What is the cheapest airline that flies from Detroit to Panama?

American Airlines is the most popular carrier operating from Detroit to Panama

What airlines fly to Panama?

American Airlines, Delta and Copa Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. American Airlines is the first choice among our users, with 31% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Detroit to Panama?

Prices for flights from Detroit to Panama are updated daily.

How many operators does momondo search for flights from Detroit to Panama?

As of September 2026, there are 4 operators available to choose from for flights from Detroit to Panama.

How old do you have to be to fly from Detroit to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$252 Cheap Flights from Detroit to Panama in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Panama

Round-trip

One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

8:45 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 53m1 stop Houston George Bush Intcntl

10:00 am - 8:52 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

10h 52m1 stop Newark

$569United Airlines

Wed, Nov 25 - Tue, Dec 1

9:30 am - 8:02 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 32m1 stop Newark

11:35 am - 10:37 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

11h 02m1 stop Houston George Bush Intcntl

$569United Airlines

Tue, Jan 19 - Tue, Feb 2

5:11 pm - 1:21 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

20h 10m2 stops Charlotte Douglas Miami

2:39 pm - 11:10 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

20h 31m2 stops Miami Charlotte Douglas

$573American Airlines

Thu, Feb 18 - Fri, Feb 26

6:00 pm - 3:14 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

21h 14m1 stop Miami

4:04 pm - 11:10 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

19h 06m2 stops Miami Charlotte Douglas

$586American Airlines

Thu, Feb 18 - Fri, Feb 26

8:45 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 53m1 stop Houston George Bush Intcntl

4:41 pm - 5:06 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

24h 25m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$642Copa Airlines

Tue, Nov 24 - Mon, Nov 30

6:15 am - 7:38 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

13h 23m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

4:41 pm - 5:06 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

24h 25m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$642Copa Airlines

Tue, Nov 24 - Mon, Nov 30

6:10 am - 2:10 amDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

21h 00m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

3:55 pm - 11:56 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

32h 01m2 stops San Salvador El Salvador Intl New York John F Kennedy Intl

$678Multiple Airlines

Sat, Oct 31 - Sat, Nov 7

5:35 am - 1:21 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

7h 46m1 stop Miami

2:39 pm - 11:53 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

9h 14m1 stop Miami

$681GOL

Thu, Feb 18 - Fri, Feb 26

6:25 am - 2:03 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

7h 38m1 stop Atlanta Hartsfield-Jackson

3:28 pm - 12:55 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

9h 27m1 stop Atlanta Hartsfield-Jackson

$845Delta

Sat, Dec 12 - Sat, Dec 19

6:25 am - 2:03 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

7h 38m1 stop Atlanta Hartsfield-Jackson

8:00 am - 6:50 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

10h 50m1 stop Atlanta Hartsfield-Jackson

$845Delta

Sat, Dec 12 - Sat, Dec 26

Cheap last minute flights

Enter your travel dates to find the best prices.

9:39 am - 7:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

10h 52m1 stop Newark

3:30 pm - 10:30 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

30h 00m1 stop Houston George Bush Intcntl

$735United Airlines

Tue, Sep 22 - Sun, Sep 27

7:11 pm - 7:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

25h 20m2 stops Chicago O'Hare Intl Newark

3:30 pm - 10:30 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

30h 00m1 stop Houston George Bush Intcntl

$739United Airlines

Tue, Sep 22 - Sun, Sep 27

7:34 am - 7:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

12h 57m2 stops Chicago O'Hare Intl Newark

3:30 pm - 6:05 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

25h 35m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$767United Airlines

Tue, Sep 22 - Sun, Sep 27

5:30 pm - 10:30 amDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 00m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

11:25 am - 4:40 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

28h 15m3 stops San José Juan Santamaria Intl Guatemala City La Aurora New York John F Kennedy Intl

$884Multiple Airlines

Tue, Sep 22 - Sun, Sep 27

8:10 am - 1:55 amDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 45m2 stops Boston Logan Intl San Salvador El Salvador Intl

