Cheap flights from Panama City to Amsterdam from $576

The cheapest month to fly to Amsterdam from Panama City is in April. Flight prices, which tend to average around $1,001, are often lower during this time because this is during the off-season. If you’re not able to fly to Amsterdam in April, then February is your next best option. Flight prices from Panama City to Amsterdam during February average around $1,002.

The cheapest day to depart from Panama City to Amsterdam is on a Wednesday when prices can be found for as low as $1,240. On the other hand, Saturday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $1,493.

The cheapest time of day to fly to Amsterdam is in the evening when flights can be purchased for as low as $1,079. Flights in the afternoon are often more expensive with an average ticket price of $1,372.

Fly from Panama City Tocumen Intl to Amsterdam Schiphol for the best Panama City Tocumen Intl - Amsterdam Schiphol flight prices

You are more likely to see cheaper flights to Amsterdam from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Amsterdam for around $1,166 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Amsterdam from Panama City for as low as $894 on momondo.

There are 3 cabin classes available to choose from on Panama City to Amsterdam flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 49% on your flight if you consider stops on a Panama City to Amsterdam flight.

As of November 2026, prices for Panama City to Amsterdam flights are approximately 20% more expensive when compared to flights at the same time last year.

Historically, on average around 13% of flights between Panama City and Amsterdam have experienced a delay on any given week. The average delay length over the past 12 months has been 214 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Sunday is statistically the day of the week which experiences the fewest number of delays on this flight route. Tuesday has historically seen more delays on average compared to the rest of the week.

According to our data, KLM have had the least number of delays on this route over the last 12 months; with about 8% of their flights experiencing any sort of delay.

Istanbul (IST) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Istanbul (IST) offer the lowest average round-trip price of $864.

Flights connecting via Madrid (MAD) have the shortest average one-way travel time: 14h 10m.

Madrid (MAD) has the shortest average layover time for this route: 1h 45m.