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Cheap flights from the United States to Santa Cruz de la Sierra from $260

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from the United States to Santa Cruz de la Sierra departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from the United States to Santa Cruz de la Sierra

Recent round-trip flight deals from the United States to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.
Copa Airlines Logo
12:51 am - 10:44 pmLAX  Los Angeles-VVI Santa Cruz de la Sierra Viru Viru Intl
18h 53m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
Copa Airlines Logo
11:47 am - 9:42 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-LAX Los Angeles
36h 55m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$444Copa Airlines
Tue, Sep 8 - Mon, Sep 21
Copa Airlines Logo
8:15 am - 3:38 amLAX  Los Angeles-VVI Santa Cruz de la Sierra Viru Viru Intl
16h 23m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
Copa Airlines Logo
11:47 am - 6:07 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-LAX Los Angeles
33h 20m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$444Copa Airlines
Wed, Sep 9 - Tue, Sep 22
Multiple Airlines Logo
3:41 pm - 2:35 amBOS  Boston Logan Intl-VVI Santa Cruz de la Sierra Viru Viru Intl
34h 54m2 stops Newark Bogotá El Dorado
Multiple Airlines Logo
11:49 am - 4:25 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-BOS Boston Logan Intl
53h 36m2 stops Panama City Tocumen Intl Newark
$572Multiple Airlines
Sat, Oct 31 - Mon, Nov 30
Multiple Airlines Logo
11:53 am - 3:38 amRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
15h 45m2 stops Newark Panama City Tocumen Intl
Multiple Airlines Logo
3:35 am - 7:57 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
16h 22m2 stops Bogotá El Dorado Washington, D.C. Dulles Intl
$581Multiple Airlines
Wed, Sep 2 - Tue, Sep 22
United Airlines Logo
7:05 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
39h 39m2 stops Newark Panama City Tocumen Intl
United Airlines Logo
11:49 am - 11:08 amVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
24h 19m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$583United Airlines
Tue, Oct 20 - Thu, Nov 5
United Airlines Logo
10:40 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
36h 04m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
United Airlines Logo
11:49 am - 12:24 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
25h 35m2 stops Panama City Tocumen Intl Chicago O'Hare Intl
$583United Airlines
Tue, Oct 20 - Thu, Nov 5
BoA Logo
10:10 am - 5:00 pmMIA  Miami-VVI Santa Cruz de la Sierra Viru Viru Intl
6h 50mnonstop
BoA Logo
11:35 pm - 6:25 amVVI  Santa Cruz de la Sierra Viru Viru Intl-MIA Miami
6h 50mnonstop
$585BoA
Tue, Sep 15 - Sun, Sep 27
BoA Logo
10:10 am - 5:00 pmMIA  Miami-VVI Santa Cruz de la Sierra Viru Viru Intl
6h 50mnonstop
BoA Logo
11:35 pm - 6:25 amVVI  Santa Cruz de la Sierra Viru Viru Intl-MIA Miami
6h 50mnonstop
$585BoA
Mon, Sep 7 - Mon, Oct 5
Avianca Logo
1:45 pm - 2:30 amMIA  Miami-VVI Santa Cruz de la Sierra Viru Viru Intl
36h 45m3 stops Managua Augusto C Sandino San Salvador El Salvador Intl Bogotá El Dorado
Avianca Logo
3:35 am - 12:10 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-MIA Miami
32h 35m2 stops Bogotá El Dorado San Salvador El Salvador Intl
$587Avianca
Sat, Sep 12 - Sun, Sep 27
Avianca Logo
1:45 pm - 2:30 amMIA  Miami-VVI Santa Cruz de la Sierra Viru Viru Intl
36h 45m3 stops Managua Augusto C Sandino San Salvador El Salvador Intl Bogotá El Dorado
Avianca Logo
3:35 am - 12:05 amVVI  Santa Cruz de la Sierra Viru Viru Intl-MIA Miami
20h 30m3 stops Bogotá El Dorado San Salvador El Salvador Intl Managua Augusto C Sandino
$587Avianca
Mon, Oct 5 - Sun, Oct 18

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Avianca flights from United States to Santa Cruz de la Sierra

