Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to Panama from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama departing on 9/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to Panama

Cheap round-trip flights

Delta Logo
6:00 am - 12:50 pmSTL-PTY
6h 50m1 stop
Delta Logo
2:05 pm - 10:02 pmPTY-STL
7h 57m1 stop
$393Delta
Find Deal
Tue, Sep 2 - Tue, Sep 9
United Airlines Logo
7:04 pm - 2:14 pmSTL-PTY
19h 10m2 stops
United Airlines Logo
3:30 pm - 9:57 amPTY-STL
18h 27m1 stop
$398United Airlines
Find Deal
Tue, Sep 2 - Tue, Sep 9
United Airlines Logo
4:17 pm - 7:38 pmSTL-PTY
26h 21m1 stop
United Airlines Logo
4:40 pm - 9:42 amPTY-STL
18h 02m1 stop
$401United Airlines
Find Deal
Sun, Feb 1 - Wed, Feb 18
Delta Logo
5:56 am - 12:56 pmMCI-PTY
7h 00m1 stop
Delta Logo
2:21 pm - 10:27 pmPTY-MCI
8h 06m1 stop
$408Delta
Find Deal
Wed, Oct 8 - Thu, Oct 16
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
3:30 pm - 9:57 amPTY-STL
18h 27m1 stop
$410United Airlines
Find Deal
Tue, Sep 9 - Sat, Sep 13
American Airlines Logo
4:54 pm - 2:03 pmMCI-PTY
21h 09m2 stops
American Airlines Logo
3:15 pm - 10:19 amPTY-MCI
19h 04m2 stops
$413American Airlines
Find Deal
Wed, Oct 8 - Thu, Oct 16
United Airlines Logo
3:20 pm - 2:14 pmSTL-PTY
22h 54m2 stops
United Airlines Logo
3:30 pm - 9:57 amPTY-STL
18h 27m1 stop
$415United Airlines
Find Deal
Tue, Sep 9 - Sat, Sep 13
American Airlines Logo
6:08 pm - 2:03 pmSTL-PTY
19h 55m1 stop
American Airlines Logo
3:15 pm - 11:56 pmPTY-STL
8h 41m1 stop
$420American Airlines
Find Deal
Thu, Oct 16 - Mon, Oct 20
Logo
5:15 am - 12:10 amMCI-PTY
18h 55m2 stops
Logo
3:25 am - 11:07 pmPTY-MCI
19h 42m2 stops
$557
Find Deal
Sat, Sep 20 - Fri, Sep 26
Logo
6:00 am - 12:45 amMCI-PTY
18h 45m2 stops
Logo
3:20 am - 11:07 pmPTY-MCI
19h 47m2 stops
$645
Find Deal
Mon, Aug 18 - Sun, Sep 7

American Airlines flights from Missouri to Panama

Our best American Airlines deals on Missouri to Panama flight tickets
American Airlines
Oct 8
MCI4:54 pmKansas City
21h 09m
2 stops
PTY2:03 pmPanama City Tocumen Intl
Oct 16
PTY3:15 pmPanama City Tocumen Intl
19h 04m
2 stops
MCI10:19 amKansas City
$413
Find similar
American Airlines
Oct 16
STL6:08 pmLambert-St Louis
19h 55m
1 stop
PTY2:03 pmPanama City Tocumen Intl
Oct 20
PTY3:15 pmPanama City Tocumen Intl
8h 41m
1 stop
STL11:56 pmLambert-St Louis
$420
Find similar
American Airlines
Sep 7
STL8:03 pmLambert-St Louis
18h 28m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Sep 13
PTY3:31 pmPanama City Tocumen Intl
20h 26m
2 stops
STL11:57 amLambert-St Louis
$432
Find similar

