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Cheap flights from Panama City, Florida to Central America from $216

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Central America departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City, Florida to Central America

Cheap round-trip flights

Delta Logo
7:00 am - 12:00 pmECP-LIR
6h 00m1 stop
Delta Logo
1:25 pm - 11:03 pmLIR-ECP
8h 38m1 stop
$425Delta
Find Deal
Mon, Sep 29 - Wed, Oct 1
United Airlines Logo
6:30 am - 12:10 pmECP-LIR
6h 40m1 stop
United Airlines Logo
1:20 pm - 9:53 amLIR-ECP
19h 33m1 stop
$433United Airlines
Find Deal
Tue, Sep 16 - Tue, Sep 23
Delta Logo
6:00 am - 10:15 pmECP-SJO
16h 15m1 stop
Delta Logo
2:20 pm - 10:42 pmSJO-ECP
8h 22m1 stop
$464Delta
Find Deal
Tue, Jan 13 - Wed, Jan 28
American Airlines Logo
6:32 am - 7:42 pmECP-SJO
14h 10m2 stops
American Airlines Logo
1:47 pm - 10:00 amSJO-ECP
19h 13m2 stops
$478American Airlines
Find Deal
Tue, Sep 30 - Tue, Mar 10
Delta Logo
6:00 am - 10:15 pmECP-SJO
16h 15m1 stop
Delta Logo
7:00 am - 5:52 pmSJO-ECP
10h 52m1 stop
$483Delta
Find Deal
Sun, Jan 11 - Fri, Jan 23
Delta Logo
6:00 am - 12:43 pmECP-LIR
6h 43m1 stop
Delta Logo
2:10 pm - 10:43 pmLIR-ECP
8h 33m1 stop
$484Delta
Find Deal
Mon, Dec 8 - Sun, Dec 14
Delta Logo
7:45 am - 10:15 pmECP-SJO
14h 30m1 stop
Delta Logo
2:20 pm - 10:42 pmSJO-ECP
8h 22m1 stop
$487Delta
Find Deal
Fri, Jan 9 - Wed, Jan 28
American Airlines Logo
6:48 am - 11:00 pmECP-SJO
16h 12m1 stop
American Airlines Logo
3:50 pm - 9:55 amSJO-ECP
18h 05m1 stop
$492American Airlines
Find Deal
Mon, Jan 12 - Mon, Jan 26
United Airlines Logo
6:30 am - 6:37 pmECP-PTY
12h 07m1 stop
United Airlines Logo
3:30 pm - 4:16 pmPTY-ECP
24h 46m1 stop
$536United Airlines
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Sat, Oct 4 - Sat, Oct 11
Southwest Logo
7:00 am - 6:55 pmECP-SJO
12h 55m1 stop
Southwest Logo
9:40 am - 10:30 pmSJO-ECP
12h 50m2 stops
$546Southwest
Find Deal
Tue, Sep 30 - Sun, Mar 1

American Airlines flights from Panama City, Florida to Central America

Our best American Airlines deals on Panama City, Florida to Central America flight tickets
American Airlines
Sep 30
ECP6:32 amPanama City NW Florida Beaches
14h 10m
2 stops
SJO7:42 pmSan José Juan Santamaria Intl
Mar 10
SJO1:47 pmSan José Juan Santamaria Intl
19h 13m
2 stops
ECP10:00 amPanama City NW Florida Beaches
$478
Find similar
American Airlines
Jan 12
ECP6:48 amPanama City NW Florida Beaches
16h 12m
1 stop
SJO11:00 pmSan José Juan Santamaria Intl
Jan 26
SJO3:50 pmSan José Juan Santamaria Intl
18h 05m
1 stop
ECP9:55 amPanama City NW Florida Beaches
$492
Find similar
American Airlines
Sep 17
ECP6:06 pmPanama City NW Florida Beaches
26h 36m
2 stops
SJO7:42 pmSan José Juan Santamaria Intl
Sep 24
SJO7:27 amSan José Juan Santamaria Intl
12h 45m
1 stop
ECP9:12 pmPanama City NW Florida Beaches
$496
Find similar

