What airlines fly to Panama?

Copa Airlines, Delta and American Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. Copa Airlines is the first choice among our users, with 27% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Detroit to Panama?

United Airlines is the most popular carrier operating from Detroit to Panama

When did momondo last update prices for flights from Detroit to Panama?

Prices for flights from Detroit to Panama are updated daily.

How many operators does momondo search for flights from Detroit to Panama?

As of November 2026, there are 4 operators available to choose from for flights from Detroit to Panama.

How old do you have to be to fly from Detroit to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$252 Cheap Flights from Detroit to Panama in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:15 am - 8:02 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

8h 47m1 stop Newark

8:55 am - 10:45 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

13h 50m1 stop Houston George Bush Intcntl

$569United Airlines

Tue, Jan 26 - Tue, Feb 2

8:35 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

11h 03m1 stop Houston George Bush Intcntl

10:00 am - 9:07 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

11h 07m1 stop Newark

$569United Airlines

Wed, Jan 27 - Thu, Feb 4

4:59 pm - 1:25 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

20h 26m2 stops Washington, D.C. Reagan-National Miami

3:24 pm - 1:06 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

20h 42m2 stops Miami Chicago O'Hare Intl

$574American Airlines

Tue, Feb 16 - Wed, Mar 31

7:40 pm - 2:24 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

19h 44m2 stops Dallas/Fort Worth Miami

1:49 pm - 9:30 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

18h 41m2 stops Miami Charlotte Douglas

$574American Airlines

Mon, Mar 29 - Tue, Apr 6

9:00 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 38m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

8:55 am - 11:44 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

14h 49m1 stop Houston George Bush Intcntl

$673Copa Airlines

Sat, Feb 13 - Tue, Mar 2

7:51 pm - 2:04 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 13m1 stop Atlanta Hartsfield-Jackson

2:25 pm - 9:28 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

18h 03m1 stop Atlanta Hartsfield-Jackson

$703Delta

Sun, Jan 10 - Thu, Mar 18

7:35 am - 9:51 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

14h 16m1 stop Atlanta Hartsfield-Jackson

2:25 pm - 9:28 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

18h 03m1 stop Atlanta Hartsfield-Jackson

$728Delta

Sat, Jan 9 - Thu, Mar 18

6:00 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

13h 38m1 stop Houston George Bush Intcntl

10:00 am - 9:54 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

11h 54m1 stop Newark

$756Copa Airlines

Sat, Feb 13 - Tue, Mar 2

9:33 pm - 8:19 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

22h 46m1 stop Fort Lauderdale

6:30 pm - 3:16 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

20h 46m2 stops Miami Houston George Bush Intcntl

$776Multiple Airlines

Wed, Dec 9 - Sat, Dec 12

8:20 pm - 4:01 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

19h 41m2 stops Dallas/Fort Worth Miami

12:03 pm - 9:13 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

21h 10m1 stop Fort Lauderdale

$780Multiple Airlines

Tue, Jan 26 - Sun, Jan 31

Cheap last minute flights

Enter your travel dates to find the best prices.

7:00 am - 8:02 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

13h 02m1 stop Newark

10:00 am - 11:44 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

13h 44m1 stop Newark

$711United Airlines

Mon, Nov 9 - Mon, Nov 16

8:45 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 53m1 stop Houston George Bush Intcntl

4:41 pm - 1:28 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

20h 47m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$716United Airlines

Mon, Nov 9 - Mon, Nov 16

8:45 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 53m1 stop Houston George Bush Intcntl

10:00 am - 8:58 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

10h 58m1 stop Newark

$721United Airlines

Sat, Nov 7 - Thu, Nov 12

7:22 pm - 2:13 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 51m2 stops New York LaGuardia Miami

