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Cheap flights from Roanoke to Panama from $491

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Panama departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Roanoke to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:26 am - 4:04 am
ROA
-
PTY
18h 38m
2 stops
United Airlines Logo
3:30 pm - 5:09 pm
PTY
-
ROA
24h 39m
2 stops
$611United Airlines
Tue, Aug 25 - Tue, Sep 1
United Airlines Logo
6:40 am - 4:04 am
ROA
-
PTY
22h 24m
2 stops
United Airlines Logo
10:00 am - 9:41 am
PTY
-
ROA
22h 41m
2 stops
$621United Airlines
Mon, Aug 31 - Fri, Sep 4
Delta Logo
6:00 am - 12:55 pm
ROA
-
PTY
7h 55m
1 stop
Delta Logo
2:20 pm - 12:27 am
PTY
-
ROA
9h 07m
1 stop
$627Delta
Tue, Aug 25 - Tue, Sep 1
United Airlines Logo
5:52 pm - 2:14 pm
ROA
-
PTY
21h 22m
2 stops
United Airlines Logo
7:55 am - 9:42 am
PTY
-
ROA
24h 47m
2 stops
$717United Airlines
Fri, Jul 24 - Wed, Jul 29
Avianca Logo
8:05 pm - 2:55 pm
ROA
-
PTY
19h 50m
3 stops
Avianca Logo
5:30 am - 7:07 pm
PTY
-
ROA
36h 37m
2 stops
$773Avianca
Tue, Aug 25 - Tue, Sep 1
Delta Logo
7:50 pm - 2:00 pm
ROA
-
PTY
18h 10m
1 stop
Delta Logo
3:20 pm - 12:23 am
PTY
-
ROA
9h 03m
1 stop
$778Delta
Sun, Dec 27 - Fri, Jan 8
Delta Logo
7:50 pm - 2:00 pm
ROA
-
PTY
18h 10m
1 stop
Delta Logo
1:40 pm - 12:23 am
PTY
-
ROA
10h 43m
1 stop
$818Delta
Sun, Dec 27 - Sat, Jan 9
Delta Logo
6:00 am - 1:05 pm
ROA
-
PTY
8h 05m
1 stop
Delta Logo
2:24 pm - 12:25 am
PTY
-
ROA
9h 01m
1 stop
$822Delta
Fri, Jul 24 - Wed, Jul 29
Delta Logo
7:50 pm - 2:00 pm
ROA
-
PTY
18h 10m
1 stop
Delta Logo
3:20 pm - 12:23 am
PTY
-
ROA
9h 03m
1 stop
$837Delta
Sat, Dec 26 - Fri, Jan 8
Delta Logo
7:50 pm - 2:00 pm
ROA
-
PTY
18h 10m
1 stop
Delta Logo
1:40 pm - 12:23 am
PTY
-
ROA
10h 43m
1 stop
$877Delta
Sat, Dec 26 - Sat, Jan 9

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American Airlines flights from Roanoke to Panama

Our best American Airlines deals on Roanoke to Panama flight tickets
American Airlines
Dec 26
ROA8:00 pmRoanoke
17h 53m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Jan 9
PTY2:27 pmPanama City Tocumen Intl
19h 09m
2 stops
ROA9:36 amRoanoke
$916
American Airlines
Dec 27
ROA4:49 pmRoanoke
21h 04m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Jan 8
PTY2:27 pmPanama City Tocumen Intl
19h 09m
2 stops
ROA9:36 amRoanoke
$935
American Airlines
Dec 27
ROA4:49 pmRoanoke
21h 04m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Jan 9
PTY4:46 pmPanama City Tocumen Intl
16h 50m
2 stops
ROA9:36 amRoanoke
$965

Delta flights from Roanoke to Panama

Our best Delta deals on Roanoke to Panama flight tickets
Delta
Aug 25
ROA6:00 amRoanoke
7h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 1
PTY2:20 pmPanama City Tocumen Intl
9h 07m
1 stop
ROA12:27 amRoanoke
$627
Delta
Dec 27
ROA7:50 pmRoanoke
18h 10m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Jan 8
PTY3:20 pmPanama City Tocumen Intl
9h 03m
1 stop
ROA12:23 amRoanoke
$778
Delta
Dec 27
ROA7:50 pmRoanoke
18h 10m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Jan 9
PTY1:40 pmPanama City Tocumen Intl
10h 43m
1 stop
ROA12:23 amRoanoke
$818

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 12, 2026.
Use the filters below to find and compare flights from Roanoke to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 8/25

10:26 am-4:04 am

2 stops18h 38m

Panama City Tocumen Intl

Tue 9/1

3:30 pm-5:09 pm

2 stops24h 39m

$611

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 8/31

6:40 am-4:04 am

2 stops22h 24m

Panama City Tocumen Intl

Fri 9/4

10:00 am-9:41 am

2 stops22h 41m

$621
Quickest round-trip

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 8/25

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Tue 9/1

2:20 pm-12:27 am

1 stop9h 07m

$627

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 7/24

5:52 pm-2:14 pm

2 stops21h 22m

Panama City Tocumen Intl

Wed 7/29

7:55 am-9:42 am

2 stops24h 47m

$717

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 8/25

8:05 pm-2:55 pm

3 stops19h 50m

Panama City Tocumen Intl

Tue 9/1

5:30 am-7:07 pm

2 stops36h 37m

$773

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 12/27

7:50 pm-2:00 pm

1 stop18h 10m

Panama City Tocumen Intl

Fri 1/8

3:20 pm-12:23 am

1 stop9h 03m

$778

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 12/27

7:50 pm-2:00 pm

1 stop18h 10m

Panama City Tocumen Intl

Sat 1/9

1:40 pm-12:23 am

1 stop10h 43m

$818

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 7/24

6:00 am-1:05 pm

1 stop8h 05m

Panama City Tocumen Intl

Wed 7/29

2:24 pm-12:25 am

1 stop9h 01m

$822

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 12/26

7:50 pm-2:00 pm

1 stop18h 10m

Panama City Tocumen Intl

Fri 1/8

3:20 pm-12:23 am

1 stop9h 03m

$837

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 12/26

7:50 pm-2:00 pm

1 stop18h 10m

Panama City Tocumen Intl

Sat 1/9

1:40 pm-12:23 am

1 stop10h 43m

$877

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Roanoke to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Roanoke to Panama flights?

You could potentially save up to 24% on your flight if you consider stops on a Roanoke to Panama flight.

Cheap Roanoke to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Panama

Fastest flight time

18h 10m

Direct flights

None
The fastest flight from Roanoke to Panama takes 18h 10m
There are no direct flights from Roanoke to Panama. There are no popular flight routes from Roanoke to Panama.
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Frequently asked questions about flying from Roanoke to Panama

  • When did momondo last update prices for flights from Roanoke Airport to Panama?

    Prices for flights from Roanoke Airport to Panama refresh daily.

  • How old do you have to be to fly from Roanoke Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Panama?

Finding the right flight to Panama from Roanoke is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama quick and easy, saving you time and money.

Can I find flights from Roanoke to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Roanoke on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Roanoke to Panama?

momondo helps you find the best flight between Roanoke and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Roanoke to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Roanoke to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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