What is the cheapest airline that flies from Detroit to Panama?

United Airlines is the most popular carrier operating from Detroit to Panama

What airlines fly to Panama?

American Airlines, Delta and Copa Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Detroit to Panama?

Prices for flights from Detroit to Panama are updated daily.

How many operators does momondo search for flights from Detroit to Panama?

As of August 2026, there are 4 operators available to choose from for flights from Detroit to Panama.

How old do you have to be to fly from Detroit to Panama?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

What documentation or ID do you need to fly to Panama?

The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$306 Cheap Flights from Detroit to Panama in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Panama

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

6:59 pm - 6:55 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

23h 56m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

3:50 pm - 12:06 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

20h 16m2 stops San Salvador El Salvador Intl New York John F Kennedy Intl

$609Multiple Airlines

Thu, Nov 12 - Mon, Nov 23

4:23 pm - 8:19 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

28h 56m1 stop Fort Lauderdale

12:03 pm - 11:27 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

10h 24m1 stop Fort Lauderdale

$628Multiple Airlines

Wed, Sep 16 - Wed, Sep 23

8:15 am - 5:12 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

8h 57m1 stop Houston George Bush Intcntl

10:00 am - 9:08 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

11h 08m1 stop Newark

$753United Airlines

Wed, Dec 2 - Wed, Dec 9

7:00 am - 8:02 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

13h 02m1 stop Newark

8:55 am - 10:27 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

13h 32m1 stop Houston George Bush Intcntl

$753United Airlines

Thu, Nov 12 - Mon, Nov 23

7:40 pm - 1:48 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 08m2 stops Charlotte Douglas Miami

2:50 pm - 10:50 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

20h 00m2 stops Miami Dallas/Fort Worth

$757American Airlines

Thu, Dec 3 - Fri, Dec 11

5:20 pm - 1:48 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

20h 28m2 stops Charlotte Douglas Miami

2:50 pm - 9:09 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

18h 19m2 stops Miami Washington, D.C. Reagan-National

$757American Airlines

Thu, Dec 3 - Fri, Dec 11

6:25 am - 2:05 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

7h 40m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 10:30 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

19h 00m1 stop Atlanta Hartsfield-Jackson

$767Delta

Mon, Nov 23 - Mon, Nov 30

7:45 pm - 2:05 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

18h 20m1 stop Atlanta Hartsfield-Jackson

3:30 pm - 10:30 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

19h 00m1 stop Atlanta Hartsfield-Jackson

$778Delta

Sun, Nov 22 - Mon, Nov 30

8:15 am - 5:12 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

8h 57m1 stop Houston George Bush Intcntl

11:35 am - 10:34 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

10h 59m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$989Copa Airlines

Sun, Jan 17 - Fri, Jan 22

8:15 am - 5:12 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

8h 57m1 stop Houston George Bush Intcntl

11:35 am - 10:34 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

10h 59m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$989Copa Airlines

Sat, Jan 16 - Fri, Jan 22

Cheap last minute flights

Enter your travel dates to find the best prices.

