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Cheap flights from Missouri to Panama from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama departing on 3/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Panama

Cheap round-trip flights

United Airlines Logo
8:20 am - 7:38 pmSTL-PTY
10h 18m1 stop
United Airlines Logo
8:55 am - 6:47 pmPTY-STL
10h 52m1 stop
$393United Airlines
Find Deal
Mon, Nov 3 - Wed, Nov 26
American Airlines Logo
5:49 pm - 3:00 pmSTL-PTY
20h 11m2 stops
American Airlines Logo
2:30 pm - 8:44 amPTY-STL
19h 14m2 stops
$398American Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
Delta Logo
1:30 pm - 1:56 pmSTL-PTY
23h 26m1 stop
Delta Logo
3:37 pm - 8:28 amPTY-STL
17h 51m1 stop
$401Delta
Find Deal
Sun, Nov 2 - Mon, Nov 24
American Airlines Logo
4:59 pm - 1:10 pmSTL-PTY
19h 11m1 stop
American Airlines Logo
2:30 pm - 9:40 pmPTY-STL
8h 10m1 stop
$403American Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
Delta Logo
5:15 pm - 1:56 pmSTL-PTY
19h 41m1 stop
Delta Logo
3:37 pm - 9:59 amPTY-STL
19h 22m1 stop
$408Delta
Find Deal
Sun, Nov 2 - Wed, Nov 26
American Airlines Logo
5:01 am - 1:10 pmMCI-PTY
7h 09m1 stop
American Airlines Logo
4:40 pm - 12:10 amPTY-MCI
8h 30m1 stop
$408American Airlines
Find Deal
Wed, Jan 14 - Tue, Jan 20
Delta Logo
6:00 am - 1:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
8:05 am - 5:59 pmPTY-STL
10h 54m1 stop
$410Delta
Find Deal
Mon, Nov 3 - Sat, Nov 22
United Airlines Logo
8:00 am - 7:38 pmMCI-PTY
10h 38m2 stops
United Airlines Logo
4:41 pm - 2:27 pmPTY-MCI
22h 46m2 stops
$413United Airlines
Find Deal
Thu, Jan 8 - Tue, Feb 3
United Airlines Logo
8:20 am - 7:38 pmSTL-PTY
10h 18m1 stop
United Airlines Logo
4:41 pm - 12:28 pmPTY-STL
20h 47m2 stops
$415United Airlines
Find Deal
Fri, Nov 7 - Wed, Nov 26
Delta Logo
1:30 pm - 1:56 pmSTL-PTY
23h 26m1 stop
Delta Logo
8:05 am - 9:58 pmPTY-STL
14h 53m1 stop
$418Delta
Find Deal
Sun, Nov 2 - Sat, Nov 22

American Airlines flights from Missouri to Panama

Our best American Airlines deals on Missouri to Panama flight tickets
American Airlines
Feb 17
STL5:49 pmLambert-St Louis
20h 11m
2 stops
PTY3:00 pmPanama City Tocumen Intl
Feb 25
PTY2:30 pmPanama City Tocumen Intl
19h 14m
2 stops
STL8:44 amLambert-St Louis
$398
Find similar
American Airlines
Feb 17
STL4:59 pmLambert-St Louis
19h 11m
1 stop
PTY1:10 pmPanama City Tocumen Intl
Feb 25
PTY2:30 pmPanama City Tocumen Intl
8h 10m
1 stop
STL9:40 pmLambert-St Louis
$403
Find similar
American Airlines
Jan 14
MCI5:01 amKansas City
7h 09m
1 stop
PTY1:10 pmPanama City Tocumen Intl
Jan 20
PTY4:40 pmPanama City Tocumen Intl
8h 30m
1 stop
MCI12:10 amKansas City
$408
Find similar

United Airlines flights from Missouri to Panama

Our best United Airlines deals on Missouri to Panama flight tickets
United Airlines
Nov 3
STL8:20 amLambert-St Louis
10h 18m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Nov 26
PTY8:55 amPanama City Tocumen Intl
10h 52m
1 stop
STL6:47 pmLambert-St Louis
$393
Find similar
United Airlines
Jan 8
MCI8:00 amKansas City
10h 38m
2 stops
PTY7:38 pmPanama City Tocumen Intl
Feb 3
PTY4:41 pmPanama City Tocumen Intl
22h 46m
2 stops
MCI2:27 pmKansas City
$413
Find similar
United Airlines
Nov 7
STL8:20 amLambert-St Louis
10h 18m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Nov 26
PTY4:41 pmPanama City Tocumen Intl
20h 47m
2 stops
STL12:28 pmLambert-St Louis
$415
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 11/3

8:20 am-7:38 pm

1 stop10h 18m

Panama City Tocumen Intl

Wed 11/26

8:55 am-6:47 pm

1 stop10h 52m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

5:49 pm-3:00 pm

2 stops20h 11m

Panama City Tocumen Intl

Wed 2/25

2:30 pm-8:44 am

2 stops19h 14m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/2

1:30 pm-1:56 pm

1 stop23h 26m

Panama City Tocumen Intl

Mon 11/24

3:37 pm-8:28 am

1 stop17h 51m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

4:59 pm-1:10 pm

1 stop19h 11m

Panama City Tocumen Intl

Wed 2/25

2:30 pm-9:40 pm

1 stop8h 10m

$403

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/2

5:15 pm-1:56 pm

1 stop19h 41m

Panama City Tocumen Intl

Wed 11/26

3:37 pm-9:59 am

1 stop19h 22m

$408

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 1/14

5:01 am-1:10 pm

1 stop7h 09m

Panama City Tocumen Intl

Tue 1/20

4:40 pm-12:10 am

1 stop8h 30m

$408

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 11/3

6:00 am-1:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Sat 11/22

8:05 am-5:59 pm

1 stop10h 54m

$410

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 1/8

8:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Tue 2/3

4:41 pm-2:27 pm

2 stops22h 46m

$413

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 11/7

8:20 am-7:38 pm

1 stop10h 18m

Panama City Tocumen Intl

Wed 11/26

4:41 pm-12:28 pm

2 stops20h 47m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/2

1:30 pm-1:56 pm

1 stop23h 26m

Panama City Tocumen Intl

Sat 11/22

8:05 am-9:58 pm

1 stop14h 53m

$418

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Missouri to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of April is, on average, the cheapest month to fly to Panama from Missouri, with most prices found around $441. If you don’t want to visit Panama in April, then you should wait until May to fly from Missouri, when ticket prices are also cheap, with an average price of $506.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from Missouri. The lowest ticket price found for a Tuesday departure recently was $509. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Panama for around $607.

What is the cheapest time of day to depart on your flight to Panama?

In the afternoon is the cheapest time of day to fly from Missouri to Panama when you can find flight prices for as low as $512. Flying to Panama in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $691 per ticket.

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $555 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Missouri for as low as $456 on momondo.

Can stopping save me money on Missouri to Panama flights?

You could potentially save up to 30% on your flight if you consider stops on a Missouri to Panama flight.

Cheap Missouri to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama

Direct flights

None
There are no direct flights from Missouri to Panama. There are no popular flight routes from Missouri to Panama.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama?

    Prices for flights from Missouri to Panama were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama?

  • How old do you have to be to fly from Missouri to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Missouri to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Panama

Compare and see reviews for airlines that fly from Missouri to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
7,973 reviews
Search Delta flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama?

It is quick and easy to find Missouri to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Missouri to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from Missouri with this policy.

How can momondo help me find flights from Missouri to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Missouri.

I’m not ready to book a flight from Missouri to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Missouri to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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