What is the cheapest airline that flies from South Carolina to Chicago O'Hare Intl?

Delta, United Airlines, and Southwest are the most popular carriers operating from South Carolina to Chicago O'Hare Intl

How many flights depart from South Carolina to Chicago O'Hare Intl Airport on average per day?

As of March 2026, 84 flights take off from South Carolina and land in Chicago O'Hare Intl Airport each day. The most common flight departure time for this route is 5:00PM, with 50% of daily flights taking off at noon.

How long does it take to fly to Chicago O'Hare Intl Airport?

On average, it takes 2h 07m to fly from South Carolina to Chicago O'Hare Intl Airport if you fly out of Greenville (the most popular airport in South Carolina) and into Chicago O'Hare Intl Airport (the most popular airport in Chicago O'Hare Intl Airport). If you’re flying out of Columbia and into Chicago O'Hare Intl Airport, then the flight time is around 2h 16m.

What airlines fly to Chicago O'Hare Intl Airport?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Chicago O'Hare Intl Airport from South Carolina according to our data. United Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Chicago O'Hare Intl Airport. Keep in mind that there are 4 different airlines that fly to Chicago O'Hare Intl Airport on a routine basis, so you have a few additional options to choose from.

How many operators does momondo search for flights from South Carolina to Chicago O'Hare Intl Airport?

As of March 2026, there are 5 operators available to choose from for flights from South Carolina to Chicago O'Hare Intl Airport.

How old do you have to be to fly from South Carolina to Chicago O'Hare Intl Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Chicago O'Hare Intl Airport.

What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$69 Cheap Flights from South Carolina to Chicago O'Hare Intl Airport in 2026

Q: How many flights depart from South Carolina to Chicago O'Hare Intl Airport on average per week?

As of March 2026, 589 flights take off from South Carolina and land in Chicago O'Hare Intl Airport each week. The most common flight departure day for this route is Mon, with 19% of weekly flights taking off on this day.

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Find the cheapest flights from South Carolina to Chicago

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:56 am - 9:17 pm

CLT

ORD

13h 21m

1 stop

12:37 pm - 3:45 pm

ORD

CLT

2h 08mnonstop

$114Frontier

Thu, Apr 23 - Mon, Apr 27

4:40 pm - 6:14 pm

CLT

ORD

2h 34mnonstop

12:37 pm - 3:45 pm

ORD

CLT

2h 08mnonstop

$116Frontier

Fri, May 1 - Mon, May 4

7:50 pm - 11:59 pm

AGS

ORD

5h 09m

1 stop

7:10 am - 2:10 pm

ORD

AGS

6h 00m

1 stop

$167Delta

Thu, Apr 30 - Tue, May 5

6:28 pm - 11:17 pm

MYR

ORD

5h 49m

1 stop

12:45 pm - 8:02 pm

ORD

MYR

6h 17m

1 stop

$170Spirit Airlines

Wed, Apr 8 - Tue, Apr 14

6:42 pm - 9:36 am

CAE

ORD

15h 54m

1 stop

2:10 pm - 5:52 pm

ORD

CAE

26h 42m

1 stop

$175Multiple Airlines

Fri, Apr 17 - Sun, Apr 19

6:42 pm - 9:36 am

CAE

ORD

15h 54m

1 stop

2:10 pm - 5:52 pm

ORD

CAE

26h 42m

1 stop

$177Multiple Airlines

Fri, Apr 17 - Sun, Apr 19

5:08 pm - 11:48 pm

AGS

ORD

7h 40m

1 stop

5:00 am - 10:34 am

ORD

AGS

4h 34m

1 stop

$187American Airlines

Sat, Apr 18 - Wed, Apr 22

6:28 pm - 11:17 pm

MYR

ORD

5h 49m

1 stop

9:06 am - 8:02 pm

ORD

MYR

9h 56m

1 stop

$190Spirit Airlines

Sat, Apr 11 - Tue, Apr 14

1:04 pm - 6:34 pm

AGS

ORD

6h 30m

1 stop

7:00 am - 12:08 pm

ORD

AGS

4h 08m

1 stop

$196Delta

Mon, Apr 6 - Mon, Apr 13

4:08 pm - 9:13 pm

AGS

ORD

6h 05m

1 stop

1:48 pm - 5:00 pm

ORD

AGS

2h 12mnonstop

$206American Airlines

Fri, Apr 10 - Mon, Apr 13

JetBlue flights from South Carolina to Chicago O'Hare Intl Airport

Our best JetBlue deals on South Carolina to Chicago O'Hare Intl Airport flight tickets

