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Cheap flights from Detroit to Panama from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$609Multiple Airlines
Wed, Sep 30 - Sun, Oct 4
Multiple Airlines Logo
6:00 am - 10:30 am
DTW
-
PTY
28h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 10:57 pm
PTY
-
DTW
31h 07m
2 stops
$625Multiple Airlines
Thu, Dec 3 - Fri, Dec 11
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$628Multiple Airlines
Thu, Oct 1 - Mon, Oct 5
Multiple Airlines Logo
5:30 pm - 2:55 pm
DTW
-
PTY
22h 25m
3 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$634Multiple Airlines
Fri, Sep 11 - Sat, Sep 19
Multiple Airlines Logo
6:00 am - 1:55 am
DTW
-
PTY
44h 55m
2 stops
Multiple Airlines Logo
3:50 pm - 11:58 pm
PTY
-
DTW
31h 08m
2 stops
$635Multiple Airlines
Sun, Aug 30 - Fri, Sep 4
Multiple Airlines Logo
4:45 pm - 2:55 pm
DTW
-
PTY
23h 10m
3 stops
Multiple Airlines Logo
11:25 am - 3:50 pm
PTY
-
DTW
27h 25m
3 stops
$641Multiple Airlines
Wed, Oct 28 - Fri, Oct 30
Multiple Airlines Logo
6:00 am - 1:55 am
DTW
-
PTY
44h 55m
2 stops
Multiple Airlines Logo
3:50 pm - 11:58 pm
PTY
-
DTW
31h 08m
2 stops
$642Multiple Airlines
Fri, Aug 21 - Fri, Aug 28
Multiple Airlines Logo
6:00 am - 10:30 am
DTW
-
PTY
29h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 11:58 pm
PTY
-
DTW
31h 08m
2 stops
$644Multiple Airlines
Sat, Aug 22 - Sat, Aug 29
Multiple Airlines Logo
10:18 am - 8:19 pm
DTW
-
PTY
11h 01m
1 stop
Multiple Airlines Logo
5:55 pm - 5:22 pm
PTY
-
DTW
46h 27m
2 stops
$648Multiple Airlines
Sat, Aug 22 - Mon, Aug 31
Multiple Airlines Logo
5:30 pm - 2:55 pm
DTW
-
PTY
22h 25m
3 stops
Multiple Airlines Logo
11:25 am - 4:32 pm
PTY
-
DTW
28h 07m
3 stops
$649Multiple Airlines
Wed, Sep 16 - Wed, Sep 30

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Delta flights from Detroit to Panama

Our best Delta deals on Detroit to Panama flight tickets
Delta
Sep 28
DTW5:20 amDetroit Metropolitan Wayne County
8h 38m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Oct 5
PTY2:23 pmPanama City Tocumen Intl
18h 05m
1 stop
DTW9:28 amDetroit Metropolitan Wayne County
$733
Delta
Nov 29
DTW6:00 pmDetroit Metropolitan Wayne County
20h 05m
1 stop
PTY2:05 pmPanama City Tocumen Intl
Dec 9
PTY3:30 pmPanama City Tocumen Intl
17h 58m
1 stop
DTW9:28 amDetroit Metropolitan Wayne County
$744
Delta
Nov 29
DTW6:00 pmDetroit Metropolitan Wayne County
20h 05m
1 stop
PTY2:05 pmPanama City Tocumen Intl
Dec 8
PTY3:30 pmPanama City Tocumen Intl
17h 58m
1 stop
DTW9:28 amDetroit Metropolitan Wayne County
$754

Avianca flights from Detroit to Panama

Our best Avianca deals on Detroit to Panama flight tickets
Avianca
Jul 1
DTW10:15 amDetroit Metropolitan Wayne County
16h 40m
2 stops
PTY1:55 amPanama City Tocumen Intl
Jul 14
PTY11:25 amPanama City Tocumen Intl
35h 26m
3 stops
DTW11:51 pmDetroit Metropolitan Wayne County
$1,141
Avianca
Jul 7
DTW2:35 pmDetroit Metropolitan Wayne County
25h 20m
3 stops
PTY2:55 pmPanama City Tocumen Intl
Jul 17
PTY3:50 pmPanama City Tocumen Intl
26h 12m
2 stops
DTW7:02 pmDetroit Metropolitan Wayne County
$1,288

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 23, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/30

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 10/4

3:50 pm-4:32 pm

2 stops23h 42m

$609

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 12/3

6:00 am-10:30 am

2 stops28h 30m

Panama City Tocumen Intl

Fri 12/11

3:50 pm-10:57 pm

2 stops31h 07m

$625

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 10/1

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Mon 10/5

3:50 pm-4:32 pm

2 stops23h 42m

$628

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 9/11

5:30 pm-2:55 pm

3 stops22h 25m

Panama City Tocumen Intl

Sat 9/19

3:50 pm-4:32 pm

2 stops23h 42m

$634

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 8/30

6:00 am-1:55 am

2 stops44h 55m

Panama City Tocumen Intl

Fri 9/4

3:50 pm-11:58 pm

2 stops31h 08m

$635

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 10/28

4:45 pm-2:55 pm

3 stops23h 10m

Panama City Tocumen Intl

Fri 10/30

11:25 am-3:50 pm

3 stops27h 25m

$641

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 8/21

6:00 am-1:55 am

2 stops44h 55m

Panama City Tocumen Intl

Fri 8/28

3:50 pm-11:58 pm

2 stops31h 08m

$642

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 8/22

6:00 am-10:30 am

2 stops29h 30m

Panama City Tocumen Intl

Sat 8/29

3:50 pm-11:58 pm

2 stops31h 08m

$644

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 8/22

10:18 am-8:19 pm

1 stop11h 01m

Panama City Tocumen Intl

Mon 8/31

5:55 pm-5:22 pm

2 stops46h 27m

$648

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/16

5:30 pm-2:55 pm

3 stops22h 25m

Panama City Tocumen Intl

Wed 9/30

11:25 am-4:32 pm

3 stops28h 07m

$649

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from Detroit, with most prices found around $514. If you don’t want to visit Panama in March, then you should wait until October to fly from Detroit, when ticket prices are also cheap, with an average price of $562.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Fastest flight time

12h 07m

Direct flights

None
The fastest flight from Detroit to Panama takes 12h 07m
There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.
Search flight deals

Frequently asked questions about flying from Detroit to Panama

  • When did momondo last update prices for flights from Detroit to Panama?

    Prices for flights from Detroit to Panama are updated daily.

  • How many operators does momondo search for flights from Detroit to Panama?

  • How old do you have to be to fly from Detroit to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $611Free CancellationRating
7.6
1,566 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $673Free CancellationRating
7.1
11,743 reviews
Search American Airlines flights
United AirlinesPriceFrom $708Free CancellationRating
7.4
9,875 reviews
Search United Airlines flights
DeltaPriceFrom $709Free CancellationRating
7.8
8,425 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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