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Cheap flights from San Francisco to Santiago from $311

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago departing on 4/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
12:10 am - 5:30 am
SFO
-
SCL
25h 20m2 stops
Avianca Logo
2:30 pm - 10:45 pm
SCL
-
SFO
35h 15m2 stops
$494Avianca
mar., mar. 17 - mié., abr. 22
American Airlines Logo
7:00 am - 8:15 am
SFO
-
SCL
20h 15m1 stop
American Airlines Logo
11:15 pm - 11:18 am
SCL
-
SFO
17h 03m1 stop
$495American Airlines
mié., feb. 4 - jue., feb. 19
American Airlines Logo
8:00 am - 7:50 am
SFO
-
SCL
18h 50m2 stops
American Airlines Logo
10:15 pm - 1:37 pm
SCL
-
SFO
20h 22m2 stops
$500American Airlines
mié., feb. 4 - jue., feb. 19
Copa Airlines Logo
1:12 am - 11:26 pm
SFO
-
SCL
19h 14m1 stop
Copa Airlines Logo
4:41 am - 11:40 pm
SCL
-
SFO
21h 59m1 stop
$503Copa Airlines
dom., may. 10 - mié., may. 20
American Airlines Logo
11:35 pm - 8:05 am
SFO
-
SCL
27h 30m1 stop
American Airlines Logo
10:15 pm - 5:16 pm
SCL
-
SFO
23h 01m1 stop
$504American Airlines
dom., mar. 1 - mié., mar. 11
American Airlines Logo
11:35 pm - 8:05 am
SFO
-
SCL
27h 30m1 stop
American Airlines Logo
10:15 pm - 2:34 pm
SCL
-
SFO
20h 19m2 stops
$508American Airlines
dom., mar. 1 - mié., mar. 11
Avianca Logo
2:20 pm - 12:30 am
SFO
-
SCL
30h 10m2 stops
Avianca Logo
4:25 pm - 11:40 pm
SCL
-
SFO
35h 15m2 stops
$519Avianca
lun., mar. 16 - vie., mar. 20
Copa Airlines Logo
1:54 am - 8:20 pm
SFO
-
SCL
14h 26m1 stop
Copa Airlines Logo
1:49 am - 11:40 pm
SCL
-
SFO
25h 51m1 stop
$523Copa Airlines
mié., mar. 18 - dom., mar. 29
American Airlines Logo
1:15 pm - 9:00 am
SFO
-
SCL
14h 45m1 stop
American Airlines Logo
11:15 pm - 5:16 pm
SCL
-
SFO
23h 01m1 stop
$535American Airlines
mar., ene. 27 - sáb., feb. 14
United Airlines Logo
11:59 pm - 8:50 am
SFO
-
SCL
27h 51m1 stop
United Airlines Logo
9:45 pm - 5:48 pm
SCL
-
SFO
24h 03m1 stop
$536United Airlines
mié., feb. 25 - lun., mar. 9

Copa Airlines flights from San Francisco to Santiago

Our best Copa Airlines deals on San Francisco to Santiago flight tickets
Copa Airlines
May 10
SFO1:12 amSan Francisco
19h 14m
1 stop
SCL11:26 pmSantiago Arturo Merino Benitez
May 20
SCL4:41 amSantiago Arturo Merino Benitez
21h 59m
1 stop
SFO11:40 pmSan Francisco
$503
Find similar
Copa Airlines
Mar 18
SFO1:54 amSan Francisco
14h 26m
1 stop
SCL8:20 pmSantiago Arturo Merino Benitez
Mar 29
SCL1:49 amSantiago Arturo Merino Benitez
25h 51m
1 stop
SFO11:40 pmSan Francisco
$523
Find similar
Copa Airlines
Apr 19
SFO1:23 amSan Francisco
18h 20m
1 stop
SCL10:43 pmSantiago Arturo Merino Benitez
May 4
SCL11:17 amSantiago Arturo Merino Benitez
15h 23m
1 stop
SFO11:40 pmSan Francisco
$541
Find similar

LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets
LATAM Airlines
Apr 5
SFO8:55 amSan Francisco
17h 40m
1 stop
SCL5:35 amSantiago Arturo Merino Benitez
Apr 15
SCL7:45 amSantiago Arturo Merino Benitez
18h 31m
2 stops
SFO11:16 pmSan Francisco
$559
Find similar
LATAM Airlines
Apr 4
SFO11:00 amSan Francisco
15h 35m
1 stop
SCL6:35 amSantiago Arturo Merino Benitez
Apr 13
SCL11:00 pmSantiago Arturo Merino Benitez
20h 57m
2 stops
SFO4:57 pmSan Francisco
$576
Find similar
LATAM Airlines
Feb 7
SFO11:50 amSan Francisco
14h 50m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Feb 18
SCL11:55 pmSantiago Arturo Merino Benitez
17h 49m
1 stop
SFO12:44 pmSan Francisco
$583
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 6, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 3/17

12:10 am-5:30 am

2 stops25h 20m

Santiago Arturo Merino Benitez

mié. 4/22

2:30 pm-10:45 pm

2 stops35h 15m

$494

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 2/4

7:00 am-8:15 am

1 stop20h 15m

Santiago Arturo Merino Benitez

jue. 2/19

11:15 pm-11:18 am

1 stop17h 03m

$495

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 2/4

8:00 am-7:50 am

2 stops18h 50m

Santiago Arturo Merino Benitez

jue. 2/19

10:15 pm-1:37 pm

2 stops20h 22m

$500

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

dom. 5/10

1:12 am-11:26 pm

1 stop19h 14m

Santiago Arturo Merino Benitez

mié. 5/20

4:41 am-11:40 pm

1 stop21h 59m

$503

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

dom. 3/1

11:35 pm-8:05 am

1 stop27h 30m

Santiago Arturo Merino Benitez

mié. 3/11

10:15 pm-5:16 pm

1 stop23h 01m

$504

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

dom. 3/1

11:35 pm-8:05 am

1 stop27h 30m

Santiago Arturo Merino Benitez

mié. 3/11

10:15 pm-2:34 pm

2 stops20h 19m

$508

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

lun. 3/16

2:20 pm-12:30 am

2 stops30h 10m

Santiago Arturo Merino Benitez

vie. 3/20

4:25 pm-11:40 pm

2 stops35h 15m

$519

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 3/18

1:54 am-8:20 pm

1 stop14h 26m

Santiago Arturo Merino Benitez

dom. 3/29

1:49 am-11:40 pm

1 stop25h 51m

$523

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 1/27

1:15 pm-9:00 am

1 stop14h 45m

Santiago Arturo Merino Benitez

sáb. 2/14

11:15 pm-5:16 pm

1 stop23h 01m

$535

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 2/25

11:59 pm-8:50 am

1 stop27h 51m

Santiago Arturo Merino Benitez

lun. 3/9

9:45 pm-5:48 pm

1 stop24h 03m

$536

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $674. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $776 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $540 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 9% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of January 2026, prices for San Francisco to Santiago flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time

14h 50m

Direct flights

None
The fastest flight from San Francisco to Santiago takes 14h 50m
There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.
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  • How far is San Francisco to Santiago Arturo Merino Benitez by plane?

    A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 14h 50m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago?

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $492Free CancellationRating
6.6
2,499 reviews
Search Avianca flights
United AirlinesPriceFrom $494Free CancellationRating
7.4
9,132 reviews
Search United Airlines flights
American AirlinesPriceFrom $498Free CancellationRating
7.2
11,084 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $542Free CancellationRating
7.6
1,564 reviews
Search Copa Airlines flights
DeltaPriceFrom $592Free CancellationRating
7.9
8,018 reviews
Search Delta flights
LATAM AirlinesPriceFrom $594Free CancellationRating
7.5
1,902 reviews
Search LATAM Airlines flights
AeromexicoPriceFrom $758Free CancellationRating
7.4
1,611 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Santiago trip

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