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Cheap flights from Quito to Santiago from $267

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Quito to Santiago departing on 10/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Quito to Santiago (UIO-SCL)

Cheap round-trip flights

JetSMART Logo
4:41 pm - 5:01 amUIO-SCL
10h 20m1 stop
JetSMART Logo
5:51 am - 4:09 pmSCL-UIO
12h 18m1 stop
$326JetSMART
Find Deal
Wed, Oct 8 - Sun, Oct 12
Logo
4:41 pm - 5:01 amUIO-SCL
10h 20m1 stop
Logo
12:55 am - 8:35 amSCL-UIO
9h 40m1 stop
$363
Find Deal
Wed, Oct 8 - Sat, Oct 11
Logo
7:45 am - 11:30 pmUIO-SCL
13h 45m2 stops
Logo
5:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$374
Find Deal
Wed, Oct 15 - Wed, Oct 22
JetSMART Logo
4:41 pm - 5:01 amUIO-SCL
10h 20m1 stop
JetSMART Logo
5:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$377JetSMART
Find Deal
Wed, Oct 15 - Wed, Oct 22
Logo
2:30 am - 11:30 pmUIO-SCL
19h 00m1 stop
Logo
5:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$385
Find Deal
Tue, Oct 14 - Wed, Oct 22
Logo
9:25 am - 5:15 amUIO-SCL
17h 50m2 stops
Logo
5:51 am - 4:09 pmSCL-UIO
12h 18m1 stop
$400
Find Deal
Wed, Oct 8 - Sun, Oct 12
Avianca Logo
7:20 pm - 3:20 pmUIO-SCL
18h 00m2 stops
Avianca Logo
1:35 am - 1:10 pmSCL-UIO
13h 35m1 stop
$443Avianca
Find Deal
Tue, Nov 11 - Wed, Nov 19
Avianca Logo
3:30 am - 3:20 pmUIO-SCL
9h 50m1 stop
Avianca Logo
7:25 am - 5:55 pmSCL-UIO
12h 30m1 stop
$453Avianca
Find Deal
Mon, Nov 10 - Thu, Nov 20
Copa Airlines Logo
3:06 am - 12:04 amUIO-SCL
18h 58m1 stop
Copa Airlines Logo
5:11 am - 2:10 pmSCL-UIO
10h 59m1 stop
$487Copa Airlines
Find Deal
Mon, Sep 15 - Tue, Sep 23
Copa Airlines Logo
3:15 pm - 3:42 amUIO-SCL
10h 27m1 stop
Copa Airlines Logo
5:22 am - 2:10 pmSCL-UIO
10h 48m1 stop
$500Copa Airlines
Find Deal
Fri, Sep 12 - Wed, Sep 24

JetSMART flights from Quito to Santiago

Our best JetSMART deals on Quito to Santiago flight tickets
JetSMART
Oct 8
UIO4:41 pmQuito Mariscal Sucr
10h 20m
1 stop
SCL5:01 amSantiago Arturo Merino Benitez
Oct 12
SCL5:51 amSantiago Arturo Merino Benitez
12h 18m
1 stop
UIO4:09 pmQuito Mariscal Sucr
$326
Find similar
JetSMART
Oct 15
UIO4:41 pmQuito Mariscal Sucr
10h 20m
1 stop
SCL5:01 amSantiago Arturo Merino Benitez
Oct 22
SCL5:51 amSantiago Arturo Merino Benitez
12h 03m
1 stop
UIO3:54 pmQuito Mariscal Sucr
$377
Find similar
JetSMART
Nov 19
UIO4:49 pmQuito Mariscal Sucr
10h 25m
1 stop
SCL5:14 amSantiago Arturo Merino Benitez
Nov 23
SCL5:59 amSantiago Arturo Merino Benitez
12h 01m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$417
Find similar

