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Cheap flights from South Carolina to Chicago from $62

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Chicago departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:35 pm - 1:00 pm
CHS
-
MDW
22h 25m
1 stop
Multiple Airlines Logo
7:30 am - 2:40 pm
MDW
-
CHS
6h 10m
1 stop
$127Multiple Airlines
Wed, Apr 29 - Wed, May 6
Multiple Airlines Logo
3:35 pm - 1:00 pm
CHS
-
MDW
22h 25m
1 stop
Multiple Airlines Logo
7:30 am - 2:40 pm
MDW
-
CHS
6h 10m
1 stop
$128Multiple Airlines
Fri, Apr 17 - Mon, Apr 20
Multiple Airlines Logo
3:35 pm - 1:00 pm
CHS
-
MDW
22h 25m
1 stop
Multiple Airlines Logo
7:30 am - 2:40 pm
MDW
-
CHS
6h 10m
1 stop
$130Multiple Airlines
Tue, May 5 - Sat, May 9
Multiple Airlines Logo
3:35 pm - 1:00 pm
CHS
-
MDW
22h 25m
1 stop
Multiple Airlines Logo
7:30 am - 2:40 pm
MDW
-
CHS
6h 10m
1 stop
$131Multiple Airlines
Tue, May 5 - Sat, May 9
Delta Logo
7:20 am - 12:46 pm
GSP
-
MDW
6h 26m
1 stop
Delta Logo
6:07 pm - 11:54 pm
MDW
-
GSP
4h 47m
1 stop
$147Delta
Sat, Mar 7 - Wed, Mar 11
Frontier Logo
10:20 pm - 2:55 pm
CLT
-
MDW
17h 35m
1 stop
Frontier Logo
8:15 am - 9:47 pm
MDW
-
CLT
12h 32m
1 stop
$154Frontier
Fri, Feb 27 - Mon, Mar 2
Frontier Logo
4:31 pm - 10:21 pm
CLT
-
MDW
6h 50m
1 stop
Frontier Logo
9:14 am - 4:35 pm
MDW
-
CLT
6h 21m
1 stop
$160Frontier
Thu, Apr 16 - Mon, Apr 20
Delta Logo
7:19 am - 12:46 pm
GSP
-
MDW
6h 27m
1 stop
Delta Logo
12:45 pm - 8:19 pm
MDW
-
GSP
6h 34m
1 stop
$208Delta
Tue, Feb 24 - Tue, Mar 3
Southwest Logo
1:55 pm - 7:30 pm
GSP
-
MDW
6h 35m
1 stop
Southwest Logo
12:50 pm - 8:00 pm
MDW
-
GSP
6h 10m
2 stops
$234Southwest
Tue, Apr 7 - Tue, Apr 14
Southwest Logo
1:55 pm - 10:15 pm
GSP
-
MDW
9h 20m
2 stops
Southwest Logo
10:10 am - 4:20 pm
MDW
-
GSP
5h 10m
2 stops
$239Southwest
Tue, Apr 7 - Tue, Apr 14

Frontier flights from South Carolina to Chicago Midway Airport

Our best Frontier deals on South Carolina to Chicago Midway Airport flight tickets
Frontier
Feb 27
CLT10:20 pmCharlotte Douglas
17h 35m
1 stop
MDW2:55 pmChicago Midway
Mar 2
MDW8:15 amChicago Midway
12h 32m
1 stop
CLT9:47 pmCharlotte Douglas
$154
Frontier
Apr 16
CLT4:31 pmCharlotte Douglas
6h 50m
1 stop
MDW10:21 pmChicago Midway
Apr 20
MDW9:14 amChicago Midway
6h 21m
1 stop
CLT4:35 pmCharlotte Douglas
$160
Frontier
May 13
CLT8:05 pmCharlotte Douglas
12h 59m
1 stop
MDW8:04 amChicago Midway
May 18
MDW9:14 amChicago Midway
6h 21m
1 stop
CLT4:35 pmCharlotte Douglas
$171

Southwest flights from South Carolina to Chicago Midway Airport

Our best Southwest deals on South Carolina to Chicago Midway Airport flight tickets
Southwest
Apr 30
CLT7:00 pmCharlotte Douglas
2h 05m
MDW8:05 pmChicago Midway
May 3
MDW7:30 pmChicago Midway
2h 00m
CLT10:30 pmCharlotte Douglas
$177
Southwest
Apr 8
CLT1:45 pmCharlotte Douglas
6h 45m
1 stop
MDW7:30 pmChicago Midway
Apr 11
MDW8:35 amChicago Midway
2h 00m
CLT11:35 amCharlotte Douglas
$191
Southwest
Mar 6
CLT7:20 pmCharlotte Douglas
2h 10m
MDW8:30 pmChicago Midway
Mar 8
MDW6:45 pmChicago Midway
1h 50m
CLT9:35 pmCharlotte Douglas
$197

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from South Carolina to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonChicago

