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Cheap flights from Panama City to Chicago from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Chicago departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City to Chicago

Cheap round-trip flights

Logo
9:25 am - 11:20 pmPTY-MDW
13h 55m1 stop
Logo
6:15 am - 7:33 pmMDW-PTY
13h 18m1 stop
$583
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Thu, Sep 11 - Sat, Sep 20
Delta Logo
3:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
$598Delta
Find Deal
Wed, Nov 5 - Wed, Nov 19
Delta Logo
2:10 pm - 8:40 amPTY-MDW
18h 30m2 stops
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$633Delta
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Fri, Oct 3 - Tue, Oct 7
Delta Logo
2:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$635Delta
Find Deal
Mon, Oct 20 - Sat, Oct 25
Delta Logo
3:37 pm - 11:32 pmPTY-MDW
8h 55m1 stop
Delta Logo
6:00 am - 2:12 pmMDW-PTY
7h 12m1 stop
$717Delta
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Thu, Nov 20 - Mon, Nov 24
Logo
8:40 am - 3:11 pmPTY-MDW
30h 31m2 stops
Logo
8:05 am - 7:33 pmMDW-PTY
11h 28m1 stop
$761
Find Deal
Fri, Oct 10 - Tue, Oct 14
Logo
3:20 am - 4:09 pmPTY-MDW
12h 49m2 stops
Logo
8:05 am - 7:33 pmMDW-PTY
11h 28m1 stop
$808
Find Deal
Thu, Oct 9 - Tue, Oct 14
Delta Logo
2:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$834Delta
Find Deal
Thu, Oct 9 - Thu, Oct 16
Logo
10:38 am - 9:22 pmPTY-MDW
10h 44m1 stop
Logo
1:37 pm - 8:06 amMDW-PTY
17h 29m2 stops
$836
Find Deal
Sat, Nov 1 - Mon, Nov 10
Delta Logo
2:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 1:56 pmMDW-PTY
6h 56m1 stop
$845Delta
Find Deal
Sat, Nov 1 - Thu, Nov 6

Delta flights from Panama City to Chicago Midway Airport

Our best Delta deals on Panama City to Chicago Midway Airport flight tickets
Delta
Nov 5
PTY3:21 pmPanama City Tocumen Intl
7h 53m
1 stop
MDW10:14 pmChicago Midway
Nov 19
MDW6:00 amChicago Midway
7h 12m
1 stop
PTY2:12 pmPanama City Tocumen Intl
$598
Find similar
Delta
Oct 3
PTY2:10 pmPanama City Tocumen Intl
18h 30m
2 stops
MDW8:40 amChicago Midway
Oct 7
MDW6:00 amChicago Midway
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
$633
Find similar
Delta
Oct 20
PTY2:21 pmPanama City Tocumen Intl
7h 53m
1 stop
MDW10:14 pmChicago Midway
Oct 25
MDW6:00 amChicago Midway
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
$635
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Chicago Midway Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Panama City to Chicago Midway Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 9/11

9:25 am-11:20 pm

1 stop13h 55m

Chicago Midway

Sat 9/20

6:15 am-7:33 pm

1 stop13h 18m

$583

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Wed 11/5

3:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Wed 11/19

6:00 am-2:12 pm

1 stop7h 12m

$598

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 10/3

2:10 pm-8:40 am

2 stops18h 30m

Chicago Midway

Tue 10/7

6:00 am-12:56 pm

1 stop6h 56m

$633

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Mon 10/20

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Sat 10/25

6:00 am-12:56 pm

1 stop6h 56m

$635

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 11/20

3:37 pm-11:32 pm

1 stop8h 55m

Chicago Midway

Mon 11/24

6:00 am-2:12 pm

1 stop7h 12m

$717

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 10/10

8:40 am-3:11 pm

2 stops30h 31m

Chicago Midway

Tue 10/14

8:05 am-7:33 pm

1 stop11h 28m

$761

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/9

3:20 am-4:09 pm

2 stops12h 49m

Chicago Midway

Tue 10/14

8:05 am-7:33 pm

1 stop11h 28m

$808

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/9

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Thu 10/16

6:00 am-12:56 pm

1 stop6h 56m

$834

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Sat 11/1

10:38 am-9:22 pm

1 stop10h 44m

Chicago Midway

Mon 11/10

1:37 pm-8:06 am

2 stops17h 29m

$836

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Sat 11/1

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Thu 11/6

6:00 am-1:56 pm

1 stop6h 56m

$845

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama City to Chicago Midway Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City Tocumen Intl to Chicago Midway?

Delta is the most popular carrier operating from Panama City Tocumen Intl to Chicago Midway

When to book flights from Panama City to Chicago Midway Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago Midway Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago Midway Airport (PTY to MDW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago Midway Airport

Direct flights

None
There are no direct flights from Panama City to Chicago Midway Airport. There are no popular flight routes from Panama City to Chicago Midway Airport.
Search flight deals

  • How far is Panama City Tocumen Intl to Chicago Midway by plane?

    There are 2319.5 mi between Panama City Tocumen Intl and Chicago Midway. A reasonable flight in good conditions will take 7h 53m.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago Midway Airport were last updated today.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago Midway Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Chicago Midway Airport.

  • What documentation or ID do you need to fly to Chicago Midway Airport?

    The necessary travel and health documents for your Chicago Midway Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Lansing
Portage
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

Finding the right flight to Chicago from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Chicago?

momondo provides multiple filters to help you find the best flight to Chicago from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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