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Cheap flights from Quito to Santiago from $216

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Quito to Santiago departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
JetSMART Logo
4:56 pm - 4:01 amUIO-SCL
10h 05m1 stop
JetSMART Logo
4:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$378JetSMART
Find Deal
dom., abr. 12 - mié., abr. 15
Multiple Airlines Logo
6:30 am - 12:30 amUIO-SCL
16h 00m2 stops
Multiple Airlines Logo
4:51 am - 4:09 pmSCL-UIO
12h 18m1 stop
$382Multiple Airlines
Find Deal
mar., mar. 24 - dom., abr. 5
JetSMART Logo
4:41 pm - 4:01 amUIO-SCL
10h 20m1 stop
JetSMART Logo
4:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$385JetSMART
Find Deal
mié., abr. 15 - vie., abr. 17
Multiple Airlines Logo
11:30 am - 4:15 amUIO-SCL
15h 45m2 stops
Multiple Airlines Logo
4:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$394Multiple Airlines
Find Deal
mié., abr. 15 - vie., abr. 17
Multiple Airlines Logo
3:30 am - 12:30 amUIO-SCL
19h 00m1 stop
Multiple Airlines Logo
4:51 am - 4:09 pmSCL-UIO
12h 18m1 stop
$397Multiple Airlines
Find Deal
lun., mar. 23 - dom., abr. 5
Multiple Airlines Logo
3:30 am - 3:20 pmUIO-SCL
9h 50m1 stop
Multiple Airlines Logo
4:51 am - 4:09 pmSCL-UIO
12h 18m1 stop
$417Multiple Airlines
Find Deal
dom., mar. 22 - dom., abr. 5
Multiple Airlines Logo
2:30 am - 1:25 pmUIO-SCL
9h 55m1 stop
Multiple Airlines Logo
4:51 am - 3:54 pmSCL-UIO
12h 03m1 stop
$419Multiple Airlines
Find Deal
mar., abr. 14 - vie., abr. 17
JetSMART Logo
4:49 pm - 5:14 amUIO-SCL
10h 25m1 stop
JetSMART Logo
5:59 am - 4:00 pmSCL-UIO
12h 01m1 stop
$423JetSMART
Find Deal
mié., ene. 7 - mié., ene. 14
JetSMART Logo
4:49 pm - 8:44 pmUIO-SCL
25h 55m1 stop
JetSMART Logo
9:29 pm - 4:00 pmSCL-UIO
20h 31m1 stop
$429JetSMART
Find Deal
vie., ene. 23 - mar., feb. 10
JetSMART Logo
4:49 pm - 8:44 pmUIO-SCL
25h 55m1 stop
JetSMART Logo
9:29 pm - 4:00 pmSCL-UIO
20h 31m1 stop
$430JetSMART
Find Deal
vie., ene. 23 - mar., feb. 10

JetSMART flights from Quito to Santiago

Our best JetSMART deals on Quito to Santiago flight tickets
JetSMART
Jan 7
UIO4:49 pmQuito Mariscal Sucr
10h 25m
1 stop
SCL5:14 amSantiago Arturo Merino Benitez
Jan 14
SCL5:59 amSantiago Arturo Merino Benitez
12h 01m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$423
Find similar
JetSMART
Jan 23
UIO4:49 pmQuito Mariscal Sucr
25h 55m
1 stop
SCL8:44 pmSantiago Arturo Merino Benitez
Feb 10
SCL9:29 pmSantiago Arturo Merino Benitez
20h 31m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$429
Find similar
JetSMART
Jan 23
UIO4:49 pmQuito Mariscal Sucr
25h 55m
1 stop
SCL8:44 pmSantiago Arturo Merino Benitez
Feb 10
SCL9:29 pmSantiago Arturo Merino Benitez
20h 31m
1 stop
UIO4:00 pmQuito Mariscal Sucr
$430
Find similar

