wed, Aug 26

11:55 pm - 3:56 am

SFO

SCL

25h 01m

3 stops

3:20 pm - 12:50 pm

SCL

SFO

24h 30m

2 stops

$708Multiple Airlines

Mon, May 4 - Tue, May 12

6:00 am - 5:35 am

SFO

SCL

20h 35m

2 stops

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$712LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets

LATAM Airlines

Sep 1

SFO11:05 amSan Francisco

15h 30m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Sep 30

SCL11:25 pmSantiago Arturo Merino Benitez

16h 34m

1 stop

SFO11:59 amSan Francisco

$691

LATAM Airlines

Aug 16

SFO8:55 amSan Francisco

17h 40m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Aug 26

SCL11:25 pmSantiago Arturo Merino Benitez

18h 46m

1 stop

SFO3:11 pmSan Francisco

$707

LATAM Airlines

Sep 1

SFO6:00 amSan Francisco

20h 35m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Sep 30

SCL11:25 pmSantiago Arturo Merino Benitez

16h 34m

1 stop

SFO11:59 amSan Francisco

$712

Avianca flights from San Francisco to Santiago

Our best Avianca deals on San Francisco to Santiago flight tickets

Avianca

May 13

SFO2:15 pmSan Francisco

35h 30m

3 stops

SCL4:45 amSantiago Arturo Merino Benitez

May 27

SCL6:40 amSantiago Arturo Merino Benitez

18h 55m

2 stops

SFO10:35 pmSan Francisco

$740

Avianca

May 18

SFO11:55 pmSan Francisco

20h 25m

2 stops

SCL11:20 pmSantiago Arturo Merino Benitez

May 31

SCL3:20 pmSantiago Arturo Merino Benitez

24h 30m

2 stops

SFO12:50 pmSan Francisco

$748

Avianca

Apr 20

SFO11:55 pmSan Francisco

25h 50m

2 stops

SCL4:45 amSantiago Arturo Merino Benitez

May 4

SCL3:20 pmSantiago Arturo Merino Benitez

24h 30m

2 stops

SFO12:50 pmSan Francisco

$791

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 5/18

11:55 pm-3:56 am

3 stops25h 01m

Santiago Arturo Merino Benitez

Sun 5/31

3:20 pm-10:35 pm

2 stops34h 15m

$657

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/12

2:15 pm-4:16 am

3 stops35h 01m

Santiago Arturo Merino Benitez

Thu 5/28

3:20 pm-12:50 pm

2 stops24h 30m

$672

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/5

2:30 am-4:16 am

3 stops22h 46m

Santiago Arturo Merino Benitez

Wed 5/13

6:40 am-10:35 pm

2 stops18h 55m

$684

Quickest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

11:05 am-5:35 am

1 stop15h 30m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$691

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/12

2:15 pm-4:16 am

3 stops35h 01m

Santiago Arturo Merino Benitez

Tue 5/19

3:20 pm-12:50 pm

2 stops24h 30m

$697

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/12

2:15 pm-4:16 am

3 stops35h 01m

Santiago Arturo Merino Benitez

Tue 5/19

3:20 pm-12:50 pm

2 stops24h 30m

$698

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/12

2:15 pm-1:30 pm

2 stops20h 15m

Santiago Arturo Merino Benitez

Tue 5/19

3:20 pm-12:50 pm

2 stops24h 30m

$706

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 8/16

8:55 am-5:35 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Wed 8/26

11:25 pm-3:11 pm

1 stop18h 46m

$707

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 5/4

11:55 pm-3:56 am

3 stops25h 01m

Santiago Arturo Merino Benitez

Tue 5/12

3:20 pm-12:50 pm

2 stops24h 30m

$708

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

6:00 am-5:35 am

2 stops20h 35m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$712

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between San Francisco and Santiago?

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $666. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $781 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $557 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 36% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of April 2026, prices for San Francisco to Santiago flights are approximately 29% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time	16h 40m
Direct flights	None

The fastest flight from San Francisco to Santiago takes 16h 40m

There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.

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Frequently asked questions about flying from San Francisco to Santiago

How far is San Francisco to Santiago Arturo Merino Benitez by plane?
A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5934.4 mi. In terms of flight time, this usually takes a little over 16h 40m.
When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.
How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
As of April 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from San Francisco to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Francisco to Santiago is LATAM Airlines (30% of total bookings). The next most popular airlines are American Airlines (20%), United Airlines (18%), and Delta (16%).

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Avianca	PriceFrom $366	Free Cancellation	Rating 6.5 2,505 reviews	Search Avianca flights
United Airlines	PriceFrom $494	Free Cancellation	Rating 7.4 9,535 reviews	Search United Airlines flights
American Airlines	PriceFrom $494	Free Cancellation	Rating 7.1 11,549 reviews	Search American Airlines flights
Copa Airlines	PriceFrom $501	Free Cancellation	Rating 7.5 1,578 reviews	Search Copa Airlines flights
Delta	PriceFrom $593	Free Cancellation	Rating 7.9 8,368 reviews	Search Delta flights
LATAM Airlines	PriceFrom $593	Free Cancellation	Rating 7.4 1,907 reviews	Search LATAM Airlines flights
Aeromexico	PriceFrom $758	Free Cancellation	Rating 7.4 1,554 reviews	Search Aeromexico flights

Viña del Mar

Valparaíso

Santa Cruz

Valle Nevado

San Fernando

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.