3:50 pm - 4:40 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

23h 50m2 stops San Salvador El Salvador Intl New York John F Kennedy Intl

$967Multiple Airlines

Sun, Sep 20 - Fri, Sep 25

8:10 am - 1:55 amDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 45m2 stops Boston Logan Intl San Salvador El Salvador Intl

11:25 am - 4:40 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

28h 15m3 stops San José Juan Santamaria Intl Guatemala City La Aurora New York John F Kennedy Intl

$983Multiple Airlines

Sun, Sep 20 - Fri, Sep 25

6:00 am - 12:16 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

7h 16m1 stop Miami

1:16 pm - 10:57 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

8h 41m1 stop Miami

$989American Airlines

Sun, Sep 20 - Fri, Sep 25

6:00 am - 12:16 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

7h 16m1 stop Miami

1:16 pm - 11:44 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

21h 28m2 stops Miami Washington, D.C. Reagan-National

$993American Airlines

Sun, Sep 20 - Fri, Sep 25

3:25 pm - 2:15 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

23h 50m3 stops Atlanta Hartsfield-Jackson Miami Bogotá El Dorado

10:10 am - 7:40 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

32h 30m3 stops Bogotá El Dorado Miami Houston George Bush Intcntl

$1,083Multiple Airlines

Tue, Sep 22 - Sun, Sep 27

5:30 pm - 2:55 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

22h 25m3 stops New York John F Kennedy Intl Guatemala City La Aurora San José Juan Santamaria Intl

11:25 am - 11:56 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

35h 31m3 stops San José Juan Santamaria Intl Guatemala City La Aurora New York John F Kennedy Intl

