Cheap flights from Detroit to Panama from $212

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama departing on 2/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:50 pm - 8:50 am
DTW
-
PTY
17h 00m
2 stops
Multiple Airlines Logo
9:45 am - 11:59 pm
PTY
-
DTW
13h 14m
2 stops
$461Multiple Airlines
Wed, Mar 18 - Wed, Mar 25
Multiple Airlines Logo
6:05 am - 1:00 am
DTW
-
PTY
18h 55m
2 stops
Multiple Airlines Logo
2:55 am - 7:22 pm
PTY
-
DTW
15h 27m
2 stops
$465Multiple Airlines
Thu, Mar 5 - Fri, Mar 13
Multiple Airlines Logo
5:09 am - 8:50 am
DTW
-
PTY
27h 41m
3 stops
Multiple Airlines Logo
11:25 am - 11:01 am
PTY
-
DTW
23h 36m
3 stops
$479Multiple Airlines
Tue, Mar 3 - Wed, Mar 4
Multiple Airlines Logo
5:45 am - 12:40 am
DTW
-
PTY
19h 55m
2 stops
Multiple Airlines Logo
2:55 am - 7:46 pm
PTY
-
DTW
15h 51m
2 stops
$480Multiple Airlines
Wed, Mar 11 - Mon, Mar 16
Multiple Airlines Logo
5:45 am - 1:00 am
DTW
-
PTY
20h 15m
2 stops
Multiple Airlines Logo
2:55 am - 7:46 pm
PTY
-
DTW
15h 51m
2 stops
$481Multiple Airlines
Tue, Mar 10 - Mon, Mar 16
Multiple Airlines Logo
8:49 am - 12:40 am
DTW
-
PTY
15h 51m
2 stops
Multiple Airlines Logo
9:55 am - 11:59 pm
PTY
-
DTW
13h 04m
2 stops
$482Multiple Airlines
Wed, Mar 4 - Tue, Mar 31
Multiple Airlines Logo
5:45 am - 12:40 am
DTW
-
PTY
18h 55m
2 stops
Multiple Airlines Logo
2:55 am - 7:46 pm
PTY
-
DTW
15h 51m
2 stops
$485Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
5:09 am - 8:50 am
DTW
-
PTY
27h 41m
3 stops
Multiple Airlines Logo
11:25 am - 11:59 pm
PTY
-
DTW
12h 34m
2 stops
$490Multiple Airlines
Tue, Mar 3 - Wed, Mar 4
Multiple Airlines Logo
12:22 pm - 1:55 am
DTW
-
PTY
14h 33m
2 stops
Multiple Airlines Logo
3:20 am - 11:59 pm
PTY
-
DTW
19h 39m
2 stops
$495Multiple Airlines
Sun, Apr 12 - Thu, Apr 16
Multiple Airlines Logo
5:00 am - 12:45 am
DTW
-
PTY
20h 45m
2 stops
Multiple Airlines Logo
3:20 am - 9:34 pm
PTY
-
DTW
17h 14m
2 stops
$502Multiple Airlines
Wed, May 13 - Tue, May 19

Avianca flights from Detroit to Panama

Our best Avianca deals on Detroit to Panama flight tickets
Avianca
Feb 10
DTW7:45 pmDetroit Metropolitan Wayne County
23h 10m
2 stops
PTY6:55 pmPanama City Tocumen Intl
Feb 25
PTY7:50 pmPanama City Tocumen Intl
14h 11m
2 stops
DTW10:01 amDetroit Metropolitan Wayne County
$768
Avianca
Feb 10
DTW2:40 pmDetroit Metropolitan Wayne County
19h 50m
2 stops
PTY10:30 amPanama City Tocumen Intl
Feb 27
PTY7:50 pmPanama City Tocumen Intl
23h 06m
2 stops
DTW6:56 pmDetroit Metropolitan Wayne County
$776
Avianca
Feb 10
DTW7:45 pmDetroit Metropolitan Wayne County
14h 45m
2 stops
PTY10:30 amPanama City Tocumen Intl
Feb 24
PTY11:25 amPanama City Tocumen Intl
22h 36m
3 stops
DTW10:01 amDetroit Metropolitan Wayne County
$797

United Airlines flights from Detroit to Panama

Our best United Airlines deals on Detroit to Panama flight tickets
United Airlines
Feb 10
DTW8:15 amDetroit Metropolitan Wayne County
8h 52m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 25
PTY10:00 amPanama City Tocumen Intl
10h 22m
1 stop
DTW8:22 pmDetroit Metropolitan Wayne County
$818
United Airlines
Feb 11
DTW8:15 amDetroit Metropolitan Wayne County
11h 23m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 23
PTY4:41 pmPanama City Tocumen Intl
20h 49m
2 stops
DTW1:30 pmDetroit Metropolitan Wayne County
$822

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/18

4:50 pm-8:50 am

2 stops17h 00m

Panama City Tocumen Intl

Wed 3/25

9:45 am-11:59 pm

2 stops13h 14m

$461

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 3/5

6:05 am-1:00 am

2 stops18h 55m

Panama City Tocumen Intl

Fri 3/13

2:55 am-7:22 pm

2 stops15h 27m

$465

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/3

5:09 am-8:50 am

3 stops27h 41m

Panama City Tocumen Intl

Wed 3/4

11:25 am-11:01 am

3 stops23h 36m

$479

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/11

5:45 am-12:40 am

2 stops19h 55m

Panama City Tocumen Intl

Mon 3/16

2:55 am-7:46 pm

2 stops15h 51m

$480

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/10

5:45 am-1:00 am

2 stops20h 15m

Panama City Tocumen Intl

Mon 3/16

2:55 am-7:46 pm

2 stops15h 51m

$481

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/4

8:49 am-12:40 am

2 stops15h 51m

Panama City Tocumen Intl

Tue 3/31

9:55 am-11:59 pm

2 stops13h 04m

$482

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 3/4

5:45 am-12:40 am

2 stops18h 55m

Panama City Tocumen Intl

Wed 3/11

2:55 am-7:46 pm

2 stops15h 51m

$485

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/3

5:09 am-8:50 am

3 stops27h 41m

Panama City Tocumen Intl

Wed 3/4

11:25 am-11:59 pm

2 stops12h 34m

$490

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 4/12

12:22 pm-1:55 am

2 stops14h 33m

Panama City Tocumen Intl

Thu 4/16

3:20 am-11:59 pm

2 stops19h 39m

$495

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 5/13

5:00 am-12:45 am

2 stops20h 45m

Panama City Tocumen Intl

Tue 5/19

3:20 am-9:34 pm

2 stops17h 14m

$502

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Panama?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama from Detroit according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Cheap Detroit to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama

Fastest flight time

8h 01m

Direct flights

None
The fastest flight from Detroit to Panama takes 8h 01m
There are no direct flights from Detroit to Panama. There are no popular flight routes from Detroit to Panama.
  • When did momondo last update prices for flights from Detroit to Panama?

    Prices for flights from Detroit to Panama are updated daily.

  • How many operators does momondo search for flights from Detroit to Panama?

  • How old do you have to be to fly from Detroit to Panama?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama

Compare and see reviews for airlines that fly from Detroit to Panama with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $578Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights
United AirlinesPriceFrom $608Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
8,128 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Panama. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

momondo helps you find the best flight between Detroit and Panama by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Sat 2/28
Sat 3/7

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