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Cheap flights from Knoxville to Central America from $151

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Central America departing on 11/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Central America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:43 pm - 2:05 pmTYS-GUA
26h 22m2 stops
Multiple Airlines Logo
1:39 pm - 8:33 amGUA-TYS
17h 54m1 stop
$329Multiple Airlines
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Thu, Dec 4 - Thu, Dec 11
Multiple Airlines Logo
7:20 pm - 5:00 amTYS-GUA
10h 40m1 stop
Multiple Airlines Logo
7:10 pm - 10:57 amGUA-TYS
14h 47m1 stop
$348Multiple Airlines
Find Deal
Tue, Jan 27 - Tue, Feb 3
Delta Logo
5:30 am - 12:35 pmTYS-SAL
9h 05m1 stop
Delta Logo
2:00 pm - 11:46 pmSAL-TYS
7h 46m1 stop
$430Delta
Find Deal
Mon, Apr 27 - Wed, Apr 29
American Airlines Logo
6:00 am - 3:42 pmTYS-PTY
9h 42m1 stop
American Airlines Logo
4:55 pm - 12:38 amPTY-TYS
7h 43m1 stop
$456American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 31
American Airlines Logo
6:18 pm - 1:47 pmTYS-PTY
19h 29m2 stops
American Airlines Logo
4:55 pm - 12:38 amPTY-TYS
7h 43m1 stop
$460American Airlines
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Wed, Dec 10 - Wed, Dec 31
Avianca Logo
7:20 pm - 7:45 amTYS-SJO
13h 25m2 stops
Avianca Logo
4:15 pm - 10:49 amSJO-TYS
17h 34m2 stops
$467Avianca
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Sat, Feb 7 - Sat, Feb 14
United Airlines Logo
9:40 am - 9:51 pmTYS-SAL
13h 11m1 stop
United Airlines Logo
4:40 pm - 7:50 pmSAL-TYS
26h 10m1 stop
$472United Airlines
Find Deal
Wed, Dec 3 - Sun, Feb 8
United Airlines Logo
7:05 am - 7:38 pmTYS-PTY
12h 33m1 stop
United Airlines Logo
8:55 am - 11:44 pmPTY-TYS
14h 49m1 stop
$476United Airlines
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Wed, Dec 3 - Wed, Dec 10
Avianca Logo
9:30 am - 11:40 pmTYS-SJO
15h 10m2 stops
Avianca Logo
5:10 pm - 10:57 amSJO-TYS
16h 47m1 stop
$485Avianca
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Fri, Jan 16 - Sat, Jan 24
Delta Logo
5:30 am - 12:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
2:20 pm - 11:44 pmPTY-TYS
8h 24m1 stop
$516Delta
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Mon, Apr 6 - Tue, Apr 7

American Airlines flights from Knoxville to Central America

Our best American Airlines deals on Knoxville to Central America flight tickets
American Airlines
Dec 10
TYS6:00 amKnoxville McGhee Tyson
9h 42m
1 stop
PTY3:42 pmPanama City Tocumen Intl
Dec 31
PTY4:55 pmPanama City Tocumen Intl
7h 43m
1 stop
TYS12:38 amKnoxville McGhee Tyson
$456
Find similar
American Airlines
Dec 10
TYS6:18 pmKnoxville McGhee Tyson
19h 29m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Dec 31
PTY4:55 pmPanama City Tocumen Intl
7h 43m
1 stop
TYS12:38 amKnoxville McGhee Tyson
$460
Find similar
American Airlines
Dec 3
TYS4:59 pmKnoxville McGhee Tyson
20h 48m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Dec 10
PTY2:50 pmPanama City Tocumen Intl
9h 07m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
$480
Find similar

Avianca flights from Knoxville to Central America

Our best Avianca deals on Knoxville to Central America flight tickets
Avianca
Feb 7
TYS7:20 pmKnoxville McGhee Tyson
13h 25m
2 stops
SJO7:45 amSan José Juan Santamaria Intl
Feb 14
SJO4:15 pmSan José Juan Santamaria Intl
17h 34m
2 stops
TYS10:49 amKnoxville McGhee Tyson
$467
Find similar
Avianca
Jan 16
TYS9:30 amKnoxville McGhee Tyson
15h 10m
2 stops
SJO11:40 pmSan José Juan Santamaria Intl
Jan 24
SJO5:10 pmSan José Juan Santamaria Intl
16h 47m
1 stop
TYS10:57 amKnoxville McGhee Tyson
$485
Find similar
Avianca
Jan 27
TYS9:30 amKnoxville McGhee Tyson
14h 40m
2 stops
GUA11:10 pmGuatemala City La Aurora
Feb 3
GUA8:10 pmGuatemala City La Aurora
13h 47m
2 stops
TYS10:57 amKnoxville McGhee Tyson
$490
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 12/4

