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Cheap flights from South Carolina to Chicago from $71

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Chicago departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from South Carolina to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:23 pm - 2:45 pmSAV  Savannah/Hilton Head-ORD Chicago O'Hare Intl
27h 22m1 stop Fort Lauderdale
Multiple Airlines Logo
7:11 am - 4:15 pmORD  Chicago O'Hare Intl-SAV Savannah/Hilton Head
8h 04m1 stop Fort Lauderdale
$160Multiple Airlines
Wed, Sep 9 - Wed, Sep 16
Multiple Airlines Logo
12:23 pm - 2:45 pmSAV  Savannah/Hilton Head-ORD Chicago O'Hare Intl
27h 22m1 stop Fort Lauderdale
Multiple Airlines Logo
7:11 am - 4:15 pmORD  Chicago O'Hare Intl-SAV Savannah/Hilton Head
8h 04m1 stop Fort Lauderdale
$165Multiple Airlines
Wed, Sep 9 - Sat, Sep 12
United Airlines Logo
3:24 pm - 5:00 pmMYR  Myrtle Beach Intl-ORD Chicago O'Hare Intl
2h 36mnonstop
United Airlines Logo
11:27 am - 2:53 pmORD  Chicago O'Hare Intl-MYR Myrtle Beach Intl
2h 26mnonstop
$197United Airlines
Sat, Sep 5 - Sun, Sep 6
American Airlines Logo
5:00 pm - 6:38 pmMYR  Myrtle Beach Intl-ORD Chicago O'Hare Intl
2h 38mnonstop
American Airlines Logo
8:15 am - 11:34 amORD  Chicago O'Hare Intl-MYR Myrtle Beach Intl
2h 19mnonstop
$197American Airlines
Sat, Sep 5 - Sun, Sep 6
United Airlines Logo
5:00 pm - 6:36 pmMYR  Myrtle Beach Intl-ORD Chicago O'Hare Intl
2h 36mnonstop
United Airlines Logo
11:55 am - 3:16 pmORD  Chicago O'Hare Intl-MYR Myrtle Beach Intl
2h 21mnonstop
$219United Airlines
Wed, Sep 30 - Sat, Oct 3
American Airlines Logo
5:00 pm - 6:38 pmMYR  Myrtle Beach Intl-ORD Chicago O'Hare Intl
2h 38mnonstop
American Airlines Logo
8:15 am - 11:34 amORD  Chicago O'Hare Intl-MYR Myrtle Beach Intl
2h 19mnonstop
$226American Airlines
Sat, Sep 5 - Mon, Sep 7
Frontier Logo
1:02 pm - 6:17 amCLT  Charlotte Douglas-ORD Chicago O'Hare Intl
18h 15m2 stops Houston George Bush Intcntl Los Angeles
Frontier Logo
7:44 pm - 8:01 amORD  Chicago O'Hare Intl-CLT Charlotte Douglas
11h 17m1 stop Orlando
$254Frontier
Tue, Sep 1 - Wed, Sep 2
Frontier Logo
8:56 am - 11:08 pmCLT  Charlotte Douglas-ORD Chicago O'Hare Intl
15h 12m1 stop Orlando
Frontier Logo
3:50 pm - 8:35 amORD  Chicago O'Hare Intl-CLT Charlotte Douglas
15h 45m1 stop Orlando
$254Frontier
Tue, Sep 8 - Wed, Sep 9
Delta Logo
3:00 pm - 6:59 pmCHS  Charleston-ORD Chicago O'Hare Intl
4h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:40 am - 11:54 amORD  Chicago O'Hare Intl-CHS Charleston
4h 14m1 stop Atlanta Hartsfield-Jackson
$257Delta
Sat, Sep 5 - Sun, Sep 6
Delta Logo
1:13 pm - 4:51 pmCHS  Charleston-ORD Chicago O'Hare Intl
4h 38m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:40 am - 11:54 amORD  Chicago O'Hare Intl-CHS Charleston
4h 14m1 stop Atlanta Hartsfield-Jackson
$257Delta
Sat, Sep 5 - Sun, Sep 6

