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Cheap flights from Myrtle Beach to Chicago from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Chicago departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Myrtle Beach to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
4:20 pm - 7:20 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 00m1 stop Nashville Intl
Southwest Logo
1:40 pm - 4:40 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 00mnonstop
$190Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
4:20 pm - 7:20 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 00m1 stop Nashville Intl
Southwest Logo
8:55 am - 1:45 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
3h 50m1 stop Nashville Intl
$200Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
11:55 am - 4:10 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
5h 15m1 stop Lambert-St Louis
Southwest Logo
1:40 pm - 4:40 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 00mnonstop
$207Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
4:20 pm - 7:20 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 00m1 stop Nashville Intl
Southwest Logo
1:40 pm - 4:40 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 00mnonstop
$207Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
11:45 am - 5:10 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
6h 25m2 stops Baltimore/Washington Greater Rochester Intl
Southwest Logo
1:40 pm - 4:40 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 00mnonstop
$212Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
11:45 am - 5:10 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
6h 25m2 stops Baltimore/Washington Greater Rochester Intl
Southwest Logo
8:55 am - 1:45 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
3h 50m1 stop Nashville Intl
$222Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
11:55 am - 4:10 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
5h 15m1 stop Lambert-St Louis
Southwest Logo
8:55 am - 7:20 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
9h 25m1 stop Nashville Intl
$222Southwest
Sat, Sep 5 - Sun, Sep 6
Delta Logo
11:43 am - 3:44 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
5h 01m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:39 pm - 9:49 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
4h 10m1 stop Atlanta Hartsfield-Jackson
$263Delta
Tue, Sep 1 - Sat, Sep 5
Delta Logo
7:01 pm - 10:56 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
1:00 pm - 6:06 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
4h 06m1 stop Atlanta Hartsfield-Jackson
$309Delta
Wed, Nov 11 - Mon, Nov 16
Delta Logo
11:43 am - 3:38 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:39 pm - 9:49 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
4h 10m1 stop Atlanta Hartsfield-Jackson
$326Delta
Sat, Aug 29 - Sat, Sep 5

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Southwest flights from Myrtle Beach to Chicago Midway Airport

Our best Southwest deals on Myrtle Beach to Chicago Midway Airport flight tickets
Southwest
Sep 5
MYR4:20 pmMyrtle Beach Intl
4h 00m
1 stop
MDW7:20 pmChicago Midway
Sep 6
MDW1:40 pmChicago Midway
2h 00m
MYR4:40 pmMyrtle Beach Intl
$190
Southwest
Sep 5
MYR4:20 pmMyrtle Beach Intl
4h 00m
1 stop
MDW7:20 pmChicago Midway
Sep 6
MDW8:55 amChicago Midway
3h 50m
1 stop
MYR1:45 pmMyrtle Beach Intl
$200
Southwest
Sep 5
MYR11:55 amMyrtle Beach Intl
5h 15m
1 stop
MDW4:10 pmChicago Midway
Sep 6
MDW1:40 pmChicago Midway
2h 00m
MYR4:40 pmMyrtle Beach Intl
$207

Delta flights from Myrtle Beach to Chicago Midway Airport

Our best Delta deals on Myrtle Beach to Chicago Midway Airport flight tickets
Delta
Sep 1
MYR11:43 amMyrtle Beach Intl
5h 01m
1 stop
MDW3:44 pmChicago Midway
Sep 5
MDW4:39 pmChicago Midway
4h 10m
1 stop
MYR9:49 pmMyrtle Beach Intl
$263
Delta
Aug 29
MYR11:43 amMyrtle Beach Intl
4h 55m
1 stop
MDW3:38 pmChicago Midway
Sep 5
MDW4:39 pmChicago Midway
4h 10m
1 stop
MYR9:49 pmMyrtle Beach Intl
$326
Delta
Aug 29
MYR11:43 amMyrtle Beach Intl
4h 55m
1 stop
MDW3:38 pmChicago Midway
Sep 5
MDW4:39 pmChicago Midway
4h 10m
1 stop
MYR9:49 pmMyrtle Beach Intl
$357

