Cheap flights from San Diego to Panama City from $267

In general, February is the cheapest month to fly from San Diego to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $494. If you’re not able to fly to Panama City in February, then October is your next best option. Flight prices from San Diego to Panama City during October average around $550.

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $544. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $1,005. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Fly from San Diego to Panama City Tocumen Intl for the best San Diego - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $724 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from San Diego for as low as $335 on momondo.

There are 3 cabin classes available to choose from on San Diego to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 68% on your flight if you consider stops on a San Diego to Panama City flight.

American Airlines is the most popular carrier operating from San Diego to Panama City Tocumen Intl

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to Panama City from San Diego according to our data. Copa Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

1 flights are operational daily from San Diego to Panama City as of October 2026. The most popular departure time for this route is 10:00PM, with 100% of flights per day taking off in the evening.

As of October 2026, there are 8 flights per week flying from San Diego to Panama City. The most common day of the week flights depart is Mon, with 25% of flights taking off on this day.