3:13 pm - 9:27 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

18h 14m2 stops Miami Chicago O'Hare Intl

$788American Airlines

Mon, Nov 9 - Mon, Nov 16

2:55 pm - 5:15 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

26h 20m3 stops Atlanta Hartsfield-Jackson Miami Bogotá El Dorado

2:30 am - 12:44 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

22h 14m3 stops Bogotá El Dorado Miami Atlanta Hartsfield-Jackson

$898Multiple Airlines

Mon, Nov 9 - Sun, Nov 15

10:07 am - 5:15 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

31h 08m3 stops Dallas/Fort Worth Miami Bogotá El Dorado

4:10 pm - 3:30 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

23h 20m3 stops Bogotá El Dorado Miami Denver Intl

$1,010Multiple Airlines

Sat, Nov 7 - Fri, Nov 13

7:24 pm - 2:13 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 49m2 stops Dallas/Fort Worth Miami

3:13 pm - 12:53 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

21h 40m2 stops Miami Charlotte Douglas

$1,024American Airlines

Sun, Nov 8 - Sat, Nov 14

7:24 pm - 2:13 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 49m2 stops Dallas/Fort Worth Miami

3:13 pm - 12:53 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

21h 40m2 stops Miami Charlotte Douglas

$1,044American Airlines

Sun, Nov 8 - Sat, Nov 14

5:45 am - 6:59 pmDTW Detroit Metropolitan Wayne County-DAV David Enrique Malek

13h 14m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl

9:20 am - 10:06 amDAV David Enrique Malek-DTW Detroit Metropolitan Wayne County

23h 46m2 stops Panama City Tocumen Intl Washington, D.C. Dulles Intl

$1,101Copa Airlines

Tue, Nov 10 - Tue, May 4

10:48 am - 8:50 amDTW Detroit Metropolitan Wayne County-DAV David Enrique Malek

22h 02m2 stops Chicago O'Hare Intl Panama City Tocumen Intl

9:20 am - 10:06 amDAV David Enrique Malek-DTW Detroit Metropolitan Wayne County

23h 46m2 stops Panama City Tocumen Intl Washington, D.C. Dulles Intl

$1,139Copa Airlines

Tue, Nov 10 - Tue, May 4

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

United Airlines

Jan 25

DTW11:15 amDetroit Metropolitan Wayne County

8h 47m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Feb 4

PTY8:55 amPanama City Tocumen Intl

13h 50m

1 stop

DTW10:45 pmDetroit Metropolitan Wayne County

$569

United Airlines

Jan 12

DTW7:00 amDetroit Metropolitan Wayne County

12h 38m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Jan 21

PTY8:55 amPanama City Tocumen Intl

13h 50m

1 stop

DTW10:45 pmDetroit Metropolitan Wayne County

$574

United Airlines

Feb 15

DTW8:15 amDetroit Metropolitan Wayne County

11h 47m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Apr 1

PTY10:55 pmPanama City Tocumen Intl

23h 09m

1 stop

DTW11:04 pmDetroit Metropolitan Wayne County

$577

Copa Airlines flights from Detroit to Panama

Our best Copa Airlines deals on Detroit to Panama flight tickets

Copa Airlines

Feb 13

DTW9:00 amDetroit Metropolitan Wayne County

10h 38m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Mar 2

PTY8:55 amPanama City Tocumen Intl

14h 49m

1 stop

DTW11:44 pmDetroit Metropolitan Wayne County

$673

Copa Airlines

Nov 10

DTW5:45 amDetroit Metropolitan Wayne County

13h 14m

2 stops

DAV6:59 pmDavid Enrique Malek

May 4

DAV9:20 amDavid Enrique Malek

23h 46m

2 stops

DTW10:06 amDetroit Metropolitan Wayne County

$1,101

Copa Airlines

Feb 1

DTW7:50 pmDetroit Metropolitan Wayne County

12h 59m

2 stops

DAV8:49 amDavid Enrique Malek

Feb 14

DAV8:47 amDavid Enrique Malek

34h 04m

2 stops

DTW6:51 pmDetroit Metropolitan Wayne County

$1,148

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Tue 1/26

11:15 am-8:02 pm

1 stop8h 47m

Panama City Tocumen Intl

Tue 2/2

8:55 am-10:45 pm

1 stop13h 50m

$569

Quickest round-trip

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/27

8:35 am-7:38 pm

1 stop11h 03m

Panama City Tocumen Intl

Thu 2/4

10:00 am-9:07 pm

1 stop11h 07m

$569

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Tue 2/16

