Which layover airport offers the lowest fares from San Francisco to Santiago?

Flights via Houston (IAH) offer the lowest average round-trip price of $650.

What is the cheapest airline that flies from San Francisco to Santiago Arturo Merino Benitez?

Air Canada and Delta are the most popular carriers operating from San Francisco to Santiago Arturo Merino Benitez

What airlines fly to Santiago?

LATAM Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Santiago from San Francisco according to our data. LATAM Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 7 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from San Francisco to Santiago?

Miami (MIA) has the shortest average layover time for this route: 1h 55m.

Which airport is the most popular layover for flights between San Francisco and Santiago?

Houston (IAH) was the most common stop: 35% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from San Francisco to Santiago?

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 14h 43m.

When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

As of July 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$325 Cheap Flights from San Francisco to Santiago in 2026

Q: What is the typical price of a round-trip flight between San Francisco and Santiago?

Prices are currently low for flights on this route. Typical prices usually range from $726 to $946. The lowest price recently found on this route was $691.

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Santiago

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:00 am - 5:20 am

SFO

SCL

17h 20m

2 stops

7:30 am - 11:11 pm

SCL

SFO

20h 41m

2 stops

$691LATAM Airlines

Fri, Nov 13 - Tue, Dec 1

1:31 am - 11:39 pm

SFO

SCL

18h 08m

1 stop

1:22 am - 5:25 pm

SCL

SFO

21h 03m

1 stop

$706Copa Airlines

Sun, Oct 25 - Tue, Nov 3

7:00 am - 5:20 am

SFO

SCL

17h 20m

2 stops

8:30 pm - 11:54 am

SCL

SFO

20h 24m

2 stops

$707LATAM Airlines

Fri, Nov 13 - Tue, Dec 1

4:15 pm - 3:00 pm

SFO

SCL

17h 45m

2 stops

9:50 pm - 11:54 am

SCL

SFO

19h 04m

2 stops

$723LATAM Airlines

Wed, Dec 2 - Sun, Dec 13

7:05 am - 5:20 am

SFO

SCL

18h 15m

2 stops

8:30 pm - 11:05 am

SCL

SFO

19h 35m

2 stops

$724LATAM Airlines

Mon, Oct 26 - Wed, Nov 4

6:00 am - 5:35 am

SFO

SCL

18h 35m

2 stops

8:30 pm - 11:54 am

SCL

SFO

20h 24m

2 stops

$728LATAM Airlines

Wed, Nov 18 - Fri, Dec 4

7:36 pm - 2:48 am

SFO

SCL

26h 12m

1 stop

1:02 am - 11:12 pm

SCL

SFO

27h 10m

1 stop

$729Copa Airlines

Sun, Nov 1 - Fri, Nov 6

7:00 am - 5:20 am

SFO

SCL

17h 20m

2 stops

9:50 pm - 11:54 am

SCL

SFO

19h 04m

2 stops

$734LATAM Airlines

Sat, Nov 14 - Wed, Nov 25

7:05 am - 5:20 am

SFO

SCL

18h 15m

2 stops

11:55 pm - 11:05 am

SCL

SFO

16h 10m

1 stop

$739LATAM Airlines

Mon, Oct 26 - Wed, Nov 4

7:36 pm - 2:48 am

SFO

SCL

26h 12m

1 stop

5:07 am - 5:25 pm

SCL

SFO

17h 18m

1 stop

$740Copa Airlines

Sun, Nov 1 - Tue, Dec 1

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Delta flights from San Francisco to Santiago

