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Cheap flights from Quito to Santiago from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Quito to Santiago departing on 4/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Quito to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetSMART Logo
4:41 pm - 4:01 am
UIO
-
SCL
10h 20m1 stop
JetSMART Logo
4:51 am - 4:09 pm
SCL
-
UIO
12h 18m1 stop
$397JetSMART
vie., may. 22 - dom., may. 24
Multiple Airlines Logo
4:41 pm - 4:01 am
UIO
-
SCL
10h 20m1 stop
Multiple Airlines Logo
2:30 pm - 12:34 am
SCL
-
UIO
11h 04m1 stop
$405Multiple Airlines
mié., abr. 22 - mar., abr. 28
JetSMART Logo
4:49 pm - 8:44 pm
UIO
-
SCL
25h 55m1 stop
JetSMART Logo
5:59 am - 4:00 pm
SCL
-
UIO
12h 01m1 stop
$410JetSMART
mié., ene. 21 - mié., feb. 11
JetSMART Logo
4:49 pm - 5:14 am
UIO
-
SCL
10h 25m1 stop
JetSMART Logo
5:59 am - 4:00 pm
SCL
-
UIO
12h 01m1 stop
$416JetSMART
dom., mar. 15 - mié., mar. 25
Multiple Airlines Logo
5:00 pm - 3:20 pm
UIO
-
SCL
20h 20m2 stops
Multiple Airlines Logo
4:51 am - 4:09 pm
SCL
-
UIO
12h 18m1 stop
$439Multiple Airlines
lun., mar. 23 - dom., abr. 5
JetSMART Logo
4:49 pm - 5:14 am
UIO
-
SCL
10h 25m1 stop
JetSMART Logo
5:59 am - 4:00 pm
SCL
-
UIO
12h 01m1 stop
$441JetSMART
dom., mar. 15 - mié., mar. 25
Multiple Airlines Logo
2:20 pm - 5:30 am
UIO
-
SCL
13h 10m1 stop
Multiple Airlines Logo
4:51 am - 4:09 pm
SCL
-
UIO
12h 18m1 stop
$446Multiple Airlines
lun., mar. 23 - dom., abr. 5
JetSMART Logo
4:49 pm - 10:39 am
UIO
-
SCL
15h 50m1 stop
JetSMART Logo
8:34 pm - 3:55 pm
SCL
-
UIO
21h 21m1 stop
$456JetSMART
mié., feb. 4 - sáb., feb. 7
JetSMART Logo
4:49 pm - 5:14 am
UIO
-
SCL
10h 25m1 stop
JetSMART Logo
9:29 pm - 4:00 pm
SCL
-
UIO
20h 31m1 stop
$460JetSMART
vie., ene. 23 - mar., feb. 10
Multiple Airlines Logo
4:41 pm - 4:01 am
UIO
-
SCL
10h 20m1 stop
Multiple Airlines Logo
6:45 pm - 11:45 am
SCL
-
UIO
18h 00m2 stops
$462Multiple Airlines
vie., abr. 24 - jue., abr. 30

JetSMART flights from Quito to Santiago

Our best JetSMART deals on Quito to Santiago flight tickets
JetSMART
May 22
UIO4:41 pmQuito Mariscal Sucr
10h 20m
1 stop
SCL4:01 amSantiago Arturo Merino Benitez
May 24
SCL4:51 amSantiago Arturo Merino Benitez
12h 18m
1 stop
UIO4:09 pmQuito Mariscal Sucr
$397
Find similar
JetSMART
Jan 21
UIO4:49 pmQuito Mariscal Sucr
25h 55m
1 stop
SCL8:44 pmSantiago Arturo Merino Benitez
Feb 11
SCL5:59 amSantiago Arturo Merino Benitez
12h 01m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$410
Find similar
JetSMART
Mar 15
UIO4:49 pmQuito Mariscal Sucr
10h 25m
1 stop
SCL5:14 amSantiago Arturo Merino Benitez
Mar 25
SCL5:59 amSantiago Arturo Merino Benitez
12h 01m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$416
Find similar