Avianca flights from Quito to Santiago

Our best Avianca deals on Quito to Santiago flight tickets
Avianca
Nov 11
UIO7:20 pmQuito Mariscal Sucr
18h 00m
2 stops
SCL3:20 pmSantiago Arturo Merino Benitez
Nov 19
SCL1:35 amSantiago Arturo Merino Benitez
13h 35m
1 stop
UIO1:10 pmQuito Mariscal Sucr
$443
Find similar
Avianca
Nov 10
UIO3:30 amQuito Mariscal Sucr
9h 50m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
Nov 20
SCL7:25 amSantiago Arturo Merino Benitez
12h 30m
1 stop
UIO5:55 pmQuito Mariscal Sucr
$453
Find similar
Avianca
Sep 29
UIO3:55 pmQuito Mariscal Sucr
11h 20m
2 stops
SCL5:15 amSantiago Arturo Merino Benitez
Oct 2
SCL12:55 amSantiago Arturo Merino Benitez
14h 25m
2 stops
UIO1:20 pmQuito Mariscal Sucr
$461
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 2, 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/8

4:41 pm-5:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

Sun 10/12

5:51 am-4:09 pm

1 stop12h 18m

$326

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/8

4:41 pm-5:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

Sat 10/11

12:55 am-8:35 am

1 stop9h 40m

$363

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/15

7:45 am-11:30 pm

2 stops13h 45m

Santiago Arturo Merino Benitez

Wed 10/22

5:51 am-3:54 pm

1 stop12h 03m

$374

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/15

4:41 pm-5:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

Wed 10/22

5:51 am-3:54 pm

1 stop12h 03m

$377

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Tue 10/14

2:30 am-11:30 pm

1 stop19h 00m

Santiago Arturo Merino Benitez

Wed 10/22

5:51 am-3:54 pm

1 stop12h 03m

$385

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/8

9:25 am-5:15 am

2 stops17h 50m

Santiago Arturo Merino Benitez

Sun 10/12

5:51 am-4:09 pm

1 stop12h 18m

$400

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Tue 11/11

7:20 pm-3:20 pm

2 stops18h 00m

Santiago Arturo Merino Benitez

Wed 11/19

1:35 am-1:10 pm

1 stop13h 35m

$443

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 11/10

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

Thu 11/20

7:25 am-5:55 pm

1 stop12h 30m

$453

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Mon 9/15

3:06 am-12:04 am

1 stop18h 58m

Santiago Arturo Merino Benitez

Tue 9/23

5:11 am-2:10 pm

1 stop10h 59m

$487

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 9/12

3:15 pm-3:42 am

1 stop10h 27m

Santiago Arturo Merino Benitez

Wed 9/24

5:22 am-2:10 pm

1 stop10h 48m

$500

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Quito to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Quito and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Quito to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $260. If you don’t want to visit Santiago in April, then you should wait until May to fly from Quito, when ticket prices are also cheap, with an average price of $270.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $404. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Wednesday is $489.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Quito to Santiago when you can find flight prices for as low as $428. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $468 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Quito when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $367 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Quito for as low as $323 on momondo.

Can stopping save me money on Quito to Santiago flights?

You could potentially save up to 31% on your flight if you consider stops on a Quito to Santiago flight.

How have Quito to Santiago flight prices changed over time?

As of September 2025, prices for Quito to Santiago flights are approximately 32% cheaper when compared to flights at the same time last year.

When to book flights from Quito to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Quito to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Quito to Santiago (UIO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Quito to Santiago

Direct flights

None
There are no direct flights from Quito to Santiago. There are no popular flight routes from Quito to Santiago.
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  • How far is Quito Mariscal Sucr to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Quito Mariscal Sucr to Santiago Arturo Merino Benitez is 2349.7 mi. A reasonable flight in good conditions will take 8h 25m.

  • When did momondo last update prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Quito to Santiago?

Best airlines flying from Quito to Santiago

Compare and see reviews for airlines that fly from Quito to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $161Free CancellationRating
6.5
222 reviews
Search JetSMART flights
Copa AirlinesPriceFrom $183Free CancellationRating
7.6
1,521 reviews
Search Copa Airlines flights
AviancaPriceFrom $207Free CancellationRating
6.7
2,423 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $360Free CancellationRating
7.5
1,846 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Quito to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Quito to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Quito to Santiago with flexible booking policies on momondo?

Flights from Quito to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Quito to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Quito. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Quito to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Quito to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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