Cheap flights from Roanoke to Panama from $835

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Panama departing on 11/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Delta Logo
6:00 am - 7:59 pmROA-PTY
13h 59m1 stop
Delta Logo
3:46 pm - 12:11 amPTY-ROA
8h 25m1 stop
$835Delta
Find Deal
Fri, Nov 21 - Fri, Dec 5
American Airlines Logo
8:06 pm - 1:43 pmROA-PTY
17h 37m2 stops
American Airlines Logo
4:43 pm - 12:26 pmPTY-ROA
19h 43m2 stops
$1,054American Airlines
Find Deal
Fri, Nov 21 - Fri, Dec 5
Delta Logo
6:00 am - 7:59 pmROA-PTY
13h 59m1 stop
Delta Logo
3:37 pm - 12:15 amPTY-ROA
8h 38m1 stop
$1,129Delta
Find Deal
Fri, Nov 21 - Mon, Dec 1
Delta Logo
6:00 am - 7:59 pmROA-PTY
13h 59m1 stop
Delta Logo
3:37 pm - 12:15 amPTY-ROA
8h 38m1 stop
$1,139Delta
Find Deal
Fri, Nov 21 - Mon, Dec 1
American Airlines Logo
12:53 pm - 1:43 pmROA-PTY
24h 50m2 stops
American Airlines Logo
2:43 pm - 1:34 pmPTY-ROA
22h 51m2 stops
$1,151American Airlines
Find Deal
Fri, Nov 21 - Mon, Dec 1
Delta Logo
7:05 am - 7:59 pmROA-PTY
12h 54m2 stops
Delta Logo
3:46 pm - 12:11 amPTY-ROA
8h 25m1 stop
$1,290Delta
Find Deal
Fri, Nov 21 - Fri, Dec 5
Delta Logo
7:05 am - 7:59 pmROA-PTY
12h 54m2 stops
Delta Logo
3:37 pm - 12:15 amPTY-ROA
8h 38m1 stop
$1,584Delta
Find Deal
Fri, Nov 21 - Mon, Dec 1
Delta Logo
7:05 am - 7:59 pmROA-PTY
12h 54m2 stops
Delta Logo
3:37 pm - 12:15 amPTY-ROA
8h 38m1 stop
$1,594Delta
Find Deal
Fri, Nov 21 - Mon, Dec 1

Delta flights from Roanoke to Panama

Our best Delta deals on Roanoke to Panama flight tickets
Delta
Nov 21
ROA6:00 amRoanoke
13h 59m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Dec 5
PTY3:46 pmPanama City Tocumen Intl
8h 25m
1 stop
ROA12:11 amRoanoke
Delta
Nov 21
ROA6:00 amRoanoke
13h 59m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Dec 1
PTY3:37 pmPanama City Tocumen Intl
8h 38m
1 stop
ROA12:15 amRoanoke
Delta
Nov 21
ROA6:00 amRoanoke
13h 59m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Dec 1
PTY3:37 pmPanama City Tocumen Intl
8h 38m
1 stop
ROA12:15 amRoanoke

American Airlines flights from Roanoke to Panama

Our best American Airlines deals on Roanoke to Panama flight tickets
American Airlines
Nov 21
ROA8:06 pmRoanoke
17h 37m
2 stops
PTY1:43 pmPanama City Tocumen Intl
Dec 5
PTY4:43 pmPanama City Tocumen Intl
19h 43m
2 stops
ROA12:26 pmRoanoke
American Airlines
Nov 21
ROA12:53 pmRoanoke
24h 50m
2 stops
PTY1:43 pmPanama City Tocumen Intl
Dec 1
PTY2:43 pmPanama City Tocumen Intl
22h 51m
2 stops
ROA1:34 pmRoanoke

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Roanoke to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

6:00 am-7:59 pm

1 stop13h 59m

Panama City Tocumen Intl

Fri 12/5

3:46 pm-12:11 am

1 stop8h 25m

$835

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

8:06 pm-1:43 pm

2 stops17h 37m

Panama City Tocumen Intl

Fri 12/5

4:43 pm-12:26 pm

2 stops19h 43m

$1,054

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

6:00 am-7:59 pm

1 stop13h 59m

Panama City Tocumen Intl

Mon 12/1

3:37 pm-12:15 am

1 stop8h 38m

$1,129

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

6:00 am-7:59 pm

1 stop13h 59m

Panama City Tocumen Intl

Mon 12/1

3:37 pm-12:15 am

1 stop8h 38m

$1,139

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

12:53 pm-1:43 pm

2 stops24h 50m

Panama City Tocumen Intl

Mon 12/1

2:43 pm-1:34 pm

2 stops22h 51m

$1,151

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

7:05 am-7:59 pm

2 stops12h 54m

Panama City Tocumen Intl

Fri 12/5

3:46 pm-12:11 am

1 stop8h 25m

$1,290

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

7:05 am-7:59 pm

2 stops12h 54m

Panama City Tocumen Intl

Mon 12/1

3:37 pm-12:15 am

1 stop8h 38m

$1,584

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 11/21

7:05 am-7:59 pm

2 stops12h 54m

Panama City Tocumen Intl

Mon 12/1

3:37 pm-12:15 am

1 stop8h 38m

$1,594

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama from

How to get the cheapest flight ticket from Roanoke to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from Roanoke. The lowest ticket price found for a Tuesday departure recently was $437. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Roanoke to Panama for around $643.

Cheap Roanoke to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Panama

Direct flights

None
There are no direct flights from Roanoke to Panama. There are no popular flight routes from Roanoke to Panama.
  • When did momondo last update prices for flights from Roanoke Airport to Panama?

    Prices for flights from Roanoke Airport to Panama refresh daily.

  • How old do you have to be to fly from Roanoke Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Panama?

Finding the right flight to Panama from Roanoke is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama quick and easy, saving you time and money.

Can I find flights from Roanoke to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Roanoke on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Roanoke to Panama?

momondo helps you find the best flight between Roanoke and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Roanoke to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Roanoke to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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1 adult
Fri 11/21
Fri 11/28

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