$1,092Multiple Airlines

Sun, Sep 20 - Fri, Sep 25

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

United Airlines

Nov 25

DTW10:59 amDetroit Metropolitan Wayne County

8h 39m

1 stop

PTY7:38 pmPanama City Tocumen Intl

Dec 3

PTY10:00 amPanama City Tocumen Intl

10h 52m

1 stop

DTW8:52 pmDetroit Metropolitan Wayne County

$569

United Airlines

Nov 25

DTW7:26 amDetroit Metropolitan Wayne County

12h 12m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Dec 2

PTY8:55 amPanama City Tocumen Intl

13h 19m

2 stops

DTW10:14 pmDetroit Metropolitan Wayne County

$573

United Airlines

Nov 27

DTW7:00 amDetroit Metropolitan Wayne County

13h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Dec 1

PTY10:00 amPanama City Tocumen Intl

10h 52m

1 stop

DTW8:52 pmDetroit Metropolitan Wayne County

$599

Copa Airlines flights from Detroit to Panama

Our best Copa Airlines deals on Detroit to Panama flight tickets

Copa Airlines

Nov 24

DTW6:15 amDetroit Metropolitan Wayne County

13h 23m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Nov 30

PTY4:41 pmPanama City Tocumen Intl

24h 25m

2 stops

DTW5:06 pmDetroit Metropolitan Wayne County

$642

Copa Airlines

Dec 23

DTW6:00 amDetroit Metropolitan Wayne County

13h 38m

2 stops

PTY7:38 pmPanama City Tocumen Intl

Dec 30

PTY8:55 amPanama City Tocumen Intl

15h 02m

1 stop

DTW11:57 pmDetroit Metropolitan Wayne County

$726

Copa Airlines

Oct 4

DTW11:15 amDetroit Metropolitan Wayne County

9h 16m

1 stop

PTY7:31 pmPanama City Tocumen Intl

Oct 16

PTY9:45 amPanama City Tocumen Intl

12h 53m

1 stop

DTW11:38 pmDetroit Metropolitan Wayne County

$898

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Wed 11/25

8:45 am-7:38 pm

1 stop10h 53m

Panama City Tocumen Intl

Tue 12/1

10:00 am-8:52 pm

1 stop10h 52m

$569

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Tue 1/19

9:30 am-8:02 pm

1 stop10h 32m

Panama City Tocumen Intl

Tue 2/2

11:35 am-10:37 pm

1 stop11h 02m

$569

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 2/18

5:11 pm-1:21 pm

2 stops20h 10m

Panama City Tocumen Intl

Fri 2/26

2:39 pm-11:10 am

2 stops20h 31m

$573

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 2/18

6:00 pm-3:14 pm

1 stop21h 14m

Panama City Tocumen Intl

Fri 2/26

4:04 pm-11:10 am

2 stops19h 06m

$586

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Tue 11/24

8:45 am-7:38 pm

1 stop10h 53m

Panama City Tocumen Intl

Mon 11/30

4:41 pm-5:06 pm

2 stops24h 25m

$642

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Tue 11/24

6:15 am-7:38 pm

2 stops13h 23m

Panama City Tocumen Intl

Mon 11/30

4:41 pm-5:06 pm

2 stops24h 25m

$642

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 10/31

6:10 am-2:10 am

2 stops21h 00m

Panama City Tocumen Intl

Sat 11/7

3:55 pm-11:56 pm

2 stops32h 01m

$678

Quickest round-trip

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 2/18

5:35 am-1:21 pm

1 stop7h 46m

Panama City Tocumen Intl

Fri 2/26

2:39 pm-11:53 pm

1 stop9h 14m

$681

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 12/12

6:25 am-2:03 pm

1 stop7h 38m

Panama City Tocumen Intl

Sat 12/19

3:28 pm-12:55 am

1 stop9h 27m

$845

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 12/12

6:25 am-2:03 pm

1 stop7h 38m

Panama City Tocumen Intl

Sat 12/26

8:00 am-6:50 pm

1 stop10h 50m

$845

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of January is, on average, the cheapest month to fly to Panama from Detroit, with most prices found around $773. If you don’t want to visit Panama in January, then you should wait until November to fly from Detroit, when ticket prices are also cheap, with an average price of $806.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Best Price Found	$252
Fastest flight time	10h 32m
Direct flights	None

The best one-way flight to Panama from Detroit in the past 72 hours is $252. The best round-trip flight deal from Detroit to Panama found on momondo in the last 72 hours is $569.

The fastest flight from Detroit to Panama takes 10h 32m

There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.

Search flight deals

Frequently asked questions about flying from Detroit to Panama

When did momondo last update prices for flights from Detroit to Panama?
Prices for flights from Detroit to Panama are updated daily.
How many operators does momondo search for flights from Detroit to Panama?
As of September 2026, there are 4 operators available to choose from for flights from Detroit to Panama.
How old do you have to be to fly from Detroit to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Airline	Rating	Free Cancellation	Price
Copa Airlines	PriceFrom $611	Free Cancellation	Rating 7.6 1,539 reviews	Search Copa Airlines flights
Delta	PriceFrom $655	Free Cancellation	Rating 7.8 8,591 reviews	Search Delta flights
United Airlines	PriceFrom $708	Free Cancellation	Rating 7.4 10,227 reviews	Search United Airlines flights
American Airlines	PriceFrom $745	Free Cancellation	Rating 7.0 12,079 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Popular cities in Panama

Flights to Panama Cityfrom $497

Flights to Bocas del Torofrom $823

Flights to Davidfrom $508

Flights to Changuinola

Cheap flights from Detroit to Panama from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 3/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Find the cheapest flights from Detroit to Panama

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

Copa Airlines flights from Detroit to Panama

Our best Copa Airlines deals on Detroit to Panama flight tickets

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How to get the cheapest flight ticket from Detroit to Panama

What is the cheapest month to fly to Panama?

What is the cheapest airline that flies from Detroit to Panama?

What airlines fly to Panama?

Cheap Detroit to Panama flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Detroit to Panama

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

Detroit flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

Complete your trip to Panama

Explore popular destinations other users love

According to popular flight searches on momondo this year