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Cheap flights from Panama City to Chicago from $268

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Chicago departing on 2/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:55 am - 11:47 pm
PTY
-
ORD
21h 52m
2 stops
Multiple Airlines Logo
7:23 pm - 8:06 am
ORD
-
PTY
11h 43m
1 stop
$465Multiple Airlines
Tue, Feb 24 - Wed, Mar 4
Multiple Airlines Logo
2:55 am - 5:03 pm
PTY
-
ORD
15h 08m
2 stops
Multiple Airlines Logo
11:33 am - 8:37 pm
ORD
-
PTY
8h 04m
1 stop
$472Multiple Airlines
Thu, Feb 12 - Mon, Mar 2
Multiple Airlines Logo
2:55 am - 5:03 pm
PTY
-
ORD
15h 08m
2 stops
Multiple Airlines Logo
7:23 pm - 8:06 am
ORD
-
PTY
11h 43m
1 stop
$479Multiple Airlines
Thu, Feb 12 - Tue, Mar 3
Multiple Airlines Logo
2:55 am - 5:03 pm
PTY
-
ORD
15h 08m
2 stops
Multiple Airlines Logo
9:18 am - 8:37 pm
ORD
-
PTY
10h 19m
1 stop
$481Multiple Airlines
Thu, Feb 12 - Sun, Mar 1
Multiple Airlines Logo
2:55 am - 7:11 pm
PTY
-
ORD
17h 16m
2 stops
Multiple Airlines Logo
7:23 pm - 8:30 am
ORD
-
PTY
12h 07m
1 stop
$485Multiple Airlines
Wed, Feb 25 - Thu, Mar 5
Multiple Airlines Logo
9:33 pm - 8:18 am
PTY
-
ORD
11h 45m
1 stop
Multiple Airlines Logo
6:57 pm - 8:50 am
ORD
-
PTY
12h 53m
2 stops
$508Multiple Airlines
Wed, Feb 4 - Sat, Feb 7
Multiple Airlines Logo
5:50 pm - 7:38 pm
PTY
-
ORD
26h 48m
2 stops
Multiple Airlines Logo
6:57 pm - 8:06 am
ORD
-
PTY
12h 09m
1 stop
$510Multiple Airlines
Wed, Jan 28 - Thu, Feb 5
Multiple Airlines Logo
5:50 pm - 9:39 am
PTY
-
ORD
16h 49m
2 stops
Multiple Airlines Logo
7:35 am - 7:20 pm
ORD
-
PTY
10h 45m
1 stop
$513Multiple Airlines
Fri, Feb 27 - Fri, Mar 6
Multiple Airlines Logo
5:50 pm - 8:18 am
PTY
-
ORD
15h 28m
2 stops
Multiple Airlines Logo
7:20 am - 8:19 pm
ORD
-
PTY
11h 59m
1 stop
$515Multiple Airlines
Tue, Feb 3 - Wed, Feb 11
Multiple Airlines Logo
9:33 pm - 8:18 am
PTY
-
ORD
11h 45m
1 stop
Multiple Airlines Logo
6:57 pm - 8:50 am
ORD
-
PTY
12h 53m
2 stops
$517Multiple Airlines
Wed, Jan 28 - Thu, Feb 5

American Airlines flights from Panama City to Chicago O'Hare Intl Airport

Our best American Airlines deals on Panama City to Chicago O'Hare Intl Airport flight tickets
American Airlines
Apr 15
PTY1:49 pmPanama City Tocumen Intl
18h 37m
2 stops
ORD8:26 amChicago O'Hare Intl
Apr 25
ORD9:01 pmChicago O'Hare Intl
15h 35m
2 stops
PTY12:36 pmPanama City Tocumen Intl
$600
American Airlines
Jan 25
PTY4:50 pmPanama City Tocumen Intl
17h 15m
2 stops
ORD9:05 amChicago O'Hare Intl
May 16
ORD9:01 pmChicago O'Hare Intl
15h 35m
2 stops
PTY12:36 pmPanama City Tocumen Intl
$774
American Airlines
Jan 25
PTY4:50 pmPanama City Tocumen Intl
17h 15m
2 stops
ORD9:05 amChicago O'Hare Intl
May 16
ORD9:01 pmChicago O'Hare Intl
15h 35m
2 stops
PTY12:36 pmPanama City Tocumen Intl
$827

