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Cheap flights from Panama City, Florida to Sioux Falls from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Sioux Falls departing on 4/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Sioux Falls

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:00 pm - 11:30 pm
ECP
-
FSD
6h 30m
1 stop
Delta Logo
4:19 pm - 10:39 pm
FSD
-
ECP
6h 20m
2 stops
$409Delta
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
6:42 am - 12:41 pm
ECP
-
FSD
5h 59m
1 stop
American Airlines Logo
5:44 am - 12:08 pm
FSD
-
ECP
6h 24m
1 stop
$416American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
6:42 am - 12:41 pm
ECP
-
FSD
5h 59m
1 stop
American Airlines Logo
12:14 pm - 11:49 pm
FSD
-
ECP
11h 35m
2 stops
$421American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
3:38 pm - 9:40 pm
ECP
-
FSD
6h 02m
1 stop
American Airlines Logo
7:00 am - 12:21 pm
FSD
-
ECP
5h 21m
1 stop
$435American Airlines
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
8:20 am - 7:10 pm
ECP
-
FSD
10h 50m
2 stops
American Airlines Logo
12:14 pm - 11:49 pm
FSD
-
ECP
11h 35m
2 stops
$467American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
3:00 pm - 10:55 pm
ECP
-
FSD
7h 55m
1 stop
American Airlines Logo
6:50 am - 2:24 pm
FSD
-
ECP
7h 34m
1 stop
$489American Airlines
Fri, Mar 13 - Wed, Mar 18
American Airlines Logo
3:00 pm - 10:55 pm
ECP
-
FSD
7h 55m
1 stop
American Airlines Logo
2:06 pm - 11:49 pm
FSD
-
ECP
9h 43m
2 stops
$525American Airlines
Fri, Mar 13 - Wed, Mar 18
United Airlines Logo
2:10 pm - 10:02 pm
ECP
-
FSD
7h 52m
1 stop
United Airlines Logo
7:43 am - 1:14 pm
FSD
-
ECP
5h 31m
1 stop
$537United Airlines
Fri, Mar 13 - Thu, Mar 19
American Airlines Logo
10:20 am - 9:40 pm
ECP
-
FSD
11h 20m
2 stops
American Airlines Logo
7:00 am - 10:30 pm
FSD
-
ECP
15h 30m
2 stops
$546American Airlines
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
7:19 am - 7:10 pm
ECP
-
FSD
11h 51m
2 stops
American Airlines Logo
2:06 pm - 11:49 pm
FSD
-
ECP
9h 43m
2 stops
$570American Airlines
Fri, Mar 13 - Wed, Mar 18

Delta flights from Panama City, Florida to Sioux Falls

Our best Delta deals on Panama City, Florida to Sioux Falls flight tickets
Delta
Feb 14
ECP5:00 pmPanama City NW Florida Beaches
6h 30m
1 stop
FSD11:30 pmSioux Falls Joe Foss Field
Feb 18
FSD1:00 pmSioux Falls Joe Foss Field
9h 39m
2 stops
ECP10:39 pmPanama City NW Florida Beaches
$394
Delta
Feb 24
ECP5:00 pmPanama City NW Florida Beaches
6h 30m
1 stop
FSD11:30 pmSioux Falls Joe Foss Field
Feb 28
FSD4:19 pmSioux Falls Joe Foss Field
6h 20m
2 stops
ECP10:39 pmPanama City NW Florida Beaches
$409

American Airlines flights from Panama City, Florida to Sioux Falls

Our best American Airlines deals on Panama City, Florida to Sioux Falls flight tickets
American Airlines
Feb 14
ECP3:00 pmPanama City NW Florida Beaches
8h 03m
1 stop
FSD11:03 pmSioux Falls Joe Foss Field
Feb 18
FSD1:26 pmSioux Falls Joe Foss Field
7h 56m
1 stop
ECP9:22 pmPanama City NW Florida Beaches
$389
American Airlines
Feb 25
ECP6:42 amPanama City NW Florida Beaches
5h 59m
1 stop
FSD12:41 pmSioux Falls Joe Foss Field
Mar 1
FSD5:44 amSioux Falls Joe Foss Field
6h 24m
1 stop
ECP12:08 pmPanama City NW Florida Beaches
$416
American Airlines
Feb 25
ECP6:42 amPanama City NW Florida Beaches
5h 59m
1 stop
FSD12:41 pmSioux Falls Joe Foss Field
Mar 1
FSD12:14 pmSioux Falls Joe Foss Field
11h 35m
2 stops
ECP11:49 pmPanama City NW Florida Beaches
$421

