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Cheap flights from San Francisco to Santiago from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Santiago departing on 12/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
12:43 am - 8:50 amSFO-SCL
27h 07m1 stop
United Airlines Logo
10:45 pm - 9:45 amSCL-SFO
16h 00m1 stop
$528United Airlines
Find Deal
mar., nov. 18 - vie., dic. 5
United Airlines Logo
7:16 am - 8:50 amSFO-SCL
20h 34m1 stop
United Airlines Logo
10:45 pm - 9:45 amSCL-SFO
16h 00m1 stop
$534United Airlines
Find Deal
vie., nov. 14 - lun., dic. 15
Copa Airlines Logo
12:36 am - 11:41 pmSFO-SCL
18h 05m1 stop
Copa Airlines Logo
3:23 am - 11:17 pmSCL-SFO
24h 54m1 stop
$537Copa Airlines
Find Deal
lun., nov. 3 - mar., nov. 11
American Airlines Logo
10:16 am - 7:45 amSFO-SCL
16h 29m1 stop
American Airlines Logo
11:55 pm - 3:07 pmSCL-SFO
20h 12m2 stops
$539American Airlines
Find Deal
mié., dic. 3 - sáb., dic. 13
American Airlines Logo
10:16 am - 9:00 amSFO-SCL
17h 44m2 stops
American Airlines Logo
10:25 pm - 11:17 amSCL-SFO
17h 52m1 stop
$541American Airlines
Find Deal
mar., dic. 2 - vie., dic. 26
Copa Airlines Logo
12:36 am - 12:06 amSFO-SCL
18h 30m1 stop
Copa Airlines Logo
5:12 am - 11:17 pmSCL-SFO
23h 05m1 stop
$557Copa Airlines
Find Deal
jue., nov. 6 - jue., nov. 13
LATAM Airlines Logo
1:00 pm - 6:00 amSFO-SCL
14h 00m1 stop
LATAM Airlines Logo
5:35 am - 12:15 amSCL-SFO
21h 40m2 stops
$582LATAM Airlines
Find Deal
mar., abr. 7 - mar., abr. 21
Delta Logo
6:00 am - 7:00 amSFO-SCL
20h 00m1 stop
Delta Logo
8:15 am - 11:51 pmSCL-SFO
20h 36m2 stops
$585Delta
Find Deal
lun., feb. 2 - sáb., feb. 14
LATAM Airlines Logo
8:25 am - 6:00 amSFO-SCL
16h 35m1 stop
LATAM Airlines Logo
11:25 pm - 2:47 pmSCL-SFO
20h 22m2 stops
$590LATAM Airlines
Find Deal
mié., nov. 19 - vie., dic. 5
Delta Logo
9:00 am - 6:55 amSFO-SCL
16h 55m1 stop
Delta Logo
5:25 pm - 9:44 amSCL-SFO
21h 19m2 stops
$594Delta
Find Deal
mar., nov. 18 - dom., dic. 7

Copa Airlines flights from San Francisco to Santiago

Our best Copa Airlines deals on San Francisco to Santiago flight tickets
Copa Airlines
Nov 3
SFO12:36 amSan Francisco
18h 05m
1 stop
SCL11:41 pmSantiago Arturo Merino Benitez
Nov 11
SCL3:23 amSantiago Arturo Merino Benitez
24h 54m
1 stop
SFO11:17 pmSan Francisco
$537
Find similar
Copa Airlines
Nov 6
SFO12:36 amSan Francisco
18h 30m
1 stop
SCL12:06 amSantiago Arturo Merino Benitez
Nov 13
SCL5:12 amSantiago Arturo Merino Benitez
23h 05m
1 stop
SFO11:17 pmSan Francisco
$557
Find similar
Copa Airlines
Dec 2
SFO12:36 amSan Francisco
14h 45m
1 stop
SCL8:21 pmSantiago Arturo Merino Benitez
Dec 9
SCL3:23 amSantiago Arturo Merino Benitez
24h 54m
1 stop
SFO11:17 pmSan Francisco
$592
Find similar