Copa Airlines flights from Quito to Santiago

Our best Copa Airlines deals on Quito to Santiago flight tickets
Copa Airlines
Nov 17
UIO6:34 pmQuito Mariscal Sucr
30h 50m
1 stop
SCL3:24 amSantiago Arturo Merino Benitez
Nov 26
SCL5:24 amSantiago Arturo Merino Benitez
9h 27m
1 stop
UIO12:51 pmQuito Mariscal Sucr
$479
Find similar
Copa Airlines
Nov 16
UIO6:34 pmQuito Mariscal Sucr
27h 07m
1 stop
SCL11:41 pmSantiago Arturo Merino Benitez
Nov 21
SCL5:24 amSantiago Arturo Merino Benitez
9h 27m
1 stop
UIO12:51 pmQuito Mariscal Sucr
$494
Find similar
Copa Airlines
Nov 15
UIO3:11 amQuito Mariscal Sucr
18h 55m
1 stop
SCL12:06 amSantiago Arturo Merino Benitez
Nov 21
SCL5:24 amSantiago Arturo Merino Benitez
9h 27m
1 stop
UIO12:51 pmQuito Mariscal Sucr
$495
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated noviembre 13, 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 4/12

4:56 pm-4:01 am

1 stop10h 05m

Santiago Arturo Merino Benitez

mié. 4/15

4:51 am-3:54 pm

1 stop12h 03m

$378

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mar. 3/24

6:30 am-12:30 am

2 stops16h 00m

Santiago Arturo Merino Benitez

dom. 4/5

4:51 am-4:09 pm

1 stop12h 18m

$382

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 4/15

4:41 pm-4:01 am

1 stop10h 20m

Santiago Arturo Merino Benitez

vie. 4/17

4:51 am-3:54 pm

1 stop12h 03m

$385

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 4/15

11:30 am-4:15 am

2 stops15h 45m

Santiago Arturo Merino Benitez

vie. 4/17

4:51 am-3:54 pm

1 stop12h 03m

$394

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

lun. 3/23

3:30 am-12:30 am

1 stop19h 00m

Santiago Arturo Merino Benitez

dom. 4/5

4:51 am-4:09 pm

1 stop12h 18m

$397

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

dom. 3/22

3:30 am-3:20 pm

1 stop9h 50m

Santiago Arturo Merino Benitez

dom. 4/5

4:51 am-4:09 pm

1 stop12h 18m

$417

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mar. 4/14

2:30 am-1:25 pm

1 stop9h 55m

Santiago Arturo Merino Benitez

vie. 4/17

4:51 am-3:54 pm

1 stop12h 03m

$419

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

mié. 1/7

4:49 pm-5:14 am

1 stop10h 25m

Santiago Arturo Merino Benitez

mié. 1/14

5:59 am-4:00 pm

1 stop12h 01m

$423

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 1/23

4:49 pm-8:44 pm

1 stop25h 55m

Santiago Arturo Merino Benitez

mar. 2/10

9:29 pm-4:00 pm

1 stop20h 31m

$429

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

vie. 1/23

4:49 pm-8:44 pm

1 stop25h 55m

Santiago Arturo Merino Benitez

mar. 2/10

9:29 pm-4:00 pm

1 stop20h 31m

$430

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Quito to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Quito to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $257. If you don’t want to visit Santiago in April, then you should wait until June to fly from Quito, when ticket prices are also cheap, with an average price of $277.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $404. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Wednesday is $489.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Quito to Santiago when you can find flight prices for as low as $428. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $468 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Quito when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $374 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Quito for as low as $307 on momondo.

Can stopping save me money on Quito to Santiago flights?

You could potentially save up to 4% on your flight if you consider stops on a Quito to Santiago flight.

How have Quito to Santiago flight prices changed over time?

As of November 2025, prices for Quito to Santiago flights are approximately 32% cheaper when compared to flights at the same time last year.

When to book flights from Quito to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Quito to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Quito to Santiago (UIO to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Quito to Santiago

Direct flights

None
There are no direct flights from Quito to Santiago. There are no popular flight routes from Quito to Santiago.
Search flight deals

  • How far is Quito Mariscal Sucr to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Quito Mariscal Sucr to Santiago Arturo Merino Benitez is 2349.7 mi. A reasonable flight in good conditions will take 6h 50m.

  • When did momondo last update prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Quito Mariscal Sucr Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Quito to Santiago?

Best airlines flying from Quito to Santiago

Compare and see reviews for airlines that fly from Quito to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $161Free CancellationRating
6.6
240 reviews
Search JetSMART flights
Copa AirlinesPriceFrom $183Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
AviancaPriceFrom $207Free CancellationRating
6.6
2,475 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $360Free CancellationRating
7.5
1,875 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Quito to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Quito to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Quito to Santiago with flexible booking policies on momondo?

Flights from Quito to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Quito to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Quito. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Quito to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Quito to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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