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Cheap flights from Santa Ana, California to Panama from $335

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Panama departing on 8/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Santa Ana, California to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:59 pm - 10:30 amSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
12h 31m2 stops San Francisco San Salvador El Salvador Intl
Multiple Airlines Logo
3:50 pm - 8:45 amPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
18h 55m2 stops San Salvador El Salvador Intl San Francisco
$698Multiple Airlines
Sun, Sep 20 - Thu, Sep 24
Multiple Airlines Logo
5:47 pm - 10:30 amSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
14h 43m2 stops San Francisco San Salvador El Salvador Intl
Multiple Airlines Logo
3:50 pm - 8:38 amPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
18h 48m2 stops San Salvador El Salvador Intl San Francisco
$709Multiple Airlines
Sat, Oct 24 - Thu, Oct 29
Multiple Airlines Logo
5:47 pm - 10:30 amSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
14h 43m2 stops San Francisco San Salvador El Salvador Intl
Multiple Airlines Logo
3:50 pm - 8:38 amPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
18h 48m2 stops San Salvador El Salvador Intl San Francisco
$721Multiple Airlines
Thu, Oct 8 - Thu, Oct 15
Multiple Airlines Logo
6:38 pm - 10:30 amSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
13h 52m2 stops San Francisco San Salvador El Salvador Intl
Multiple Airlines Logo
5:30 am - 8:45 amPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
29h 15m2 stops San Salvador El Salvador Intl San Francisco
$753Multiple Airlines
Thu, Sep 24 - Mon, Sep 28
United Airlines Logo
6:30 pm - 1:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
17h 15m2 stops Denver Intl Houston George Bush Intcntl
United Airlines Logo
8:55 am - 8:45 pmPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
14h 50m2 stops Houston George Bush Intcntl San Francisco
$809United Airlines
Thu, Oct 29 - Tue, Nov 3
United Airlines Logo
6:36 pm - 2:14 pmSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
17h 38m2 stops Denver Intl Houston George Bush Intcntl
United Airlines Logo
10:00 am - 9:51 pmPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
13h 51m1 stop Houston George Bush Intcntl
$813United Airlines
Tue, Oct 13 - Tue, Oct 20
United Airlines Logo
6:25 pm - 6:37 pmSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
22h 12m2 stops Denver Intl Houston George Bush Intcntl
United Airlines Logo
3:30 pm - 2:03 pmPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
24h 33m2 stops Houston George Bush Intcntl San Francisco
$814United Airlines
Sun, Sep 20 - Sun, Sep 27
United Airlines Logo
4:14 pm - 2:14 pmSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
20h 00m2 stops Denver Intl Houston George Bush Intcntl
United Airlines Logo
3:30 pm - 12:03 pmPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
22h 33m2 stops Houston George Bush Intcntl San Francisco
$819United Airlines
Fri, Sep 18 - Fri, Sep 25
United Airlines Logo
8:00 am - 1:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
27h 45m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 9:55 pmPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
16h 00m1 stop Houston George Bush Intcntl
$821United Airlines
Thu, Oct 29 - Tue, Nov 3
United Airlines Logo
8:13 am - 6:37 pmSNA  Santa Ana J. Wayne/Orange Cnty-PTY Panama City Tocumen Intl
8h 24m1 stop Houston George Bush Intcntl
United Airlines Logo
10:00 am - 9:51 pmPTY  Panama City Tocumen Intl-SNA Santa Ana J. Wayne/Orange Cnty
13h 51m1 stop Houston George Bush Intcntl
$825United Airlines
Sun, Sep 20 - Thu, Sep 24

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Copa Airlines flights from Santa Ana, California to Panama

Our best Copa Airlines deals on Santa Ana, California to Panama flight tickets
Copa Airlines
Nov 6
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
8h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Nov 11
PTY8:55 amPanama City Tocumen Intl
16h 00m
1 stop
SNA9:55 pmSanta Ana J. Wayne/Orange Cnty
$844
Copa Airlines
Sep 29
SNA8:10 amSanta Ana J. Wayne/Orange Cnty
8h 27m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 29
PTY7:55 amPanama City Tocumen Intl
16h 00m
1 stop
SNA9:55 pmSanta Ana J. Wayne/Orange Cnty
$854
Copa Airlines
Jan 19
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
8h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Jan 28
PTY11:35 amPanama City Tocumen Intl
13h 18m
1 stop
SNA9:53 pmSanta Ana J. Wayne/Orange Cnty
$858