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

4:20 pm-7:20 pm

1 stop4h 00m

Chicago Midway

Sun 9/6

1:40 pm-4:40 pm

Nonstop2h 00m

$190

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

4:20 pm-7:20 pm

1 stop4h 00m

Chicago Midway

Sun 9/6

8:55 am-1:45 pm

1 stop3h 50m

$200

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

11:55 am-4:10 pm

1 stop5h 15m

Chicago Midway

Sun 9/6

1:40 pm-4:40 pm

Nonstop2h 00m

$207

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

4:20 pm-7:20 pm

1 stop4h 00m

Chicago Midway

Sun 9/6

1:40 pm-4:40 pm

Nonstop2h 00m

$207

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

11:45 am-5:10 pm

2 stops6h 25m

Chicago Midway

Sun 9/6

1:40 pm-4:40 pm

Nonstop2h 00m

$212

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

11:45 am-5:10 pm

2 stops6h 25m

Chicago Midway

Sun 9/6

8:55 am-1:45 pm

1 stop3h 50m

$222

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

11:55 am-4:10 pm

1 stop5h 15m

Chicago Midway

Sun 9/6

8:55 am-7:20 pm

1 stop9h 25m

$222

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Tue 9/1

11:43 am-3:44 pm

1 stop5h 01m

Chicago Midway

Sat 9/5

4:39 pm-9:49 pm

1 stop4h 10m

$263

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Wed 11/11

7:01 pm-10:56 pm

1 stop4h 55m

Chicago Midway

Mon 11/16

1:00 pm-6:06 pm

1 stop4h 06m

$309

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 8/29

11:43 am-3:38 pm

1 stop4h 55m

Chicago Midway

Sat 9/5

4:39 pm-9:49 pm

1 stop4h 10m

$326

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Myrtle Beach to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Saturday is the cheapest day to fly to Chicago Midway Airport from Myrtle Beach. The lowest ticket price found for a Saturday departure recently was $403. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Sunday is the most expensive day to depart from Myrtle Beach because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $528.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Myrtle Beach in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $422 when looking at flights departing in the afternoon. Try not to purchase tickets in the evening because they tend to be around $492. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Myrtle Beach Intl to Chicago Midway flight route?

Fly from Myrtle Beach Intl to Chicago Midway for the best Myrtle Beach Intl - Chicago Midway flight prices

What cabin class options are available on Myrtle Beach to Chicago Midway Airport flights?

There is only 1 cabin class available to choose from on Myrtle Beach to Chicago Midway Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Chicago Midway Airport flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Chicago Midway Airport.

When to book flights from Myrtle Beach to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Chicago Midway Airport (MYR to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Chicago Midway Airport

Best Price Found

$243

Fastest flight time

2h 05m

Direct flights

Every day
The best one-way flight to Chicago Midway Airport from Myrtle Beach in the past 72 hours is $243. The best round-trip flight deal from Myrtle Beach to Chicago Midway Airport found on momondo in the last 72 hours is $392.
The fastest flight from Myrtle Beach to Chicago Midway Airport takes 2h 05m
Direct flights go from Myrtle Beach to Chicago Midway Airport every day.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Chicago Midway Airport

  • How far is Myrtle Beach Intl to Chicago Midway by plane?

    The distance between Myrtle Beach Intl and Chicago Midway is about 738.5 mi. By plane, this route typically takes 2h 05m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Chicago Midway Airport?

    Prices for flights from Myrtle Beach Intl Airport to Chicago Midway Airport refresh daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Chicago Midway Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The required travel and health documents for your Chicago Midway Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago Midway Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Chicago Midway Airport?

  • What is the most popular airline from Myrtle Beach to Chicago Midway Airport?

Best airlines flying from Myrtle Beach to Chicago Midway Airport

Compare and see reviews for airlines that fly from Myrtle Beach to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $271Free CancellationRating
8.0
4,218 reviews
Search Southwest flights

  • Southwest Flights From Myrtle Beach to Chicago Midway Airport

    Southwest operates around 6 flights from Myrtle Beach to Chicago Midway Airport every week. The average price of these flights found in the last 72 hours has been $418, but momondo users have found Southwest deals from Myrtle Beach to Chicago Midway Airport from as low as $271 round-trip. Southwest has been scored 8.0/10 in 4,218 reviews.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
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Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Chicago?

It is quick and easy to find Myrtle Beach to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Myrtle Beach to Chicago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Myrtle Beach to Chicago flights to just show those with flexible booking policies.

How can momondo help me find flights from Myrtle Beach to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Chicago.

I’m not ready to book a flight from Myrtle Beach to Chicago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Chicago, momondo offers a useful price alert feature which will track prices for flights to Chicago from Myrtle Beach and alert you when they change.

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