Which airport is the most popular layover for flights between San Francisco and Santiago?

Houston (IAH) was the most common stop: 38% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from San Francisco to Santiago?

Flights via Houston (IAH) offer the lowest average round-trip price of $668.

Which layover airport has the shortest connection time from San Francisco to Santiago?

Miami (MIA) has the shortest average layover time for this route: 1h 55m.

Which layover airport has the shortest travel time from San Francisco to Santiago?

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 14h 47m.

What airlines fly to Santiago?

LATAM Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to Santiago from San Francisco according to our data. LATAM Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 7 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from San Francisco to Santiago Arturo Merino Benitez?

Avianca and LATAM Airlines are the most popular carriers operating from San Francisco to Santiago Arturo Merino Benitez

When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

As of March 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$302 Cheap Flights from San Francisco to Santiago in 2026

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Find the cheapest flights from San Francisco to Santiago

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One-way

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Cheap round-trip flights

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4:15 pm - 2:05 pm

SFO

SCL

18h 50m

2 stops

11:25 pm - 3:11 pm

SCL

SFO

19h 46m

1 stop

$632LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

7:00 am - 5:35 am

SFO

SCL

19h 35m

1 stop

4:10 am - 11:12 pm

SCL

SFO

22h 02m

2 stops

$636LATAM Airlines

Tue, Aug 18 - Tue, Aug 25

2:15 pm - 2:15 pm

SFO

SCL

21h 00m

2 stops

6:40 am - 11:55 pm

SCL

SFO

20h 15m

2 stops

$644Avianca

Mon, Apr 20 - Sat, May 30

11:55 pm - 11:20 pm

SFO

SCL

20h 25m

2 stops

6:40 am - 11:55 pm

SCL

SFO

20h 15m

2 stops

$645Avianca

Mon, Apr 27 - Tue, May 12

8:55 am - 5:35 am

SFO

SCL

17h 40m

1 stop

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$646LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

6:00 am - 5:35 am

SFO

SCL

20h 35m

2 stops

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$651LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

