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Cheap flights from Panama City to Chicago from $350

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Chicago departing on 8/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Panama City to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
3:30 pm - 10:10 pm
PTY
-
MDW
7h 40m
1 stop
Delta Logo
6:00 am - 2:05 pm
MDW
-
PTY
7h 05m
1 stop
$762Delta
Wed, Dec 2 - Sun, Dec 6
Delta Logo
2:23 pm - 10:45 pm
PTY
-
MDW
8h 22m
1 stop
Delta Logo
6:05 am - 12:58 pm
MDW
-
PTY
6h 53m
1 stop
$764Delta
Mon, Sep 14 - Fri, Sep 18
Delta Logo
3:30 pm - 10:10 pm
PTY
-
MDW
7h 40m
1 stop
Delta Logo
6:00 am - 2:05 pm
MDW
-
PTY
7h 05m
1 stop
$783Delta
Thu, Nov 26 - Mon, Nov 30
Delta Logo
2:23 pm - 10:45 pm
PTY
-
MDW
8h 22m
1 stop
Delta Logo
6:05 am - 12:58 pm
MDW
-
PTY
6h 53m
1 stop
$785Delta
Mon, Sep 14 - Fri, Sep 18
Delta Logo
2:20 pm - 10:36 pm
PTY
-
MDW
8h 16m
1 stop
Delta Logo
6:05 am - 12:55 pm
MDW
-
PTY
6h 50m
1 stop
$795Delta
Thu, Aug 27 - Mon, Aug 31
Multiple Airlines Logo
10:00 am - 9:53 pm
PTY
-
MDW
12h 53m
1 stop
Multiple Airlines Logo
7:25 am - 7:49 am
MDW
-
PTY
23h 24m
2 stops
$796Multiple Airlines
Mon, Nov 2 - Wed, Nov 18
Multiple Airlines Logo
10:25 am - 10:47 pm
PTY
-
MDW
12h 22m
2 stops
Multiple Airlines Logo
6:05 am - 8:31 pm
MDW
-
PTY
14h 26m
1 stop
$799Multiple Airlines
Tue, Sep 1 - Mon, Sep 7
Multiple Airlines Logo
9:33 pm - 12:07 pm
PTY
-
MDW
14h 34m
2 stops
Multiple Airlines Logo
6:40 am - 8:31 pm
MDW
-
PTY
13h 51m
1 stop
$812Multiple Airlines
Fri, Oct 9 - Mon, Oct 12
Delta Logo
2:20 pm - 10:36 pm
PTY
-
MDW
8h 16m
1 stop
Delta Logo
6:05 am - 12:55 pm
MDW
-
PTY
6h 50m
1 stop
$816Delta
Thu, Aug 20 - Sun, Aug 23
Multiple Airlines Logo
9:33 pm - 10:58 am
PTY
-
MDW
13h 25m
2 stops
Multiple Airlines Logo
12:03 pm - 8:31 pm
MDW
-
PTY
8h 28m
1 stop
$829Multiple Airlines
Fri, Sep 11 - Tue, Sep 15

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Delta flights from Panama City to Chicago Midway Airport

Our best Delta deals on Panama City to Chicago Midway Airport flight tickets
Delta
Dec 2
PTY3:30 pmPanama City Tocumen Intl
7h 40m
1 stop
MDW10:10 pmChicago Midway
Dec 6
MDW6:00 amChicago Midway
7h 05m
1 stop
PTY2:05 pmPanama City Tocumen Intl
$762
Delta
Sep 14
PTY2:23 pmPanama City Tocumen Intl
8h 22m
1 stop
MDW10:45 pmChicago Midway
Sep 18
MDW6:05 amChicago Midway
6h 53m
1 stop
PTY12:58 pmPanama City Tocumen Intl
$764
Delta
Nov 26
PTY3:30 pmPanama City Tocumen Intl
7h 40m
1 stop
MDW10:10 pmChicago Midway
Nov 30
MDW6:00 amChicago Midway
7h 05m
1 stop
PTY2:05 pmPanama City Tocumen Intl
$783

