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Cheap flights from Myrtle Beach to Chicago from $121

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Chicago departing on 10/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Myrtle Beach to Chicago (MYR-MDW)

Cheap round-trip flights

Frontier Logo
4:36 pm - 7:11 amMYR-MDW
15h 35m1 stop
Frontier Logo
8:15 am - 3:19 pmMDW-MYR
6h 04m1 stop
$153Frontier
Find Deal
Thu, Sep 25 - Mon, Sep 29
Frontier Logo
4:36 pm - 7:11 amMYR-MDW
15h 35m1 stop
Frontier Logo
8:15 am - 3:19 pmMDW-MYR
6h 04m1 stop
$155Frontier
Find Deal
Thu, Sep 25 - Mon, Sep 29
Frontier Logo
4:04 pm - 9:51 amMYR-MDW
18h 47m2 stops
Frontier Logo
8:15 am - 3:19 pmMDW-MYR
6h 04m1 stop
$193Frontier
Find Deal
Fri, Sep 19 - Mon, Sep 22
Frontier Logo
3:49 pm - 10:47 pmMYR-MDW
31h 58m2 stops
Frontier Logo
8:25 am - 3:04 pmMDW-MYR
5h 39m1 stop
$198Frontier
Find Deal
Fri, Oct 10 - Sun, Oct 12
Southwest Logo
6:30 am - 7:40 amMYR-MDW
2h 10mnonstop
Southwest Logo
2:30 pm - 5:25 pmMDW-MYR
1h 55mnonstop
$255Southwest
Find Deal
Tue, Sep 30 - Tue, Oct 7
Logo
12:06 pm - 11:25 pmMYR-MDW
12h 19m1 stop
Logo
5:56 pm - 8:55 pmMDW-MYR
25h 59m1 stop
$257
Find Deal
Tue, Oct 7 - Tue, Oct 14
Southwest Logo
7:10 am - 8:20 amMYR-MDW
2h 10mnonstop
Southwest Logo
1:45 pm - 4:40 pmMDW-MYR
1h 55mnonstop
$264Southwest
Find Deal
Tue, Oct 28 - Sat, Nov 1
Logo
1:12 pm - 11:25 pmMYR-MDW
11h 13m1 stop
Logo
11:57 am - 6:43 pmMDW-MYR
5h 46m1 stop
$275
Find Deal
Thu, Oct 23 - Sun, Oct 26
Delta Logo
6:00 am - 9:40 amMYR-MDW
4h 40m1 stop
Delta Logo
6:00 am - 1:50 pmMDW-MYR
6h 50m1 stop
$284Delta
Find Deal
Thu, Oct 2 - Tue, Oct 7
Delta Logo
10:55 am - 4:25 pmMYR-MDW
6h 30m1 stop
Delta Logo
6:00 am - 1:29 pmMDW-MYR
6h 29m1 stop
$307Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4

Southwest flights from Myrtle Beach to Chicago Midway Airport

Our best Southwest deals on Myrtle Beach to Chicago Midway Airport flight tickets
Southwest
Sep 30
MYR6:30 amMyrtle Beach Intl
2h 10m
MDW7:40 amChicago Midway
Oct 7
MDW2:30 pmChicago Midway
1h 55m
MYR5:25 pmMyrtle Beach Intl
$255
Find similar
Southwest
Oct 28
MYR7:10 amMyrtle Beach Intl
2h 10m
MDW8:20 amChicago Midway
Nov 1
MDW1:45 pmChicago Midway
1h 55m
MYR4:40 pmMyrtle Beach Intl
$264
Find similar
Southwest
Sep 30
MYR8:20 amMyrtle Beach Intl
4h 25m
1 stop
MDW11:45 amChicago Midway
Oct 7
MDW2:30 pmChicago Midway
1h 55m
MYR5:25 pmMyrtle Beach Intl
$265
Find similar

Frontier flights from Myrtle Beach to Chicago Midway Airport

Our best Frontier deals on Myrtle Beach to Chicago Midway Airport flight tickets
Frontier
Sep 25
MYR4:36 pmMyrtle Beach Intl
15h 35m
1 stop
MDW7:11 amChicago Midway
Sep 29
MDW8:15 amChicago Midway
6h 04m
1 stop
MYR3:19 pmMyrtle Beach Intl
$153
Find similar
Frontier
Sep 25
MYR4:36 pmMyrtle Beach Intl
15h 35m
1 stop
MDW7:11 amChicago Midway
Sep 29
MDW8:15 amChicago Midway
6h 04m
1 stop
MYR3:19 pmMyrtle Beach Intl
$155
Find similar
Frontier
Sep 19
MYR4:04 pmMyrtle Beach Intl
18h 47m
2 stops
MDW9:51 amChicago Midway
Sep 22
MDW8:15 amChicago Midway
6h 04m
1 stop
MYR3:19 pmMyrtle Beach Intl
$193
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momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Thu 9/25