11:55 pm - 4:45 am

SFO

SCL

25h 50m

2 stops

3:20 pm - 11:55 pm

SCL

SFO

35h 35m

2 stops

$656Avianca

Thu, May 7 - Mon, May 11

8:55 am - 5:35 am

SFO

SCL

17h 40m

1 stop

11:25 pm - 11:59 am

SCL

SFO

16h 34m

1 stop

$662LATAM Airlines

Tue, Sep 1 - Wed, Sep 30

10:30 pm - 7:45 pm

SFO

SCL

18h 15m

2 stops

11:25 pm - 3:11 pm

SCL

SFO

19h 46m

1 stop

$665LATAM Airlines

Wed, Sep 2 - Wed, Sep 30

11:55 pm - 11:20 pm

SFO

SCL

20h 25m

2 stops

6:40 am - 11:55 pm

SCL

SFO

20h 15m

2 stops

$666Avianca

Sun, Apr 26 - Sat, May 9

LATAM Airlines flights from San Francisco to Santiago

Our best LATAM Airlines deals on San Francisco to Santiago flight tickets

LATAM Airlines

Sep 1

SFO4:15 pmSan Francisco

18h 50m

2 stops

SCL2:05 pmSantiago Arturo Merino Benitez

Sep 30

SCL11:25 pmSantiago Arturo Merino Benitez

19h 46m

1 stop

SFO3:11 pmSan Francisco

$632

LATAM Airlines

Aug 18

SFO7:00 amSan Francisco

19h 35m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Aug 25

SCL4:10 amSantiago Arturo Merino Benitez

22h 02m

2 stops

SFO11:12 pmSan Francisco

$636

LATAM Airlines

Sep 1

SFO8:55 amSan Francisco

17h 40m

1 stop

SCL5:35 amSantiago Arturo Merino Benitez

Sep 30

SCL11:25 pmSantiago Arturo Merino Benitez

16h 34m

1 stop

SFO11:59 amSan Francisco

$646

Avianca flights from San Francisco to Santiago

Our best Avianca deals on San Francisco to Santiago flight tickets

Avianca

Apr 20

SFO2:15 pmSan Francisco

21h 00m

2 stops

SCL2:15 pmSantiago Arturo Merino Benitez

May 30

SCL6:40 amSantiago Arturo Merino Benitez

20h 15m

2 stops

SFO11:55 pmSan Francisco

$644

Avianca

Apr 27

SFO11:55 pmSan Francisco

20h 25m

2 stops

SCL11:20 pmSantiago Arturo Merino Benitez

May 12

SCL6:40 amSantiago Arturo Merino Benitez

20h 15m

2 stops

SFO11:55 pmSan Francisco

$645

Avianca

May 7

SFO11:55 pmSan Francisco

25h 50m

2 stops

SCL4:45 amSantiago Arturo Merino Benitez

May 11

SCL3:20 pmSantiago Arturo Merino Benitez

35h 35m

2 stops

SFO11:55 pmSan Francisco

$656

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

4:15 pm-2:05 pm

2 stops18h 50m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-3:11 pm

1 stop19h 46m

$632

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 8/18

7:00 am-5:35 am

1 stop19h 35m

Santiago Arturo Merino Benitez

Tue 8/25

4:10 am-11:12 pm

2 stops22h 02m

$636

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

2:15 pm-2:15 pm

2 stops21h 00m

Santiago Arturo Merino Benitez

Sat 5/30

6:40 am-11:55 pm

2 stops20h 15m

$644

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/27

11:55 pm-11:20 pm

2 stops20h 25m

Santiago Arturo Merino Benitez

Tue 5/12

6:40 am-11:55 pm

2 stops20h 15m

$645

Quickest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

8:55 am-5:35 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$646

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

6:00 am-5:35 am

2 stops20h 35m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$651

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 5/7

11:55 pm-4:45 am

2 stops25h 50m

Santiago Arturo Merino Benitez

Mon 5/11

3:20 pm-11:55 pm

2 stops35h 35m

$656

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/1

8:55 am-5:35 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-11:59 am

1 stop16h 34m

$662

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 9/2

10:30 pm-7:45 pm

2 stops18h 15m

Santiago Arturo Merino Benitez

Wed 9/30

11:25 pm-3:11 pm

1 stop19h 46m

$665

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 4/26

11:55 pm-11:20 pm

2 stops20h 25m

Santiago Arturo Merino Benitez

Sat 5/9

6:40 am-11:55 pm

2 stops20h 15m

$666

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Santiago?

In general, January is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $666. If you don’t want to visit Santiago in January, then you should wait until October to fly from San Francisco, when ticket prices are also cheap, with an average price of $683.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $781 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $557 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 18% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of March 2026, prices for San Francisco to Santiago flights are approximately 3% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Fastest flight time	15h 35m
Direct flights	None

The fastest flight from San Francisco to Santiago takes 15h 35m

There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.

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How far is San Francisco to Santiago Arturo Merino Benitez by plane?
A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 15h 35m.
When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.
How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
As of March 2026, there are 7 operators available to choose from for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from San Francisco to Santiago?
Based on momondo bookings for this flight route, the most popular airline on flight routes from San Francisco to Santiago is LATAM Airlines (30% of total bookings). The next most popular airlines are American Airlines (19%), United Airlines (18%), and Delta (17%).

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo

Airline	Rating	Free Cancellation	Price
Avianca	PriceFrom $366	Free Cancellation	Rating 6.5 2,499 reviews	Search Avianca flights
United Airlines	PriceFrom $494	Free Cancellation	Rating 7.4 9,409 reviews	Search United Airlines flights
American Airlines	PriceFrom $494	Free Cancellation	Rating 7.1 11,414 reviews	Search American Airlines flights
Copa Airlines	PriceFrom $501	Free Cancellation	Rating 7.5 1,569 reviews	Search Copa Airlines flights
Delta	PriceFrom $556	Free Cancellation	Rating 7.9 8,276 reviews	Search Delta flights
LATAM Airlines	PriceFrom $593	Free Cancellation	Rating 7.4 1,918 reviews	Search LATAM Airlines flights
Aeromexico	PriceFrom $758	Free Cancellation	Rating 7.4 1,569 reviews	Search Aeromexico flights

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Valparaíso

Santa Cruz

Valle Nevado

San Fernando

Pichilemu

Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.