What airlines fly to Panama?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. Delta is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Detroit to Panama?

Prices for flights from Detroit to Panama are updated daily.

How many operators does momondo search for flights from Detroit to Panama?

As of December 2025, there are 3 operators available to choose from for flights from Detroit to Panama.

How old do you have to be to fly from Detroit to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$219 Cheap Flights from Detroit to Panama in 2025/26

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Find the cheapest flights from Detroit to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:23 pm - 8:06 am

DTW

PTY

14h 43m1 stop

7:50 pm - 12:01 pm

PTY

DTW

40h 11m2 stops

$479Multiple Airlines

Wed, Dec 31 - Wed, Feb 4

5:45 am - 12:40 am

DTW

PTY

19h 55m2 stops

2:55 am - 9:41 pm

PTY

DTW

17h 46m2 stops

$483Multiple Airlines

Mon, Mar 9 - Mon, Mar 9

8:00 am - 12:40 am

DTW

PTY

16h 40m2 stops

9:45 am - 10:12 pm

PTY

DTW

12h 27m2 stops

$485Multiple Airlines

Mon, Jan 19 - Mon, Jan 26

4:21 pm - 8:06 am

DTW

PTY

15h 45m1 stop

5:50 pm - 10:12 pm

PTY

DTW

28h 22m2 stops

$492Multiple Airlines

Mon, Jan 19 - Wed, Jan 21

2:55 pm - 8:34 pm

DTW

PTY

29h 39m1 stop

7:50 pm - 11:16 am

PTY

DTW

39h 26m2 stops

$496Multiple Airlines

Sat, Jan 17 - Sat, Jan 24

5:23 pm - 8:06 am

DTW

PTY

14h 43m1 stop

7:50 pm - 12:01 pm

PTY

DTW

40h 11m2 stops

$502Multiple Airlines

Tue, Dec 30 - Wed, Feb 4

5:23 pm - 8:06 am

DTW

PTY

14h 43m1 stop

2:55 pm - 11:16 am

PTY

DTW

20h 21m2 stops

$506Multiple Airlines

Wed, Dec 31 - Sun, Feb 1

4:21 pm - 8:06 am

DTW

PTY

15h 45m1 stop

10:25 am - 10:12 pm

PTY

DTW

11h 47m1 stop

$507Multiple Airlines

Mon, Jan 19 - Mon, Jan 26

6:35 am - 12:40 am

DTW

PTY

18h 05m2 stops

2:55 am - 9:41 pm

PTY

DTW

18h 46m2 stops

$524Multiple Airlines

Wed, Jan 28 - Fri, Feb 27

5:15 am - 12:40 am

DTW

PTY

19h 25m2 stops

2:55 am - 10:44 pm

PTY

DTW

19h 49m2 stops

$526Multiple Airlines

Wed, Jan 21 - Mon, Jan 26

United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

United Airlines

Dec 16

DTW6:00 amDetroit Metropolitan Wayne County

13h 38m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Jan 21

PTY4:41 pmPanama City Tocumen Intl

20h 40m

2 stops

DTW1:21 pmDetroit Metropolitan Wayne County

$756

Find similar

United Airlines

Dec 8

DTW9:03 amDetroit Metropolitan Wayne County

10h 59m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Dec 15

PTY11:35 amPanama City Tocumen Intl

12h 22m

1 stop

DTW11:57 pmDetroit Metropolitan Wayne County

$1,014

Find similar

United Airlines

Dec 16

DTW6:00 amDetroit Metropolitan Wayne County

13h 38m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Jan 5

PTY11:55 pmPanama City Tocumen Intl

17h 08m

2 stops

DTW5:03 pmDetroit Metropolitan Wayne County

$1,193

Find similar

American Airlines flights from Detroit to Panama

Our best American Airlines deals on Detroit to Panama flight tickets

American Airlines

Dec 18

DTW5:35 amDetroit Metropolitan Wayne County

8h 18m

1 stop

PTY1:53 pmPanama City Tocumen Intl

Dec 27

PTY4:55 pmPanama City Tocumen Intl

21h 57m

2 stops

DTW2:52 pmDetroit Metropolitan Wayne County

$821

Find similar

American Airlines

Dec 18

DTW5:11 pmDetroit Metropolitan Wayne County

20h 42m

2 stops

PTY1:53 pmPanama City Tocumen Intl

Dec 27

PTY4:55 pmPanama City Tocumen Intl

18h 16m

2 stops

DTW11:11 amDetroit Metropolitan Wayne County

$878

Find similar

American Airlines

Dec 18

DTW5:35 amDetroit Metropolitan Wayne County

8h 18m

1 stop

PTY1:53 pmPanama City Tocumen Intl

Dec 28

PTY4:55 pmPanama City Tocumen Intl

23h 58m

1 stop

DTW4:53 pmDetroit Metropolitan Wayne County

$883

Find similar

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/31

5:23 pm-8:06 am

1 stop14h 43m

Panama City Tocumen Intl

Wed 2/4

7:50 pm-12:01 pm

2 stops40h 11m

$479

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/9

5:45 am-12:40 am

2 stops19h 55m

Panama City Tocumen Intl

Mon 3/9

2:55 am-9:41 pm

2 stops17h 46m

$483

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 1/19

8:00 am-12:40 am

2 stops16h 40m

Panama City Tocumen Intl

Mon 1/26

9:45 am-10:12 pm

2 stops12h 27m

$485

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 1/19

4:21 pm-8:06 am

1 stop15h 45m

Panama City Tocumen Intl

Wed 1/21

5:50 pm-10:12 pm

2 stops28h 22m

$492

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 1/17

2:55 pm-8:34 pm

1 stop29h 39m

Panama City Tocumen Intl

Sat 1/24

7:50 pm-11:16 am

2 stops39h 26m

$496

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 12/30

5:23 pm-8:06 am

1 stop14h 43m

Panama City Tocumen Intl

Wed 2/4

7:50 pm-12:01 pm

2 stops40h 11m

$502

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/31

5:23 pm-8:06 am

1 stop14h 43m

Panama City Tocumen Intl

Sun 2/1

2:55 pm-11:16 am

2 stops20h 21m

$506

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 1/19

4:21 pm-8:06 am

1 stop15h 45m

Panama City Tocumen Intl

Mon 1/26

10:25 am-10:12 pm

1 stop11h 47m

$507

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/28

6:35 am-12:40 am

2 stops18h 05m

Panama City Tocumen Intl

Fri 2/27

2:55 am-9:41 pm

2 stops18h 46m

$524

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/21

5:15 am-12:40 am

2 stops19h 25m

Panama City Tocumen Intl

Mon 1/26

2:55 am-10:44 pm

2 stops19h 49m

$526

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Detroit. The lowest ticket price found for a Wednesday departure recently was $733. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Panama for around $891.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Detroit to Panama when you can find flight prices for as low as $767. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $794 per ticket.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Fastest flight time	8h 45m
Direct flights	None

The fastest flight from Detroit to Panama takes 8h 45m

There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.

Search flight deals

When did momondo last update prices for flights from Detroit to Panama?
Prices for flights from Detroit to Panama are updated daily.
How many operators does momondo search for flights from Detroit to Panama?
As of December 2025, there are 3 operators available to choose from for flights from Detroit to Panama.
How old do you have to be to fly from Detroit to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $578	Free Cancellation	Rating 7.2 11,047 reviews	Search American Airlines flights
United Airlines	PriceFrom $608	Free Cancellation	Rating 7.4 9,066 reviews	Search United Airlines flights
Delta	PriceFrom $608	Free Cancellation	Rating 7.9 8,011 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.