JetBlue

May 5

CHS6:00 amCharleston

16h 36m

1 stop

ORD9:36 pmChicago O'Hare Intl

May 9

ORD8:34 amChicago O'Hare Intl

7h 23m

1 stop

CHS4:57 pmCharleston

$298

JetBlue

Mar 26

CHS10:32 amCharleston

7h 52m

1 stop

ORD5:24 pmChicago O'Hare Intl

Mar 28

ORD11:00 amChicago O'Hare Intl

5h 53m

1 stop

CHS5:53 pmCharleston

$381

JetBlue

Apr 3

CHS7:28 pmCharleston

13h 37m

1 stop

ORD8:05 amChicago O'Hare Intl

Apr 5

ORD8:55 amChicago O'Hare Intl

6h 07m

1 stop

CHS4:02 pmCharleston

$393

Frontier flights from South Carolina to Chicago O'Hare Intl Airport

Our best Frontier deals on South Carolina to Chicago O'Hare Intl Airport flight tickets

Frontier

Apr 23

CLT8:56 amCharlotte Douglas

13h 21m

1 stop

ORD9:17 pmChicago O'Hare Intl

Apr 27

ORD12:37 pmChicago O'Hare Intl

2h 08m

CLT3:45 pmCharlotte Douglas

$114

Frontier

May 1

CLT4:40 pmCharlotte Douglas

2h 34m

ORD6:14 pmChicago O'Hare Intl

May 4

ORD12:37 pmChicago O'Hare Intl

2h 08m

CLT3:45 pmCharlotte Douglas

$116

Frontier

Apr 11

CLT7:09 pmCharlotte Douglas

2h 30m

ORD8:39 pmChicago O'Hare Intl

Apr 26

ORD12:38 pmChicago O'Hare Intl

2h 08m

CLT3:46 pmCharlotte Douglas

$117

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Thu 4/23

8:56 am-9:17 pm

1 stop13h 21m

Chicago O'Hare Intl

Mon 4/27

12:37 pm-3:45 pm

Nonstop2h 08m

$114

Quickest round-trip

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Fri 5/1

4:40 pm-6:14 pm

Nonstop2h 34m

Chicago O'Hare Intl

Mon 5/4

12:37 pm-3:45 pm

Nonstop2h 08m

$116

AugustaChicago

AGS - ORD

AGSORD

Augusta Bush Field

Thu 4/30

7:50 pm-11:59 pm

1 stop5h 09m

Chicago O'Hare Intl

Tue 5/5

7:10 am-2:10 pm

1 stop6h 00m

$167

Myrtle BeachChicago

MYR - ORD

MYRORD

Myrtle Beach Intl

Wed 4/8

6:28 pm-11:17 pm

1 stop5h 49m

Chicago O'Hare Intl

Tue 4/14

12:45 pm-8:02 pm

1 stop6h 17m

$170

ColumbiaChicago

CAE - ORD

CAEORD

Columbia Metropolitan

Fri 4/17

6:42 pm-9:36 am

1 stop15h 54m

Chicago O'Hare Intl

Sun 4/19

2:10 pm-5:52 pm

1 stop26h 42m

$175

ColumbiaChicago

CAE - ORD

CAEORD

Columbia Metropolitan

Fri 4/17

6:42 pm-9:36 am

1 stop15h 54m

Chicago O'Hare Intl

Sun 4/19

2:10 pm-5:52 pm

1 stop26h 42m

$177

AugustaChicago

AGS - ORD

AGSORD

Augusta Bush Field

Sat 4/18

5:08 pm-11:48 pm

1 stop7h 40m

Chicago O'Hare Intl

Wed 4/22

5:00 am-10:34 am

1 stop4h 34m

$187

Myrtle BeachChicago

MYR - ORD

MYRORD

Myrtle Beach Intl

Sat 4/11

6:28 pm-11:17 pm

1 stop5h 49m

Chicago O'Hare Intl

Tue 4/14

9:06 am-8:02 pm

1 stop9h 56m

$190

AugustaChicago

AGS - ORD

AGSORD

Augusta Bush Field

Mon 4/6

1:04 pm-6:34 pm

1 stop6h 30m

Chicago O'Hare Intl

Mon 4/13

7:00 am-12:08 pm

1 stop4h 08m

$196

AugustaChicago

AGS - ORD

AGSORD

Augusta Bush Field

Fri 4/10

4:08 pm-9:13 pm

1 stop6h 05m

Chicago O'Hare Intl

Mon 4/13

1:48 pm-5:00 pm

Nonstop2h 12m

$206

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of September is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from South Carolina averaging around $301.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Friday when prices can be found for as low as $399. This is often the case because there is less demand to fly during this day of the week. On the other hand, Monday is the most expensive day to depart from South Carolina because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $684.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from South Carolina in the evening is the least expensive time of day to depart. momondo users have found prices as low as $356 when looking at flights departing in the evening. Try not to purchase tickets at noon because they tend to be around $544. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest South Carolina to Chicago O'Hare Intl flight route?