Avianca flights from Panama City to Chicago O'Hare Intl Airport

Our best Avianca deals on Panama City to Chicago O'Hare Intl Airport flight tickets
Avianca
Jan 15
PTY2:55 amPanama City Tocumen Intl
18h 25m
1 stop
ORD8:20 pmChicago O'Hare Intl
Jan 20
ORD10:20 pmChicago O'Hare Intl
17h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$291
Avianca
Jan 15
PTY2:55 amPanama City Tocumen Intl
17h 00m
2 stops
ORD6:55 pmChicago O'Hare Intl
Jan 20
ORD10:20 pmChicago O'Hare Intl
17h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$526
Avianca
Mar 30
PTY10:05 pmPanama City Tocumen Intl
15h 10m
1 stop
ORD1:15 pmChicago O'Hare Intl
May 1
ORD2:35 pmChicago O'Hare Intl
10h 10m
1 stop
PTY12:45 amPanama City Tocumen Intl
$566

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Chicago O'Hare Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 13, 2026.
Use the filters below to find and compare flights from Panama City to Chicago O'Hare Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 2/24

2:55 am-11:47 pm

2 stops21h 52m

Chicago O'Hare Intl

Wed 3/4

7:23 pm-8:06 am

1 stop11h 43m

$465

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 2/12

2:55 am-5:03 pm

2 stops15h 08m

Chicago O'Hare Intl

Mon 3/2

11:33 am-8:37 pm

1 stop8h 04m

$472

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 2/12

2:55 am-5:03 pm

2 stops15h 08m

Chicago O'Hare Intl

Tue 3/3

7:23 pm-8:06 am

1 stop11h 43m

$479

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 2/12

2:55 am-5:03 pm

2 stops15h 08m

Chicago O'Hare Intl

Sun 3/1

9:18 am-8:37 pm

1 stop10h 19m

$481

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 2/25

2:55 am-7:11 pm

2 stops17h 16m

Chicago O'Hare Intl

Thu 3/5

7:23 pm-8:30 am

1 stop12h 07m

$485

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 2/4

9:33 pm-8:18 am

1 stop11h 45m

Chicago O'Hare Intl

Sat 2/7

6:57 pm-8:50 am

2 stops12h 53m

$508

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 1/28

5:50 pm-7:38 pm

2 stops26h 48m

Chicago O'Hare Intl

Thu 2/5

6:57 pm-8:06 am

1 stop12h 09m

$510

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 2/27

5:50 pm-9:39 am

2 stops16h 49m

Chicago O'Hare Intl

Fri 3/6

7:35 am-7:20 pm

1 stop10h 45m

$513

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 2/3

5:50 pm-8:18 am

2 stops15h 28m

Chicago O'Hare Intl

Wed 2/11

7:20 am-8:19 pm

1 stop11h 59m

$515

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 1/28

9:33 pm-8:18 am

1 stop11h 45m

Chicago O'Hare Intl

Thu 2/5

6:57 pm-8:50 am

2 stops12h 53m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama City to Chicago O'Hare Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Chicago O'Hare Intl Airport?

What is the cheapest month to fly to Chicago O'Hare Intl Airport?

The month of October is another great option to travel to Chicago O'Hare Intl Airport, with average flight prices from Panama City averaging around $479.

What is the cheapest day to depart on your flight to Chicago O'Hare Intl Airport?

The cheapest day to depart on your flight to Chicago O'Hare Intl Airport is on a Wednesday when prices can be found for as low as $493. This is often the case because there is less demand to fly during this day of the week. On the other hand, Tuesday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $799.

