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Cheap flights from Panama City to Chicago from $307

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Chicago departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City to Chicago

Cheap round-trip flights

Logo
9:33 pm - 9:33 amPTY-MDW
12h 00m1 stop
Logo
10:33 am - 7:29 pmMDW-PTY
8h 56m1 stop
$462
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Thu, Oct 16 - Mon, Oct 20
Delta Logo
2:10 pm - 8:40 amPTY-MDW
18h 30m2 stops
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$552Delta
Find Deal
Fri, Oct 3 - Tue, Oct 7
Logo
9:25 am - 11:46 pmPTY-MDW
14h 21m1 stop
Logo
10:33 am - 8:55 amMDW-PTY
22h 22m2 stops
$602
Find Deal
Thu, Oct 16 - Mon, Oct 20
Delta Logo
2:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$606Delta
Find Deal
Sat, Oct 11 - Sat, Oct 18
Delta Logo
3:37 pm - 11:32 pmPTY-MDW
8h 55m1 stop
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
$661Delta
Find Deal
Thu, Nov 20 - Mon, Nov 24
Delta Logo
2:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$688Delta
Find Deal
Tue, Oct 14 - Tue, Oct 21
Logo
10:28 pm - 9:45 pmPTY-MDW
23h 17m2 stops
Logo
6:25 am - 7:43 pmMDW-PTY
12h 18m1 stop
$698
Find Deal
Thu, Oct 30 - Thu, Nov 6
Delta Logo
8:00 am - 4:15 pmPTY-MDW
9h 15m1 stop
Delta Logo
6:00 am - 2:02 pmMDW-PTY
7h 02m1 stop
$742Delta
Find Deal
Tue, Dec 30 - Thu, Jan 29
Logo
9:25 am - 6:39 pmPTY-MDW
9h 14m1 stop
Logo
6:25 am - 7:43 pmMDW-PTY
12h 18m1 stop
$749
Find Deal
Thu, Oct 30 - Thu, Nov 6
Delta Logo
2:10 pm - 11:48 amPTY-MDW
21h 38m1 stop
Delta Logo
6:00 am - 12:55 pmMDW-PTY
6h 55m1 stop
$795Delta
Find Deal
Mon, Sep 29 - Sun, Oct 5

Delta flights from Panama City to Chicago Midway Airport

Our best Delta deals on Panama City to Chicago Midway Airport flight tickets
Delta
Oct 3
PTY2:10 pmPanama City Tocumen Intl
18h 30m
2 stops
MDW8:40 amChicago Midway
Oct 7
MDW6:00 amChicago Midway
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
$552
Find similar
Delta
Oct 11
PTY2:21 pmPanama City Tocumen Intl
7h 53m
1 stop
MDW10:14 pmChicago Midway
Oct 18
MDW6:00 amChicago Midway
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
$606
Find similar
Delta
Nov 20
PTY3:37 pmPanama City Tocumen Intl
8h 55m
1 stop
MDW11:32 pmChicago Midway
Nov 24
MDW6:00 amChicago Midway
7h 12m
1 stop
PTY2:12 pmPanama City Tocumen Intl
$661
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama City to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/16

9:33 pm-9:33 am

1 stop12h 00m

Chicago Midway

Mon 10/20

10:33 am-7:29 pm

1 stop8h 56m

$462

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 10/3

2:10 pm-8:40 am

2 stops18h 30m

Chicago Midway

Tue 10/7

6:00 am-12:56 pm

1 stop6h 56m

$552

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/16

9:25 am-11:46 pm

1 stop14h 21m

Chicago Midway

Mon 10/20

10:33 am-8:55 am

2 stops22h 22m

$602

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Sat 10/11

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Sat 10/18

6:00 am-12:56 pm

1 stop6h 56m

$606

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 11/20

3:37 pm-11:32 pm

1 stop8h 55m

Chicago Midway

Mon 11/24

6:00 am-2:12 pm

1 stop7h 12m

$661

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 10/14

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Tue 10/21

6:00 am-12:56 pm

1 stop6h 56m

$688

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/30

10:28 pm-9:45 pm

2 stops23h 17m

Chicago Midway

Thu 11/6

6:25 am-7:43 pm

1 stop12h 18m

$698

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 12/30

8:00 am-4:15 pm

1 stop9h 15m

Chicago Midway

Thu 1/29

6:00 am-2:02 pm

1 stop7h 02m

$742

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/30

9:25 am-6:39 pm

1 stop9h 14m

Chicago Midway

Thu 11/6

6:25 am-7:43 pm

1 stop12h 18m

$749

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Mon 9/29

2:10 pm-11:48 am

1 stop21h 38m

Chicago Midway

Sun 10/5

6:00 am-12:55 pm

1 stop6h 55m

$795

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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When to book flights from Panama City to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago Midway Airport (PTY to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago Midway Airport

Direct flights

None
There are no direct flights from Panama City to Chicago Midway Airport. There are no popular flight routes from Panama City to Chicago Midway Airport.
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  • How far is Panama City Tocumen Intl to Chicago Midway by plane?

    There are 2319.5 mi between Panama City Tocumen Intl and Chicago Midway. A reasonable flight in good conditions will take 7h 53m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport were last updated today.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The necessary travel and health documents for your Chicago Midway Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • How do I get Price Alerts for flights from Panama City to Chicago Midway Airport?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Panama City from Chicago Midway Airport. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Panama City to Chicago Midway Airport with momondo?

    By using tools like our “Price Calendar”, you can see the best day to fly round-trip for your travels. Our “Price Forecast” tool uses AI to predict whether you should purchase or hold off on booking for potentially cheaper prices. Explore shows you all flight options from a city or airport to build your own unique adventure. The Discover blog also provides valuable insights for saving money while booking your experience. After searching you can toggle on “Price Alerts” to track prices for your desired flight and book at the ideal moment.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Lansing
Portage
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

Finding the right flight to Chicago from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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