Delta flights from Panama City, Florida to Central America

Our best Delta deals on Panama City, Florida to Central America flight tickets
Delta
Sep 29
ECP7:00 amPanama City NW Florida Beaches
6h 00m
1 stop
LIR12:00 pmLiberia
Oct 1
LIR1:25 pmLiberia
8h 38m
1 stop
ECP11:03 pmPanama City NW Florida Beaches
$425
Find similar
Delta
Jan 13
ECP6:00 amPanama City NW Florida Beaches
16h 15m
1 stop
SJO10:15 pmSan José Juan Santamaria Intl
Jan 28
SJO2:20 pmSan José Juan Santamaria Intl
8h 22m
1 stop
ECP10:42 pmPanama City NW Florida Beaches
$464
Find similar
Delta
Jan 11
ECP6:00 amPanama City NW Florida Beaches
16h 15m
1 stop
SJO10:15 pmSan José Juan Santamaria Intl
Jan 23
SJO7:00 amSan José Juan Santamaria Intl
10h 52m
1 stop
ECP5:52 pmPanama City NW Florida Beaches
$483
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Central America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityLiberia

ECP - LIR

ECPLIR

Panama City NW Florida Beaches

Mon 9/29

7:00 am-12:00 pm

1 stop6h 00m

Liberia

Wed 10/1

1:25 pm-11:03 pm

1 stop8h 38m

$425

Panama CityLiberia

ECP - LIR

ECPLIR

Panama City NW Florida Beaches

Tue 9/16

6:30 am-12:10 pm

1 stop6h 40m

Liberia

Tue 9/23

1:20 pm-9:53 am

1 stop19h 33m

$433

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Tue 1/13

6:00 am-10:15 pm

1 stop16h 15m

San José Juan Santamaria Intl

Wed 1/28

2:20 pm-10:42 pm

1 stop8h 22m

$464

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Tue 9/30

6:32 am-7:42 pm

2 stops14h 10m

San José Juan Santamaria Intl

Tue 3/10

1:47 pm-10:00 am

2 stops19h 13m

$478

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Sun 1/11

6:00 am-10:15 pm

1 stop16h 15m

San José Juan Santamaria Intl

Fri 1/23

7:00 am-5:52 pm

1 stop10h 52m

$483

Panama CityLiberia

ECP - LIR

ECPLIR

Panama City NW Florida Beaches

Mon 12/8

6:00 am-12:43 pm

1 stop6h 43m

Liberia

Sun 12/14

2:10 pm-10:43 pm

1 stop8h 33m

$484

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Fri 1/9

7:45 am-10:15 pm

1 stop14h 30m

San José Juan Santamaria Intl

Wed 1/28

2:20 pm-10:42 pm

1 stop8h 22m

$487

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Mon 1/12

6:48 am-11:00 pm

1 stop16h 12m

San José Juan Santamaria Intl

Mon 1/26

3:50 pm-9:55 am

1 stop18h 05m

$492

Panama CityPanama City

ECP - PTY

ECPPTY

Panama City NW Florida Beaches

Sat 10/4

6:30 am-6:37 pm

1 stop12h 07m

Panama City Tocumen Intl

Sat 10/11

3:30 pm-4:16 pm

1 stop24h 46m

$536

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Tue 9/30

7:00 am-6:55 pm

1 stop12h 55m

San José Juan Santamaria Intl

Sun 3/1

9:40 am-10:30 pm

2 stops12h 50m

$546

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Panama City, Florida to Central America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Central America?

In general, October is the cheapest month to fly from Panama City, Florida to Central America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $495. If you don’t want to visit Central America in October, then you should wait until July to fly from Panama City, Florida, when ticket prices are also cheap, with an average price of $526.

What is the cheapest day to depart on your flight to Central America?

The cheapest day to depart from Panama City, Florida to Central America is on a Wednesday. Travelers who choose to depart for Central America on a Wednesday will often find tickets for as low as $543. On the other hand, Monday is the most expensive day to depart from Panama City, Florida because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $810.

Can stopping save me money on Panama City, Florida to Central America flights?

You could potentially save up to 19% on your flight if you consider stops on a Panama City, Florida to Central America flight.

Cheap Panama City, Florida to Central America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Central America

Direct flights

None
There are no direct flights from Panama City, Florida to Central America. There are no popular flight routes from Panama City, Florida to Central America.
Search flight deals

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Central America?

    Prices for flights from Panama City NW Florida Beaches Airport to Central America are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Central America?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Central America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Central America.

  • What documentation or ID do you need to fly to Central America?

    The travel and health documents you'll need for your trip to Central America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Central America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Panama City, Florida to Central America

Compare and see reviews for airlines that fly from Panama City, Florida to Central America with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $404Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
DeltaPriceFrom $419Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $499Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Central America?

Finding the right flight to Central America from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Central America quick and easy, saving you time and money.

Can I find flights from Panama City to Central America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Central America from Panama City with this policy.

How can momondo help me find flights from Panama City to Central America?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Central America from Panama City.

I’m not ready to book a flight from Panama City to Central America right now. Can momondo alert me if prices change?

Price alerts on flights to Central America from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Central America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to Central America

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Popular flights according to clicks in the last 7 days on momondo
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