Cheap flights from San Diego to Panama City from $233

In general, September is the cheapest month to fly from San Diego to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $388. If you’re not able to fly to Panama City in September, then August is your next best option. Flight prices from San Diego to Panama City during August average around $439.

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $404. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $1,200. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $551 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from San Diego for as low as $338 on momondo.

There are 3 cabin classes available to choose from on San Diego to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 24% on your flight if you consider stops on a San Diego to Panama City flight.

Houston (IAH) was the most common stop: 71% of momondo users choosing 1-stop flights on this route connected there.

Flights via Houston (IAH) offer the lowest average round-trip price of $523.

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 9h 30m.

Atlanta (ATL) has the shortest average layover time for this route: 2h 14m.

1 flights are operational daily from San Diego to Panama City as of March 2026. The most popular departure time for this route is 9:00PM, with 100% of flights per day taking off in the evening.

As of March 2026, there are 8 flights per week flying from San Diego to Panama City. The most common day of the week flights depart is Mon, with 25% of flights taking off on this day.