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Cheap flights from Knoxville to Columbus from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Columbus departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Columbus

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:15 am - 1:27 pm
TYS
-
CMH
6h 12m
1 stop
Delta Logo
8:11 am - 1:16 pm
CMH
-
TYS
5h 05m
1 stop
$265Delta
Wed, Jul 8 - Wed, Jul 15
Southwest Logo
7:10 am - 3:00 pm
TYS
-
CMH
7h 50m
2 stops
Southwest Logo
4:20 pm - 9:20 pm
CMH
-
TYS
5h 00m
1 stop
$270Southwest
Wed, Jul 8 - Wed, Jul 15
Delta Logo
5:22 pm - 9:12 pm
TYS
-
CMH
3h 50m
1 stop
Delta Logo
6:35 am - 10:20 am
CMH
-
TYS
3h 45m
1 stop
$279Delta
Wed, Aug 19 - Sun, Aug 23
Southwest Logo
7:00 am - 2:55 pm
TYS
-
CMH
7h 55m
2 stops
Southwest Logo
7:35 am - 2:00 pm
CMH
-
TYS
6h 25m
1 stop
$285Southwest
Wed, Aug 19 - Sun, Aug 23
Multiple Airlines Logo
12:50 pm - 7:05 pm
TYS
-
CMH
6h 15m
1 stop
Multiple Airlines Logo
5:44 pm - 8:36 am
CMH
-
TYS
14h 52m
2 stops
$289Multiple Airlines
Fri, Aug 14 - Sun, Aug 16
Southwest Logo
7:00 am - 2:55 pm
TYS
-
CMH
7h 55m
2 stops
Southwest Logo
12:45 pm - 8:45 pm
CMH
-
TYS
8h 00m
2 stops
$290Southwest
Wed, Aug 19 - Sun, Aug 23
United Airlines Logo
7:00 am - 11:40 am
TYS
-
CMH
4h 40m
1 stop
United Airlines Logo
11:05 am - 4:58 pm
CMH
-
TYS
5h 53m
1 stop
$291United Airlines
Tue, Aug 25 - Wed, Aug 26
United Airlines Logo
7:00 am - 2:18 pm
TYS
-
CMH
7h 18m
2 stops
United Airlines Logo
7:59 pm - 11:59 pm
CMH
-
TYS
4h 00m
1 stop
$296United Airlines
Tue, Aug 25 - Wed, Aug 26
American Airlines Logo
5:00 am - 8:47 am
TYS
-
CMH
3h 47m
1 stop
American Airlines Logo
2:00 pm - 5:49 pm
CMH
-
TYS
3h 49m
1 stop
$299American Airlines
Tue, Jun 30 - Sat, Jul 4
American Airlines Logo
8:05 pm - 11:56 pm
TYS
-
CMH
3h 51m
1 stop
American Airlines Logo
5:26 pm - 11:51 pm
CMH
-
TYS
6h 25m
1 stop
$301American Airlines
Wed, Jul 15 - Mon, Jul 20

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American Airlines flights from Knoxville to Columbus Airport

Our best American Airlines deals on Knoxville to Columbus Airport flight tickets
American Airlines
Jun 30
TYS5:00 amKnoxville McGhee Tyson
3h 47m
1 stop
CMH8:47 amColumbus
Jul 4
CMH2:00 pmColumbus
3h 49m
1 stop
TYS5:49 pmKnoxville McGhee Tyson
$299
American Airlines
Jul 15
TYS8:05 pmKnoxville McGhee Tyson
3h 51m
1 stop
CMH11:56 pmColumbus
Jul 20
CMH5:26 pmColumbus
6h 25m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$301
American Airlines
Jul 17
TYS8:05 pmKnoxville McGhee Tyson
3h 51m
1 stop
CMH11:56 pmColumbus
Jul 18
CMH6:00 amColumbus
4h 46m
1 stop
TYS10:46 amKnoxville McGhee Tyson
$337

