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Cheap flights from Knoxville to Sao Paulo from $273

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sao Paulo departing on 11/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
6:00 am - 6:30 amTYS-GRU
22h 30m2 stops
Multiple Airlines Logo
12:55 pm - 5:28 pmGRU-TYS
30h 33m1 stop
$789Multiple Airlines
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Wed, Dec 31 - Thu, Jan 29
Multiple Airlines Logo
8:15 am - 10:35 amTYS-GRU
24h 20m2 stops
Multiple Airlines Logo
12:00 pm - 12:05 pmGRU-TYS
26h 05m2 stops
$839Multiple Airlines
Find Deal
Wed, Dec 31 - Thu, Jan 29
American Airlines Logo
7:01 pm - 8:50 amTYS-GRU
11h 49m1 stop
American Airlines Logo
11:00 pm - 3:46 pmGRU-TYS
18h 46m1 stop
$1,029American Airlines
Find Deal
Wed, Dec 31 - Thu, Jan 29
American Airlines Logo
4:29 pm - 8:10 amTYS-GRU
13h 41m1 stop
American Airlines Logo
12:15 am - 3:20 pmGRU-TYS
17h 05m2 stops
$1,033American Airlines
Find Deal
Wed, Dec 31 - Wed, Jan 28
LATAM Airlines Logo
7:20 pm - 8:00 pmTYS-GRU
22h 40m2 stops
LATAM Airlines Logo
10:35 am - 11:07 amGRU-TYS
25h 32m2 stops
$1,045LATAM Airlines
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Sun, Mar 1 - Wed, Apr 1
United Airlines Logo
5:39 pm - 7:15 amTYS-GRU
35h 36m1 stop
United Airlines Logo
10:20 pm - 4:49 pmGRU-TYS
19h 29m1 stop
$1,048United Airlines
Find Deal
Sun, Mar 1 - Wed, Apr 1
United Airlines Logo
5:39 pm - 7:15 amTYS-GRU
35h 36m1 stop
United Airlines Logo
10:20 pm - 7:34 pmGRU-TYS
22h 14m2 stops
$1,053United Airlines
Find Deal
Sun, Mar 1 - Wed, Apr 1
LATAM Airlines Logo
4:00 pm - 4:30 pmTYS-GRU
46h 30m2 stops
LATAM Airlines Logo
4:30 pm - 11:44 pmGRU-TYS
33h 14m2 stops
$1,077LATAM Airlines
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Sun, Feb 1 - Sun, Feb 22
Delta Logo
7:20 pm - 5:40 amTYS-GRU
33h 20m1 stop
Delta Logo
11:45 pm - 1:26 pmGRU-TYS
14h 41m1 stop
$1,147Delta
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Sun, Mar 22 - Wed, Mar 25
Delta Logo
12:00 pm - 6:15 amTYS-GRU
17h 15m2 stops
Delta Logo
7:35 am - 11:44 pmGRU-TYS
17h 09m2 stops
$1,180Delta
Find Deal
Sun, Mar 22 - Wed, Mar 25

American Airlines flights from Knoxville to Sao Paulo Guarulhos Intl Airport

Our best American Airlines deals on Knoxville to Sao Paulo Guarulhos Intl Airport flight tickets
American Airlines
Dec 31
TYS7:01 pmKnoxville McGhee Tyson
11h 49m
1 stop
GRU8:50 amSao Paulo Guarulhos Intl
Jan 29
GRU11:00 pmSao Paulo Guarulhos Intl
18h 46m
1 stop
TYS3:46 pmKnoxville McGhee Tyson
$1,029
Find similar
American Airlines
Dec 31
TYS4:29 pmKnoxville McGhee Tyson
13h 41m
1 stop
GRU8:10 amSao Paulo Guarulhos Intl
Jan 28
GRU12:15 amSao Paulo Guarulhos Intl
17h 05m
2 stops
TYS3:20 pmKnoxville McGhee Tyson
$1,033
Find similar
American Airlines
Feb 1
TYS12:21 pmKnoxville McGhee Tyson
19h 49m
1 stop
GRU10:10 amSao Paulo Guarulhos Intl
Feb 21
GRU12:15 amSao Paulo Guarulhos Intl
15h 58m
2 stops
TYS2:13 pmKnoxville McGhee Tyson
$1,125
Find similar

LATAM Airlines flights from Knoxville to Sao Paulo Guarulhos Intl Airport

Our best LATAM Airlines deals on Knoxville to Sao Paulo Guarulhos Intl Airport flight tickets
LATAM Airlines
Mar 1
TYS7:20 pmKnoxville McGhee Tyson
22h 40m
2 stops
GRU8:00 pmSao Paulo Guarulhos Intl
Apr 1
GRU10:35 amSao Paulo Guarulhos Intl
25h 32m
2 stops
TYS11:07 amKnoxville McGhee Tyson
$1,045
Find similar
LATAM Airlines
Feb 1
TYS4:00 pmKnoxville McGhee Tyson
46h 30m
2 stops
GRU4:30 pmSao Paulo Guarulhos Intl
Feb 22
GRU4:30 pmSao Paulo Guarulhos Intl
33h 14m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
$1,077
Find similar
LATAM Airlines
Feb 1
TYS7:20 pmKnoxville McGhee Tyson
32h 20m
1 stop
GRU5:40 amSao Paulo Guarulhos Intl
Feb 22
GRU11:45 pmSao Paulo Guarulhos Intl
13h 22m
1 stop
TYS11:07 amKnoxville McGhee Tyson
$1,107
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sao Paulo Guarulhos Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Knoxville to Sao Paulo Guarulhos Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Wed 12/31

