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Cheap flights from San Diego to Santa Cruz de la Sierra from $315

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Santa Cruz de la Sierra departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from San Diego to Santa Cruz de la Sierra

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
1:24 pm - 10:40 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
30h 16m2 stops San Francisco Panama City Tocumen Intl
United Airlines Logo
11:47 am - 9:32 amVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
24h 45m2 stops Panama City Tocumen Intl Chicago O'Hare Intl
$783United Airlines
Sat, Aug 29 - Mon, Sep 7
United Airlines Logo
7:41 pm - 10:44 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
24h 03m3 stops San Francisco Chicago O'Hare Intl Panama City Tocumen Intl
United Airlines Logo
11:47 am - 10:58 amVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
50h 11m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$794United Airlines
Mon, Aug 31 - Mon, Sep 7
United Airlines Logo
9:45 pm - 10:44 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 59m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
United Airlines Logo
11:47 am - 11:35 amVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
26h 48m2 stops Panama City Tocumen Intl Los Angeles
$803United Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
1:24 pm - 10:40 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
30h 16m2 stops San Francisco Panama City Tocumen Intl
United Airlines Logo
11:47 am - 5:26 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
32h 39m2 stops Panama City Tocumen Intl Los Angeles
$812United Airlines
Mon, Aug 17 - Tue, Sep 29
Multiple Airlines Logo
9:45 pm - 3:38 amSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
26h 53m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
Multiple Airlines Logo
1:12 am - 10:58 amVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
36h 46m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$819Multiple Airlines
Tue, Sep 1 - Tue, Sep 8
Multiple Airlines Logo
9:45 pm - 10:40 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
45h 55m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
Multiple Airlines Logo
1:12 am - 10:19 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
24h 07m2 stops Panama City Tocumen Intl Newark
$837Multiple Airlines
Mon, Aug 17 - Mon, Sep 28
United Airlines Logo
12:40 pm - 10:44 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
31h 04m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
United Airlines Logo
11:47 am - 9:32 amVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
24h 45m2 stops Panama City Tocumen Intl Chicago O'Hare Intl
$853United Airlines
Thu, Sep 3 - Mon, Sep 7
Copa Airlines Logo
10:00 pm - 10:44 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 44m1 stop Panama City Tocumen Intl
Copa Airlines Logo
1:12 am - 6:29 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
20h 17m1 stop Panama City Tocumen Intl
$855Copa Airlines
Fri, Sep 4 - Thu, Sep 10
Copa Airlines Logo
10:00 pm - 10:40 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 40m1 stop Panama City Tocumen Intl
Copa Airlines Logo
11:47 am - 6:30 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
33h 43m1 stop Panama City Tocumen Intl
$857Copa Airlines
Wed, Aug 19 - Sat, Aug 22
Copa Airlines Logo
10:00 pm - 10:40 pmSAN  San Diego-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 40m1 stop Panama City Tocumen Intl
Copa Airlines Logo
11:47 am - 6:29 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-SAN San Diego
33h 42m1 stop Panama City Tocumen Intl
$863Copa Airlines
Mon, Aug 17 - Tue, Sep 29

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Copa Airlines flights from San Diego to Santa Cruz de la Sierra

Our best Copa Airlines deals on San Diego to Santa Cruz de la Sierra flight tickets
Copa Airlines
Sep 4
SAN10:00 pmSan Diego
21h 44m
1 stop
VVI10:44 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 10
VVI1:12 amSanta Cruz de la Sierra Viru Viru Intl
20h 17m
1 stop
SAN6:29 pmSan Diego
$855
Copa Airlines
Aug 19
SAN10:00 pmSan Diego
21h 40m
1 stop
VVI10:40 pmSanta Cruz de la Sierra Viru Viru Intl
Aug 22
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
33h 43m
1 stop
SAN6:30 pmSan Diego
$857
Copa Airlines
Aug 17
SAN10:00 pmSan Diego
21h 40m
1 stop
VVI10:40 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 29
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
33h 42m
1 stop
SAN6:29 pmSan Diego
$863

