Cheap flights from Panama City to Mexico City from $182

The cheapest month to fly to Mexico City from Panama City is in December. Flight prices, which tend to average around $342, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to Mexico City from Panama City during January instead. Flights to Mexico City in January, while not as cheap as those in December, still average around $350.

Our data shows that Friday is the least expensive day to fly to Mexico City. Tickets to fly out on this day can be as low as $386. On the other hand, Wednesday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $477.

According to our data, the cheapest time of day to fly to Mexico City is at noon. momondo users have found flights departing from Panama City to Mexico City at noon for as low as $390. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the afternoon is when there is more demand to fly to Mexico City, so prices are often more expensive at around $498 per ticket.

Fly from Panama City Tocumen Intl to Mexico City Benito Juarez for the best Panama City Tocumen Intl - Mexico City Benito Juarez flight prices

You are more likely to see cheaper flights to Mexico City from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico City for around $397 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico City from Panama City for as low as $348 on momondo.

There are 3 cabin classes available to choose from on Panama City to Mexico City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 22% on your flight if you consider stops on a Panama City to Mexico City flight.

As of August 2026, prices for Panama City to Mexico City flights are approximately 8% more expensive when compared to flights at the same time last year.

Aeromexico and Copa Airlines are the most popular carriers operating from Panama City Tocumen Intl to Mexico City Benito Juarez

Copa Airlines, Aeromexico and Avianca are the top three most popular airlines that fly to Mexico City from Panama City according to our data. Copa Airlines is the first choice among our users, with 59% of people opting to fly with this airline when traveling to Mexico City. Keep in mind that there are 3 different airlines that fly to Mexico City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 4% of flights between Panama City and Mexico City have experienced a delay on any given week. The average delay length over the past 12 months has been 124 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 3% of their flights experiencing any sort of delay.

Bogotá (BOG) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via San Salvador (SAL) offer the lowest average round-trip price of $293.

Flights connecting via San Salvador (SAL) have the shortest average one-way travel time: 6h 25m.

San Salvador (SAL) has the shortest average layover time for this route: 1h 45m.

As of August 2026, there are 7 flights per day flying from Panama City to Mexico City. The most common time of day flights depart is 9:00AM, with 46% of flights taking off at noon.

54 flights are operational weekly from Panama City to Mexico City as of August 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.