9:15 am - 2:05 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

29h 50m2 stops Monterrey Gen Mariano Escobedo Mexico City Benito Juarez

3:50 pm - 11:59 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

31h 09m2 stops San Salvador El Salvador Intl New York John F Kennedy Intl

$898Multiple Airlines

Mon, Aug 10 - Wed, Aug 12

9:15 am - 2:05 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

53h 50m2 stops Monterrey Gen Mariano Escobedo Mexico City Benito Juarez

3:05 pm - 7:17 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

27h 12m2 stops Mexico City Benito Juarez Monterrey Gen Mariano Escobedo

$1,006Aeromexico

Mon, Aug 10 - Thu, Aug 13

6:10 am - 8:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

15h 21m1 stop Atlanta Hartsfield-Jackson

10:25 am - 12:40 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

13h 15m2 stops Miami Atlanta Hartsfield-Jackson

$1,259Multiple Airlines

Mon, Aug 10 - Wed, Aug 12

6:10 am - 8:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

15h 21m1 stop Atlanta Hartsfield-Jackson

9:48 pm - 12:40 amPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

25h 52m2 stops Miami Atlanta Hartsfield-Jackson

$1,302Multiple Airlines

Mon, Aug 10 - Thu, Aug 13

6:00 am - 12:35 amDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

19h 35m2 stops Fort Lauderdale Bogotá El Dorado

11:25 am - 11:59 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

35h 34m3 stops San José Juan Santamaria Intl Guatemala City La Aurora New York John F Kennedy Intl

$1,360Multiple Airlines

Mon, Aug 10 - Wed, Aug 12

5:35 pm - 8:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

27h 56m1 stop Atlanta Hartsfield-Jackson

10:00 am - 4:40 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

29h 40m1 stop Atlanta Hartsfield-Jackson

$1,448Multiple Airlines

Mon, Aug 10 - Thu, Aug 13

6:10 am - 8:31 pmDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

15h 21m1 stop Atlanta Hartsfield-Jackson

12:03 pm - 12:55 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

23h 52m1 stop Fort Lauderdale

$1,509Multiple Airlines

Mon, Aug 10 - Wed, Aug 12

10:15 am - 9:15 amDTW Detroit Metropolitan Wayne County-PTY Panama City Tocumen Intl

24h 00m2 stops Montreal Pierre Elliott Trudeau Intl Bogotá El Dorado

11:25 am - 9:40 pmPTY Panama City Tocumen Intl-DTW Detroit Metropolitan Wayne County

33h 15m3 stops San José Juan Santamaria Intl San Salvador El Salvador Intl Montreal Pierre Elliott Trudeau Intl

