What airlines fly to Central America?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Central America from Knoxville according to our data. American Airlines is the first choice among our users, with 67% of people opting to fly with this airline when traveling to Central America. Keep in mind that there are 3 different airlines that fly to Central America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Central America?

Avianca, Delta, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Central America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Central America?

Prices for flights from Knoxville McGhee Tyson Airport to Central America refresh daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Central America?

As of May 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Central America.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Central America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Central America.

What documentation or ID do you need to fly to Central America?

The required travel and health documents for your Central America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Central America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$213 Cheap Flights from Knoxville to Central America in 2026

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Find the cheapest flights from Knoxville to Central America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:05 pm - 2:41 pm

TYS

GUA

18h 36m

1 stop

8:27 am - 11:12 pm

GUA

TYS

36h 45m

2 stops

$487Multiple Airlines

Mon, Aug 3 - Thu, Aug 13

5:59 pm - 2:41 pm

TYS

GUA

22h 42m

1 stop

8:27 am - 11:12 pm

GUA

TYS

36h 45m

2 stops

$495Multiple Airlines

Sat, Aug 1 - Thu, Aug 13

6:00 am - 12:24 pm

TYS

PTY

7h 24m

1 stop

1:24 pm - 11:59 pm

PTY

TYS

9h 35m

1 stop

$527American Airlines

Thu, Aug 6 - Thu, Aug 13

7:14 pm - 12:24 pm

TYS

PTY

18h 10m

2 stops

1:24 pm - 10:48 am

PTY

TYS

20h 24m

2 stops

$531American Airlines

Thu, Aug 6 - Thu, Aug 13

7:20 pm - 11:29 am

TYS

SAL

18h 09m

1 stop

3:40 pm - 9:48 am

SAL

TYS

16h 08m

2 stops

$555United Airlines

Mon, Aug 17 - Fri, Aug 21

8:00 am - 6:40 pm

TYS

SJO

12h 40m

2 stops

9:00 am - 9:45 pm

SJO

TYS

10h 45m

2 stops

$556Southwest

Wed, Sep 16 - Sun, Sep 20

7:15 am - 2:14 pm

TYS

PTY

7h 59m

1 stop

3:30 pm - 9:48 am

PTY

TYS

17h 18m

2 stops

$561United Airlines

Mon, Aug 17 - Fri, Aug 21

5:40 am - 1:09 pm

TYS

PTY

8h 29m

1 stop

2:24 pm - 9:38 am

PTY

TYS

18h 14m

1 stop

$573Delta

Mon, Jun 8 - Thu, Jun 18

7:10 am - 6:40 pm

TYS

SJO

13h 30m

2 stops

9:00 am - 9:45 pm

SJO

TYS

10h 45m

2 stops

$588Southwest

Thu, Sep 17 - Sun, Sep 20

7:46 pm - 1:09 pm

TYS

PTY

18h 23m

1 stop

2:24 pm - 9:38 am

PTY

TYS

18h 14m

1 stop

$600Delta

Sun, Jun 7 - Thu, Jun 18

Copa Airlines flights from Knoxville to Central America

Our best Copa Airlines deals on Knoxville to Central America flight tickets

Copa Airlines

Jun 14

TYS7:15 amKnoxville McGhee Tyson

17h 24m

1 stop

SJO10:39 pmSan José Juan Santamaria Intl

Jun 19

SJO12:30 amSan José Juan Santamaria Intl

15h 37m

1 stop

TYS6:07 pmKnoxville McGhee Tyson

$958

Copa Airlines

May 14

TYS6:01 pmKnoxville McGhee Tyson

20h 14m

2 stops

SAL12:15 pmSan Salvador El Salvador Intl

May 16

SAL1:50 pmSan Salvador El Salvador Intl

18h 59m

2 stops

TYS10:49 amKnoxville McGhee Tyson

$1,037

GOL flights from Knoxville to Central America

Our best GOL deals on Knoxville to Central America flight tickets

GOL

Jun 16

TYS6:00 amKnoxville McGhee Tyson

14h 41m

1 stop

SAL6:41 pmSan Salvador El Salvador Intl

Jun 30

SAL12:23 pmSan Salvador El Salvador Intl

20h 35m

2 stops

TYS10:58 amKnoxville McGhee Tyson

$633

GOL

Jun 27

TYS4:43 pmKnoxville McGhee Tyson

20h 43m

2 stops

MGA11:26 amManagua Augusto C Sandino

Jul 8

MGA7:00 amManagua Augusto C Sandino

12h 33m

2 stops

TYS9:33 pmKnoxville McGhee Tyson

$705

GOL

Jun 6

TYS7:59 pmKnoxville McGhee Tyson

17h 50m

2 stops

SJO11:49 amSan José Juan Santamaria Intl

Jun 13

SJO12:51 pmSan José Juan Santamaria Intl

19h 45m

2 stops

TYS10:36 amKnoxville McGhee Tyson

$766

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 8/3

10:05 pm-2:41 pm

1 stop18h 36m

Guatemala City La Aurora

Thu 8/13

8:27 am-11:12 pm

2 stops36h 45m

$487