American Airlines flights from San Francisco to Santiago

Our best American Airlines deals on San Francisco to Santiago flight tickets
American Airlines
Oct 29
SFO12:27 pmSan Francisco
16h 28m
1 stop
SCL8:55 amSantiago Arturo Merino Benitez
Nov 2
SCL11:15 pmSantiago Arturo Merino Benitez
25h 07m
1 stop
SFO7:22 pmSan Francisco
$534
Find similar
American Airlines
Dec 3
SFO10:16 amSan Francisco
16h 29m
1 stop
SCL7:45 amSantiago Arturo Merino Benitez
Dec 13
SCL11:55 pmSantiago Arturo Merino Benitez
20h 12m
2 stops
SFO3:07 pmSan Francisco
$539
Find similar
American Airlines
Dec 2
SFO10:16 amSan Francisco
17h 44m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Dec 26
SCL10:25 pmSantiago Arturo Merino Benitez
17h 52m
1 stop
SFO11:17 amSan Francisco
$541
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated octubre 20, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 11/18

12:43 am-8:50 am

1 stop27h 07m

Santiago Arturo Merino Benitez

vie. 12/5

10:45 pm-9:45 am

1 stop16h 00m

$528

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

vie. 11/14

7:16 am-8:50 am

1 stop20h 34m

Santiago Arturo Merino Benitez

lun. 12/15

10:45 pm-9:45 am

1 stop16h 00m

$534

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

lun. 11/3

12:36 am-11:41 pm

1 stop18h 05m

Santiago Arturo Merino Benitez

mar. 11/11

3:23 am-11:17 pm

1 stop24h 54m

$537

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 12/3

10:16 am-7:45 am

1 stop16h 29m

Santiago Arturo Merino Benitez

sáb. 12/13

11:55 pm-3:07 pm

2 stops20h 12m

$539

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 12/2

10:16 am-9:00 am

2 stops17h 44m

Santiago Arturo Merino Benitez

vie. 12/26

10:25 pm-11:17 am

1 stop17h 52m

$541

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

jue. 11/6

12:36 am-12:06 am

1 stop18h 30m

Santiago Arturo Merino Benitez

jue. 11/13

5:12 am-11:17 pm

1 stop23h 05m

$557

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 4/7

1:00 pm-6:00 am

1 stop14h 00m

Santiago Arturo Merino Benitez

mar. 4/21

5:35 am-12:15 am

2 stops21h 40m

$582

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

lun. 2/2

6:00 am-7:00 am

1 stop20h 00m

Santiago Arturo Merino Benitez

sáb. 2/14

8:15 am-11:51 pm

2 stops20h 36m

$585

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 11/19

8:25 am-6:00 am

1 stop16h 35m

Santiago Arturo Merino Benitez

vie. 12/5

11:25 pm-2:47 pm

2 stops20h 22m

$590

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 11/18

9:00 am-6:55 am

1 stop16h 55m

Santiago Arturo Merino Benitez

dom. 12/7

5:25 pm-9:44 am

2 stops21h 19m

$594

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Francisco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from San Francisco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $683. If you don’t want to visit Santiago in October, then you should wait until August to fly from San Francisco, when ticket prices are also cheap, with an average price of $708.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $812. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,066.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from San Francisco to Santiago when you can find flight prices for as low as $831. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,007 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $811 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from San Francisco for as low as $651 on momondo.

Can stopping save me money on San Francisco to Santiago flights?

You could potentially save up to 33% on your flight if you consider stops on a San Francisco to Santiago flight.

How have San Francisco to Santiago flight prices changed over time?

As of October 2025, prices for San Francisco to Santiago flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Santiago (SFO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Santiago

Direct flights

None
There are no direct flights from San Francisco to Santiago. There are no popular flight routes from San Francisco to Santiago.
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  • How far is San Francisco to Santiago Arturo Merino Benitez by plane?

    A flight from San Francisco to Santiago Arturo Merino Benitez will travel around 5935.3 mi. In terms of flight time, this usually takes a little over 14h 00m.

  • When did momondo last update prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from San Francisco Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Santiago?

Best airlines flying from San Francisco to Santiago

Compare and see reviews for airlines that fly from San Francisco to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $492Free CancellationRating
6.6
2,457 reviews
Search Avianca flights
Copa AirlinesPriceFrom $510Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $534Free CancellationRating
7.4
8,988 reviews
Search United Airlines flights
DeltaPriceFrom $594Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $620Free CancellationRating
7.2
11,024 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $639Free CancellationRating
7.5
1,868 reviews
Search LATAM Airlines flights
AeromexicoPriceFrom $758Free CancellationRating
7.4
1,680 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from San Francisco.

Can I find flights from San Francisco to Santiago with flexible booking policies on momondo?

Flights from San Francisco to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Santiago?

Once all potential San Francisco to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from San Francisco. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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