4:59 pm-1:25 pm

2 stops20h 26m

Panama City Tocumen Intl

Wed 3/31

3:24 pm-1:06 pm

2 stops20h 42m

$574

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/29

7:40 pm-2:24 pm

2 stops19h 44m

Panama City Tocumen Intl

Tue 4/6

1:49 pm-9:30 am

2 stops18h 41m

$574

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 2/13

9:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Tue 3/2

8:55 am-11:44 pm

1 stop14h 49m

$673

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sun 1/10

7:51 pm-2:04 pm

1 stop18h 13m

Panama City Tocumen Intl

Thu 3/18

2:25 pm-9:28 am

1 stop18h 03m

$703

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 1/9

7:35 am-9:51 pm

1 stop14h 16m

Panama City Tocumen Intl

Thu 3/18

2:25 pm-9:28 am

1 stop18h 03m

$728

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 2/13

6:00 am-7:38 pm

1 stop13h 38m

Panama City Tocumen Intl

Tue 3/2

10:00 am-9:54 pm

1 stop11h 54m

$756

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/9

9:33 pm-8:19 pm

1 stop22h 46m

Panama City Tocumen Intl

Sat 12/12

6:30 pm-3:16 pm

2 stops20h 46m

$776

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Tue 1/26

8:20 pm-4:01 pm

2 stops19h 41m

Panama City Tocumen Intl

Sun 1/31

12:03 pm-9:13 am

1 stop21h 10m

$780

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of January is, on average, the cheapest month to fly to Panama from Detroit, with most prices found around $812. If you don’t want to visit Panama in January, then you should wait until August to fly from Detroit, when ticket prices are also cheap, with an average price of $829.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Best Price Found	$252
Fastest flight time	8h 39m
Direct flights	None

The best one-way flight to Panama from Detroit in the past 72 hours is $252. The best round-trip flight deal from Detroit to Panama found on momondo in the last 72 hours is $569.

The fastest flight from Detroit to Panama takes 8h 39m

There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.

Search flight deals

Frequently asked questions about flying from Detroit to Panama

When did momondo last update prices for flights from Detroit to Panama?
Prices for flights from Detroit to Panama are updated daily.
How many operators does momondo search for flights from Detroit to Panama?
As of November 2026, there are 4 operators available to choose from for flights from Detroit to Panama.
How old do you have to be to fly from Detroit to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $568	Free Cancellation	Rating 7.3 10,462 reviews	Search United Airlines flights
Copa Airlines	PriceFrom $611	Free Cancellation	Rating 7.6 1,552 reviews	Search Copa Airlines flights
Delta	PriceFrom $655	Free Cancellation	Rating 7.8 8,700 reviews	Search Delta flights
American Airlines	PriceFrom $728	Free Cancellation	Rating 7.0 12,228 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Popular cities in Panama

Flights to Panama Cityfrom $486

Flights to Bocas del Torofrom $1,052

Flights to Davidfrom $460

Flights to Changuinola

Cheap flights from Detroit to Panama from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 2/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

Copa Airlines flights from Detroit to Panama

Our best Copa Airlines deals on Detroit to Panama flight tickets

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See travel insights to Panama from

How to get the cheapest flight ticket from Detroit to Panama

What is the cheapest month to fly to Panama?

What is the cheapest airline that flies from Detroit to Panama?

What airlines fly to Panama?

Cheap Detroit to Panama flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Detroit to Panama

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

Detroit flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

Complete your trip to Panama

Explore popular destinations other users love

According to popular flight searches on momondo this year