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Cheap flights from Louisville to Panama from $443

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Panama departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 6:37 pm
SDF
-
PTY
13h 37m
1 stop
United Airlines Logo
7:55 am - 9:59 pm
PTY
-
SDF
13h 04m
1 stop
$443United Airlines
Di, Apr 21 - Sa, Apr 25
United Airlines Logo
9:15 am - 7:38 pm
SDF
-
PTY
10h 23m
1 stop
United Airlines Logo
10:00 am - 7:55 pm
PTY
-
SDF
9h 55m
1 stop
$445United Airlines
Mo, Feb 23 - Mi, Mrz 4
United Airlines Logo
5:35 am - 7:38 pm
SDF
-
PTY
14h 03m
2 stops
United Airlines Logo
8:55 am - 7:51 pm
PTY
-
SDF
10h 56m
1 stop
$449United Airlines
Mo, Feb 23 - Mi, Mrz 4
United Airlines Logo
7:20 am - 6:37 pm
SDF
-
PTY
12h 17m
2 stops
United Airlines Logo
10:00 am - 8:00 pm
PTY
-
SDF
9h 00m
1 stop
$453United Airlines
Di, Apr 21 - Sa, Apr 25
United Airlines Logo
9:15 am - 5:07 pm
SDF
-
PTY
7h 52m
1 stop
United Airlines Logo
8:55 am - 9:46 pm
PTY
-
SDF
12h 51m
1 stop
$455United Airlines
Mo, Feb 23 - Mi, Mrz 4
United Airlines Logo
5:35 am - 8:02 pm
SDF
-
PTY
14h 27m
2 stops
United Airlines Logo
4:41 pm - 1:17 pm
PTY
-
SDF
20h 36m
2 stops
$459United Airlines
Mo, Feb 23 - Mi, Mrz 4
American Airlines Logo
6:12 pm - 1:40 pm
SDF
-
PTY
19h 28m
2 stops
American Airlines Logo
1:40 pm - 11:30 am
PTY
-
SDF
20h 50m
2 stops
$463American Airlines
Mo, Mrz 2 - So, Mrz 8
United Airlines Logo
6:14 am - 6:37 pm
SDF
-
PTY
13h 23m
1 stop
United Airlines Logo
10:55 pm - 4:49 pm
PTY
-
SDF
16h 54m
2 stops
$466United Airlines
Fr, Aug 7 - Mo, Aug 17
United Airlines Logo
9:15 am - 5:07 pm
SDF
-
PTY
7h 52m
1 stop
United Airlines Logo
4:41 pm - 1:23 pm
PTY
-
SDF
20h 42m
2 stops
$469United Airlines
Di, Feb 24 - Fr, Feb 27
United Airlines Logo
7:20 am - 7:31 pm
SDF
-
PTY
13h 11m
2 stops
United Airlines Logo
7:55 am - 8:16 pm
PTY
-
SDF
11h 21m
2 stops
$473United Airlines
Sa, Apr 18 - Sa, Apr 25

American Airlines flights from Louisville to Panama

Our best American Airlines deals on Louisville to Panama flight tickets
American Airlines
Mar 2
SDF6:12 pmLouisville Intl
19h 28m
2 stops
PTY1:40 pmPanama City Tocumen Intl
Mar 8
PTY1:40 pmPanama City Tocumen Intl
20h 50m
2 stops
SDF11:30 amLouisville Intl
$463
American Airlines
Mar 2
SDF6:06 amLouisville Intl
7h 34m
1 stop
PTY1:40 pmPanama City Tocumen Intl
Mar 8
PTY3:10 pmPanama City Tocumen Intl
22h 53m
2 stops
SDF3:03 pmLouisville Intl
$483
American Airlines
Mar 14
SDF5:06 pmLouisville Intl
20h 34m
2 stops
PTY12:40 pmPanama City Tocumen Intl
Mar 22
PTY1:40 pmPanama City Tocumen Intl
20h 50m
2 stops
SDF11:30 amLouisville Intl
$568

