Cheap flights from the United States to Panama from $157

The month of September is, on average, the cheapest month to fly to Panama from United States, with most prices found around $528. If you don’t want to visit Panama in September, then you should wait until June to fly from United States, when ticket prices are also cheap, with an average price of $547.

According to our data, Wednesday is the cheapest day to fly to Panama from United States. The lowest ticket price found for a Wednesday departure recently was $617. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from United States to Panama for around $663.

In the morning is the cheapest time of day to fly from United States to Panama when you can find flight prices for as low as $619. Flying to Panama in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $639 per ticket.

Fly from Boston Logan Intl to Panama City Tocumen Intl for the best United States - Panama flight prices

You are more likely to see cheaper flights to Panama from United States when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $611 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from United States for as low as $513 on momondo.

There are 3 cabin classes available to choose from on United States to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Avianca and Copa Airlines are the most popular carriers operating from United States to Panama

Copa Airlines, United Airlines and Delta are the top three most popular airlines that fly to Panama from United States according to our data. Copa Airlines is the first choice among our users, with 67% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 6 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Historically, on average around 11% of flights between United States and Panama have experienced a delay on any given week. The average delay length over the past 12 months has been 128 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 7% of their flights experiencing any sort of delay.

The number of flights available between United States and Panama is 52 per day as of February 2026. The most frequent departure time is 1:00AM, with 43% of daily flights leaving in the morning.

369 flights are operational weekly from United States to Panama as of February 2026. The most popular departure day for this route is Sun, with 15% of flights per week taking off on this day.