Our best Delta deals on San Francisco to Santiago flight tickets

Delta

Nov 13

SFO6:00 amSan Francisco

20h 40m

1 stop

SCL7:40 amSantiago Arturo Merino Benitez

Dec 1

SCL11:10 pmSantiago Arturo Merino Benitez

25h 27m

1 stop

SFO7:37 pmSan Francisco

$785

Delta

Nov 22

SFO11:45 pmSan Francisco

24h 50m

2 stops

SCL5:35 amSantiago Arturo Merino Benitez

Nov 26

SCL11:55 pmSantiago Arturo Merino Benitez

15h 04m

1 stop

SFO9:59 amSan Francisco

$790

Delta

Aug 3

SFO7:13 amSan Francisco

19h 22m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Aug 9

SCL10:55 pmSantiago Arturo Merino Benitez

28h 41m

1 stop

SFO12:36 amSan Francisco

$1,105

LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets

LATAM Airlines

Nov 13

SFO7:00 amSan Francisco

17h 20m

2 stops

SCL5:20 amSantiago Arturo Merino Benitez

Dec 1

SCL7:30 amSantiago Arturo Merino Benitez

20h 41m

2 stops

SFO11:11 pmSan Francisco

$691

LATAM Airlines

Nov 13

SFO7:00 amSan Francisco

17h 20m

2 stops

SCL5:20 amSantiago Arturo Merino Benitez

Dec 1

SCL8:30 pmSantiago Arturo Merino Benitez

20h 24m

2 stops

SFO11:54 amSan Francisco

$707

LATAM Airlines

Dec 2

SFO4:15 pmSan Francisco

17h 45m

2 stops

SCL3:00 pmSantiago Arturo Merino Benitez

Dec 13

SCL9:50 pmSantiago Arturo Merino Benitez

19h 04m

2 stops

SFO11:54 amSan Francisco

$723

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 11/13

7:00 am-5:20 am

2 stops17h 20m

Santiago Arturo Merino Benitez

Tue 12/1

7:30 am-11:11 pm

2 stops20h 41m

$691

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 10/25

1:31 am-11:39 pm

1 stop18h 08m

Santiago Arturo Merino Benitez

Tue 11/3

1:22 am-5:25 pm

1 stop21h 03m

$706

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 11/13

7:00 am-5:20 am

2 stops17h 20m

Santiago Arturo Merino Benitez

Tue 12/1

8:30 pm-11:54 am

2 stops20h 24m

$707

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 12/2

4:15 pm-3:00 pm

2 stops17h 45m

Santiago Arturo Merino Benitez

Sun 12/13

9:50 pm-11:54 am

2 stops19h 04m

$723

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 10/26

7:05 am-5:20 am

2 stops18h 15m

Santiago Arturo Merino Benitez

Wed 11/4

8:30 pm-11:05 am

2 stops19h 35m

$724

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 11/18

6:00 am-5:35 am

2 stops18h 35m

Santiago Arturo Merino Benitez

Fri 12/4

8:30 pm-11:54 am

2 stops20h 24m

$728

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 11/1

7:36 pm-2:48 am

1 stop26h 12m

Santiago Arturo Merino Benitez

Fri 11/6

1:02 am-11:12 pm

1 stop27h 10m

$729

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 11/14

7:00 am-5:20 am

2 stops17h 20m

Santiago Arturo Merino Benitez

Wed 11/25

9:50 pm-11:54 am

2 stops19h 04m

$734

Quickest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 10/26

7:05 am-5:20 am

2 stops18h 15m

Santiago Arturo Merino Benitez

Wed 11/4

11:55 pm-11:05 am

1 stop16h 10m

$739

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 11/1

7:36 pm-2:48 am

1 stop26h 12m

Santiago Arturo Merino Benitez

Tue 12/1

5:07 am-5:25 pm

1 stop17h 18m

$740

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between San Francisco and Santiago?

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $670. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight from San Francisco to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $833 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $709 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 2% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of July 2026, prices for San Francisco to Santiago flights are approximately 73% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time	16h 35m
Direct flights	None

The fastest flight from San Francisco to Santiago takes 16h 35m

There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.

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Frequently asked questions about flying from San Francisco to Santiago

How far is San Francisco to Santiago Arturo Merino Benitez by plane?
A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5934.4 mi. In terms of flight time, this usually takes a little over 16h 35m.
When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.
How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
As of July 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from San Francisco to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Francisco to Santiago is LATAM Airlines (29% of total bookings). The next most popular airlines are United Airlines (20%), American Airlines (19%), and Delta (15%).

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Avianca	PriceFrom $290	Free Cancellation	Rating 6.5 2,524 reviews	Search Avianca flights
Copa Airlines	PriceFrom $470	Free Cancellation	Rating 7.6 1,566 reviews	Search Copa Airlines flights
Air Canada	PriceFrom $482	Free Cancellation	Rating 7.1 11,361 reviews	Search Air Canada flights
American Airlines	PriceFrom $494	Free Cancellation	Rating 7.1 11,839 reviews	Search American Airlines flights
United Airlines	PriceFrom $494	Free Cancellation	Rating 7.4 10,016 reviews	Search United Airlines flights
Delta	PriceFrom $547	Free Cancellation	Rating 7.8 8,483 reviews	Search Delta flights
LATAM Airlines	PriceFrom $583	Free Cancellation	Rating 7.5 1,963 reviews	Search LATAM Airlines flights

Viña del Mar

Valparaíso

Santa Cruz

San Fernando

Valle Nevado

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.