CHS - MDW

CHSMDW

Charleston

Wed 4/29

3:35 pm-1:00 pm

1 stop22h 25m

Chicago Midway

Wed 5/6

7:30 am-2:40 pm

1 stop6h 10m

$127

CharlestonChicago

CHS - MDW

CHSMDW

Charleston

Fri 4/17

3:35 pm-1:00 pm

1 stop22h 25m

Chicago Midway

Mon 4/20

7:30 am-2:40 pm

1 stop6h 10m

$128

CharlestonChicago

CHS - MDW

CHSMDW

Charleston

Tue 5/5

3:35 pm-1:00 pm

1 stop22h 25m

Chicago Midway

Sat 5/9

7:30 am-2:40 pm

1 stop6h 10m

$130

CharlestonChicago

CHS - MDW

CHSMDW

Charleston

Tue 5/5

3:35 pm-1:00 pm

1 stop22h 25m

Chicago Midway

Sat 5/9

7:30 am-2:40 pm

1 stop6h 10m

$131

GreenvilleChicago

GSP - MDW

GSPMDW

Greenville

Sat 3/7

7:20 am-12:46 pm

1 stop6h 26m

Chicago Midway

Wed 3/11

6:07 pm-11:54 pm

1 stop4h 47m

$147

CharlotteChicago

CLT - MDW

CLTMDW

Charlotte Douglas

Fri 2/27

10:20 pm-2:55 pm

1 stop17h 35m

Chicago Midway

Mon 3/2

8:15 am-9:47 pm

1 stop12h 32m

$154

CharlotteChicago

CLT - MDW

CLTMDW

Charlotte Douglas

Thu 4/16

4:31 pm-10:21 pm

1 stop6h 50m

Chicago Midway

Mon 4/20

9:14 am-4:35 pm

1 stop6h 21m

$160

GreenvilleChicago

GSP - MDW

GSPMDW

Greenville

Tue 2/24

7:19 am-12:46 pm

1 stop6h 27m

Chicago Midway

Tue 3/3

12:45 pm-8:19 pm

1 stop6h 34m

$208

GreenvilleChicago

GSP - MDW

GSPMDW

Greenville

Tue 4/7

1:55 pm-7:30 pm

1 stop6h 35m

Chicago Midway

Tue 4/14

12:50 pm-8:00 pm

2 stops6h 10m

$234

GreenvilleChicago

GSP - MDW

GSPMDW

Greenville

Tue 4/7

1:55 pm-10:15 pm

2 stops9h 20m

Chicago Midway

Tue 4/14

10:10 am-4:20 pm

2 stops5h 10m

$239

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from South Carolina to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago Midway Airport?

The month of October is, on average, the cheapest month to fly to Chicago Midway Airport from South Carolina, with most prices found around $229. If you are unable to visit Chicago Midway Airport during the month of October, then departing from South Carolina during the month July is also very affordable. Most momondo users find prices during this month for around $285.

What is the cheapest day to depart on your flight to Chicago Midway Airport?

According to our data, Wednesday is the cheapest day to fly to Chicago Midway Airport from South Carolina. The lowest ticket price found for a Wednesday departure recently was $321. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Sunday is the most expensive day to depart from South Carolina because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $536.

What is the cheapest time of day to depart on your flight to Chicago Midway Airport?

Flying to Chicago Midway Airport from South Carolina in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $319 when looking at flights departing in the afternoon. Try not to purchase tickets in the evening because they tend to be around $423. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest South Carolina to Chicago Midway flight route?

Fly from Myrtle Beach Intl to Chicago Midway for the best South Carolina - Chicago Midway flight prices

What cabin class options are available on South Carolina to Chicago Midway flights?

There is only 1 cabin class available to choose from on South Carolina to Chicago Midway flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Chicago Midway Airport flights?

You could potentially save up to 45% on your flight if you consider stops on a South Carolina to Chicago Midway Airport flight.

Cheap South Carolina to Chicago Midway Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Chicago Midway Airport

Best Price Found

$197

Fastest flight time

2h 00m

Direct flights

Every day
The best one-way flight to Chicago Midway Airport from South Carolina in the past 72 hours is $197. The best round-trip flight deal from South Carolina to Chicago Midway Airport found on momondo in the last 72 hours is $316.
The fastest flight from South Carolina to Chicago Midway Airport takes 2h 00m
Direct flights go from South Carolina to Chicago Midway Airport every day.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Chicago Midway Airport?

    Prices for flights from South Carolina to Chicago Midway Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Chicago Midway Airport?

  • How old do you have to be to fly from South Carolina to Chicago Midway Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The required travel and health documents for your Chicago Midway Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago Midway Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to Chicago Midway Airport?

Best airlines flying from South Carolina to Chicago Midway Airport

Compare and see reviews for airlines that fly from South Carolina to Chicago Midway Airport with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $180Free CancellationRating
7.9
8,174 reviews
Search Delta flights
SouthwestPriceFrom $190Free CancellationRating
8.0
4,281 reviews
Search Southwest flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Schererville
Valparaiso
Munster
Crown Point
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Chicago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Chicago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Chicago.

I’m not ready to book a flight from South Carolina to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from South Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Chicago Midway Airport trip

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