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Cheap flights from Knoxville to Central America from $134

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Central America departing on 9/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Central America

Cheap round-trip flights

Logo
4:31 pm - 11:14 amTYS-SJO
20h 43m1 stop
Logo
12:19 pm - 11:18 amSJO-TYS
20h 59m1 stop
$288
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Wed, Sep 17 - Wed, Sep 24
Logo
4:31 pm - 10:27 amTYS-SJO
19h 56m2 stops
Logo
12:19 pm - 11:18 amSJO-TYS
20h 59m1 stop
$304
Find Deal
Wed, Sep 17 - Wed, Sep 24
American Airlines Logo
8:36 pm - 11:35 amTYS-SAL
16h 59m2 stops
American Airlines Logo
12:35 pm - 11:50 pmSAL-TYS
9h 15m1 stop
$419American Airlines
Find Deal
Sun, Sep 14 - Fri, Sep 19
American Airlines Logo
6:10 am - 11:35 amTYS-SAL
7h 25m1 stop
American Airlines Logo
12:35 pm - 11:50 pmSAL-TYS
9h 15m1 stop
$453American Airlines
Find Deal
Fri, Sep 5 - Sun, Sep 7
Avianca Logo
5:50 am - 3:35 amTYS-SJO
22h 45m1 stop
Avianca Logo
5:10 pm - 9:45 amSJO-TYS
15h 35m1 stop
$465Avianca
Find Deal
Sat, Jan 17 - Sat, Jan 24
United Airlines Logo
7:00 am - 7:38 pmTYS-PTY
12h 38m1 stop
United Airlines Logo
4:41 pm - 8:09 pmPTY-TYS
27h 28m1 stop
$497United Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
United Airlines Logo
9:30 am - 6:37 pmTYS-PTY
10h 07m1 stop
United Airlines Logo
3:30 pm - 7:52 pmPTY-TYS
27h 22m1 stop
$517United Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 18
Delta Logo
5:30 am - 1:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
8:05 am - 3:06 pmPTY-TYS
7h 01m1 stop
$557Delta
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Mon, Jan 5 - Sun, Jan 18
Delta Logo
5:45 am - 12:03 pmTYS-RTB
8h 18m1 stop
Delta Logo
1:18 pm - 11:44 pmRTB-TYS
8h 26m1 stop
$571Delta
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Sat, Sep 20 - Sat, Sep 27
Avianca Logo
7:23 pm - 12:50 pmTYS-PTY
17h 27m3 stops
Avianca Logo
2:55 am - 6:42 pmPTY-TYS
15h 47m2 stops
$2,204Avianca
Find Deal
Mon, Jan 5 - Sat, Jan 17

Avianca flights from Knoxville to Central America

Our best Avianca deals on Knoxville to Central America flight tickets
Avianca
Aug 29
TYS5:45 amKnoxville McGhee Tyson
25h 05m
1 stop
GUA4:50 amGuatemala City La Aurora
Sep 8
GUA7:05 pmGuatemala City La Aurora
13h 23m
1 stop
TYS10:28 amKnoxville McGhee Tyson
$450
Find similar
Avianca
Jan 17
TYS5:50 amKnoxville McGhee Tyson
22h 45m
1 stop
SJO3:35 amSan José Juan Santamaria Intl
Jan 24
SJO5:10 pmSan José Juan Santamaria Intl
15h 35m
1 stop
TYS9:45 amKnoxville McGhee Tyson
$465
Find similar
Avianca
Sep 4
TYS7:25 pmKnoxville McGhee Tyson
14h 15m
2 stops
SJO7:40 amSan José Juan Santamaria Intl
Sep 7
SJO3:05 pmSan José Juan Santamaria Intl
17h 23m
2 stops
TYS10:28 amKnoxville McGhee Tyson
$907
Find similar

American Airlines flights from Knoxville to Central America

Our best American Airlines deals on Knoxville to Central America flight tickets
American Airlines
Sep 14
TYS8:36 pmKnoxville McGhee Tyson
16h 59m
2 stops
SAL11:35 amSan Salvador El Salvador Intl
Sep 19
SAL12:35 pmSan Salvador El Salvador Intl
9h 15m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
$419
Find similar
American Airlines
Sep 5
TYS6:10 amKnoxville McGhee Tyson
7h 25m
1 stop
SAL11:35 amSan Salvador El Salvador Intl
Sep 7
SAL12:35 pmSan Salvador El Salvador Intl
9h 15m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
$453
Find similar
American Airlines
Sep 5
TYS6:10 amKnoxville McGhee Tyson
7h 25m
1 stop
SAL11:35 amSan Salvador El Salvador Intl
Sep 7
SAL12:35 pmSan Salvador El Salvador Intl
20h 16m
2 stops
TYS10:51 amKnoxville McGhee Tyson
$457
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 9/17

