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Cheap flights from South Carolina to Chicago from $82

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Chicago departing on 9/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
4:20 pm - 7:20 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 00m1 stop Nashville Intl
Southwest Logo
1:40 pm - 4:40 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 00mnonstop
$190Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
5:00 pm - 8:35 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 35m1 stop Baltimore/Washington
Southwest Logo
1:40 pm - 4:40 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 00mnonstop
$190Southwest
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
8:10 am - 9:15 amMYR  Myrtle Beach Intl-MDW Chicago Midway
2h 05mnonstop
Southwest Logo
7:55 am - 11:05 amMDW  Chicago Midway-MYR Myrtle Beach Intl
2h 10mnonstop
$197Southwest
Thu, Sep 24 - Sat, Sep 26
Southwest Logo
4:20 pm - 7:20 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 00m1 stop Nashville Intl
Southwest Logo
8:55 am - 1:45 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
3h 50m1 stop Nashville Intl
$200Southwest
Sat, Sep 5 - Sun, Sep 6
Delta Logo
6:58 pm - 10:44 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
4h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:30 pm - 9:41 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
4h 11m1 stop Atlanta Hartsfield-Jackson
$217Delta
Wed, Sep 16 - Sat, Sep 19
Delta Logo
10:52 am - 3:17 pmMYR  Myrtle Beach Intl-MDW Chicago Midway
5h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:28 am - 6:06 pmMDW  Chicago Midway-MYR Myrtle Beach Intl
5h 38m1 stop Atlanta Hartsfield-Jackson
$239Delta
Wed, Nov 4 - Tue, Nov 17
Delta Logo
6:26 pm - 10:44 pmCHS  Charleston-MDW Chicago Midway
5h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:05 am - 1:07 pmMDW  Chicago Midway-CHS Charleston
6h 02m1 stop Atlanta Hartsfield-Jackson
$257Delta
Sat, Sep 12 - Tue, Sep 15
Frontier Logo
9:05 pm - 11:59 amCLT  Charlotte Douglas-MDW Chicago Midway
15h 54m1 stop Dallas/Fort Worth
Frontier Logo
6:25 am - 6:22 pmMDW  Chicago Midway-CLT Charlotte Douglas
34h 57m2 stops Atlanta Hartsfield-Jackson Miami
$312Frontier
Fri, Sep 25 - Fri, Oct 2
Frontier Logo
8:56 am - 10:47 pmCLT  Charlotte Douglas-MDW Chicago Midway
14h 51m2 stops Orlando Atlanta Hartsfield-Jackson
Frontier Logo
12:54 pm - 10:11 amMDW  Chicago Midway-CLT Charlotte Douglas
20h 17m1 stop Dallas/Fort Worth
$312Frontier
Tue, Sep 8 - Thu, Sep 10
Frontier Logo
10:41 pm - 12:07 pmCLT  Charlotte Douglas-MDW Chicago Midway
14h 26m1 stop Dallas/Fort Worth
Frontier Logo
1:02 pm - 10:49 amMDW  Chicago Midway-CLT Charlotte Douglas
20h 47m1 stop Dallas/Fort Worth
$320Frontier
Fri, Oct 9 - Tue, Oct 13

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Southwest flights from South Carolina to Chicago Midway Airport

Our best Southwest deals on South Carolina to Chicago Midway Airport flight tickets
Southwest
Sep 5
MYR5:00 pmMyrtle Beach Intl
4h 35m
1 stop
MDW8:35 pmChicago Midway
Sep 6
MDW1:40 pmChicago Midway
2h 00m
MYR4:40 pmMyrtle Beach Intl
$190
Southwest
Sep 24
MYR8:10 amMyrtle Beach Intl
2h 05m
MDW9:15 amChicago Midway
Sep 26
MDW7:55 amChicago Midway
2h 10m
MYR11:05 amMyrtle Beach Intl
$197
Southwest
Sep 5
MYR5:00 pmMyrtle Beach Intl
4h 35m
1 stop
MDW8:35 pmChicago Midway
Sep 6
MDW8:55 amChicago Midway
3h 50m
1 stop
MYR1:45 pmMyrtle Beach Intl
$200

Delta flights from South Carolina to Chicago Midway Airport

Our best Delta deals on South Carolina to Chicago Midway Airport flight tickets
Delta
Sep 16
MYR6:58 pmMyrtle Beach Intl
4h 46m
1 stop
MDW10:44 pmChicago Midway
Sep 19
MDW4:30 pmChicago Midway
4h 11m
1 stop
MYR9:41 pmMyrtle Beach Intl
$217
Delta
Nov 3
MYR4:30 pmMyrtle Beach Intl
7h 03m
1 stop
MDW10:33 pmChicago Midway
Nov 18
MDW6:00 amChicago Midway
6h 33m
1 stop
MYR1:33 pmMyrtle Beach Intl
$239
Delta
Sep 12
CHS6:26 pmCharleston
5h 18m
1 stop
MDW10:44 pmChicago Midway
Sep 15
MDW6:05 amChicago Midway
6h 02m
1 stop
CHS1:07 pmCharleston
$257

