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Cheap flights from Detroit to Panama from $199

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:40 pm - 8:34 pm
DTW
-
PTY
8h 54m
1 stop
Multiple Airlines Logo
10:26 am - 12:39 am
PTY
-
DTW
13h 13m
1 stop
$552Multiple Airlines
Sat, May 2 - Sat, May 9
Multiple Airlines Logo
6:05 am - 12:35 am
DTW
-
PTY
43h 30m
3 stops
Multiple Airlines Logo
4:25 am - 11:59 pm
PTY
-
DTW
18h 34m
2 stops
$562Multiple Airlines
Tue, Mar 31 - Wed, Apr 8
Multiple Airlines Logo
10:10 pm - 7:39 am
DTW
-
PTY
10h 29m
1 stop
Multiple Airlines Logo
9:12 am - 9:21 pm
PTY
-
DTW
11h 09m
1 stop
$567Multiple Airlines
Sun, Apr 26 - Fri, May 1
Multiple Airlines Logo
9:16 am - 9:15 am
DTW
-
PTY
24h 59m
2 stops
Multiple Airlines Logo
3:10 pm - 7:02 pm
PTY
-
DTW
26h 52m
3 stops
$568Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
4:50 pm - 9:15 am
DTW
-
PTY
17h 25m
2 stops
Multiple Airlines Logo
10:10 am - 8:13 pm
PTY
-
DTW
33h 03m
3 stops
$570Multiple Airlines
Mon, Apr 13 - Mon, Apr 20
Multiple Airlines Logo
4:50 pm - 12:35 am
DTW
-
PTY
32h 45m
2 stops
Multiple Airlines Logo
4:25 am - 11:59 pm
PTY
-
DTW
18h 34m
2 stops
$572Multiple Airlines
Tue, Mar 31 - Wed, Apr 8
Multiple Airlines Logo
6:05 am - 9:15 am
DTW
-
PTY
28h 10m
3 stops
Multiple Airlines Logo
3:10 pm - 8:13 pm
PTY
-
DTW
28h 03m
3 stops
$574Multiple Airlines
Mon, Apr 13 - Mon, Apr 20
Multiple Airlines Logo
6:50 am - 5:00 pm
DTW
-
PTY
35h 10m
3 stops
Multiple Airlines Logo
5:55 pm - 7:02 pm
PTY
-
DTW
24h 07m
3 stops
$581Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
7:21 am - 12:35 am
DTW
-
PTY
18h 14m
2 stops
Multiple Airlines Logo
5:55 pm - 7:02 pm
PTY
-
DTW
24h 07m
3 stops
$588Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
6:05 am - 12:35 am
DTW
-
PTY
43h 30m
3 stops
Multiple Airlines Logo
4:25 am - 10:37 pm
PTY
-
DTW
17h 12m
3 stops
$589Multiple Airlines
Tue, Mar 31 - Wed, Apr 8

American Airlines flights from Detroit to Panama

Our best American Airlines deals on Detroit to Panama flight tickets
American Airlines
Jul 23
DTW5:27 pmDetroit Metropolitan Wayne County
19h 47m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 31
PTY1:14 pmPanama City Tocumen Intl
19h 21m
2 stops
DTW9:35 amDetroit Metropolitan Wayne County
$684
American Airlines
Apr 1
DTW6:00 amDetroit Metropolitan Wayne County
7h 40m
1 stop
PTY12:40 pmPanama City Tocumen Intl
Apr 15
PTY1:49 pmPanama City Tocumen Intl
18h 55m
2 stops
DTW9:44 amDetroit Metropolitan Wayne County
$872
American Airlines
Apr 1
DTW6:00 amDetroit Metropolitan Wayne County
7h 40m
1 stop
PTY12:40 pmPanama City Tocumen Intl
Apr 15
PTY1:49 pmPanama City Tocumen Intl
18h 55m
2 stops
DTW9:44 amDetroit Metropolitan Wayne County
$912

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 5/2

12:40 pm-8:34 pm

1 stop8h 54m

Panama City Tocumen Intl

Sat 5/9

10:26 am-12:39 am

1 stop13h 13m

$552

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/31

6:05 am-12:35 am

3 stops43h 30m

Panama City Tocumen Intl

Wed 4/8

4:25 am-11:59 pm

2 stops18h 34m

$562
Quickest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 4/26

10:10 pm-7:39 am

1 stop10h 29m

Panama City Tocumen Intl

Fri 5/1

9:12 am-9:21 pm

1 stop11h 09m

$567

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 4/15

9:16 am-9:15 am

2 stops24h 59m

Panama City Tocumen Intl

Wed 4/22

3:10 pm-7:02 pm

3 stops26h 52m

$568

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 4/13

4:50 pm-9:15 am

2 stops17h 25m

Panama City Tocumen Intl

Mon 4/20

10:10 am-8:13 pm

3 stops33h 03m

$570

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/31

4:50 pm-12:35 am

2 stops32h 45m

Panama City Tocumen Intl

Wed 4/8

4:25 am-11:59 pm

2 stops18h 34m

$572

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 4/13

6:05 am-9:15 am

3 stops28h 10m

Panama City Tocumen Intl

Mon 4/20

3:10 pm-8:13 pm

3 stops28h 03m

$574

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 4/15

6:50 am-5:00 pm

3 stops35h 10m

Panama City Tocumen Intl

Wed 4/22

5:55 pm-7:02 pm

3 stops24h 07m

$581

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 4/15

7:21 am-12:35 am

2 stops18h 14m

Panama City Tocumen Intl

Wed 4/22

5:55 pm-7:02 pm

3 stops24h 07m

$588

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/31

6:05 am-12:35 am

3 stops43h 30m

Panama City Tocumen Intl

Wed 4/8

4:25 am-10:37 pm

3 stops17h 12m

$589

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Fastest flight time

8h 54m

Direct flights

None
The fastest flight from Detroit to Panama takes 8h 54m
There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.
Search flight deals

  • When did momondo last update prices for flights from Detroit to Panama?

    Prices for flights from Detroit to Panama are updated daily.

  • How many operators does momondo search for flights from Detroit to Panama?

  • How old do you have to be to fly from Detroit to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $514Free CancellationRating
7.5
1,572 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $608Free CancellationRating
7.4
9,443 reviews
Search United Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
8,300 reviews
Search Delta flights
American AirlinesPriceFrom $628Free CancellationRating
7.1
11,476 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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