$1,701Avianca

Mon, Aug 10 - Thu, Aug 13

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

United Airlines

Nov 12

DTW7:00 amDetroit Metropolitan Wayne County

13h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Nov 23

PTY8:55 amPanama City Tocumen Intl

13h 32m

1 stop

DTW10:27 pmDetroit Metropolitan Wayne County

$753

United Airlines

Nov 5

DTW7:00 amDetroit Metropolitan Wayne County

13h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Nov 13

PTY10:00 amPanama City Tocumen Intl

10h 58m

1 stop

DTW8:58 pmDetroit Metropolitan Wayne County

$778

United Airlines

Nov 5

DTW7:00 amDetroit Metropolitan Wayne County

13h 02m

1 stop

PTY8:02 pmPanama City Tocumen Intl

Nov 13

PTY4:41 pmPanama City Tocumen Intl

16h 51m

2 stops

DTW9:32 amDetroit Metropolitan Wayne County

$782

American Airlines flights from Detroit to Panama

Our best American Airlines deals on Detroit to Panama flight tickets

American Airlines

Dec 3

DTW5:20 pmDetroit Metropolitan Wayne County

20h 28m

2 stops

PTY1:48 pmPanama City Tocumen Intl

Dec 11

PTY2:50 pmPanama City Tocumen Intl

18h 19m

2 stops

DTW9:09 amDetroit Metropolitan Wayne County

$757

American Airlines

Nov 2

DTW7:22 pmDetroit Metropolitan Wayne County

18h 51m

2 stops

PTY2:13 pmPanama City Tocumen Intl

Nov 9

PTY3:13 pmPanama City Tocumen Intl

8h 41m

1 stop

DTW11:54 pmDetroit Metropolitan Wayne County

$812

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/12

6:59 pm-6:55 pm

2 stops23h 56m

Panama City Tocumen Intl

Mon 11/23

3:50 pm-12:06 pm

2 stops20h 16m

$609

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/16

4:23 pm-8:19 pm

1 stop28h 56m

Panama City Tocumen Intl

Wed 9/23

12:03 pm-11:27 pm

1 stop10h 24m

$628

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/2

8:15 am-5:12 pm

1 stop8h 57m

Panama City Tocumen Intl

Wed 12/9

10:00 am-9:08 pm

1 stop11h 08m

$753

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 11/12

7:00 am-8:02 pm

1 stop13h 02m

Panama City Tocumen Intl

Mon 11/23

8:55 am-10:27 pm

1 stop13h 32m

$753

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 12/3

7:40 pm-1:48 pm

2 stops18h 08m

Panama City Tocumen Intl

Fri 12/11

2:50 pm-10:50 am

2 stops20h 00m

$757

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Thu 12/3

5:20 pm-1:48 pm

2 stops20h 28m

Panama City Tocumen Intl

Fri 12/11

2:50 pm-9:09 am

2 stops18h 19m

$757

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Mon 11/23

6:25 am-2:05 pm

1 stop7h 40m

Panama City Tocumen Intl

Mon 11/30

3:30 pm-10:30 am

1 stop19h 00m

$767

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sun 11/22

7:45 pm-2:05 pm

1 stop18h 20m

Panama City Tocumen Intl

Mon 11/30

3:30 pm-10:30 am

1 stop19h 00m

$778

Quickest round-trip

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sun 1/17

8:15 am-5:12 pm

1 stop8h 57m

Panama City Tocumen Intl

Fri 1/22

11:35 am-10:34 pm

2 stops10h 59m

$989

DetroitPanama City

DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl

DTWPTY

Detroit Metropolitan Wayne County

Sat 1/16

8:15 am-5:12 pm

1 stop8h 57m

Panama City Tocumen Intl

Fri 1/22

11:35 am-10:34 pm

2 stops10h 59m

$989

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama?

The month of January is, on average, the cheapest month to fly to Panama from Detroit, with most prices found around $753. If you don’t want to visit Panama in January, then you should wait until September to fly from Detroit, when ticket prices are also cheap, with an average price of $768.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Fastest flight time	8h 57m
Direct flights	None

The fastest flight from Detroit to Panama takes 8h 57m

There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.

Search flight deals

Frequently asked questions about flying from Detroit to Panama

When did momondo last update prices for flights from Detroit to Panama?
Prices for flights from Detroit to Panama are updated daily.
How many operators does momondo search for flights from Detroit to Panama?
As of August 2026, there are 4 operators available to choose from for flights from Detroit to Panama.
How old do you have to be to fly from Detroit to Panama?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.
What documentation or ID do you need to fly to Panama?
The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Airline	Rating	Free Cancellation	Price
Copa Airlines	PriceFrom $611	Free Cancellation	Rating 7.6 1,563 reviews	Search Copa Airlines flights
Delta	PriceFrom $655	Free Cancellation	Rating 7.8 8,496 reviews	Search Delta flights
American Airlines	PriceFrom $673	Free Cancellation	Rating 7.1 11,892 reviews	Search American Airlines flights
United Airlines	PriceFrom $708	Free Cancellation	Rating 7.4 10,089 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Flights to Panama Cityfrom $453

Flights to Bocas del Torofrom $705

Flights to Davidfrom $406

Flights to Changuinola

Cheap flights from Detroit to Panama from $306

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets

American Airlines flights from Detroit to Panama

Our best American Airlines deals on Detroit to Panama flight tickets

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How to get the cheapest flight ticket from Detroit to Panama

What is the cheapest month to fly to Panama?

What is the cheapest airline that flies from Detroit to Panama?

What airlines fly to Panama?

Cheap Detroit to Panama flight deals and tips

Fastest flight time

Direct flights

Frequently asked questions about flying from Detroit to Panama

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo

Why use momondo?

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo

Detroit flight routes

According to popular flight searches on momondo this year

Panama flight routes

According to popular flight searches on momondo this year

Fly your favorite airline to Panama

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama

List of cabin classes available on flights landing in Panama. Availability may vary depending on flight origin and airline.

Complete your trip to Panama

Explore popular destinations other users love

According to popular flight searches on momondo this year