What airlines fly to Panama?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. Delta is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Detroit to Panama?

Delta is the most popular carrier operating from Detroit to Panama

When did momondo last update prices for flights from Detroit to Panama?

Prices for flights from Detroit to Panama are updated daily.

How many operators does momondo search for flights from Detroit to Panama?

As of October 2025, there are 3 operators available to choose from for flights from Detroit to Panama.

How old do you have to be to fly from Detroit to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$201 Cheap Flights from Detroit to Panama in 2025/26

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Find the cheapest flights from Detroit to Panama

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:10 am - 12:40 amDTW-PTY

18h 30m2 stops

2:55 am - 10:46 pmPTY-DTW

19h 51m2 stops

$439Multiple Airlines

Find Deal

Wed, Nov 12 - Tue, Nov 18

6:11 am - 1:00 amDTW-PTY

18h 49m2 stops

2:55 am - 9:23 pmPTY-DTW

18h 28m2 stops

$458Multiple Airlines

Find Deal

Thu, Feb 5 - Sat, Feb 7

7:00 am - 1:00 amDTW-PTY

18h 00m2 stops

2:55 pm - 2:09 pmPTY-DTW

23h 14m2 stops

$463Multiple Airlines

Find Deal

Thu, Feb 5 - Sun, Feb 8

6:10 am - 8:19 pmDTW-PTY

14h 09m1 stop

12:03 pm - 11:54 pmPTY-DTW

11h 51m1 stop

$467Multiple Airlines

Find Deal

Wed, Nov 12 - Tue, Nov 18

7:10 am - 3:54 pmDTW-PTY

8h 44m1 stop

10:47 am - 9:42 pmPTY-DTW

10h 55m1 stop

$470Multiple Airlines

Find Deal

Thu, Nov 13 - Wed, Nov 19

7:10 am - 3:54 pmDTW-PTY

8h 44m1 stop

10:47 am - 9:42 pmPTY-DTW

10h 55m1 stop

$475Multiple Airlines

Find Deal

Thu, Nov 13 - Wed, Nov 19

5:30 am - 1:27 pmDTW-PTY

7h 57m1 stop

2:27 pm - 11:57 pmPTY-DTW

9h 30m1 stop

$599American Airlines

Find Deal

Thu, Jan 22 - Thu, Jan 29

5:24 pm - 1:27 pmDTW-PTY

20h 03m2 stops

2:27 pm - 11:57 pmPTY-DTW

9h 30m1 stop

$603American Airlines

Find Deal

Thu, Jan 22 - Thu, Jan 29

10:49 am - 6:38 pmDTW-PTY

8h 49m1 stop

7:55 am - 11:59 pmPTY-DTW

15h 04m1 stop

$624United Airlines

Find Deal

Wed, Mar 11 - Fri, Mar 20

7:30 am - 7:02 pmDTW-PTY

12h 32m2 stops

7:55 am - 11:59 pmPTY-DTW

15h 04m1 stop

$628United Airlines

Find Deal

Wed, Mar 11 - Fri, Mar 20

American Airlines flights from Detroit to Panama

Our best American Airlines deals on Detroit to Panama flight tickets

American Airlines

Jan 22

DTW5:30 amDetroit Metropolitan Wayne County

7h 57m

1 stop

PTY1:27 pmPanama City Tocumen Intl

Jan 29

PTY2:27 pmPanama City Tocumen Intl

9h 30m

1 stop

DTW11:57 pmDetroit Metropolitan Wayne County

$599

Find similar

American Airlines

Jan 22

DTW5:24 pmDetroit Metropolitan Wayne County

20h 03m

2 stops

PTY1:27 pmPanama City Tocumen Intl

Jan 29

PTY2:27 pmPanama City Tocumen Intl

9h 30m

1 stop

DTW11:57 pmDetroit Metropolitan Wayne County

$603

Find similar

American Airlines

Oct 22

DTW4:58 pmDetroit Metropolitan Wayne County

22h 05m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Dec 26

PTY4:55 pmPanama City Tocumen Intl

16h 35m

2 stops

DTW9:30 amDetroit Metropolitan Wayne County

$863

Find similar

United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

United Airlines

Mar 11

DTW10:49 amDetroit Metropolitan Wayne County

8h 49m

1 stop

PTY6:38 pmPanama City Tocumen Intl

Mar 20

PTY7:55 amPanama City Tocumen Intl

15h 04m

1 stop

DTW11:59 pmDetroit Metropolitan Wayne County

$624

Find similar

United Airlines

Mar 11

DTW7:30 amDetroit Metropolitan Wayne County

12h 32m

2 stops

PTY7:02 pmPanama City Tocumen Intl

Mar 20

PTY7:55 amPanama City Tocumen Intl

15h 04m

1 stop

DTW11:59 pmDetroit Metropolitan Wayne County

$628

Find similar

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 11/12

6:10 am-12:40 am

2 stops18h 30m

Panama City Tocumen Intl

Tue 11/18

2:55 am-10:46 pm

2 stops19h 51m

$439

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 2/5

6:11 am-1:00 am

2 stops18h 49m

Panama City Tocumen Intl

Sat 2/7

2:55 am-9:23 pm

2 stops18h 28m

$458

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 2/5

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 2/8

2:55 pm-2:09 pm

2 stops23h 14m

$463

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 11/12

6:10 am-8:19 pm

1 stop14h 09m

Panama City Tocumen Intl

Tue 11/18

12:03 pm-11:54 pm

1 stop11h 51m

$467

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/13

7:10 am-3:54 pm

1 stop8h 44m

Panama City Tocumen Intl

Wed 11/19

10:47 am-9:42 pm

1 stop10h 55m

$470

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/13

7:10 am-3:54 pm

1 stop8h 44m

Panama City Tocumen Intl

Wed 11/19

10:47 am-9:42 pm

1 stop10h 55m

$475

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 1/22

5:30 am-1:27 pm

1 stop7h 57m

Panama City Tocumen Intl

Thu 1/29

2:27 pm-11:57 pm

1 stop9h 30m

$599

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 1/22

5:24 pm-1:27 pm

2 stops20h 03m

Panama City Tocumen Intl

Thu 1/29

2:27 pm-11:57 pm

1 stop9h 30m

$603

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/11

10:49 am-6:38 pm

1 stop8h 49m

Panama City Tocumen Intl

Fri 3/20

7:55 am-11:59 pm

1 stop15h 04m

$624

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/11

7:30 am-7:02 pm

2 stops12h 32m

Panama City Tocumen Intl

Fri 3/20

7:55 am-11:59 pm

1 stop15h 04m

$628

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Detroit. The lowest ticket price found for a Wednesday departure recently was $733. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Panama for around $891.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Detroit to Panama when you can find flight prices for as low as $767. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $794 per ticket.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Direct flights	None

There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.

Search flight deals

When did momondo last update prices for flights from Detroit to Panama?
Prices for flights from Detroit to Panama are updated daily.
How many operators does momondo search for flights from Detroit to Panama?
As of October 2025, there are 3 operators available to choose from for flights from Detroit to Panama.
How old do you have to be to fly from Detroit to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $578	Free Cancellation	Rating 7.2 11,043 reviews	Search American Airlines flights
United Airlines	PriceFrom $608	Free Cancellation	Rating 7.4 8,982 reviews	Search United Airlines flights
Delta	PriceFrom $608	Free Cancellation	Rating 7.9 7,984 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.