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United Airlines flights from South Carolina to Chicago O'Hare Intl Airport

Our best United Airlines deals on South Carolina to Chicago O'Hare Intl Airport flight tickets
United Airlines
Sep 5
MYR3:24 pmMyrtle Beach Intl
2h 36m
ORD5:00 pmChicago O'Hare Intl
Sep 6
ORD11:27 amChicago O'Hare Intl
2h 26m
MYR2:53 pmMyrtle Beach Intl
$197
United Airlines
Sep 29
MYR5:00 pmMyrtle Beach Intl
2h 36m
ORD6:36 pmChicago O'Hare Intl
Oct 3
ORD11:55 amChicago O'Hare Intl
2h 21m
MYR3:16 pmMyrtle Beach Intl
$219
United Airlines
Sep 5
MYR10:23 amMyrtle Beach Intl
7h 36m
1 stop
ORD4:59 pmChicago O'Hare Intl
Sep 6
ORD11:27 amChicago O'Hare Intl
2h 26m
MYR2:53 pmMyrtle Beach Intl
$224

American Airlines flights from South Carolina to Chicago O'Hare Intl Airport

Our best American Airlines deals on South Carolina to Chicago O'Hare Intl Airport flight tickets
American Airlines
Sep 3
MYR7:33 pmMyrtle Beach Intl
5h 19m
1 stop
ORD11:52 pmChicago O'Hare Intl
Sep 6
ORD8:15 amChicago O'Hare Intl
2h 19m
MYR11:34 amMyrtle Beach Intl
$236
American Airlines
Sep 5
SAV12:55 pmSavannah/Hilton Head
5h 48m
1 stop
ORD5:43 pmChicago O'Hare Intl
Sep 6
ORD8:00 amChicago O'Hare Intl
2h 22m
SAV11:22 amSavannah/Hilton Head
$247
American Airlines
Sep 8
SAV11:53 amSavannah/Hilton Head
2h 36m
ORD1:29 pmChicago O'Hare Intl
Sep 15
ORD1:19 pmChicago O'Hare Intl
4h 45m
1 stop
SAV7:04 pmSavannah/Hilton Head
$255