WestJet flights from Panama City to Chicago Midway Airport

Our best WestJet deals on Panama City to Chicago Midway Airport flight tickets
WestJet
Nov 26
PTY10:20 amPanama City Tocumen Intl
31h 30m
2 stops
MDW4:50 pmChicago Midway
Nov 30
MDW10:35 amChicago Midway
20h 45m
2 stops
PTY8:20 amPanama City Tocumen Intl
$2,263
WestJet
Nov 19
PTY10:20 amPanama City Tocumen Intl
50h 31m
2 stops
MDW11:51 amChicago Midway
Nov 23
MDW10:35 amChicago Midway
20h 45m
2 stops
PTY8:20 amPanama City Tocumen Intl
$2,322
WestJet
Dec 26
PTY10:20 amPanama City Tocumen Intl
31h 30m
2 stops
MDW4:50 pmChicago Midway
Jan 2
MDW10:35 amChicago Midway
20h 45m
2 stops
PTY8:20 amPanama City Tocumen Intl
$2,333

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 18, 2026.
Use the filters below to find and compare flights from Panama City to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Wed 12/2

3:30 pm-10:10 pm

1 stop7h 40m

Chicago Midway

Sun 12/6

6:00 am-2:05 pm

1 stop7h 05m

$762

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Mon 9/14

2:23 pm-10:45 pm

1 stop8h 22m

Chicago Midway

Fri 9/18

6:05 am-12:58 pm

1 stop6h 53m

$764

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 11/26

3:30 pm-10:10 pm

1 stop7h 40m

Chicago Midway

Mon 11/30

6:00 am-2:05 pm

1 stop7h 05m

$783

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Mon 9/14

2:23 pm-10:45 pm

1 stop8h 22m

Chicago Midway

Fri 9/18

6:05 am-12:58 pm

1 stop6h 53m

$785

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 8/27

2:20 pm-10:36 pm

1 stop8h 16m

Chicago Midway

Mon 8/31

6:05 am-12:55 pm

1 stop6h 50m

$795

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Mon 11/2

10:00 am-9:53 pm

1 stop12h 53m

Chicago Midway

Wed 11/18

7:25 am-7:49 am

2 stops23h 24m

$796

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 9/1

10:25 am-10:47 pm

2 stops12h 22m

Chicago Midway

Mon 9/7

6:05 am-8:31 pm

1 stop14h 26m

$799

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 10/9

9:33 pm-12:07 pm

2 stops14h 34m

Chicago Midway

Mon 10/12

6:40 am-8:31 pm

1 stop13h 51m

$812

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 8/20

2:20 pm-10:36 pm

1 stop8h 16m

Chicago Midway

Sun 8/23

6:05 am-12:55 pm

1 stop6h 50m

$816

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 9/11

9:33 pm-10:58 am

2 stops13h 25m

Chicago Midway

Tue 9/15

12:03 pm-8:31 pm

1 stop8h 28m

$829

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

When to book flights from Panama City to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago Midway Airport (PTY to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago Midway Airport

Fastest flight time

7h 40m

Direct flights

None
The fastest flight from Panama City to Chicago Midway Airport takes 7h 40m
There are no direct flights from Panama City to Chicago Midway Airport. There are no popular flight routes from Panama City to Chicago Midway Airport.
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Frequently asked questions about flying from Panama City to Chicago Midway Airport

  • How far is Panama City Tocumen Intl to Chicago Midway by plane?

    There are 2319.5 mi between Panama City Tocumen Intl and Chicago Midway. A reasonable flight in good conditions will take 7h 40m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport were last updated today.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The necessary travel and health documents for your Chicago Midway Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Frequently asked questions about flying from Panama City to Chicago Midway Airport

  • How do I get Price Alerts for flights from Panama City to Chicago Midway Airport?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Panama City from Chicago Midway Airport. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Panama City to Chicago Midway Airport with momondo?

    By using tools like our “Price Calendar”, you can see the best day to fly round-trip for your travels. Our “Price Forecast” tool uses AI to predict whether you should purchase or hold off on booking for potentially cheaper prices. Explore shows you all flight options from a city or airport to build your own unique adventure. The Discover blog also provides valuable insights for saving money while booking your experience. After searching you can toggle on “Price Alerts” to track prices for your desired flight and book at the ideal moment.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Portage
Benton Harbor
Saint Joseph
Lansing
Valparaiso
Schererville
Munster
Chesterton
Monticello
Crown Point
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

Finding the right flight to Chicago from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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