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Cheap flights from Detroit to Panama from $234

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 8/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$609Multiple Airlines
Tue, Sep 15 - Tue, Sep 29
Multiple Airlines Logo
6:00 am - 10:30 am
DTW
-
PTY
29h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 4:50 pm
PTY
-
DTW
24h 00m
2 stops
$616Multiple Airlines
Sat, Oct 24 - Sat, Oct 31
Multiple Airlines Logo
6:00 am - 10:30 am
DTW
-
PTY
29h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$617Multiple Airlines
Thu, Sep 24 - Mon, Sep 28
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
5:30 am - 4:32 pm
PTY
-
DTW
34h 02m
2 stops
$626Multiple Airlines
Wed, Sep 30 - Sun, Oct 4
Multiple Airlines Logo
4:45 pm - 10:30 am
DTW
-
PTY
18h 45m
2 stops
Multiple Airlines Logo
3:50 pm - 3:50 pm
PTY
-
DTW
23h 00m
2 stops
$628Multiple Airlines
Tue, Oct 27 - Wed, Oct 28
Multiple Airlines Logo
6:30 am - 8:34 pm
DTW
-
PTY
15h 04m
1 stop
Multiple Airlines Logo
9:33 pm - 4:50 pm
PTY
-
DTW
18h 17m
2 stops
$631Multiple Airlines
Tue, Jun 16 - Tue, Aug 4
Multiple Airlines Logo
5:40 pm - 8:34 pm
DTW
-
PTY
27h 54m
1 stop
Multiple Airlines Logo
10:25 am - 12:42 am
PTY
-
DTW
13h 17m
2 stops
$633Multiple Airlines
Wed, Aug 19 - Wed, Aug 26
Multiple Airlines Logo
5:30 pm - 2:55 pm
DTW
-
PTY
22h 25m
3 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$634Multiple Airlines
Wed, Sep 16 - Wed, Sep 30
Multiple Airlines Logo
2:02 pm - 8:34 pm
DTW
-
PTY
31h 32m
1 stop
Multiple Airlines Logo
9:33 pm - 4:50 pm
PTY
-
DTW
18h 17m
2 stops
$637Multiple Airlines
Tue, Jun 16 - Tue, Aug 4
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
11:25 am - 4:32 pm
PTY
-
DTW
28h 07m
3 stops
$642Multiple Airlines
Wed, Sep 30 - Sun, Oct 4

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United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets
United Airlines
Sep 16
DTW10:55 amDetroit Metropolitan Wayne County
8h 42m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Sep 24
PTY10:00 amPanama City Tocumen Intl
11h 30m
1 stop
DTW10:30 pmDetroit Metropolitan Wayne County
$733
United Airlines
Sep 15
DTW7:40 pmDetroit Metropolitan Wayne County
19h 34m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Sep 29
PTY9:45 amPanama City Tocumen Intl
9h 52m
1 stop
DTW8:37 pmDetroit Metropolitan Wayne County
$737
United Airlines
Oct 15
DTW6:15 amDetroit Metropolitan Wayne County
8h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Oct 23
PTY9:45 amPanama City Tocumen Intl
9h 52m
1 stop
DTW8:37 pmDetroit Metropolitan Wayne County
$760

Delta flights from Detroit to Panama

Our best Delta deals on Detroit to Panama flight tickets
Delta
Aug 23
DTW7:45 pmDetroit Metropolitan Wayne County
18h 28m
1 stop
PTY1:13 pmPanama City Tocumen Intl
Aug 31
PTY2:28 pmPanama City Tocumen Intl
8h 12m
1 stop
DTW11:40 pmDetroit Metropolitan Wayne County
$744
Delta
Aug 9
DTW8:57 pmDetroit Metropolitan Wayne County
17h 16m
1 stop
PTY1:13 pmPanama City Tocumen Intl
Aug 17
PTY2:28 pmPanama City Tocumen Intl
17h 56m
1 stop
DTW9:24 amDetroit Metropolitan Wayne County
$756
Delta
Aug 23
DTW7:45 pmDetroit Metropolitan Wayne County
18h 28m
1 stop
PTY1:13 pmPanama City Tocumen Intl
Aug 30
PTY2:28 pmPanama City Tocumen Intl
17h 56m
1 stop
DTW9:24 amDetroit Metropolitan Wayne County
$771

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 9/15

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Tue 9/29

3:50 pm-4:32 pm

2 stops23h 42m

$609

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 10/24

6:00 am-10:30 am

2 stops29h 30m

Panama City Tocumen Intl

Sat 10/31

3:50 pm-4:50 pm

2 stops24h 00m

$616

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 9/24

6:00 am-10:30 am

2 stops29h 30m

Panama City Tocumen Intl

Mon 9/28

3:50 pm-4:32 pm

2 stops23h 42m

$617

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/30

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 10/4

5:30 am-4:32 pm

2 stops34h 02m

$626

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 10/27

4:45 pm-10:30 am

2 stops18h 45m

Panama City Tocumen Intl

Wed 10/28

3:50 pm-3:50 pm

2 stops23h 00m

$628
Quickest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 6/16

6:30 am-8:34 pm

1 stop15h 04m

Panama City Tocumen Intl

Tue 8/4

9:33 pm-4:50 pm

2 stops18h 17m

$631

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 8/19

5:40 pm-8:34 pm

1 stop27h 54m

Panama City Tocumen Intl

Wed 8/26

10:25 am-12:42 am

2 stops13h 17m

$633

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/16

5:30 pm-2:55 pm

3 stops22h 25m

Panama City Tocumen Intl

Wed 9/30

3:50 pm-4:32 pm

2 stops23h 42m

$634

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 6/16

2:02 pm-8:34 pm

1 stop31h 32m

Panama City Tocumen Intl

Tue 8/4

9:33 pm-4:50 pm

2 stops18h 17m

$637

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/30

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 10/4

11:25 am-4:32 pm

3 stops28h 07m

$642

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from Detroit, with most prices found around $514. If you don’t want to visit Panama in March, then you should wait until October to fly from Detroit, when ticket prices are also cheap, with an average price of $562.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Fastest flight time

18h 00m

Direct flights

None
The fastest flight from Detroit to Panama takes 18h 00m
There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.
Search flight deals

Frequently asked questions about flying from Detroit to Panama

  • When did momondo last update prices for flights from Detroit to Panama?

    Prices for flights from Detroit to Panama are updated daily.

  • How many operators does momondo search for flights from Detroit to Panama?

  • How old do you have to be to fly from Detroit to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $611Free CancellationRating
7.5
1,580 reviews
Search Copa Airlines flights
DeltaPriceFrom $668Free CancellationRating
7.9
8,458 reviews
Search Delta flights
American AirlinesPriceFrom $673Free CancellationRating
7.1
11,668 reviews
Search American Airlines flights
United AirlinesPriceFrom $708Free CancellationRating
7.4
9,684 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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