Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to Panama from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama departing on 5/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 1:02 pm
STL
-
PTY
7h 02m
1 stop
Delta Logo
2:27 pm - 11:34 pm
PTY
-
STL
9h 07m
1 stop
$415Delta
ד', אפר' 29 - ד', מאי 6
United Airlines Logo
7:45 am - 6:37 pm
STL
-
PTY
10h 52m
2 stops
United Airlines Logo
3:30 pm - 9:30 am
PTY
-
STL
18h 00m
1 stop
$419United Airlines
ד', אפר' 29 - ד', מאי 6
United Airlines Logo
6:30 am - 6:37 pm
STL
-
PTY
12h 07m
2 stops
United Airlines Logo
3:30 pm - 8:35 am
PTY
-
STL
17h 05m
2 stops
$423United Airlines
ג', אפר' 21 - ש', אפר' 25
United Airlines Logo
6:15 am - 2:14 pm
MCI
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 10:02 am
PTY
-
MCI
18h 32m
1 stop
$430United Airlines
ד', מאי 13 - ג', מאי 26
United Airlines Logo
6:00 am - 4:12 pm
STL
-
PTY
10h 12m
1 stop
United Airlines Logo
7:55 am - 10:27 pm
PTY
-
STL
14h 32m
1 stop
$432United Airlines
ב', אפר' 20 - ו', אפר' 24
United Airlines Logo
8:00 am - 6:37 pm
MCI
-
PTY
10h 37m
2 stops
United Airlines Logo
3:30 pm - 9:02 am
PTY
-
MCI
17h 32m
2 stops
$434United Airlines
ד', מאי 13 - ה', מאי 21
American Airlines Logo
1:29 pm - 12:46 pm
STL
-
PTY
23h 17m
2 stops
American Airlines Logo
1:49 pm - 8:54 am
PTY
-
STL
19h 05m
2 stops
$436American Airlines
ו', אפר' 10 - ו', אפר' 17
Copa Airlines Logo
8:34 am - 6:37 pm
MCI
-
PTY
10h 03m
1 stop
Copa Airlines Logo
9:45 am - 11:59 pm
PTY
-
MCI
14h 14m
1 stop
$440Copa Airlines
ד', יולי 29 - ד', אוג' 5
American Airlines Logo
6:54 pm - 12:46 pm
STL
-
PTY
17h 52m
2 stops
American Airlines Logo
1:49 pm - 12:48 pm
PTY
-
STL
22h 59m
2 stops
$441American Airlines
ה', מאי 14 - א', מאי 17
Copa Airlines Logo
8:34 am - 6:37 pm
MCI
-
PTY
10h 03m
1 stop
Copa Airlines Logo
9:45 am - 10:29 am
PTY
-
MCI
24h 44m
2 stops
$444Copa Airlines
ד', יולי 29 - ד', אוג' 5

American Airlines flights from Missouri to Panama

Our best American Airlines deals on Missouri to Panama flight tickets
American Airlines
Apr 10
STL1:29 pmLambert-St Louis
23h 17m
2 stops
PTY12:46 pmPanama City Tocumen Intl
Apr 17
PTY1:49 pmPanama City Tocumen Intl
19h 05m
2 stops
STL8:54 amLambert-St Louis
$436
American Airlines
May 14
STL6:54 pmLambert-St Louis
17h 52m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 17
PTY1:49 pmPanama City Tocumen Intl
22h 59m
2 stops
STL12:48 pmLambert-St Louis
$441
American Airlines
Mar 9
STL11:22 amLambert-St Louis
25h 18m
1 stop
PTY12:40 pmPanama City Tocumen Intl
Mar 16
PTY3:10 pmPanama City Tocumen Intl
8h 48m
1 stop
STL11:58 pmLambert-St Louis
$442

Copa Airlines flights from Missouri to Panama

Our best Copa Airlines deals on Missouri to Panama flight tickets
Copa Airlines
Jul 29
MCI8:34 amKansas City
10h 03m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Aug 5
PTY9:45 amPanama City Tocumen Intl
14h 14m
1 stop
MCI11:59 pmKansas City
$440
Copa Airlines
Jul 29
MCI8:34 amKansas City
10h 03m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Aug 5
PTY9:45 amPanama City Tocumen Intl
24h 44m
2 stops
MCI10:29 amKansas City
$444
Copa Airlines
May 18
STL5:23 pmLambert-St Louis
22h 49m
2 stops
PTY4:12 pmPanama City Tocumen Intl
May 24
PTY9:45 amPanama City Tocumen Intl
13h 42m
1 stop
STL11:27 pmLambert-St Louis
$446

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated פברואר 9, 2026.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

ד' 4/29

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

ד' 5/6

2:27 pm-11:34 pm

1 stop9h 07m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

ד' 4/29

7:45 am-6:37 pm

2 stops10h 52m

Panama City Tocumen Intl

ד' 5/6

3:30 pm-9:30 am

1 stop18h 00m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

ג' 4/21

6:30 am-6:37 pm

2 stops12h 07m

Panama City Tocumen Intl

ש' 4/25

3:30 pm-8:35 am

2 stops17h 05m

$423

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

ד' 5/13

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

ג' 5/26

3:30 pm-10:02 am

1 stop18h 32m

$430

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

ב' 4/20

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

ו' 4/24

7:55 am-10:27 pm

1 stop14h 32m

$432

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

ד' 5/13

8:00 am-6:37 pm

2 stops10h 37m

Panama City Tocumen Intl

ה' 5/21

3:30 pm-9:02 am

2 stops17h 32m

$434

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

ו' 4/10

1:29 pm-12:46 pm

2 stops23h 17m

Panama City Tocumen Intl

ו' 4/17

1:49 pm-8:54 am

2 stops19h 05m

$436

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

ד' 7/29

8:34 am-6:37 pm

1 stop10h 03m

Panama City Tocumen Intl

ד' 8/5

9:45 am-11:59 pm

1 stop14h 14m

$440

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

ה' 5/14

6:54 pm-12:46 pm

2 stops17h 52m

Panama City Tocumen Intl

א' 5/17

1:49 pm-12:48 pm

2 stops22h 59m

$441

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

ד' 7/29

8:34 am-6:37 pm

1 stop10h 03m

Panama City Tocumen Intl

ד' 8/5

9:45 am-10:29 am

2 stops24h 44m

$444

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama from

How to get the cheapest flight ticket from Missouri to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from Missouri, with most prices found around $435. If you don’t want to visit Panama in April, then you should wait until November to fly from Missouri, when ticket prices are also cheap, with an average price of $510.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $567 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Missouri for as low as $416 on momondo.

Can stopping save me money on Missouri to Panama flights?

You could potentially save up to 2% on your flight if you consider stops on a Missouri to Panama flight.

Cheap Missouri to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama

Fastest flight time

7h 30m

Direct flights

None
The fastest flight from Missouri to Panama takes 7h 30m
There are no direct flights from Missouri to Panama. There are no popular flight routes from Missouri to Panama.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama?

    Prices for flights from Missouri to Panama were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama?

  • How old do you have to be to fly from Missouri to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama

Compare and see reviews for airlines that fly from Missouri to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $227Free CancellationRating
7.9
8,173 reviews
Search Delta flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.2
11,255 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama?

It is quick and easy to find Missouri to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Missouri to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Missouri.

I’m not ready to book a flight from Missouri to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
ד' 3/11
ד' 3/18
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama

Popular cities in Panama

Popular flights according to clicks in the last 7 days on momondo
Flights to Panama Cityfrom $278
Flights to Bocas del Torofrom $708
Flights to Davidfrom $380
Flights to Changuinola