Southwest flights from Knoxville to Columbus Airport

Our best Southwest deals on Knoxville to Columbus Airport flight tickets
Southwest
Jul 8
TYS7:10 amKnoxville McGhee Tyson
7h 50m
2 stops
CMH3:00 pmColumbus
Jul 15
CMH4:20 pmColumbus
5h 00m
1 stop
TYS9:20 pmKnoxville McGhee Tyson
$270
Southwest
Aug 19
TYS7:00 amKnoxville McGhee Tyson
7h 55m
2 stops
CMH2:55 pmColumbus
Aug 23
CMH7:35 amColumbus
6h 25m
1 stop
TYS2:00 pmKnoxville McGhee Tyson
$285
Southwest
Aug 19
TYS7:00 amKnoxville McGhee Tyson
7h 55m
2 stops
CMH2:55 pmColumbus
Aug 23
CMH12:45 pmColumbus
8h 00m
2 stops
TYS8:45 pmKnoxville McGhee Tyson
$290

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Columbus Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 7/8

7:15 am-1:27 pm

1 stop6h 12m

Columbus

Wed 7/15

8:11 am-1:16 pm

1 stop5h 05m

$265

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 7/8

7:10 am-3:00 pm

2 stops7h 50m

Columbus

Wed 7/15

4:20 pm-9:20 pm

1 stop5h 00m

$270
Quickest round-trip

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 8/19

5:22 pm-9:12 pm

1 stop3h 50m

Columbus

Sun 8/23

6:35 am-10:20 am

1 stop3h 45m

$279

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 8/19

7:00 am-2:55 pm

2 stops7h 55m

Columbus

Sun 8/23

7:35 am-2:00 pm

1 stop6h 25m

$285

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Fri 8/14

12:50 pm-7:05 pm

1 stop6h 15m

Columbus

Sun 8/16

5:44 pm-8:36 am

2 stops14h 52m

$289

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 8/19

7:00 am-2:55 pm

2 stops7h 55m

Columbus

Sun 8/23

12:45 pm-8:45 pm

2 stops8h 00m

$290

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Tue 8/25

7:00 am-11:40 am

1 stop4h 40m

Columbus

Wed 8/26

11:05 am-4:58 pm

1 stop5h 53m

$291

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Tue 8/25

7:00 am-2:18 pm

2 stops7h 18m

Columbus

Wed 8/26

7:59 pm-11:59 pm

1 stop4h 00m

$296

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Tue 6/30

5:00 am-8:47 am

1 stop3h 47m

Columbus

Sat 7/4

2:00 pm-5:49 pm

1 stop3h 49m

$299

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 7/15

8:05 pm-11:56 pm

1 stop3h 51m

Columbus

Mon 7/20

5:26 pm-11:51 pm

1 stop6h 25m

$301

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Columbus from

How to get the cheapest flight ticket from Knoxville to Columbus Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to Columbus?

American Airlines and Southwest are the most popular carriers operating from Knoxville McGhee Tyson to Columbus

What airlines fly to Columbus Airport?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Columbus Airport from Knoxville according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Columbus Airport. Keep in mind that there are 3 different airlines that fly to Columbus Airport on a routine basis, so you have a few additional options to choose from.

When to book flights from Knoxville to Columbus Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Columbus Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Columbus Airport (TYS to CMH) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Columbus Airport

Fastest flight time

3h 32m

Direct flights

None
The fastest flight from Knoxville to Columbus Airport takes 3h 32m
There are no direct flights from Knoxville to Columbus Airport. There are no popular flight routes from Knoxville to Columbus Airport.
Search flight deals

Frequently asked questions about flying from Knoxville to Columbus Airport

  • How far is Knoxville McGhee Tyson to Columbus by plane?

    There are 284.5 mi between Knoxville McGhee Tyson and Columbus. In terms of flight time, this usually takes a little over 3h 32m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Columbus Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Columbus Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Columbus Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Columbus Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Columbus Airport.

  • What documentation or ID do you need to fly to Columbus Airport?

    The travel and health documents you'll need for your trip to Columbus Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Columbus Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Columbus Airport?

Best airlines flying from Knoxville to Columbus Airport

Compare and see reviews for airlines that fly from Knoxville to Columbus Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights
United AirlinesPriceFrom $294Free CancellationRating
7.4
9,842 reviews
Search United Airlines flights

Traveling to a place near Columbus?

Book flights to Columbus if you plan to visit one of these locations
Grove City
Reynoldsburg
Zanesville
Lancaster
Logan
Chillicothe
Worthington
Hilliard
Westerville
Bellville
Gahanna
Marysville
Milledgeville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Columbus?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Columbus from Knoxville.

Can I find flights from Knoxville to Columbus with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Columbus from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Columbus?

Once all potential Knoxville to Columbus flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Columbus right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Columbus from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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