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Cheap flights from Quito to Santiago from $213

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Quito to Santiago departing on 12/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Quito to Santiago

Cheap round-trip flights

JetSMART Logo
4:36 pm - 8:31 pmUIO-SCL
25h 55m1 stop
JetSMART Logo
9:36 pm - 3:49 pmSCL-UIO
20h 13m1 stop
$378JetSMART
Find Deal
Wed, Mar 11 - Sat, Mar 21
JetSMART Logo
4:49 pm - 5:14 amUIO-SCL
10h 25m1 stop
JetSMART Logo
5:59 am - 4:00 pmSCL-UIO
12h 01m1 stop
$405JetSMART
Find Deal
Wed, Nov 19 - Sun, Nov 23
JetSMART Logo
4:49 pm - 2:30 pmUIO-SCL
19h 41m1 stop
JetSMART Logo
9:29 pm - 4:00 pmSCL-UIO
20h 31m1 stop
$408JetSMART
Find Deal
Fri, Dec 26 - Sat, Jan 10
Multiple Airlines Logo
4:41 pm - 5:01 amUIO-SCL
10h 20m1 stop
Multiple Airlines Logo
4:25 pm - 1:10 pmSCL-UIO
22h 45m1 stop
$409Multiple Airlines
Find Deal
Fri, Oct 17 - Wed, Nov 5
JetSMART Logo
4:49 pm - 10:39 amUIO-SCL
15h 50m1 stop
JetSMART Logo
9:29 pm - 4:00 pmSCL-UIO
20h 31m1 stop
$410JetSMART
Find Deal
Fri, Feb 20 - Thu, Feb 26
JetSMART Logo
4:49 pm - 5:14 amUIO-SCL
10h 25m1 stop
JetSMART Logo
5:59 am - 4:00 pmSCL-UIO
12h 01m1 stop
$415JetSMART
Find Deal
Fri, Nov 7 - Sun, Nov 23
Multiple Airlines Logo
7:55 am - 11:30 pmUIO-SCL
13h 35m2 stops
Multiple Airlines Logo
5:59 am - 4:00 pmSCL-UIO
12h 01m1 stop
$424Multiple Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 29
Avianca Logo
6:00 am - 11:30 pmUIO-SCL
15h 30m2 stops
Avianca Logo
1:35 am - 1:10 pmSCL-UIO
13h 35m1 stop
$427Avianca
Find Deal
Mon, Oct 6 - Thu, Nov 6
Avianca Logo
9:45 am - 11:30 pmUIO-SCL
11h 45m1 stop
Avianca Logo
1:35 am - 1:10 pmSCL-UIO
13h 35m1 stop
$438Avianca
Find Deal
Mon, Oct 6 - Thu, Nov 6
Copa Airlines Logo
3:10 am - 12:04 amUIO-SCL
18h 54m1 stop
Copa Airlines Logo
12:29 pm - 12:32 amSCL-UIO
14h 03m1 stop
$487Copa Airlines
Find Deal
Tue, Sep 30 - Wed, Oct 8

JetSMART flights from Quito to Santiago

Our best JetSMART deals on Quito to Santiago flight tickets
JetSMART
Mar 11
UIO4:36 pmQuito Mariscal Sucr
25h 55m
1 stop
SCL8:31 pmSantiago Arturo Merino Benitez
Mar 21
SCL9:36 pmSantiago Arturo Merino Benitez
20h 13m
1 stop
UIO3:49 pmQuito Mariscal Sucr
$378
Find similar
JetSMART
Nov 19
UIO4:49 pmQuito Mariscal Sucr
10h 25m
1 stop
SCL5:14 amSantiago Arturo Merino Benitez
Nov 23
SCL5:59 amSantiago Arturo Merino Benitez
12h 01m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$405
Find similar
JetSMART
Dec 26
UIO4:49 pmQuito Mariscal Sucr
19h 41m
1 stop
SCL2:30 pmSantiago Arturo Merino Benitez
Jan 10
SCL9:29 pmSantiago Arturo Merino Benitez
20h 31m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$408
Find similar