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 2/24

5:00 pm-11:30 pm

1 stop6h 30m

Sioux Falls Joe Foss Field

Sat 2/28

4:19 pm-10:39 pm

2 stops6h 20m

$409

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Wed 2/25

6:42 am-12:41 pm

1 stop5h 59m

Sioux Falls Joe Foss Field

Sun 3/1

5:44 am-12:08 pm

1 stop6h 24m

$416

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Wed 2/25

6:42 am-12:41 pm

1 stop5h 59m

Sioux Falls Joe Foss Field

Sun 3/1

12:14 pm-11:49 pm

2 stops11h 35m

$421

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 2/24

3:38 pm-9:40 pm

1 stop6h 02m

Sioux Falls Joe Foss Field

Sat 2/28

7:00 am-12:21 pm

1 stop5h 21m

$435

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Wed 2/25

8:20 am-7:10 pm

2 stops10h 50m

Sioux Falls Joe Foss Field

Sun 3/1

12:14 pm-11:49 pm

2 stops11h 35m

$467

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Fri 3/13

3:00 pm-10:55 pm

1 stop7h 55m

Sioux Falls Joe Foss Field

Wed 3/18

6:50 am-2:24 pm

1 stop7h 34m

$489

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Fri 3/13

3:00 pm-10:55 pm

1 stop7h 55m

Sioux Falls Joe Foss Field

Wed 3/18

2:06 pm-11:49 pm

2 stops9h 43m

$525

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Fri 3/13

2:10 pm-10:02 pm

1 stop7h 52m

Sioux Falls Joe Foss Field

Thu 3/19

7:43 am-1:14 pm

1 stop5h 31m

$537

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Tue 2/24

10:20 am-9:40 pm

2 stops11h 20m

Sioux Falls Joe Foss Field

Sat 2/28

7:00 am-10:30 pm

2 stops15h 30m

$546

Panama CitySioux Falls

ECP - FSD

ECPFSD

Panama City NW Florida Beaches

Fri 3/13

7:19 am-7:10 pm

2 stops11h 51m

Sioux Falls Joe Foss Field

Wed 3/18

2:06 pm-11:49 pm

2 stops9h 43m

$570

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Sioux Falls from

How to get the cheapest flight ticket from Panama City, Florida to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Panama City, Florida to Sioux Falls flights?

You could potentially save up to 29% on your flight if you consider stops on a Panama City, Florida to Sioux Falls flight.

When to book flights from Panama City, Florida to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Sioux Falls (ECP to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Sioux Falls

Fastest flight time

6h 30m

Direct flights

None
The fastest flight from Panama City, Florida to Sioux Falls takes 6h 30m
There are no direct flights from Panama City, Florida to Sioux Falls. There are no popular flight routes from Panama City, Florida to Sioux Falls.
Search flight deals

  • How far is Panama City NW Florida Beaches to Sioux Falls Joe Foss Field by plane?

    There are 1106.0 mi between Panama City NW Florida Beaches and Sioux Falls Joe Foss Field. Typically, this will take 6h 30m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Sioux Falls Joe Foss Field Airport were last updated today.

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Sioux Falls Joe Foss Field Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Sioux Falls?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Sioux Falls. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Sioux Falls with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Panama City to Sioux Falls flights to just show those with flexible booking policies.

How can momondo help me find flights from Panama City to Sioux Falls?

momondo helps you find the best flight between Panama City and Sioux Falls by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Sioux Falls right now. Can momondo alert me if prices change?

Price alerts on flights to Sioux Falls from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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