United Airlines flights from San Diego to Santa Cruz de la Sierra

Our best United Airlines deals on San Diego to Santa Cruz de la Sierra flight tickets
United Airlines
Aug 29
SAN1:24 pmSan Diego
30h 16m
2 stops
VVI10:40 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 7
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
24h 45m
2 stops
SAN9:32 amSan Diego
$783
United Airlines
Aug 31
SAN7:41 pmSan Diego
24h 03m
3 stops
VVI10:44 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 7
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
50h 11m
2 stops
SAN10:58 amSan Diego
$794
United Airlines
Sep 6
SAN9:45 pmSan Diego
21h 59m
2 stops
VVI10:44 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 10
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
26h 48m
2 stops
SAN11:35 amSan Diego
$803

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from San Diego to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Sat 8/29

1:24 pm-10:40 pm

2 stops30h 16m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/7

11:47 am-9:32 am

2 stops24h 45m

$783

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Mon 8/31

7:41 pm-10:44 pm

3 stops24h 03m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/7

11:47 am-10:58 am

2 stops50h 11m

$794

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Sun 9/6

9:45 pm-10:44 pm

2 stops21h 59m

Santa Cruz de la Sierra Viru Viru Intl

Thu 9/10

11:47 am-11:35 am

2 stops26h 48m

$803

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Mon 8/17

1:24 pm-10:40 pm

2 stops30h 16m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/29

11:47 am-5:26 pm

2 stops32h 39m

$812

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Tue 9/1

9:45 pm-3:38 am

2 stops26h 53m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/8

1:12 am-10:58 am

2 stops36h 46m

$819

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Mon 8/17

9:45 pm-10:40 pm

2 stops45h 55m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/28

1:12 am-10:19 pm

2 stops24h 07m

$837

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Thu 9/3

12:40 pm-10:44 pm

2 stops31h 04m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/7

11:47 am-9:32 am

2 stops24h 45m

$853
Quickest round-trip

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Fri 9/4

10:00 pm-10:44 pm

1 stop21h 44m

Santa Cruz de la Sierra Viru Viru Intl

Thu 9/10

1:12 am-6:29 pm

1 stop20h 17m

$855

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Wed 8/19

10:00 pm-10:40 pm

1 stop21h 40m

Santa Cruz de la Sierra Viru Viru Intl

Sat 8/22

11:47 am-6:30 pm

1 stop33h 43m

$857

San DiegoSanta Cruz de la Sierra

SAN San Diego - VVI Santa Cruz de la Sierra Viru Viru Intl

SANVVI

San Diego

Mon 8/17

10:00 pm-10:40 pm

1 stop21h 40m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/29

11:47 am-6:29 pm

1 stop33h 42m

$863

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Diego to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on San Diego to Santa Cruz de la Sierra flights?

You could potentially save up to 63% on your flight if you consider stops on a San Diego to Santa Cruz de la Sierra flight.

When to book flights from San Diego to Santa Cruz de la Sierra

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Santa Cruz de la Sierra according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Santa Cruz de la Sierra (SAN to VVI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Santa Cruz de la Sierra

Fastest flight time

20h 48m

Direct flights

None
The fastest flight from San Diego to Santa Cruz de la Sierra takes 20h 48m
There are no direct flights from San Diego to Santa Cruz de la Sierra. There are no popular flight routes from San Diego to Santa Cruz de la Sierra.
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Frequently asked questions about flying from San Diego to Santa Cruz de la Sierra

  • How far is San Diego to Santa Cruz de la Sierra Viru Viru Intl by plane?

    Santa Cruz de la Sierra Viru Viru Intl is 4985.8 mi away from San Diego. By plane, this route typically takes 20h 48m.

  • When did momondo last update prices for flights from San Diego Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from San Diego Airport to Santa Cruz de la Sierra Viru Viru Intl Airport were last updated today.

  • How old do you have to be to fly from San Diego Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The travel and health documents required for your trip to Santa Cruz de la Sierra Viru Viru Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santa Cruz de la Sierra Viru Viru Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Santa Cruz de la Sierra?

Finding the right flight to Santa Cruz de la Sierra from San Diego is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santa Cruz de la Sierra quick and easy, saving you time and money.

Can I find flights from San Diego to Santa Cruz de la Sierra with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santa Cruz de la Sierra from San Diego which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from San Diego to Santa Cruz de la Sierra?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santa Cruz de la Sierra from San Diego.

I’m not ready to book a flight from San Diego to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Diego to Santa Cruz de la Sierra flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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