Fly from Myrtle Beach Intl to Chicago O'Hare Intl for the best South Carolina - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $359 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from South Carolina for as low as $268 on momondo.

What cabin class options are available on South Carolina to Chicago O'Hare Intl flights?

There are 4 cabin classes available to choose from on South Carolina to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Chicago O'Hare Intl Airport flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Chicago O'Hare Intl Airport.

Cheap South Carolina to Chicago O'Hare Intl Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Chicago O'Hare Intl Airport

Best Price Found	$148
Fastest flight time	2h 07m
Direct flights	Every day

The best one-way flight to Chicago O'Hare Intl Airport from South Carolina in the past 72 hours is $148. The best round-trip flight deal from South Carolina to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $288.

The fastest flight from South Carolina to Chicago O'Hare Intl Airport takes 2h 07m

Direct flights go from South Carolina to Chicago O'Hare Intl Airport every day.

Search flight deals

When did momondo last update prices for flights from South Carolina to Chicago O'Hare Intl Airport?
Prices for flights from South Carolina to Chicago O'Hare Intl Airport were last updated today.
How many operators does momondo search for flights from South Carolina to Chicago O'Hare Intl Airport?
As of March 2026, there are 5 operators available to choose from for flights from South Carolina to Chicago O'Hare Intl Airport.
How old do you have to be to fly from South Carolina to Chicago O'Hare Intl Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Chicago O'Hare Intl Airport.
What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?
The required travel and health documents for your Chicago O'Hare Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago O'Hare Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from South Carolina to Chicago O'Hare Intl Airport?
Based on momondo bookings for flights between South Carolina and Chicago O'Hare Intl Airport, the leading plane model is Embraer 175 (Enhanced Winglets), making up 21.09% of the total bookings. Other popular models include Canadair (Bombardier) Regional Jet CRJ-550 with 15.69%, Embraer 175 with 15.17%, and Airbus A319 with 10.78%.

Best airlines flying from South Carolina to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from South Carolina to Chicago O'Hare Intl Airport with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $60	Free Cancellation	Rating 6.3 8,535 reviews	Search Spirit Airlines flights
Delta	PriceFrom $107	Free Cancellation	Rating 7.9 8,321 reviews	Search Delta flights
American Airlines	PriceFrom $135	Free Cancellation	Rating 7.1 11,491 reviews	Search American Airlines flights
United Airlines	PriceFrom $178	Free Cancellation	Rating 7.4 9,470 reviews	Search United Airlines flights

Lake Geneva

Schaumburg

South Haven

Rockford

Merrillville

Gurnee

Rosemont

Naperville

New Buffalo

Orland Park

Kenosha

Oak Brook

Joliet

Janesville

Racine

Hammond

Aurora

Elgin

Tinley Park

South Holland

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Chicago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Chicago. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Chicago?

Once you have performed a search for South Carolina to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from South Carolina to Chicago from $69

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Chicago departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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JetBlue flights from South Carolina to Chicago O'Hare Intl Airport

Our best JetBlue deals on South Carolina to Chicago O'Hare Intl Airport flight tickets

Frontier flights from South Carolina to Chicago O'Hare Intl Airport

Our best Frontier deals on South Carolina to Chicago O'Hare Intl Airport flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Chicago O'Hare Intl Airport that are best for you.

See travel insights to Chicago from

How to get the cheapest flight ticket from South Carolina to Chicago O'Hare Intl Airport

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

What is the cheapest South Carolina to Chicago O'Hare Intl flight route?

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

What cabin class options are available on South Carolina to Chicago O'Hare Intl flights?

Can stopping save me money on South Carolina to Chicago O'Hare Intl Airport flights?

What is the cheapest airline that flies from South Carolina to Chicago O'Hare Intl?

What airlines fly to Chicago O'Hare Intl Airport?

How many flights depart from South Carolina to Chicago O'Hare Intl Airport on average per day?

How many flights depart from South Carolina to Chicago O'Hare Intl Airport on average per week?

How long does it take to fly to Chicago O'Hare Intl Airport?

Cheap South Carolina to Chicago O'Hare Intl Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Chicago O'Hare Intl Airport

Best Price Found

Fastest flight time

Direct flights

Best airlines flying from South Carolina to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from South Carolina to Chicago O'Hare Intl Airport with momondo

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Why use momondo?

An easier way to manage your Chicago O'Hare Intl Airport trip

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List of cabin classes available on flights landing in Chicago. Availability may vary depending on flight origin and airline.

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