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Cheap flights from Missouri to Panama from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama departing on 2/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 5:07 pmSTL-PTY
10h 07m1 stop
United Airlines Logo
4:41 pm - 9:23 amPTY-STL
17h 42m1 stop
$394United Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:00 am - 7:38 pmSTL-PTY
12h 38m1 stop
United Airlines Logo
10:00 am - 10:59 pmPTY-STL
13h 59m2 stops
$398United Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
Delta Logo
6:48 pm - 2:02 pmSTL-PTY
18h 14m1 stop
Delta Logo
2:20 pm - 8:07 amPTY-STL
17h 47m1 stop
$401Delta
Find Deal
Sun, Feb 22 - Thu, Jun 18
United Airlines Logo
8:05 am - 5:07 pmMCI-PTY
8h 02m1 stop
United Airlines Logo
8:55 am - 4:53 pmPTY-MCI
8h 58m1 stop
$409United Airlines
Find Deal
Thu, Jan 8 - Tue, Feb 3
United Airlines Logo
6:00 am - 5:07 pmSTL-PTY
10h 07m1 stop
United Airlines Logo
4:41 pm - 9:22 amPTY-STL
17h 41m1 stop
$411United Airlines
Find Deal
Fri, Jan 23 - Tue, Jan 27
United Airlines Logo
8:05 am - 5:07 pmMCI-PTY
8h 02m1 stop
United Airlines Logo
4:41 pm - 10:32 amPTY-MCI
18h 51m2 stops
$413United Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 22
Delta Logo
10:13 am - 2:02 pmSTL-PTY
26h 49m1 stop
Delta Logo
2:20 pm - 8:07 amPTY-STL
17h 47m1 stop
$418Delta
Find Deal
Sat, Feb 21 - Thu, Jun 18
American Airlines Logo
11:42 am - 1:27 pmMCI-PTY
24h 45m1 stop
American Airlines Logo
4:04 pm - 11:57 pmPTY-MCI
8h 53m1 stop
$419American Airlines
Find Deal
Mon, Feb 9 - Thu, Feb 12
American Airlines Logo
6:59 pm - 3:14 pmSTL-PTY
19h 15m2 stops
American Airlines Logo
2:52 pm - 11:07 amPTY-STL
21h 15m2 stops
$420American Airlines
Find Deal
Thu, Feb 26 - Sun, Mar 1
American Airlines Logo
5:11 pm - 3:38 pmMCI-PTY
21h 27m2 stops
American Airlines Logo
2:27 pm - 11:02 amPTY-MCI
21h 35m1 stop
$424American Airlines
Find Deal
Wed, Jan 14 - Tue, Jan 20

Delta flights from Missouri to Panama

Our best Delta deals on Missouri to Panama flight tickets
Delta
May 4
STL6:00 amLambert-St Louis
6h 55m
1 stop
PTY12:55 pmPanama City Tocumen Intl
May 7
PTY2:20 pmPanama City Tocumen Intl
9h 18m
1 stop
STL11:38 pmLambert-St Louis
$394
Find similar
Delta
Feb 22
STL6:48 pmLambert-St Louis
18h 14m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Jun 18
PTY2:20 pmPanama City Tocumen Intl
17h 47m
1 stop
STL8:07 amLambert-St Louis
$401
Find similar
Delta
Feb 21
STL10:13 amLambert-St Louis
26h 49m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Jun 18
PTY2:20 pmPanama City Tocumen Intl
17h 47m
1 stop
STL8:07 amLambert-St Louis
$418
Find similar

United Airlines flights from Missouri to Panama

Our best United Airlines deals on Missouri to Panama flight tickets
United Airlines
Feb 17
STL6:00 amLambert-St Louis
10h 07m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 25
PTY10:00 amPanama City Tocumen Intl
13h 59m
2 stops
STL10:59 pmLambert-St Louis
$398
Find similar
United Airlines
Jan 8
MCI8:05 amKansas City
8h 02m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 3
PTY8:55 amPanama City Tocumen Intl
8h 58m
1 stop
MCI4:53 pmKansas City
$409
Find similar
United Airlines
Jan 23
STL6:00 amLambert-St Louis
10h 07m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Jan 27
PTY4:41 pmPanama City Tocumen Intl
17h 41m
1 stop
STL9:22 amLambert-St Louis
$411
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

10:00 am-10:59 pm

2 stops13h 59m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/22

6:48 pm-2:02 pm

1 stop18h 14m

Panama City Tocumen Intl

Thu 6/18

2:20 pm-8:07 am

1 stop17h 47m

$401

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 1/8

8:05 am-5:07 pm

1 stop8h 02m

Panama City Tocumen Intl

Tue 2/3

8:55 am-4:53 pm

1 stop8h 58m

$409

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/23

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-9:22 am

1 stop17h 41m

$411

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 1/8

8:05 am-5:07 pm

1 stop8h 02m

Panama City Tocumen Intl

Thu 1/22

4:41 pm-10:32 am

2 stops18h 51m

$413

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 2/21

10:13 am-2:02 pm

1 stop26h 49m

Panama City Tocumen Intl

Thu 6/18

2:20 pm-8:07 am

1 stop17h 47m

$418

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 2/9

11:42 am-1:27 pm

1 stop24h 45m

Panama City Tocumen Intl

Thu 2/12

4:04 pm-11:57 pm

1 stop8h 53m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 2/26

6:59 pm-3:14 pm

2 stops19h 15m

Panama City Tocumen Intl

Sun 3/1

2:52 pm-11:07 am

2 stops21h 15m

$420

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 1/14

5:11 pm-3:38 pm

2 stops21h 27m

Panama City Tocumen Intl

Tue 1/20

2:27 pm-11:02 am

1 stop21h 35m

$424

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Missouri to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from Missouri, with most prices found around $441. If you don’t want to visit Panama in April, then you should wait until May to fly from Missouri, when ticket prices are also cheap, with an average price of $500.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from Missouri. The lowest ticket price found for a Tuesday departure recently was $509. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Panama for around $607.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from Missouri to Panama when you can find flight prices for as low as $512. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $691 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $549 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Missouri for as low as $410 on momondo.

Can stopping save me money on Missouri to Panama flights?

You could potentially save up to 39% on your flight if you consider stops on a Missouri to Panama flight.

Cheap Missouri to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama

Direct flights

None
There are no direct flights from Missouri to Panama. There are no popular flight routes from Missouri to Panama.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama?

    Prices for flights from Missouri to Panama were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama?

  • How old do you have to be to fly from Missouri to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama

Compare and see reviews for airlines that fly from Missouri to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
8,009 reviews
Search Delta flights
American AirlinesPriceFrom $394Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
9,015 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama?

It is quick and easy to find Missouri to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Missouri to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Missouri.

I’m not ready to book a flight from Missouri to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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