Cheap flights from Santa Ana to Chicago from $147

The month of May is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Santa Ana averaging around $368.

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Thursday when prices can be found for as low as $353. This is often the case because there is less demand to fly during this day of the week. On the other hand, Sunday is the most expensive day to depart from Santa Ana because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $435.

Flying to Chicago O'Hare Intl Airport from Santa Ana in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $276 when looking at flights departing in the afternoon. Try not to purchase tickets at noon because they tend to be around $459. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Santa Ana J. Wayne/Orange Cnty to Chicago O'Hare Intl for the best Santa Ana J. Wayne/Orange Cnty - Chicago O'Hare Intl flight prices

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Santa Ana when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $404 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Santa Ana for as low as $333 on momondo.

There are 4 cabin classes available to choose from on Santa Ana J. Wayne/Orange Cnty to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Alaska Airlines, Southwest, and United Airlines are the most popular carriers operating from Santa Ana J. Wayne/Orange Cnty to Chicago O'Hare Intl

American Airlines, United Airlines and Spirit Airlines are the top three most popular airlines that fly to Chicago O'Hare Intl Airport from Santa Ana according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Chicago O'Hare Intl Airport. Keep in mind that there are 8 different airlines that fly to Chicago O'Hare Intl Airport on a routine basis, so you have a few additional options to choose from.

Historically, on average around 9% of flights between Santa Ana and Chicago have experienced a delay on any given week. The average delay length over the past 12 months has been 179 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, United Airlines have had the least number of delays on this route over the last 12 months; with about 5% of their flights experiencing any sort of delay.

As of March 2026, there are 19 flights per day flying from Santa Ana to Chicago O'Hare Intl Airport. The most common time of day flights depart is 11:00AM, with 74% of flights taking off at noon.

As of March 2026, there are 137 flights per week flying from Santa Ana to Chicago O'Hare Intl Airport. The most common day of the week flights depart is Wed, with 16% of flights taking off on this day.