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SavannahChicago

SAV Savannah/Hilton Head - ORD Chicago O'Hare Intl

SAVORD

Savannah/Hilton Head

Wed 9/9

12:23 pm-2:45 pm

1 stop27h 22m

Chicago O'Hare Intl

Wed 9/16

7:11 am-4:15 pm

1 stop8h 04m

$160

SavannahChicago

SAV Savannah/Hilton Head - ORD Chicago O'Hare Intl

SAVORD

Savannah/Hilton Head

Wed 9/9

12:23 pm-2:45 pm

1 stop27h 22m

Chicago O'Hare Intl

Sat 9/12

7:11 am-4:15 pm

1 stop8h 04m

$165

Myrtle BeachChicago

MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl

MYRORD

Myrtle Beach Intl

Sat 9/5

3:24 pm-5:00 pm

Nonstop2h 36m

Chicago O'Hare Intl

Sun 9/6

11:27 am-2:53 pm

Nonstop2h 26m

$197
Quickest round-trip

Myrtle BeachChicago

MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl

MYRORD

Myrtle Beach Intl

Sat 9/5

5:00 pm-6:38 pm

Nonstop2h 38m

Chicago O'Hare Intl

Sun 9/6

8:15 am-11:34 am

Nonstop2h 19m

$197

Myrtle BeachChicago

MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl

MYRORD

Myrtle Beach Intl

Wed 9/30

5:00 pm-6:36 pm

Nonstop2h 36m

Chicago O'Hare Intl

Sat 10/3

11:55 am-3:16 pm

Nonstop2h 21m

$219

Myrtle BeachChicago

MYR Myrtle Beach Intl - ORD Chicago O'Hare Intl

MYRORD

Myrtle Beach Intl

Sat 9/5

5:00 pm-6:38 pm

Nonstop2h 38m

Chicago O'Hare Intl

Mon 9/7

8:15 am-11:34 am

Nonstop2h 19m

$226

CharlotteChicago

CLT Charlotte Douglas - ORD Chicago O'Hare Intl

CLTORD

Charlotte Douglas

Tue 9/1

1:02 pm-6:17 am

2 stops18h 15m

Chicago O'Hare Intl

Wed 9/2

7:44 pm-8:01 am

1 stop11h 17m

$254

CharlotteChicago

CLT Charlotte Douglas - ORD Chicago O'Hare Intl

CLTORD

Charlotte Douglas

Tue 9/8

8:56 am-11:08 pm

1 stop15h 12m

Chicago O'Hare Intl

Wed 9/9

3:50 pm-8:35 am

1 stop15h 45m

$254

CharlestonChicago

CHS Charleston - ORD Chicago O'Hare Intl

CHSORD

Charleston

Sat 9/5

3:00 pm-6:59 pm

1 stop4h 59m

Chicago O'Hare Intl

Sun 9/6

6:40 am-11:54 am

1 stop4h 14m

$257

CharlestonChicago

CHS Charleston - ORD Chicago O'Hare Intl

CHSORD

Charleston

Sat 9/5

1:13 pm-4:51 pm

1 stop4h 38m

Chicago O'Hare Intl

Sun 9/6

6:40 am-11:54 am

1 stop4h 14m

$257

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from South Carolina to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of August is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from South Carolina averaging around $333.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $421. This is often the case because there is less demand to fly during this day of the week. On the other hand, Monday is the most expensive day to depart from South Carolina because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $704.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from South Carolina in the evening is the least expensive time of day to depart. momondo users have found prices as low as $393 when looking at flights departing in the evening. Try not to purchase tickets at noon because they tend to be around $566. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest South Carolina to Chicago O'Hare Intl flight route?

Fly from Myrtle Beach Intl to Chicago O'Hare Intl for the best South Carolina - Chicago O'Hare Intl flight prices

How far in advance should I book a flight from South Carolina to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $376 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from South Carolina for as low as $195 on momondo.

What cabin class options are available on South Carolina to Chicago O'Hare Intl Airport flights?

There are 4 cabin classes available to choose from on South Carolina to Chicago O'Hare Intl Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Chicago O'Hare Intl Airport flights?

You could potentially save up to 29% on your flight if you consider stops on a South Carolina to Chicago O'Hare Intl Airport flight.

Cheap South Carolina to Chicago O'Hare Intl Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Chicago O'Hare Intl Airport

Best Price Found

$206

Fastest flight time

2h 02m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from South Carolina in the past 72 hours is $206. The best round-trip flight deal from South Carolina to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $289.
The fastest flight from South Carolina to Chicago O'Hare Intl Airport takes 2h 02m
Direct flights go from South Carolina to Chicago O'Hare Intl Airport every day.
Search flight deals

Frequently asked questions about flying from South Carolina to Chicago O'Hare Intl Airport

  • When did momondo last update prices for flights from South Carolina to Chicago O'Hare Intl Airport?

    Prices for flights from South Carolina to Chicago O'Hare Intl Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from South Carolina to Chicago O'Hare Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to Chicago O'Hare Intl Airport?

Best airlines flying from South Carolina to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from South Carolina to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $156Free CancellationRating
7.8
8,502 reviews
Search Delta flights
United AirlinesPriceFrom $202Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights
American AirlinesPriceFrom $209Free CancellationRating
7.1
11,923 reviews
Search American Airlines flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
Merrillville
Rockford
South Haven
Gurnee
Rosemont
Oak Brook
Orland Park
Naperville
Joliet
New Buffalo
Kenosha
Hammond
Racine
Aurora
Janesville
Elgin
South Holland
Evanston

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Chicago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Chicago. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Chicago?

Once you have performed a search for South Carolina to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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