United Airlines flights from Louisville to Panama

Our best United Airlines deals on Louisville to Panama flight tickets
United Airlines
Apr 21
SDF6:00 amLouisville Intl
13h 37m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Apr 25
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
SDF9:59 pmLouisville Intl
$443
United Airlines
Feb 23
SDF9:15 amLouisville Intl
10h 23m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Mar 4
PTY10:00 amPanama City Tocumen Intl
9h 55m
1 stop
SDF7:55 pmLouisville Intl
$445
United Airlines
Feb 23
SDF5:35 amLouisville Intl
14h 03m
2 stops
PTY7:38 pmPanama City Tocumen Intl
Mar 4
PTY8:55 amPanama City Tocumen Intl
10h 56m
1 stop
SDF7:51 pmLouisville Intl
$449

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated Februar 11, 2026.
Use the filters below to find and compare flights from Louisville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Di 4/21

6:00 am-6:37 pm

1 stop13h 37m

Panama City Tocumen Intl

Sa 4/25

7:55 am-9:59 pm

1 stop13h 04m

$443

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mo 2/23

9:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Mi 3/4

10:00 am-7:55 pm

1 stop9h 55m

$445

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mo 2/23

5:35 am-7:38 pm

2 stops14h 03m

Panama City Tocumen Intl

Mi 3/4

8:55 am-7:51 pm

1 stop10h 56m

$449

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Di 4/21

7:20 am-6:37 pm

2 stops12h 17m

Panama City Tocumen Intl

Sa 4/25

10:00 am-8:00 pm

1 stop9h 00m

$453

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mo 2/23

9:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Mi 3/4

8:55 am-9:46 pm

1 stop12h 51m

$455

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mo 2/23

5:35 am-8:02 pm

2 stops14h 27m

Panama City Tocumen Intl

Mi 3/4

4:41 pm-1:17 pm

2 stops20h 36m

$459

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mo 3/2

6:12 pm-1:40 pm

2 stops19h 28m

Panama City Tocumen Intl

So 3/8

1:40 pm-11:30 am

2 stops20h 50m

$463

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Fr 8/7

6:14 am-6:37 pm

1 stop13h 23m

Panama City Tocumen Intl

Mo 8/17

10:55 pm-4:49 pm

2 stops16h 54m

$466

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Di 2/24

9:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Fr 2/27

4:41 pm-1:23 pm

2 stops20h 42m

$469

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sa 4/18

7:20 am-7:31 pm

2 stops13h 11m

Panama City Tocumen Intl

Sa 4/25

7:55 am-8:16 pm

2 stops11h 21m

$473

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama from

How to get the cheapest flight ticket from Louisville to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Panama?

United Airlines, Delta and American Airlines are the top three most popular airlines that fly to Panama from Louisville according to our data. United Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 3 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Cheap Louisville to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Panama

Fastest flight time

11h 07m

Direct flights

None
The fastest flight from Louisville to Panama takes 11h 07m
There are no direct flights from Louisville to Panama. There are no popular flight routes from Louisville to Panama.
Search flight deals

  • When did momondo last update prices for flights from Louisville Intl Airport to Panama?

    Prices for flights from Louisville Intl Airport to Panama refresh daily.

  • How many operators does momondo search for flights from Louisville Intl Airport to Panama?

  • How old do you have to be to fly from Louisville Intl Airport to Panama?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Louisville Intl Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Louisville to Panama

Compare and see reviews for airlines that fly from Louisville to Panama with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $351Free CancellationRating
7.4
9,276 reviews
Search United Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
11,267 reviews
Search American Airlines flights
DeltaPriceFrom $430Free CancellationRating
7.9
8,179 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Panama?

It is quick and easy to find Louisville to Panama flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama that suits you.

Can I find flights from Louisville to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from Louisville with this policy.

How can momondo help me find flights from Louisville to Panama?

Once you have performed a search for Louisville to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Louisville to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Louisville to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama trip

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