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Cheap flights from Detroit to La Crosse from $255

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to La Crosse departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Detroit to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:27 pm - 12:21 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
8h 54m1 stop Chicago O'Hare Intl
American Airlines Logo
5:53 am - 9:33 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
14h 40m1 stop Chicago O'Hare Intl
$410American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:40 am - 12:22 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
18h 42m1 stop Chicago O'Hare Intl
American Airlines Logo
6:02 am - 4:55 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
9h 53m1 stop Chicago O'Hare Intl
$452American Airlines
Fri, Sep 4 - Sun, Sep 6
American Airlines Logo
9:03 pm - 11:49 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
15h 46m1 stop Chicago O'Hare Intl
American Airlines Logo
5:53 am - 9:33 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
14h 40m1 stop Chicago O'Hare Intl
$498American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
7:15 am - 2:42 pmDTW  Detroit Metropolitan Wayne County-LSE La Crosse
8h 27m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
5:53 am - 12:22 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
5h 29m1 stop Chicago O'Hare Intl
$501American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:36 am - 11:22 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
5h 46m1 stop Chicago O'Hare Intl
American Airlines Logo
5:22 pm - 11:34 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
5h 12m1 stop Chicago O'Hare Intl
$522American Airlines
Fri, Sep 18 - Sun, Sep 20
American Airlines Logo
6:44 am - 6:23 pmDTW  Detroit Metropolitan Wayne County-LSE La Crosse
12h 39m1 stop Chicago O'Hare Intl
American Airlines Logo
6:49 pm - 4:04 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
20h 15m1 stop Chicago O'Hare Intl
$547American Airlines
Fri, Nov 27 - Mon, Nov 30
American Airlines Logo
4:08 pm - 11:54 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
20h 46m1 stop Chicago O'Hare Intl
American Airlines Logo
6:02 am - 9:38 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
14h 36m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
$552American Airlines
Fri, Sep 4 - Sun, Sep 6
American Airlines Logo
4:08 pm - 12:22 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
9h 14m1 stop Chicago O'Hare Intl
American Airlines Logo
12:19 pm - 12:31 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
23h 12m1 stop Chicago O'Hare Intl
$574American Airlines
Thu, Aug 27 - Mon, Aug 31
American Airlines Logo
8:00 am - 12:21 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
17h 21m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
American Airlines Logo
5:53 am - 7:22 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
12h 29m2 stops Chicago O'Hare Intl Philadelphia
$575American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
9:03 pm - 12:22 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
4h 19m1 stop Chicago O'Hare Intl
American Airlines Logo
5:53 am - 12:22 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
5h 29m1 stop Chicago O'Hare Intl
$579American Airlines
Fri, Sep 4 - Sat, Sep 12

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American Airlines flights from Detroit to La Crosse

Our best American Airlines deals on Detroit to La Crosse flight tickets
American Airlines
Sep 5
DTW4:27 pmDetroit Metropolitan Wayne County
8h 54m
1 stop
LSE12:21 amLa Crosse
Sep 12
LSE5:53 amLa Crosse
14h 40m
1 stop
DTW9:33 pmDetroit Metropolitan Wayne County
$410
American Airlines
Sep 4
DTW6:40 amDetroit Metropolitan Wayne County
18h 42m
1 stop
LSE12:22 amLa Crosse
Sep 6
LSE6:02 amLa Crosse
9h 53m
1 stop
DTW4:55 pmDetroit Metropolitan Wayne County
$452
American Airlines
Sep 6
DTW9:03 pmDetroit Metropolitan Wayne County
15h 46m
1 stop
LSE11:49 amLa Crosse
Sep 13
LSE5:53 amLa Crosse
14h 40m
1 stop
DTW9:33 pmDetroit Metropolitan Wayne County
$498

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Detroit to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sat 9/5

4:27 pm-12:21 am

1 stop8h 54m

La Crosse

Sat 9/12

5:53 am-9:33 pm

1 stop14h 40m

$410

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Fri 9/4

6:40 am-12:22 am

1 stop18h 42m

La Crosse

Sun 9/6

6:02 am-4:55 pm

1 stop9h 53m

$452

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sun 9/6

9:03 pm-11:49 am

1 stop15h 46m

La Crosse

Sun 9/13

5:53 am-9:33 pm

1 stop14h 40m

$498

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sat 9/5

7:15 am-2:42 pm

2 stops8h 27m

La Crosse

Sat 9/12

5:53 am-12:22 pm

1 stop5h 29m

$501

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Fri 9/18

6:36 am-11:22 am

1 stop5h 46m

La Crosse

Sun 9/20

5:22 pm-11:34 pm

1 stop5h 12m

$522

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Fri 11/27

6:44 am-6:23 pm

1 stop12h 39m

La Crosse

Mon 11/30

6:49 pm-4:04 pm

1 stop20h 15m

$547

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Fri 9/4

4:08 pm-11:54 am

1 stop20h 46m

La Crosse

Sun 9/6

6:02 am-9:38 pm

2 stops14h 36m

$552

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Thu 8/27

4:08 pm-12:22 am

1 stop9h 14m

La Crosse

Mon 8/31

12:19 pm-12:31 pm

1 stop23h 12m

$574

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sat 9/5

8:00 am-12:21 am

2 stops17h 21m

La Crosse

Sat 9/12

5:53 am-7:22 pm

2 stops12h 29m

$575
Quickest round-trip

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Fri 9/4

9:03 pm-12:22 am

1 stop4h 19m

La Crosse

Sat 9/12

5:53 am-12:22 pm

1 stop5h 29m

$579

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to La Crosse from

How to get the cheapest flight ticket from Detroit to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Detroit to La Crosse?

American Airlines is the most popular carrier operating from Detroit to La Crosse

When to book flights from Detroit to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to La Crosse (DTT to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to La Crosse

Fastest flight time

4h 44m

Direct flights

None
The fastest flight from Detroit to La Crosse takes 4h 44m
There are no direct flights from Detroit to La Crosse. There are no popular flight routes from Detroit to La Crosse.
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Frequently asked questions about flying from Detroit to La Crosse

  • How far is Detroit to La Crosse by plane?

    La Crosse is 425.0 mi away from Detroit. Flights usually cover this in 4h 44m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to La Crosse Airport?

    Prices for flights from Detroit to La Crosse Airport are updated daily.

  • How old do you have to be to fly from Detroit to La Crosse Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to La Crosse?

It is quick and easy to find Detroit to La Crosse flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to La Crosse that suits you.

Can I find flights from Detroit to La Crosse with flexible booking policies on momondo?

momondo does allow users to show only those flights to La Crosse from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Detroit.

I’m not ready to book a flight from Detroit to La Crosse right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Detroit to La Crosse now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to La Crosse and let you know when they change.

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