12:43 pm-2:05 pm

2 stops26h 22m

Guatemala City La Aurora

Thu 12/11

1:39 pm-8:33 am

1 stop17h 54m

$329

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Tue 1/27

7:20 pm-5:00 am

1 stop10h 40m

Guatemala City La Aurora

Tue 2/3

7:10 pm-10:57 am

1 stop14h 47m

$348

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Mon 4/27

5:30 am-12:35 pm

1 stop9h 05m

San Salvador El Salvador Intl

Wed 4/29

2:00 pm-11:46 pm

1 stop7h 46m

$430

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/10

6:00 am-3:42 pm

1 stop9h 42m

Panama City Tocumen Intl

Wed 12/31

4:55 pm-12:38 am

1 stop7h 43m

$456

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/10

6:18 pm-1:47 pm

2 stops19h 29m

Panama City Tocumen Intl

Wed 12/31

4:55 pm-12:38 am

1 stop7h 43m

$460

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sat 2/7

7:20 pm-7:45 am

2 stops13h 25m

San José Juan Santamaria Intl

Sat 2/14

4:15 pm-10:49 am

2 stops17h 34m

$467

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Wed 12/3

9:40 am-9:51 pm

1 stop13h 11m

San Salvador El Salvador Intl

Sun 2/8

4:40 pm-7:50 pm

1 stop26h 10m

$472

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 12/3

7:05 am-7:38 pm

1 stop12h 33m

Panama City Tocumen Intl

Wed 12/10

8:55 am-11:44 pm

1 stop14h 49m

$476

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Fri 1/16

9:30 am-11:40 pm

2 stops15h 10m

San José Juan Santamaria Intl

Sat 1/24

5:10 pm-10:57 am

1 stop16h 47m

$485

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 4/6

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Tue 4/7

2:20 pm-11:44 pm

1 stop8h 24m

$516

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Central America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Central America?

In general, August is the cheapest month to fly from Knoxville to Central America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $511. If you don’t want to visit Central America in August, then you should wait until March to fly from Knoxville, when ticket prices are also cheap, with an average price of $606.

What is the cheapest day to depart on your flight to Central America?

The cheapest day to depart from Knoxville to Central America is on a Wednesday. Travelers who choose to depart for Central America on a Wednesday will often find tickets for as low as $565. On the other hand, Friday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $766.

What is the cheapest time of day to depart on your flight to Central America?

Our data shows that the cheapest Knoxville to Central America flights are usually those with departure times in the evening. Our users have found flights to Central America in the evening for as low as $436. Try not to purchase tickets in the morning because they tend to be around $675. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Central America?

You are more likely to see cheaper flights to Central America from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Central America for around $666 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Central America from Knoxville for as low as $537 on momondo.

Cheap Knoxville to Central America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Central America

Direct flights

None
There are no direct flights from Knoxville to Central America. There are no popular flight routes from Knoxville to Central America.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Central America?

    Prices for flights from Knoxville McGhee Tyson Airport to Central America refresh daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Central America?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Central America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Central America.

  • What documentation or ID do you need to fly to Central America?

    The required travel and health documents for your Central America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Central America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Central America

Compare and see reviews for airlines that fly from Knoxville to Central America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $269Free CancellationRating
7.9
8,001 reviews
Search Delta flights
American AirlinesPriceFrom $382Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
United AirlinesPriceFrom $387Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Central America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Central America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Central America with flexible booking policies on momondo?

Yes. All flights to Central America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Central America?

momondo helps you find the best flight between Knoxville and Central America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Central America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Central America from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Central America trip

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Find better results for your trip to Central America

Popular cities in Central America

Popular flights according to clicks in the last 7 days on momondo
Flights to San Joséfrom $144
Flights to San Salvadorfrom $102
Flights to Guatemala Cityfrom $145
Flights to Panama Cityfrom $250
Flights to Managuafrom $195
Flights to Liberiafrom $232
Flights to San Pedro Sulafrom $110
Flights to Belize Cityfrom $213
Flights to Coxen Holefrom $330
Flights to Floresfrom $396
Flights to Bocas del Torofrom $685
Flights to Davidfrom $359