Our best Avianca deals on United States to Santa Cruz de la Sierra flight tickets
Avianca
Oct 5
MIA3:50 pmMiami
34h 40m
2 stops
VVI2:30 amSanta Cruz de la Sierra Viru Viru Intl
Oct 18
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
34h 25m
3 stops
MIA2:00 pmMiami
$587
Avianca
Aug 20
MIA6:25 amMiami
20h 05m
3 stops
VVI2:30 amSanta Cruz de la Sierra Viru Viru Intl
Aug 25
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
20h 30m
3 stops
MIA12:05 amMiami
$588
Avianca
Sep 26
MIA2:45 amMiami
23h 45m
1 stop
VVI2:30 amSanta Cruz de la Sierra Viru Viru Intl
Oct 7
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
14h 30m
1 stop
MIA6:05 pmMiami
$589

Copa Airlines flights from United States to Santa Cruz de la Sierra

Our best Copa Airlines deals on United States to Santa Cruz de la Sierra flight tickets
Copa Airlines
Sep 8
LAX12:51 amLos Angeles
18h 53m
2 stops
VVI10:44 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 21
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
36h 55m
2 stops
LAX9:42 pmLos Angeles
$444
Copa Airlines
Sep 8
LAX3:18 pmLos Angeles
33h 20m
2 stops
VVI3:38 amSanta Cruz de la Sierra Viru Viru Intl
Sep 22
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
33h 20m
2 stops
LAX6:07 pmLos Angeles
$449
Copa Airlines
Sep 7
LAX6:59 pmLos Angeles
24h 45m
2 stops
VVI10:44 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 21
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
35h 36m
2 stops
LAX8:23 pmLos Angeles
$454

momondo Fare Finder

 
Customize your flight search to find flights from United States to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from the United States to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Los AngelesSanta Cruz de la Sierra

LAX Los Angeles - VVI Santa Cruz de la Sierra Viru Viru Intl

LAXVVI

Los Angeles

Tue 9/8

12:51 am-10:44 pm

2 stops18h 53m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/21

11:47 am-9:42 pm

2 stops36h 55m

$444

Los AngelesSanta Cruz de la Sierra

LAX Los Angeles - VVI Santa Cruz de la Sierra Viru Viru Intl

LAXVVI

Los Angeles

Wed 9/9

8:15 am-3:38 am

2 stops16h 23m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/22

11:47 am-6:07 pm

2 stops33h 20m

$444

BostonSanta Cruz de la Sierra

BOS Boston Logan Intl - VVI Santa Cruz de la Sierra Viru Viru Intl

BOSVVI

Boston Logan Intl

Sat 10/31

3:41 pm-2:35 am

2 stops34h 54m

Santa Cruz de la Sierra Viru Viru Intl

Mon 11/30

11:49 am-4:25 pm

2 stops53h 36m

$572

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Wed 9/2

11:53 am-3:38 am

2 stops15h 45m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/22

3:35 am-7:57 pm

2 stops16h 22m

$581

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Tue 10/20

7:05 am-10:44 pm

2 stops39h 39m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/5

11:49 am-11:08 am

2 stops24h 19m

$583

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Tue 10/20

10:40 am-10:44 pm

2 stops36h 04m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/5

11:49 am-12:24 pm

2 stops25h 35m

$583
Quickest round-trip

MiamiSanta Cruz de la Sierra

MIA Miami - VVI Santa Cruz de la Sierra Viru Viru Intl

MIAVVI

Miami

Tue 9/15

10:10 am-5:00 pm

Nonstop6h 50m

Santa Cruz de la Sierra Viru Viru Intl

Sun 9/27

11:35 pm-6:25 am

Nonstop6h 50m

$585

MiamiSanta Cruz de la Sierra

MIA Miami - VVI Santa Cruz de la Sierra Viru Viru Intl

MIAVVI

Miami

Mon 9/7

10:10 am-5:00 pm

Nonstop6h 50m

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/5

11:35 pm-6:25 am

Nonstop6h 50m

$585

MiamiSanta Cruz de la Sierra

MIA Miami - VVI Santa Cruz de la Sierra Viru Viru Intl

MIAVVI

Miami

Sat 9/12

1:45 pm-2:30 am

3 stops36h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sun 9/27

3:35 am-12:10 pm

2 stops32h 35m

$587

MiamiSanta Cruz de la Sierra

MIA Miami - VVI Santa Cruz de la Sierra Viru Viru Intl

MIAVVI

Miami

Mon 10/5

1:45 pm-2:30 am

3 stops36h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sun 10/18

3:35 am-12:05 am

3 stops20h 30m

$587

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santa Cruz de la Sierra from