Delta flights from Missouri to Panama

Our best Delta deals on Missouri to Panama flight tickets
Delta
Sep 2
STL6:00 amLambert-St Louis
6h 50m
1 stop
PTY12:50 pmPanama City Tocumen Intl
Sep 9
PTY2:05 pmPanama City Tocumen Intl
7h 57m
1 stop
STL10:02 pmLambert-St Louis
$393
Find similar
Delta
Oct 8
MCI5:56 amKansas City
7h 00m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 16
PTY2:21 pmPanama City Tocumen Intl
8h 06m
1 stop
MCI10:27 pmKansas City
$408
Find similar
Delta
Nov 12
MCI6:00 amKansas City
6h 52m
1 stop
PTY1:52 pmPanama City Tocumen Intl
Nov 23
PTY8:05 amPanama City Tocumen Intl
8h 38m
1 stop
MCI3:43 pmKansas City
$428
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/2

6:00 am-12:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Tue 9/9

2:05 pm-10:02 pm

1 stop7h 57m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/2

7:04 pm-2:14 pm

2 stops19h 10m

Panama City Tocumen Intl

Tue 9/9

3:30 pm-9:57 am

1 stop18h 27m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/1

4:17 pm-7:38 pm

1 stop26h 21m

Panama City Tocumen Intl

Wed 2/18

4:40 pm-9:42 am

1 stop18h 02m

$401

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 10/8

5:56 am-12:56 pm

1 stop7h 00m

Panama City Tocumen Intl

Thu 10/16

2:21 pm-10:27 pm

1 stop8h 06m

$408

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/9

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Sat 9/13

3:30 pm-9:57 am

1 stop18h 27m

$410

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 10/8

4:54 pm-2:03 pm

2 stops21h 09m

Panama City Tocumen Intl

Thu 10/16

3:15 pm-10:19 am

2 stops19h 04m

$413

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/9

3:20 pm-2:14 pm

2 stops22h 54m

Panama City Tocumen Intl

Sat 9/13

3:30 pm-9:57 am

1 stop18h 27m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:08 pm-2:03 pm

1 stop19h 55m

Panama City Tocumen Intl

Mon 10/20

3:15 pm-11:56 pm

1 stop8h 41m

$420

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sat 9/20

5:15 am-12:10 am

2 stops18h 55m

Panama City Tocumen Intl

Fri 9/26

3:25 am-11:07 pm

2 stops19h 42m

$557

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 8/18

6:00 am-12:45 am

2 stops18h 45m

Panama City Tocumen Intl

Sun 9/7

3:20 am-11:07 pm

2 stops19h 47m

$645

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama from

How to get the cheapest flight ticket from Missouri to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from Missouri, with most prices found around $441. If you don’t want to visit Panama in April, then you should wait until October to fly from Missouri, when ticket prices are also cheap, with an average price of $469.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from Missouri. The lowest ticket price found for a Tuesday departure recently was $509. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Panama for around $607.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from Missouri to Panama when you can find flight prices for as low as $512. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $691 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $542 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Missouri for as low as $451 on momondo.

Can stopping save me money on Missouri to Panama flights?

You could potentially save up to 39% on your flight if you consider stops on a Missouri to Panama flight.

Cheap Missouri to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama

Best Price Found

$164

Fastest flight time

6h 50m

Direct flights

None

Airports in Panama

1 airport
The best one-way flight to Panama from Missouri in the past 72 hours is $164. The best round-trip flight deal from Missouri to Panama found on momondo in the last 72 hours is $393.
The fastest flight from Missouri to Panama takes 6h 50m
There are no direct flights from Missouri to Panama. Popular non-direct routes for this connection are Springfield-Branson Airport - Panama City Tocumen Intl Airport, Lambert-St Louis Airport - Panama City Tocumen Intl Airport and Kansas City Airport - Panama City Tocumen Intl Airport.
There is 1 airport near Panama: Panama City Tocumen Intl (PTY)
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama?

    Prices for flights from Missouri to Panama were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama?

  • How old do you have to be to fly from Missouri to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama

Compare and see reviews for airlines that fly from Missouri to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
8.0
7,985 reviews
Search Delta flights
United AirlinesPriceFrom $397Free CancellationRating
7.4
8,917 reviews
Search United Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama?

It is quick and easy to find Missouri to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Missouri to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Missouri.

I’m not ready to book a flight from Missouri to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 8/12
Tue 8/19
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo
Flights to Panama Cityfrom $274
Flights to Bocas del Torofrom $671
Flights to Davidfrom $359
Flights to Changuinola