Our Hampton Inn Opelousas hotel features a new and upscale design and is located near many things to do in Louisiana’s third oldest city near the Atchafalaya River. We are located off Interstate 49 within 5 miles of the Wal-Mart Distribution Center, a top employer in this historic area filled with music, authentic cuisine and beautiful architecture. After a busy day, relax in one of our spacious rooms or suites on a clean and fresh Hampton bed®. Rooms have a 42-inch HDTV with premium channels for watching your favorite shows and a large work desk with ergonomic chair for getting work done. Upgrade for a room with more space and a sofa bed. With free hot breakfast daily, start your day on the right foot. Even if you’re in a hurry, you have time to grab Hampton’s On the Run™ Breakfast Bags, available Monday through Friday. Ask our friendly team for lunch and dinner options in Opelousas. Spend time at the outdoor seasonal pool and get in a complete workout in our fitness center. Our hotel offers easy access to many top Opelousas, LA meeting spaces, free self-parking and free remote printing so you’ll get the most out of your stay with us.