6:00 am-6:30 am

2 stops22h 30m

Sao Paulo Guarulhos Intl

Thu 1/29

12:55 pm-5:28 pm

1 stop30h 33m

$789

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Wed 12/31

8:15 am-10:35 am

2 stops24h 20m

Sao Paulo Guarulhos Intl

Thu 1/29

12:00 pm-12:05 pm

2 stops26h 05m

$839

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Wed 12/31

7:01 pm-8:50 am

1 stop11h 49m

Sao Paulo Guarulhos Intl

Thu 1/29

11:00 pm-3:46 pm

1 stop18h 46m

$1,029

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Wed 12/31

4:29 pm-8:10 am

1 stop13h 41m

Sao Paulo Guarulhos Intl

Wed 1/28

12:15 am-3:20 pm

2 stops17h 05m

$1,033

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/1

7:20 pm-8:00 pm

2 stops22h 40m

Sao Paulo Guarulhos Intl

Wed 4/1

10:35 am-11:07 am

2 stops25h 32m

$1,045

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/1

5:39 pm-7:15 am

1 stop35h 36m

Sao Paulo Guarulhos Intl

Wed 4/1

10:20 pm-4:49 pm

1 stop19h 29m

$1,048

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/1

5:39 pm-7:15 am

1 stop35h 36m

Sao Paulo Guarulhos Intl

Wed 4/1

10:20 pm-7:34 pm

2 stops22h 14m

$1,053

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 2/1

4:00 pm-4:30 pm

2 stops46h 30m

Sao Paulo Guarulhos Intl

Sun 2/22

4:30 pm-11:44 pm

2 stops33h 14m

$1,077

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/22

7:20 pm-5:40 am

1 stop33h 20m

Sao Paulo Guarulhos Intl

Wed 3/25

11:45 pm-1:26 pm

1 stop14h 41m

$1,147

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/22

12:00 pm-6:15 am

2 stops17h 15m

Sao Paulo Guarulhos Intl

Wed 3/25

7:35 am-11:44 pm

2 stops17h 09m

$1,180

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Sao Paulo Guarulhos Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Sao Paulo Guarulhos Intl Airport?

On average, the least expensive day to fly to Sao Paulo Guarulhos Intl Airport from Knoxville is on a Thursday. momondo users have found tickets for Thursday departures for as low as $1,167. However, this price may fluctuate depending on the airline, the season, and holidays. The most expensive day to fly to Sao Paulo Guarulhos Intl Airport is Tuesday, with ticket prices averaging around $1,210.

What is the cheapest time of day to depart on your flight to Sao Paulo Guarulhos Intl Airport?

Our data shows that the cheapest Knoxville to Sao Paulo Guarulhos Intl Airport flights are usually those with departure times in the afternoon. Our users have found flights to Sao Paulo Guarulhos Intl Airport in the afternoon for as low as $1,167. Flights in the evening are often more expensive with an average ticket price of $1,167.

When to book flights from Knoxville to Sao Paulo Guarulhos Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sao Paulo Guarulhos Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sao Paulo Guarulhos Intl Airport (TYS to GRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sao Paulo Guarulhos Intl Airport

Direct flights

None
There are no direct flights from Knoxville to Sao Paulo Guarulhos Intl Airport. There are no popular flight routes from Knoxville to Sao Paulo Guarulhos Intl Airport.
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  • How far is Knoxville McGhee Tyson to Sao Paulo Guarulhos Intl by plane?

    Sao Paulo Guarulhos Intl is 4773.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 11h 49m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sao Paulo Guarulhos Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sao Paulo Guarulhos Intl Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sao Paulo Guarulhos Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Sao Paulo Guarulhos Intl Airport.

  • What documentation or ID do you need to fly to Sao Paulo Guarulhos Intl Airport?

    The travel and health documents required for your trip to Sao Paulo Guarulhos Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Sao Paulo Guarulhos Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Sao Paulo?

Book flights to Sao Paulo if you plan to visit one of these locations
Guarulhos
Santos
Campinas
Guarujá
Aparecida

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sao Paulo?

It is quick and easy to find Knoxville to Sao Paulo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Sao Paulo that suits you.

Can I find flights from Knoxville to Sao Paulo with flexible booking policies on momondo?

All flight searches from Knoxville to Sao Paulo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Sao Paulo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Sao Paulo from Knoxville.

I’m not ready to book a flight from Knoxville to Sao Paulo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Sao Paulo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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