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Cheap flights from Quito to Santiago from $220

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Quito to Santiago departing on 3/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Quito to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetSMART Logo
4:49 pm - 10:39 am
UIO
-
SCL
15h 50m
1 stop
JetSMART Logo
4:56 am - 4:04 pm
SCL
-
UIO
12h 08m
1 stop
$408JetSMART
dom., mar. 22 - vie., may. 15
JetSMART Logo
4:49 pm - 10:39 am
UIO
-
SCL
15h 50m
1 stop
JetSMART Logo
5:59 am - 4:00 pm
SCL
-
UIO
12h 01m
1 stop
$411JetSMART
mié., mar. 18 - mié., mar. 25
JetSMART Logo
4:49 pm - 10:39 am
UIO
-
SCL
15h 50m
1 stop
JetSMART Logo
4:56 am - 4:04 pm
SCL
-
UIO
12h 08m
1 stop
$422JetSMART
dom., mar. 22 - vie., may. 15
JetSMART Logo
4:49 pm - 4:11 am
UIO
-
SCL
10h 22m
1 stop
JetSMART Logo
4:56 am - 4:04 pm
SCL
-
UIO
12h 08m
1 stop
$426JetSMART
vie., abr. 10 - dom., abr. 12
JetSMART Logo
4:49 pm - 10:39 am
UIO
-
SCL
15h 50m
1 stop
JetSMART Logo
5:59 am - 4:00 pm
SCL
-
UIO
12h 01m
1 stop
$431JetSMART
dom., mar. 15 - mié., mar. 25
JetSMART Logo
4:49 pm - 4:11 am
UIO
-
SCL
10h 22m
1 stop
JetSMART Logo
4:56 am - 4:04 pm
SCL
-
UIO
12h 08m
1 stop
$432JetSMART
vie., abr. 10 - dom., abr. 12
JetSMART Logo
4:49 pm - 4:11 am
UIO
-
SCL
10h 22m
1 stop
JetSMART Logo
4:56 am - 4:04 pm
SCL
-
UIO
12h 08m
1 stop
$435JetSMART
dom., abr. 5 - dom., abr. 12
JetSMART Logo
4:49 pm - 10:39 am
UIO
-
SCL
15h 50m
1 stop
JetSMART Logo
5:59 am - 4:00 pm
SCL
-
UIO
12h 01m
1 stop
$440JetSMART
mié., mar. 18 - dom., mar. 22
JetSMART Logo
4:49 pm - 5:16 am
UIO
-
SCL
10h 27m
1 stop
JetSMART Logo
4:41 am - 4:04 pm
SCL
-
UIO
12h 23m
1 stop
$441JetSMART
mié., abr. 1 - mié., abr. 8
JetSMART Logo
4:49 pm - 5:14 am
UIO
-
SCL
10h 25m
1 stop
JetSMART Logo
4:56 am - 4:04 pm
SCL
-
UIO
12h 08m
1 stop
$446JetSMART
dom., mar. 22 - vie., may. 15

JetSMART flights from Quito to Santiago

Our best JetSMART deals on Quito to Santiago flight tickets
JetSMART
May 27
UIO4:49 pmQuito Mariscal Sucr
10h 27m
1 stop
SCL4:16 amSantiago Arturo Merino Benitez
Jun 3
SCL4:41 amSantiago Arturo Merino Benitez
12h 23m
1 stop
UIO4:04 pmQuito Mariscal Sucr
$381
JetSMART
May 6
UIO4:49 pmQuito Mariscal Sucr
10h 27m
1 stop
SCL4:16 amSantiago Arturo Merino Benitez
May 13
SCL4:41 amSantiago Arturo Merino Benitez
12h 23m
1 stop
UIO4:04 pmQuito Mariscal Sucr
$387
JetSMART
May 1
UIO4:49 pmQuito Mariscal Sucr
10h 22m
1 stop
SCL4:11 amSantiago Arturo Merino Benitez
May 10
SCL4:56 amSantiago Arturo Merino Benitez
12h 08m
1 stop
UIO4:04 pmQuito Mariscal Sucr
$393