4:36 pm-7:11 am

1 stop15h 35m

Chicago Midway

Mon 9/29

8:15 am-3:19 pm

1 stop6h 04m

$153

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Thu 9/25

4:36 pm-7:11 am

1 stop15h 35m

Chicago Midway

Mon 9/29

8:15 am-3:19 pm

1 stop6h 04m

$155

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Fri 9/19

4:04 pm-9:51 am

2 stops18h 47m

Chicago Midway

Mon 9/22

8:15 am-3:19 pm

1 stop6h 04m

$193

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Fri 10/10

3:49 pm-10:47 pm

2 stops31h 58m

Chicago Midway

Sun 10/12

8:25 am-3:04 pm

1 stop5h 39m

$198

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Tue 9/30

6:30 am-7:40 am

Nonstop2h 10m

Chicago Midway

Tue 10/7

2:30 pm-5:25 pm

Nonstop1h 55m

$255

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Tue 10/7

12:06 pm-11:25 pm

1 stop12h 19m

Chicago Midway

Tue 10/14

5:56 pm-8:55 pm

1 stop25h 59m

$257

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Tue 10/28

7:10 am-8:20 am

Nonstop2h 10m

Chicago Midway

Sat 11/1

1:45 pm-4:40 pm

Nonstop1h 55m

$264

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Thu 10/23

1:12 pm-11:25 pm

1 stop11h 13m

Chicago Midway

Sun 10/26

11:57 am-6:43 pm

1 stop5h 46m

$275

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Thu 10/2

6:00 am-9:40 am

1 stop4h 40m

Chicago Midway

Tue 10/7

6:00 am-1:50 pm

1 stop6h 50m

$284

Myrtle BeachChicago

MYR - MDW

MYRMDW

Myrtle Beach Intl

Tue 3/3

10:55 am-4:25 pm

1 stop6h 30m

Chicago Midway

Wed 3/4

6:00 am-1:29 pm

1 stop6h 29m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Myrtle Beach to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Wednesday is the cheapest day to fly to Chicago Midway Airport from Myrtle Beach. The lowest ticket price found for a Wednesday departure recently was $412. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Sunday is the most expensive day to depart from Myrtle Beach because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $462.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from Myrtle Beach in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $396 when looking at flights departing in the afternoon. Try not to purchase tickets at noon because they tend to be around $484. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Myrtle Beach Intl to Chicago Midway flight route?

Fly from Myrtle Beach Intl to Chicago Midway for the best Myrtle Beach Intl - Chicago Midway flight prices

What cabin class options are available on Myrtle Beach Intl to Chicago Midway flights?

There is only 1 cabin class available to choose from on Myrtle Beach Intl to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Myrtle Beach to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Chicago Midway Airport (MYR to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Chicago Midway Airport

Best Price Found

$129

Fastest flight time

2h 05m

Direct flights

Every day
The best one-way flight to Chicago Midway Airport from Myrtle Beach in the past 72 hours is $129. The best round-trip flight deal from Myrtle Beach to Chicago Midway Airport found on momondo in the last 72 hours is $261.
The fastest flight from Myrtle Beach to Chicago Midway Airport takes 2h 05m
Direct flights go from Myrtle Beach to Chicago Midway Airport every day.
Search flight deals

  • How far is Myrtle Beach Intl to Chicago Midway by plane?

    The distance between Myrtle Beach Intl and Chicago Midway is about 738.5 mi. By plane, this route typically takes 2h 05m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Chicago Midway Airport?

    Prices for flights from Myrtle Beach Intl Airport to Chicago Midway Airport refresh daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Chicago Midway Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Chicago Midway Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The required travel and health documents for your Chicago Midway Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago Midway Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Chicago Midway Airport?

  • What is the most popular airline from Myrtle Beach to Chicago Midway Airport?

Best airlines flying from Myrtle Beach to Chicago Midway Airport

Compare and see reviews for airlines that fly from Myrtle Beach to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $239Free CancellationRating
8.0
4,241 reviews
Search Southwest flights

  • Southwest Flights From Myrtle Beach to Chicago Midway Airport

    Southwest operates around 5 flights from Myrtle Beach to Chicago Midway Airport every week. The average price of these flights found in the last 72 hours has been $399, but momondo users have found Southwest deals from Myrtle Beach to Chicago Midway Airport from as low as $239 round-trip. Southwest has been scored 8.0/10 in 4,241 reviews.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Lansing
Portage
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Chicago?

It is quick and easy to find Myrtle Beach to Chicago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Chicago that suits you.

Can I find flights from Myrtle Beach to Chicago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Myrtle Beach to Chicago flights to just show those with flexible booking policies.

How can momondo help me find flights from Myrtle Beach to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Chicago.

I’m not ready to book a flight from Myrtle Beach to Chicago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Chicago, momondo offers a useful price alert feature which will track prices for flights to Chicago from Myrtle Beach and alert you when they change.

An easier way to manage your Chicago Midway Airport trip

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