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 8/1

5:59 pm-2:41 pm

1 stop22h 42m

Guatemala City La Aurora

Thu 8/13

8:27 am-11:12 pm

2 stops36h 45m

$495

Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 8/6

6:00 am-12:24 pm

1 stop7h 24m

Panama City Tocumen Intl

Thu 8/13

1:24 pm-11:59 pm

1 stop9h 35m

$527

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 8/6

7:14 pm-12:24 pm

2 stops18h 10m

Panama City Tocumen Intl

Thu 8/13

1:24 pm-10:48 am

2 stops20h 24m

$531

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Mon 8/17

7:20 pm-11:29 am

1 stop18h 09m

San Salvador El Salvador Intl

Fri 8/21

3:40 pm-9:48 am

2 stops16h 08m

$555

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 9/16

8:00 am-6:40 pm

2 stops12h 40m

San José Juan Santamaria Intl

Sun 9/20

9:00 am-9:45 pm

2 stops10h 45m

$556

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/17

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 8/21

3:30 pm-9:48 am

2 stops17h 18m

$561

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 6/8

5:40 am-1:09 pm

1 stop8h 29m

Panama City Tocumen Intl

Thu 6/18

2:24 pm-9:38 am

1 stop18h 14m

$573

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Thu 9/17

7:10 am-6:40 pm

2 stops13h 30m

San José Juan Santamaria Intl

Sun 9/20

9:00 am-9:45 pm

2 stops10h 45m

$588

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 6/7

7:46 pm-1:09 pm

1 stop18h 23m

Panama City Tocumen Intl

Thu 6/18

2:24 pm-9:38 am

1 stop18h 14m

$600

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Central America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Central America?

In general, July is the cheapest month to fly from Knoxville to Central America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $111. If you don’t want to visit Central America in July, then you should wait until April to fly from Knoxville, when ticket prices are also cheap, with an average price of $114.

Can stopping save me money on Knoxville to Central America flights?

You could potentially save up to 21% on your flight if you consider stops on a Knoxville to Central America flight.

Cheap Knoxville to Central America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Central America

Fastest flight time	6h 00m
Direct flights	None

The fastest flight from Knoxville to Central America takes 6h 00m

There are no direct flights from Knoxville to Central America. There are no popular flight routes from Knoxville to Central America.

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Frequently asked questions about flying from Knoxville to Central America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Central America?
Prices for flights from Knoxville McGhee Tyson Airport to Central America refresh daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Central America?
As of May 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Central America.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Central America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Central America.
What documentation or ID do you need to fly to Central America?
The required travel and health documents for your Central America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Central America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Central America

Compare and see reviews for airlines that fly from Knoxville to Central America with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $261	Free Cancellation	Rating 7.4 9,701 reviews	Search United Airlines flights
American Airlines	PriceFrom $414	Free Cancellation	Rating 7.1 11,661 reviews	Search American Airlines flights
Delta	PriceFrom $536	Free Cancellation	Rating 7.9 8,446 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Central America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Central America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Central America with flexible booking policies on momondo?

Yes. All flights to Central America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Central America?

momondo helps you find the best flight between Knoxville and Central America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Central America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Central America from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.