LATAM Airlines flights from Quito to Santiago

Our best LATAM Airlines deals on Quito to Santiago flight tickets
LATAM Airlines
Jan 22
UIO3:05 pmQuito Mariscal Sucr
6h 50m
1 stop
SCL11:55 pmSantiago Arturo Merino Benitez
Apr 15
SCL7:45 pmSantiago Arturo Merino Benitez
8h 40m
1 stop
UIO3:25 amQuito Mariscal Sucr
$486
LATAM Airlines
Jan 22
UIO9:56 amQuito Mariscal Sucr
11h 59m
1 stop
SCL11:55 pmSantiago Arturo Merino Benitez
Apr 15
SCL8:39 pmSantiago Arturo Merino Benitez
15h 31m
2 stops
UIO11:10 amQuito Mariscal Sucr
$494
LATAM Airlines
Feb 6
UIO6:15 amQuito Mariscal Sucr
20h 15m
2 stops
SCL4:30 amSantiago Arturo Merino Benitez
Feb 27
SCL6:40 amSantiago Arturo Merino Benitez
18h 20m
2 stops
UIO11:00 pmQuito Mariscal Sucr
$498

momondo Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 14, 2026.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/22

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

vie. 5/15

4:56 am-4:04 pm

1 stop12h 08m

$408

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 3/18

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

mié. 3/25

5:59 am-4:00 pm

1 stop12h 01m

$411

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/22

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

vie. 5/15

4:56 am-4:04 pm

1 stop12h 08m

$422

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 4/10

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

dom. 4/12

4:56 am-4:04 pm

1 stop12h 08m

$426

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/15

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

mié. 3/25

5:59 am-4:00 pm

1 stop12h 01m

$431

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 4/10

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

dom. 4/12

4:56 am-4:04 pm

1 stop12h 08m

$432

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 4/5

4:49 pm-4:11 am

1 stop10h 22m

Santiago Arturo Merino Benitez

dom. 4/12

4:56 am-4:04 pm

1 stop12h 08m

$435

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 3/18

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

dom. 3/22

5:59 am-4:00 pm

1 stop12h 01m

$440

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 4/1

4:49 pm-5:16 am

1 stop10h 27m

Santiago Arturo Merino Benitez

mié. 4/8

4:41 am-4:04 pm

1 stop12h 23m

$441

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/22

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

vie. 5/15

4:56 am-4:04 pm

1 stop12h 08m

$446

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Quito to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Quito and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Quito to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $253. If you don’t want to visit Santiago in April, then you should wait until May to fly from Quito, when ticket prices are also cheap, with an average price of $272.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Quito when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $379 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Quito for as low as $320 on momondo.

Can stopping save me money on Quito to Santiago flights?

You could potentially save up to 9% on your flight if you consider stops on a Quito to Santiago flight.

How have Quito to Santiago flight prices changed over time?

As of January 2026, prices for Quito to Santiago flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Quito to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Quito to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Quito to Santiago (UIO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Quito to Santiago

Fastest flight time

10h 25m

Direct flights

None
The fastest flight from Quito to Santiago takes 10h 25m
There are no direct flights from Quito to Santiago. There are no popular flight routes from Quito to Santiago.
Search flight deals

  • How far is Quito Mariscal Sucr to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Quito Mariscal Sucr to Santiago Arturo Merino Benitez is 2349.7 mi. A reasonable flight in good conditions will take 10h 25m.

  • When did momondo last update prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Quito to Santiago?

Best airlines flying from Quito to Santiago

Compare and see reviews for airlines that fly from Quito to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $183Free CancellationRating
6.7
260 reviews
Search JetSMART flights
AviancaPriceFrom $194Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
Copa AirlinesPriceFrom $275Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $360Free CancellationRating
7.5
1,904 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Quito to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Quito to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Quito to Santiago with flexible booking policies on momondo?

Flights from Quito to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Quito to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Quito. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Quito to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Quito to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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