Copa Airlines flights from Quito to Santiago

Our best Copa Airlines deals on Quito to Santiago flight tickets
Copa Airlines
Sep 30
UIO3:10 amQuito Mariscal Sucr
18h 54m
1 stop
SCL12:04 amSantiago Arturo Merino Benitez
Oct 31
SCL3:23 amSantiago Arturo Merino Benitez
11h 28m
1 stop
UIO12:51 pmQuito Mariscal Sucr
$487
Find similar
Copa Airlines
Sep 30
UIO3:10 amQuito Mariscal Sucr
18h 54m
1 stop
SCL12:04 amSantiago Arturo Merino Benitez
Oct 7
SCL3:35 amSantiago Arturo Merino Benitez
10h 52m
1 stop
UIO12:27 pmQuito Mariscal Sucr
$508
Find similar
Copa Airlines
Sep 18
UIO6:28 pmQuito Mariscal Sucr
9h 30m
1 stop
SCL5:58 amSantiago Arturo Merino Benitez
Sep 25
SCL5:22 amSantiago Arturo Merino Benitez
10h 48m
1 stop
UIO2:10 pmQuito Mariscal Sucr
$514
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 3/11

4:36 pm-8:31 pm

1 stop25h 55m

Santiago Arturo Merino Benitez

Sat 3/21

9:36 pm-3:49 pm

1 stop20h 13m

$378

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 11/19

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

Sun 11/23

5:59 am-4:00 pm

1 stop12h 01m

$405

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 12/26

4:49 pm-2:30 pm

1 stop19h 41m

Santiago Arturo Merino Benitez

Sat 1/10

9:29 pm-4:00 pm

1 stop20h 31m

$408

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 10/17

4:41 pm-5:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

Wed 11/5

4:25 pm-1:10 pm

1 stop22h 45m

$409

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 2/20

4:49 pm-10:39 am

1 stop15h 50m

Santiago Arturo Merino Benitez

Thu 2/26

9:29 pm-4:00 pm

1 stop20h 31m

$410

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 11/7

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

Sun 11/23

5:59 am-4:00 pm

1 stop12h 01m

$415

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/8

7:55 am-11:30 pm

2 stops13h 35m

Santiago Arturo Merino Benitez

Wed 10/29

5:59 am-4:00 pm

1 stop12h 01m

$424

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 10/6

6:00 am-11:30 pm

2 stops15h 30m

Santiago Arturo Merino Benitez

Thu 11/6

1:35 am-1:10 pm

1 stop13h 35m

$427

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 10/6

9:45 am-11:30 pm

1 stop11h 45m

Santiago Arturo Merino Benitez

Thu 11/6

1:35 am-1:10 pm

1 stop13h 35m

$438

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Tue 9/30

3:10 am-12:04 am

1 stop18h 54m

Santiago Arturo Merino Benitez

Wed 10/8

12:29 pm-12:32 am

1 stop14h 03m

$487

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Quito to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Quito and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Quito to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $256. If you don’t want to visit Santiago in April, then you should wait until May to fly from Quito, when ticket prices are also cheap, with an average price of $270.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $404. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Wednesday is $489.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Quito to Santiago when you can find flight prices for as low as $428. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $468 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Quito when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $369 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Quito for as low as $318 on momondo.

Can stopping save me money on Quito to Santiago flights?

You could potentially save up to 31% on your flight if you consider stops on a Quito to Santiago flight.

How have Quito to Santiago flight prices changed over time?

As of September 2025, prices for Quito to Santiago flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from Quito to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Quito to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Quito to Santiago (UIO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Quito to Santiago

Direct flights

None
There are no direct flights from Quito to Santiago. There are no popular flight routes from Quito to Santiago.
Search flight deals

  • How far is Quito Mariscal Sucr to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Quito Mariscal Sucr to Santiago Arturo Merino Benitez is 2349.7 mi. A reasonable flight in good conditions will take 9h 50m.

  • When did momondo last update prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Quito to Santiago?

Best airlines flying from Quito to Santiago

Compare and see reviews for airlines that fly from Quito to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $161Free CancellationRating
6.5
225 reviews
Search JetSMART flights
Copa AirlinesPriceFrom $183Free CancellationRating
7.6
1,533 reviews
Search Copa Airlines flights
AviancaPriceFrom $207Free CancellationRating
6.7
2,436 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $354Free CancellationRating
7.5
1,849 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Quito to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Quito to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Quito to Santiago with flexible booking policies on momondo?

Flights from Quito to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Quito to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Quito. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Quito to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Quito to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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