Cheap flights from Panama City to Mexico City from $175

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Mexico City departing on 12/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
9:18 am - 12:10 pm
PTY
-
MEX
3h 52mnonstop
Copa Airlines Logo
3:30 pm - 8:07 pm
MEX
-
PTY
3h 37mnonstop
$276Copa Airlines
Tue, Dec 30 - Fri, Jan 2
Copa Airlines Logo
10:13 pm - 1:00 am
PTY
-
MEX
3h 47mnonstop
Copa Airlines Logo
9:25 am - 2:06 pm
MEX
-
PTY
3h 41mnonstop
$282Copa Airlines
Thu, Jan 1 - Sat, Jan 10
Aeromexico Logo
2:55 pm - 6:00 pm
PTY
-
MEX
4h 05mnonstop
Aeromexico Logo
8:55 am - 1:40 pm
MEX
-
PTY
3h 45mnonstop
$311Aeromexico
Thu, Dec 18 - Tue, Dec 30
Avianca Logo
9:45 am - 3:00 am
PTY
-
MEX
18h 15m1 stop
Avianca Logo
11:10 pm - 2:00 pm
MEX
-
PTY
13h 50m1 stop
$317Avianca
Sat, Feb 7 - Tue, Feb 17
Avianca Logo
9:45 am - 10:55 pm
PTY
-
MEX
14h 10m1 stop
Avianca Logo
1:50 pm - 12:40 am
MEX
-
PTY
9h 50m1 stop
$327Avianca
Thu, Dec 25 - Wed, Dec 31
Copa Airlines Logo
9:18 am - 12:10 pm
PTY
-
MEX
3h 52mnonstop
Copa Airlines Logo
5:55 am - 10:40 am
MEX
-
PTY
3h 45mnonstop
$331Copa Airlines
Thu, Dec 25 - Sun, Dec 28
Avianca Logo
2:55 pm - 3:00 am
PTY
-
MEX
13h 05m1 stop
Avianca Logo
11:10 pm - 8:50 am
MEX
-
PTY
8h 40m1 stop
$333Avianca
Tue, Jan 20 - Tue, Jan 27
Avianca Logo
7:50 pm - 1:15 am
PTY
-
MEX
6h 25m1 stop
Avianca Logo
12:40 am - 2:00 pm
MEX
-
PTY
12h 20m1 stop
$335Avianca
Fri, Jan 16 - Sat, Jan 17
Avianca Logo
7:50 pm - 1:15 am
PTY
-
MEX
6h 25m1 stop
Avianca Logo
4:00 am - 10:30 am
MEX
-
PTY
5h 30m1 stop
$336Avianca
Wed, Dec 31 - Wed, Dec 31
Multiple Airlines Logo
10:13 pm - 1:00 am
PTY
-
MEX
3h 47mnonstop
Multiple Airlines Logo
4:00 am - 10:30 am
MEX
-
PTY
5h 30m1 stop
$343Multiple Airlines
Thu, Jan 1 - Mon, Jan 5

Aeromexico flights from Panama City to Mexico City

Our best Aeromexico deals on Panama City to Mexico City flight tickets
Aeromexico
Dec 18
PTY2:55 pmPanama City Tocumen Intl
4h 05m
MEX6:00 pmMexico City Benito Juarez
Dec 30
MEX8:55 amMexico City Benito Juarez
3h 45m
PTY1:40 pmPanama City Tocumen Intl
Aeromexico
Dec 18
PTY2:55 pmPanama City Tocumen Intl
4h 05m
MEX6:00 pmMexico City Benito Juarez
Dec 23
MEX8:55 amMexico City Benito Juarez
3h 45m
PTY1:40 pmPanama City Tocumen Intl
Aeromexico
Dec 18
PTY2:55 pmPanama City Tocumen Intl
4h 05m
MEX6:00 pmMexico City Benito Juarez
Dec 25
MEX8:55 amMexico City Benito Juarez
3h 45m
PTY1:40 pmPanama City Tocumen Intl

Copa Airlines flights from Panama City to Mexico City

Our best Copa Airlines deals on Panama City to Mexico City flight tickets
Copa Airlines
Dec 30
PTY9:18 amPanama City Tocumen Intl
3h 52m
MEX12:10 pmMexico City Benito Juarez
Jan 2
MEX3:30 pmMexico City Benito Juarez
3h 37m
PTY8:07 pmPanama City Tocumen Intl
Copa Airlines
Jan 1
PTY10:13 pmPanama City Tocumen Intl
3h 47m
MEX1:00 amMexico City Benito Juarez
Jan 10
MEX9:25 amMexico City Benito Juarez
3h 41m
PTY2:06 pmPanama City Tocumen Intl
Copa Airlines
Dec 25
PTY9:18 amPanama City Tocumen Intl
3h 52m
MEX12:10 pmMexico City Benito Juarez
Dec 28
MEX5:55 amMexico City Benito Juarez
3h 45m
PTY10:40 amPanama City Tocumen Intl