What is the cheapest time of day to depart on your flight to Chicago O'Hare Intl Airport?

Flying to Chicago O'Hare Intl Airport from Panama City in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $532 when looking at flights departing in the afternoon. Try not to purchase tickets in the morning because they tend to be around $687. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Panama City Tocumen Intl to Chicago O'Hare Intl flight route?

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama City Tocumen Intl - Chicago O'Hare Intl flight prices

How far in advance should I book a flight to Chicago O'Hare Intl Airport?

You are more likely to see cheaper flights to Chicago O'Hare Intl Airport from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago O'Hare Intl Airport for around $571 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago O'Hare Intl Airport from Panama City for as low as $463 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Chicago O'Hare Intl flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to Chicago O'Hare Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Chicago O'Hare Intl Airport flights?

You could potentially save up to 44% on your flight if you consider stops on a Panama City to Chicago O'Hare Intl Airport flight.

How have Panama City to Chicago O'Hare Intl Airport flight prices changed over time?

As of January 2026, prices for Panama City to Chicago O'Hare Intl Airport flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to Chicago O'Hare Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago O'Hare Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago O'Hare Intl Airport (PTY to ORD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago O'Hare Intl Airport

Best Price Found

$485

Fastest flight time

5h 36m

Direct flights

Every day
The best one-way flight to Chicago O'Hare Intl Airport from Panama City in the past 72 hours is $485. The best round-trip flight deal from Panama City to Chicago O'Hare Intl Airport found on momondo in the last 72 hours is $1,093.
The fastest flight from Panama City to Chicago O'Hare Intl Airport takes 5h 36m
Direct flights go from Panama City to Chicago O'Hare Intl Airport every day.
Search flight deals

  • How far is Panama City Tocumen Intl to Chicago O'Hare Intl by plane?

    Panama City Tocumen Intl and Chicago O'Hare Intl are 2334.5 mi apart from one another. By plane, this route typically takes 5h 36m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago O'Hare Intl Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago O'Hare Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Chicago O'Hare Intl Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago O'Hare Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City Tocumen Intl Airport to Chicago O'Hare Intl Airport.

  • What documentation or ID do you need to fly to Chicago O'Hare Intl Airport?

    The travel and health documents you'll need for your trip to Chicago O'Hare Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago O'Hare Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Chicago O'Hare Intl Airport?

  • What is the most popular airline from Panama City to Chicago O'Hare Intl Airport?

Best airlines flying from Panama City to Chicago O'Hare Intl Airport

Compare and see reviews for airlines that fly from Panama City to Chicago O'Hare Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $405Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $423Free CancellationRating
7.4
9,152 reviews
Search United Airlines flights

  • Copa Airlines Flights From Panama City to Chicago O'Hare Intl Airport

    Copa Airlines flies from Panama City to Chicago O'Hare Intl Airport around 12 times per week, with 1,558 momondo users rating the airline 7.6/10. The cheapest Copa Airlines deal from Panama City to Chicago O'Hare Intl Airport in the last 72 hours was $405 (round-trip), much lower than the average airfare cost of $584 for Copa Airlines flights on this route.

  • United Airlines Flights From Panama City to Chicago O'Hare Intl Airport

    Across 9,152 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Panama City to Chicago O'Hare Intl Airport about 12 times each week, with ticket deals ranging from $423 to $485. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lake Geneva
Schaumburg
South Haven
Rockford
Merrillville
Gurnee
Rosemont
Naperville
Kenosha
New Buffalo
Joliet
Oak Brook
Orland Park
Racine
Hammond
Janesville
Tinley Park
Elgin
Aurora
South Holland

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama City to Chicago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Panama City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama City to Chicago?

Once you have performed a search for Panama City to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Chicago, momondo offers a useful price alert feature which will track prices for flights to Chicago from Panama City and alert you when they change.

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