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Cheap flights from Panama City to Chicago from $287

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Chicago departing on 11/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
3:22 pm - 10:22 pmPTY-MDW
8h 00m1 stop
Delta Logo
6:00 am - 8:00 pmMDW-PTY
13h 00m1 stop
$424Delta
Find Deal
Tue, Dec 23 - Fri, Jan 2
Multiple Airlines Logo
2:55 am - 4:57 pmPTY-MDW
15h 02m2 stops
Multiple Airlines Logo
2:59 pm - 8:06 amMDW-PTY
16h 07m1 stop
$536Multiple Airlines
Find Deal
Tue, Nov 25 - Sun, Dec 7
Delta Logo
8:00 am - 10:22 pmPTY-MDW
15h 22m1 stop
Delta Logo
6:00 am - 1:55 pmMDW-PTY
6h 55m1 stop
$542Delta
Find Deal
Tue, Dec 30 - Thu, Jan 29
Multiple Airlines Logo
8:10 am - 4:57 pmPTY-MDW
9h 47m1 stop
Multiple Airlines Logo
2:59 pm - 8:50 amMDW-PTY
16h 51m2 stops
$584Multiple Airlines
Find Deal
Wed, Nov 26 - Sat, Dec 6
Delta Logo
3:27 pm - 10:44 pmPTY-MDW
8h 17m1 stop
Delta Logo
6:00 am - 2:02 pmMDW-PTY
7h 02m1 stop
$585Delta
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Fri, Feb 13 - Tue, Feb 17
Delta Logo
2:20 pm - 6:31 pmPTY-MDW
28h 11m2 stops
Delta Logo
6:00 am - 12:55 pmMDW-PTY
6h 55m1 stop
$599Delta
Find Deal
Fri, May 1 - Tue, May 5
Multiple Airlines Logo
8:10 am - 4:57 pmPTY-MDW
9h 47m1 stop
Multiple Airlines Logo
2:59 pm - 8:06 amMDW-PTY
16h 07m1 stop
$608Multiple Airlines
Find Deal
Wed, Nov 26 - Sat, Dec 6
Delta Logo
2:20 pm - 4:25 pmPTY-MDW
26h 05m1 stop
Delta Logo
6:00 am - 12:55 pmMDW-PTY
6h 55m1 stop
$613Delta
Find Deal
Fri, May 1 - Tue, May 5
Delta Logo
3:22 pm - 10:22 pmPTY-MDW
8h 00m1 stop
Delta Logo
6:00 am - 8:00 pmMDW-PTY
13h 00m1 stop
$623Delta
Find Deal
Tue, Dec 23 - Fri, Jan 2
Multiple Airlines Logo
8:10 am - 4:57 pmPTY-MDW
9h 47m1 stop
Multiple Airlines Logo
8:42 pm - 5:01 pmMDW-PTY
19h 19m2 stops
$624Multiple Airlines
Find Deal
Wed, Nov 26 - Fri, Dec 5

Delta flights from Panama City to Chicago Midway Airport

Our best Delta deals on Panama City to Chicago Midway Airport flight tickets
Delta
Dec 23
PTY3:22 pmPanama City Tocumen Intl
8h 00m
1 stop
MDW10:22 pmChicago Midway
Jan 2
MDW6:00 amChicago Midway
13h 00m
1 stop
PTY8:00 pmPanama City Tocumen Intl
$424
Find similar
Delta
Dec 30
PTY8:00 amPanama City Tocumen Intl
15h 22m
1 stop
MDW10:22 pmChicago Midway
Jan 29
MDW6:00 amChicago Midway
6h 55m
1 stop
PTY1:55 pmPanama City Tocumen Intl
$542
Find similar
Delta
Feb 13
PTY3:27 pmPanama City Tocumen Intl
8h 17m
1 stop
MDW10:44 pmChicago Midway
Feb 17
MDW6:00 amChicago Midway
7h 02m
1 stop
PTY2:02 pmPanama City Tocumen Intl
$585
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Panama City to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 12/23

3:22 pm-10:22 pm

1 stop8h 00m

Chicago Midway

Fri 1/2

6:00 am-8:00 pm

1 stop13h 00m

$424

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 11/25

2:55 am-4:57 pm

2 stops15h 02m

Chicago Midway

Sun 12/7

2:59 pm-8:06 am

1 stop16h 07m

$536

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 12/30

8:00 am-10:22 pm

1 stop15h 22m

Chicago Midway

Thu 1/29

6:00 am-1:55 pm

1 stop6h 55m

$542

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Wed 11/26

8:10 am-4:57 pm

1 stop9h 47m

Chicago Midway

Sat 12/6

2:59 pm-8:50 am

2 stops16h 51m

$584

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 2/13

3:27 pm-10:44 pm

1 stop8h 17m

Chicago Midway

Tue 2/17

6:00 am-2:02 pm

1 stop7h 02m

$585

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 5/1

2:20 pm-6:31 pm

2 stops28h 11m

Chicago Midway

Tue 5/5

6:00 am-12:55 pm

1 stop6h 55m

$599

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Wed 11/26

8:10 am-4:57 pm

1 stop9h 47m

Chicago Midway

Sat 12/6

2:59 pm-8:06 am

1 stop16h 07m

$608

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 5/1

2:20 pm-4:25 pm

1 stop26h 05m

Chicago Midway

Tue 5/5

6:00 am-12:55 pm

1 stop6h 55m

$613

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 12/23

3:22 pm-10:22 pm

1 stop8h 00m

Chicago Midway

Fri 1/2

6:00 am-8:00 pm

1 stop13h 00m

$623

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Wed 11/26

8:10 am-4:57 pm

1 stop9h 47m

Chicago Midway

Fri 12/5

8:42 pm-5:01 pm

2 stops19h 19m

$624

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama City to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Chicago Midway?

Delta is the most popular carrier operating from Panama City Tocumen Intl to Chicago Midway

When to book flights from Panama City to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago Midway Airport (PTY to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago Midway Airport

Direct flights

None
There are no direct flights from Panama City to Chicago Midway Airport. There are no popular flight routes from Panama City to Chicago Midway Airport.
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  • How far is Panama City Tocumen Intl to Chicago Midway by plane?

    There are 2319.5 mi between Panama City Tocumen Intl and Chicago Midway. A reasonable flight in good conditions will take 8h 00m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport were last updated today.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The necessary travel and health documents for your Chicago Midway Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

Finding the right flight to Chicago from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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