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 12/30

9:18 am-12:10 pm

Nonstop3h 52m

Mexico City Benito Juarez

Fri 1/2

3:30 pm-8:07 pm

Nonstop3h 37m

$276

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 1/1

10:13 pm-1:00 am

Nonstop3h 47m

Mexico City Benito Juarez

Sat 1/10

9:25 am-2:06 pm

Nonstop3h 41m

$282

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 12/18

2:55 pm-6:00 pm

Nonstop4h 05m

Mexico City Benito Juarez

Tue 12/30

8:55 am-1:40 pm

Nonstop3h 45m

$311

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 2/7

9:45 am-3:00 am

1 stop18h 15m

Mexico City Benito Juarez

Tue 2/17

11:10 pm-2:00 pm

1 stop13h 50m

$317

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 12/25

9:45 am-10:55 pm

1 stop14h 10m

Mexico City Benito Juarez

Wed 12/31

1:50 pm-12:40 am

1 stop9h 50m

$327

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 12/25

9:18 am-12:10 pm

Nonstop3h 52m

Mexico City Benito Juarez

Sun 12/28

5:55 am-10:40 am

Nonstop3h 45m

$331

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 1/20

2:55 pm-3:00 am

1 stop13h 05m

Mexico City Benito Juarez

Tue 1/27

11:10 pm-8:50 am

1 stop8h 40m

$333

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 1/16

7:50 pm-1:15 am

1 stop6h 25m

Mexico City Benito Juarez

Sat 1/17

12:40 am-2:00 pm

1 stop12h 20m

$335

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 12/31

7:50 pm-1:15 am

1 stop6h 25m

Mexico City Benito Juarez

Wed 12/31

4:00 am-10:30 am

1 stop5h 30m

$336

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 1/1

10:13 pm-1:00 am

Nonstop3h 47m

Mexico City Benito Juarez

Mon 1/5

4:00 am-10:30 am

1 stop5h 30m

$343

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Mexico City from

How to get the cheapest flight ticket from Panama City to Mexico City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Mexico City?

What is the cheapest month to fly to Mexico City?

The cheapest month to fly to Mexico City from Panama City is in July. Flight prices, which tend to average around $342, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of July, then book flights to Mexico City from Panama City during August instead. Flights to Mexico City in August, while not as cheap as those in July, still average around $349.

What is the cheapest day to depart on your flight to Mexico City?

Our data shows that Tuesday is the least expensive day to fly to Mexico City. Tickets to fly out on this day can be as low as $412. On the other hand, Saturday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $493.

What is the cheapest time of day to depart on your flight to Mexico City?

According to our data, the cheapest time of day to fly to Mexico City is at noon. momondo users have found flights departing from Panama City to Mexico City at noon for as low as $370. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the afternoon is when there is more demand to fly to Mexico City, so prices are often more expensive at around $649 per ticket.

What is the cheapest Panama City Tocumen Intl to Mexico City Benito Juarez flight route?

Fly from Panama City Tocumen Intl to Mexico City Benito Juarez for the best Panama City Tocumen Intl - Mexico City Benito Juarez flight prices

How far in advance should I book a flight to Mexico City?

You are more likely to see cheaper flights to Mexico City from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico City for around $388 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico City from Panama City for as low as $347 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Mexico City Benito Juarez flights?

There are 3 cabin classes available to choose from on Panama City Tocumen Intl to Mexico City Benito Juarez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Mexico City flights?

You could potentially save up to 1% on your flight if you consider stops on a Panama City to Mexico City flight.

How have Panama City to Mexico City flight prices changed over time?

As of December 2025, prices for Panama City to Mexico City flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to Mexico City

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Mexico City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Mexico City (PTY to MEX) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Mexico City

Best Price Found

$289

Fastest flight time

3h 43m

Direct flights

Every day

Airports in Mexico City

1 airport
The best one-way flight to Mexico City from Panama City in the past 72 hours is $289. The best round-trip flight deal from Panama City to Mexico City found on momondo in the last 72 hours is $269.
The fastest flight from Panama City to Mexico City takes 3h 43m
Direct flights go from Panama City to Mexico City every day.
There is 1 airport in Mexico City. From Panama City there are direct flights to Mexico City Benito Juarez (MEX).
  • How far is Panama City Tocumen Intl to Mexico City Benito Juarez by plane?

    Mexico City Benito Juarez is 1496.2 mi away from Panama City Tocumen Intl. 3h 43m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Mexico City Benito Juarez Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Mexico City Benito Juarez Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Mexico City Benito Juarez Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Mexico City Benito Juarez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Mexico City Benito Juarez Airport.

  • What documentation or ID do you need to fly to Mexico City Benito Juarez Airport?

    The necessary travel and health documents for your Mexico City Benito Juarez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Mexico City?

  • What is the most popular airline from Panama City to Mexico City?

Best airlines flying from Panama City to Mexico City

Compare and see reviews for airlines that fly from Panama City to Mexico City with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $195Free CancellationRating
7.4
1,642 reviews
Search Aeromexico flights
Copa AirlinesPriceFrom $250Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
AviancaPriceFrom $293Free CancellationRating
6.6
2,480 reviews
Search Avianca flights
  • Copa Airlines Flights From Panama City to Mexico City

    The lowest priced Copa Airlines flight from Panama City to Mexico City from the last 72 hours was $250. Generally, Copa Airlines has 36 flights on this route every week with an average price of $418. Copa Airlines is rated 7.6/10 by our users.

  • Aeromexico Flights From Panama City to Mexico City

    $195 is the best Aeromexico flight deal from Panama City to Mexico City found on momondo over the last 72 hours. The average Aeromexico ticket price found was closer to $344, however, with flight time and availability significantly affecting the price. Aeromexico (7.4/10 from 1,642 user reviews) flies into Mexico City from Panama City 7 times in an average week so prices can vary.

Traveling to a place near Mexico City?

Book flights to Mexico City if you plan to visit one of these locations
Cuernavaca
Tepoztlán
Taxco
Valle de Bravo

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Mexico City?

Finding the right flight to Mexico City from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Mexico City quick and easy, saving you time and money.

Can I find flights from Panama City to Mexico City with flexible booking policies on momondo?

All flight searches from Panama City to Mexico City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to Mexico City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama City to Mexico City.

I’m not ready to book a flight from Panama City to Mexico City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Mexico City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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1 adult
Sat 1/10
Sat 1/17

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Airports servicing Mexico City Federal District