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Cheap flights from Detroit to La Crosse from $222

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to La Crosse departing on 7/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:33 am - 5:11 pm
DTW
-
LSE
11h 38m
1 stop
American Airlines Logo
12:01 pm - 9:49 am
LSE
-
DTW
20h 48m
1 stop
$371American Airlines
Sat, Jul 18 - Tue, Jul 21
American Airlines Logo
7:00 am - 5:11 pm
DTW
-
LSE
11h 11m
2 stops
American Airlines Logo
5:57 pm - 5:41 pm
LSE
-
DTW
22h 44m
1 stop
$439American Airlines
Sat, Jul 18 - Tue, Jul 21
Multiple Airlines Logo
8:01 pm - 7:14 pm
DTW
-
LSE
24h 13m
1 stop
Multiple Airlines Logo
5:26 pm - 4:53 pm
LSE
-
DTW
22h 27m
2 stops
$463Multiple Airlines
Thu, Jun 11 - Thu, Jun 18
American Airlines Logo
8:58 pm - 12:19 am
DTW
-
LSE
4h 21m
1 stop
American Airlines Logo
11:52 am - 4:59 pm
LSE
-
DTW
4h 07m
1 stop
$505American Airlines
Thu, Jun 11 - Wed, Jun 17
American Airlines Logo
1:43 pm - 12:19 am
DTW
-
LSE
11h 36m
2 stops
American Airlines Logo
5:25 pm - 10:03 am
LSE
-
DTW
15h 38m
1 stop
$509American Airlines
Thu, Jun 11 - Wed, Jun 17
American Airlines Logo
6:00 am - 5:11 pm
DTW
-
LSE
12h 11m
2 stops
American Airlines Logo
12:01 pm - 12:41 am
LSE
-
DTW
11h 40m
2 stops
$514American Airlines
Sat, Jul 18 - Tue, Jul 21
American Airlines Logo
4:17 pm - 12:19 am
DTW
-
LSE
9h 02m
2 stops
American Airlines Logo
11:52 am - 12:33 am
LSE
-
DTW
11h 41m
2 stops
$516American Airlines
Thu, Jun 11 - Wed, Jun 17
Multiple Airlines Logo
8:01 pm - 7:14 pm
DTW
-
LSE
24h 13m
1 stop
Multiple Airlines Logo
5:26 pm - 11:47 am
LSE
-
DTW
17h 21m
1 stop
$519Multiple Airlines
Thu, Jun 11 - Thu, Jun 18
American Airlines Logo
5:40 am - 9:12 am
DTW
-
LSE
4h 32m
1 stop
American Airlines Logo
6:24 pm - 10:54 pm
LSE
-
DTW
3h 30m
1 stop
$532American Airlines
Fri, Sep 11 - Sun, Sep 13
American Airlines Logo
6:45 am - 12:19 am
DTW
-
LSE
18h 34m
1 stop
American Airlines Logo
5:25 pm - 10:03 am
LSE
-
DTW
15h 38m
1 stop
$538American Airlines
Thu, Jun 11 - Wed, Jun 17

American Airlines flights from Detroit to La Crosse

Our best American Airlines deals on Detroit to La Crosse flight tickets
American Airlines
Jul 18
DTW6:33 amDetroit Metropolitan Wayne County
11h 38m
1 stop
LSE5:11 pmLa Crosse
Jul 21
LSE12:01 pmLa Crosse
20h 48m
1 stop
DTW9:49 amDetroit Metropolitan Wayne County
$371
American Airlines
Jul 18
DTW7:00 amDetroit Metropolitan Wayne County
11h 11m
2 stops
LSE5:11 pmLa Crosse
Jul 21
LSE5:57 pmLa Crosse
22h 44m
1 stop
DTW5:41 pmDetroit Metropolitan Wayne County
$439
American Airlines
Jun 11
DTW8:58 pmDetroit Metropolitan Wayne County
4h 21m
1 stop
LSE12:19 amLa Crosse
Jun 17
LSE11:52 amLa Crosse
4h 07m
1 stop
DTW4:59 pmDetroit Metropolitan Wayne County
$505

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Detroit to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Sat 7/18

6:33 am-5:11 pm

1 stop11h 38m

La Crosse

Tue 7/21

12:01 pm-9:49 am

1 stop20h 48m

$371

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Sat 7/18

7:00 am-5:11 pm

2 stops11h 11m

La Crosse

Tue 7/21

5:57 pm-5:41 pm

1 stop22h 44m

$439

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Thu 6/11

8:01 pm-7:14 pm

1 stop24h 13m

La Crosse

Thu 6/18

5:26 pm-4:53 pm

2 stops22h 27m

$463

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Thu 6/11

8:58 pm-12:19 am

1 stop4h 21m

La Crosse

Wed 6/17

11:52 am-4:59 pm

1 stop4h 07m

$505

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Thu 6/11

1:43 pm-12:19 am

2 stops11h 36m

La Crosse

Wed 6/17

5:25 pm-10:03 am

1 stop15h 38m

$509

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Sat 7/18

6:00 am-5:11 pm

2 stops12h 11m

La Crosse

Tue 7/21

12:01 pm-12:41 am

2 stops11h 40m

$514

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Thu 6/11

4:17 pm-12:19 am

2 stops9h 02m

La Crosse

Wed 6/17

11:52 am-12:33 am

2 stops11h 41m

$516

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Thu 6/11

8:01 pm-7:14 pm

1 stop24h 13m

La Crosse

Thu 6/18

5:26 pm-11:47 am

1 stop17h 21m

$519
Quickest round-trip

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Fri 9/11

5:40 am-9:12 am

1 stop4h 32m

La Crosse

Sun 9/13

6:24 pm-10:54 pm

1 stop3h 30m

$532

DetroitLa Crosse

DTW - LSE

DTWLSE

Detroit Metropolitan Wayne County

Thu 6/11

6:45 am-12:19 am

1 stop18h 34m

La Crosse

Wed 6/17

5:25 pm-10:03 am

1 stop15h 38m

$538

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Detroit to La Crosse?

American Airlines is the most popular carrier operating from Detroit to La Crosse

When to book flights from Detroit to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to La Crosse (DTT to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to La Crosse

Fastest flight time

4h 11m

Direct flights

None
The fastest flight from Detroit to La Crosse takes 4h 11m
There are no direct flights from Detroit to La Crosse. There are no popular flight routes from Detroit to La Crosse.
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Frequently asked questions about flying from Detroit to La Crosse

  • How far is Detroit to La Crosse by plane?

    La Crosse is 425.0 mi away from Detroit. Flights usually cover this in 4h 11m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to La Crosse Airport?

    Prices for flights from Detroit to La Crosse Airport are updated daily.

  • How old do you have to be to fly from Detroit to La Crosse Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to La Crosse?

It is quick and easy to find Detroit to La Crosse flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to La Crosse that suits you.

Can I find flights from Detroit to La Crosse with flexible booking policies on momondo?

momondo does allow users to show only those flights to La Crosse from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Detroit.

I’m not ready to book a flight from Detroit to La Crosse right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Detroit to La Crosse now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to La Crosse and let you know when they change.

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