Avianca flights from Quito to Santiago

Our best Avianca deals on Quito to Santiago flight tickets
Avianca
Apr 22
UIO7:45 amQuito Mariscal Sucr
13h 45m
2 stops
SCL10:30 pmSantiago Arturo Merino Benitez
Apr 28
SCL2:30 pmSantiago Arturo Merino Benitez
17h 30m
2 stops
UIO7:00 amQuito Mariscal Sucr
$464
Find similar
Avianca
Jan 1
UIO6:30 amQuito Mariscal Sucr
16h 00m
2 stops
SCL12:30 amSantiago Arturo Merino Benitez
Jan 21
SCL4:25 pmSantiago Arturo Merino Benitez
18h 30m
1 stop
UIO8:55 amQuito Mariscal Sucr
$467
Find similar
Avianca
Dec 18
UIO10:05 amQuito Mariscal Sucr
12h 25m
1 stop
SCL12:30 amSantiago Arturo Merino Benitez
Mar 17
SCL4:25 pmSantiago Arturo Merino Benitez
10h 55m
1 stop
UIO1:20 amQuito Mariscal Sucr
$470
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 5/22

4:41 pm-4:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

dom. 5/24

4:51 am-4:09 pm

1 stop12h 18m

$397

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 4/22

4:41 pm-4:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

mar. 4/28

2:30 pm-12:34 am

1 stop11h 04m

$405

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 1/21

4:49 pm-8:44 pm

1 stop25h 55m

Santiago Arturo Merino Benitez

mié. 2/11

5:59 am-4:00 pm

1 stop12h 01m

$410

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/15

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

mié. 3/25

5:59 am-4:00 pm

1 stop12h 01m

$416

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

lun. 3/23

5:00 pm-3:20 pm

2 stops20h 20m

Santiago Arturo Merino Benitez

dom. 4/5

4:51 am-4:09 pm

1 stop12h 18m

$439

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/15

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

mié. 3/25

5:59 am-4:00 pm

1 stop12h 01m

$441

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

lun. 3/23

2:20 pm-5:30 am

1 stop13h 10m

Santiago Arturo Merino Benitez

dom. 4/5

4:51 am-4:09 pm

1 stop12h 18m

$446

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 2/4

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

sáb. 2/7

8:34 pm-3:55 pm

1 stop21h 21m

$456

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 1/23

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

mar. 2/10

9:29 pm-4:00 pm

1 stop20h 31m

$460

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 4/24

4:41 pm-4:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

jue. 4/30

6:45 pm-11:45 am

2 stops18h 00m

$462

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Quito to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Quito to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $254. If you don’t want to visit Santiago in April, then you should wait until May to fly from Quito, when ticket prices are also cheap, with an average price of $270.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $404. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Wednesday is $489.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Quito to Santiago when you can find flight prices for as low as $428. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $468 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Quito when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $376 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Quito for as low as $311 on momondo.

Can stopping save me money on Quito to Santiago flights?

You could potentially save up to 5% on your flight if you consider stops on a Quito to Santiago flight.

How have Quito to Santiago flight prices changed over time?

As of December 2025, prices for Quito to Santiago flights are approximately 34% cheaper when compared to flights at the same time last year.

When to book flights from Quito to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Quito to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Quito to Santiago (UIO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Quito to Santiago

Fastest flight time

17h 35m

Direct flights

None
The fastest flight from Quito to Santiago takes 17h 35m
There are no direct flights from Quito to Santiago. There are no popular flight routes from Quito to Santiago.
Search flight deals

  • How far is Quito Mariscal Sucr to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Quito Mariscal Sucr to Santiago Arturo Merino Benitez is 2349.7 mi. A reasonable flight in good conditions will take 17h 35m.

  • When did momondo last update prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Quito to Santiago?

Best airlines flying from Quito to Santiago

Compare and see reviews for airlines that fly from Quito to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $166Free CancellationRating
6.6
252 reviews
Search JetSMART flights
AviancaPriceFrom $194Free CancellationRating
6.6
2,478 reviews
Search Avianca flights
Copa AirlinesPriceFrom $275Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $360Free CancellationRating
7.5
1,889 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Quito to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Quito to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Quito to Santiago with flexible booking policies on momondo?

Flights from Quito to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Quito to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Quito. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Quito to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Quito to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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