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

4:20 pm-7:20 pm

1 stop4h 00m

Chicago Midway

Sun 9/6

1:40 pm-4:40 pm

Nonstop2h 00m

$190

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

5:00 pm-8:35 pm

1 stop4h 35m

Chicago Midway

Sun 9/6

1:40 pm-4:40 pm

Nonstop2h 00m

$190
Quickest round-trip

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Thu 9/24

8:10 am-9:15 am

Nonstop2h 05m

Chicago Midway

Sat 9/26

7:55 am-11:05 am

Nonstop2h 10m

$197

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Sat 9/5

4:20 pm-7:20 pm

1 stop4h 00m

Chicago Midway

Sun 9/6

8:55 am-1:45 pm

1 stop3h 50m

$200

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Wed 9/16

6:58 pm-10:44 pm

1 stop4h 46m

Chicago Midway

Sat 9/19

4:30 pm-9:41 pm

1 stop4h 11m

$217

Myrtle BeachChicago

MYR Myrtle Beach Intl - MDW Chicago Midway

MYRMDW

Myrtle Beach Intl

Wed 11/4

10:52 am-3:17 pm

1 stop5h 25m

Chicago Midway

Tue 11/17

11:28 am-6:06 pm

1 stop5h 38m

$239

CharlestonChicago

CHS Charleston - MDW Chicago Midway

CHSMDW

Charleston

Sat 9/12

6:26 pm-10:44 pm

1 stop5h 18m

Chicago Midway

Tue 9/15

6:05 am-1:07 pm

1 stop6h 02m

$257

CharlotteChicago

CLT Charlotte Douglas - MDW Chicago Midway

CLTMDW

Charlotte Douglas

Fri 9/25

9:05 pm-11:59 am

1 stop15h 54m

Chicago Midway

Fri 10/2

6:25 am-6:22 pm

2 stops34h 57m

$312

CharlotteChicago

CLT Charlotte Douglas - MDW Chicago Midway

CLTMDW

Charlotte Douglas

Tue 9/8

8:56 am-10:47 pm

2 stops14h 51m

Chicago Midway

Thu 9/10

12:54 pm-10:11 am

1 stop20h 17m

$312

CharlotteChicago

CLT Charlotte Douglas - MDW Chicago Midway

CLTMDW

Charlotte Douglas

Fri 10/9

10:41 pm-12:07 pm

1 stop14h 26m

Chicago Midway

Tue 10/13

1:02 pm-10:49 am

1 stop20h 47m

$320

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from South Carolina to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago Midway Airport?

The month of October is, on average, the cheapest month to fly to Chicago Midway Airport from South Carolina, with most prices found around $0. If you are unable to visit Chicago Midway Airport during the month of October, then departing from South Carolina during the month March is also very affordable. Most momondo users find prices during this month for around $0.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Friday is the cheapest day to fly to Chicago Midway Airport from South Carolina. The lowest ticket price found for a Friday departure recently was $405. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Tuesday is the most expensive day to depart from South Carolina because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $481.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from South Carolina in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $402 when looking at flights departing in the afternoon. Try not to purchase tickets in the morning because they tend to be around $448. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest South Carolina to Chicago Midway flight route?

Fly from Charleston to Chicago Midway for the best South Carolina - Chicago Midway flight prices

What cabin class options are available on South Carolina to Chicago Midway Airport flights?

There is only 1 cabin class available to choose from on South Carolina to Chicago Midway Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Chicago Midway Airport flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Chicago Midway Airport.

Cheap South Carolina to Chicago Midway Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Chicago Midway Airport

Best Price Found

$227

Fastest flight time

1h 55m

Direct flights

Every day
The best one-way flight to Chicago Midway Airport from South Carolina in the past 72 hours is $227. The best round-trip flight deal from South Carolina to Chicago Midway Airport found on momondo in the last 72 hours is $345.
The fastest flight from South Carolina to Chicago Midway Airport takes 1h 55m
Direct flights go from South Carolina to Chicago Midway Airport every day.
Search flight deals

Frequently asked questions about flying from South Carolina to Chicago Midway Airport

  • When did momondo last update prices for flights from South Carolina to Chicago Midway Airport?

    Prices for flights from South Carolina to Chicago Midway Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Chicago Midway Airport?

  • How old do you have to be to fly from South Carolina to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The required travel and health documents for your Chicago Midway Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago Midway Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to Chicago Midway Airport?

Best airlines flying from South Carolina to Chicago Midway Airport

Compare and see reviews for airlines that fly from South Carolina to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.8
8,508 reviews
Search Delta flights
SouthwestPriceFrom $271Free CancellationRating
8.0
4,219 reviews
Search Southwest flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
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New Buffalo
Hammond
Portage
Benton Harbor
Lansing
Saint Joseph
Valparaiso
Schererville
Munster
Chesterton
Monticello
Crown Point
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Chicago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Chicago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Chicago.

I’m not ready to book a flight from South Carolina to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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