4:31 pm-11:14 am

1 stop20h 43m

San José Juan Santamaria Intl

Wed 9/24

12:19 pm-11:18 am

1 stop20h 59m

$288

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 9/17

4:31 pm-10:27 am

2 stops19h 56m

San José Juan Santamaria Intl

Wed 9/24

12:19 pm-11:18 am

1 stop20h 59m

$304

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Sun 9/14

8:36 pm-11:35 am

2 stops16h 59m

San Salvador El Salvador Intl

Fri 9/19

12:35 pm-11:50 pm

1 stop9h 15m

$419

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Fri 9/5

6:10 am-11:35 am

1 stop7h 25m

San Salvador El Salvador Intl

Sun 9/7

12:35 pm-11:50 pm

1 stop9h 15m

$453

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sat 1/17

5:50 am-3:35 am

1 stop22h 45m

San José Juan Santamaria Intl

Sat 1/24

5:10 pm-9:45 am

1 stop15h 35m

$465

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 11/13

7:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Sun 11/16

4:41 pm-8:09 pm

1 stop27h 28m

$497

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 10/11

9:30 am-6:37 pm

1 stop10h 07m

Panama City Tocumen Intl

Sat 10/18

3:30 pm-7:52 pm

1 stop27h 22m

$517

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/5

5:30 am-1:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Sun 1/18

8:05 am-3:06 pm

1 stop7h 01m

$557

KnoxvilleCoxen Hole

TYS - RTB

TYSRTB

Knoxville McGhee Tyson

Sat 9/20

5:45 am-12:03 pm

1 stop8h 18m

Coxen Hole Roatan

Sat 9/27

1:18 pm-11:44 pm

1 stop8h 26m

$571

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/5

7:23 pm-12:50 pm

3 stops17h 27m

Panama City Tocumen Intl

Sat 1/17

2:55 am-6:42 pm

2 stops15h 47m

$2,204

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Central America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Central America?

In general, August is the cheapest month to fly from Knoxville to Central America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $511. If you don’t want to visit Central America in August, then you should wait until May to fly from Knoxville, when ticket prices are also cheap, with an average price of $619.

What is the cheapest day to depart on your flight to Central America?

The cheapest day to depart from Knoxville to Central America is on a Wednesday. Travelers who choose to depart for Central America on a Wednesday will often find tickets for as low as $565. On the other hand, Friday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $766.

What is the cheapest time of day to depart on your flight to Central America?

Our data shows that the cheapest Knoxville to Central America flights are usually those with departure times in the evening. Our users have found flights to Central America in the evening for as low as $436. Try not to purchase tickets in the morning because they tend to be around $675. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Central America?

You are more likely to see cheaper flights to Central America from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Central America for around $685 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Central America from Knoxville for as low as $503 on momondo.

Cheap Knoxville to Central America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Central America

Direct flights

None
There are no direct flights from Knoxville to Central America. There are no popular flight routes from Knoxville to Central America.
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  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Central America?

    Prices for flights from Knoxville McGhee Tyson Airport to Central America refresh daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Central America?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Central America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Central America.

  • What documentation or ID do you need to fly to Central America?

    The required travel and health documents for your Central America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Central America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Central America

Compare and see reviews for airlines that fly from Knoxville to Central America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $269Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $382Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $387Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Central America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Central America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Central America with flexible booking policies on momondo?

Yes. All flights to Central America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Central America?

momondo helps you find the best flight between Knoxville and Central America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Central America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Central America from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Central America trip

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Find better results for your trip to Central America

Popular cities in Central America

Popular flights according to clicks in the last 7 days on momondo
Flights to San José, San José Provincefrom $128
Flights to San Salvadorfrom $102
Flights to Guatemala Cityfrom $129
Flights to Panama Cityfrom $272
Flights to Managuafrom $234
Flights to Liberiafrom $235
Flights to San Pedro Sulafrom $110
Flights to Belize Cityfrom $260
Flights to Coxen Holefrom $373
Flights to Floresfrom $458
Flights to Bocas del Torofrom $691
Flights to Davidfrom $359