How to get the cheapest flight ticket from United States to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Cruz de la Sierra?

The cheapest month to fly to Santa Cruz de la Sierra from United States is in November. Flight prices, which tend to average around $603, are often lower during this time because this is during the off-season. If you don’t want to visit Santa Cruz de la Sierra in November, then you should wait until October to fly from United States, when ticket prices are also cheap, with an average price of $605.

What is the cheapest United States to Santa Cruz de la Sierra Viru Viru Intl flight route?

Fly from Miami to Santa Cruz de la Sierra Viru Viru Intl for the best United States - Santa Cruz de la Sierra Viru Viru Intl flight prices

How far in advance should I book a flight to Santa Cruz de la Sierra?

You are more likely to see cheaper flights to Santa Cruz de la Sierra from United States when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Cruz de la Sierra for around $777 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Cruz de la Sierra from United States for as low as $613 on momondo.

What cabin class options are available on United States to Santa Cruz de la Sierra flights?

There are 3 cabin classes available to choose from on United States to Santa Cruz de la Sierra flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on United States to Santa Cruz de la Sierra flights?

You could potentially save up to 23% on your flight if you consider stops on a United States to Santa Cruz de la Sierra flight.

Cheap United States to Santa Cruz de la Sierra flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from United States to Santa Cruz de la Sierra

Best Price Found

$326

Fastest flight time

5h 50m

Direct flights

Tue, Wed, Fri, Sat and Sun

Airports in Santa Cruz de la Sierra

1 airport
The best one-way flight to Santa Cruz de la Sierra from United States in the past 72 hours is $326. The best round-trip flight deal from United States to Santa Cruz de la Sierra found on momondo in the last 72 hours is $633.
The fastest flight from United States to Santa Cruz de la Sierra takes 5h 50m
Direct flights go from United States to Santa Cruz de la Sierra on Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Santa Cruz de la Sierra. From United States there are direct flights to Santa Cruz de la Sierra Viru Viru Intl (VVI).
Search flight deals

Frequently asked questions about flying from the United States to Santa Cruz de la Sierra

  • When did momondo last update prices for flights from United States to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from United States to Santa Cruz de la Sierra Viru Viru Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from United States to Santa Cruz de la Sierra Viru Viru Intl Airport?

  • How old do you have to be to fly from United States to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from United States to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The necessary travel and health documents for your Santa Cruz de la Sierra Viru Viru Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from United States to Santa Cruz de la Sierra?

Best airlines flying from United States to Santa Cruz de la Sierra

Compare and see reviews for airlines that fly from United States to Santa Cruz de la Sierra with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $278Free CancellationRating
6.5
2,523 reviews
Search Avianca flights
Copa AirlinesPriceFrom $312Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $354Free CancellationRating
7.4
10,072 reviews
Search United Airlines flights
BoAPriceFrom $509Free CancellationRating
6.9
135 reviews
Search BoA flights
LATAM AirlinesPriceFrom $550Free CancellationRating
7.4
1,973 reviews
Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from United States to Santa Cruz de la Sierra?

Finding the right flight to Santa Cruz de la Sierra from United States is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santa Cruz de la Sierra quick and easy, saving you time and money.

Can I find flights from United States to Santa Cruz de la Sierra with flexible booking policies on momondo?

All flight searches from United States to Santa Cruz de la Sierra on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from United States to Santa Cruz de la Sierra?

momondo provides multiple filters to help you find the best flight to Santa Cruz de la Sierra from United States. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from United States to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

Yes. momondo can track prices for United States to Santa Cruz de la Sierra flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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