United Airlines flights from Santa Ana, California to Panama

Our best United Airlines deals on Santa Ana, California to Panama flight tickets
United Airlines
Oct 29
SNA6:30 pmSanta Ana J. Wayne/Orange Cnty
17h 15m
2 stops
PTY1:45 pmPanama City Tocumen Intl
Nov 3
PTY8:55 amPanama City Tocumen Intl
14h 50m
2 stops
SNA8:45 pmSanta Ana J. Wayne/Orange Cnty
$809
United Airlines
Oct 13
SNA6:36 pmSanta Ana J. Wayne/Orange Cnty
17h 38m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Oct 20
PTY10:00 amPanama City Tocumen Intl
13h 51m
1 stop
SNA9:51 pmSanta Ana J. Wayne/Orange Cnty
$813
United Airlines
Sep 20
SNA6:25 pmSanta Ana J. Wayne/Orange Cnty
22h 12m
2 stops
PTY6:37 pmPanama City Tocumen Intl
Sep 27
PTY3:30 pmPanama City Tocumen Intl
24h 33m
2 stops
SNA2:03 pmSanta Ana J. Wayne/Orange Cnty
$814

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Sun 9/20

7:59 pm-10:30 am

2 stops12h 31m

Panama City Tocumen Intl

Thu 9/24

3:50 pm-8:45 am

2 stops18h 55m

$698

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Sat 10/24

5:47 pm-10:30 am

2 stops14h 43m

Panama City Tocumen Intl

Thu 10/29

3:50 pm-8:38 am

2 stops18h 48m

$709

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Thu 10/8

5:47 pm-10:30 am

2 stops14h 43m

Panama City Tocumen Intl

Thu 10/15

3:50 pm-8:38 am

2 stops18h 48m

$721

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Thu 9/24

6:38 pm-10:30 am

2 stops13h 52m

Panama City Tocumen Intl

Mon 9/28

5:30 am-8:45 am

2 stops29h 15m

$753

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Thu 10/29

6:30 pm-1:45 pm

2 stops17h 15m

Panama City Tocumen Intl

Tue 11/3

8:55 am-8:45 pm

2 stops14h 50m

$809

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Tue 10/13

6:36 pm-2:14 pm

2 stops17h 38m

Panama City Tocumen Intl

Tue 10/20

10:00 am-9:51 pm

1 stop13h 51m

$813

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Sun 9/20

6:25 pm-6:37 pm

2 stops22h 12m

Panama City Tocumen Intl

Sun 9/27

3:30 pm-2:03 pm

2 stops24h 33m

$814

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Fri 9/18

4:14 pm-2:14 pm

2 stops20h 00m

Panama City Tocumen Intl

Fri 9/25

3:30 pm-12:03 pm

2 stops22h 33m

$819

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Thu 10/29

8:00 am-1:45 pm

1 stop27h 45m

Panama City Tocumen Intl

Tue 11/3

8:55 am-9:55 pm

1 stop16h 00m

$821
Quickest round-trip

Santa AnaPanama City

SNA Santa Ana J. Wayne/Orange Cnty - PTY Panama City Tocumen Intl

SNAPTY

Santa Ana J. Wayne/Orange Cnty

Sun 9/20

8:13 am-6:37 pm

1 stop8h 24m

Panama City Tocumen Intl

Thu 9/24

10:00 am-9:51 pm

1 stop13h 51m

$825

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santa Ana, California to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Santa Ana, California to Panama flights?

You could potentially save up to 15% on your flight if you consider stops on a Santa Ana, California to Panama flight.

Cheap Santa Ana, California to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Panama

Fastest flight time

8h 24m

Direct flights

None
The fastest flight from Santa Ana, California to Panama takes 8h 24m
There are no direct flights from Santa Ana, California to Panama. There are no popular flight routes from Santa Ana, California to Panama.
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Frequently asked questions about flying from Santa Ana, California to Panama

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Panama?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Panama are updated daily.

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents you'll need for your trip to Panama may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Panama?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Panama for you.

Can I find flights from Santa Ana to Panama with flexible booking policies on momondo?

Yes. All flights to Panama from Santa Ana on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Santa Ana to Panama?

momondo provides multiple filters to help you find the best flight to Panama from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to Panama right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama from Santa Ana. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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