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Cheap flights from Knoxville to the Cayman Islands from $569

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 5/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:31 pm - 4:05 pm
TYS
-
GCM
24h 34m
1 stop
Multiple Airlines Logo
12:40 pm - 9:48 pm
GCM
-
TYS
8h 08m
1 stop
$569Multiple Airlines
Thu, May 14 - Mon, May 18
Multiple Airlines Logo
9:00 am - 4:05 pm
TYS
-
GCM
8h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
-
TYS
8h 53m
1 stop
$591Multiple Airlines
Sat, Apr 25 - Sun, May 3
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
12:01 pm - 8:34 am
GCM
-
TYS
19h 33m
2 stops
$596American Airlines
Sat, Jun 20 - Fri, Jun 26
Multiple Airlines Logo
9:00 am - 4:05 pm
TYS
-
GCM
8h 05m
1 stop
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
-
TYS
8h 53m
1 stop
$604Multiple Airlines
Sat, Apr 25 - Sun, May 3
Multiple Airlines Logo
12:56 pm - 5:20 pm
TYS
-
GCM
29h 24m
2 stops
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
-
TYS
8h 53m
1 stop
$605Multiple Airlines
Sat, Apr 25 - Sun, May 3
Multiple Airlines Logo
12:56 pm - 5:20 pm
TYS
-
GCM
29h 24m
2 stops
Multiple Airlines Logo
12:40 pm - 10:33 pm
GCM
-
TYS
8h 53m
1 stop
$615Multiple Airlines
Sat, Apr 25 - Sun, May 3
American Airlines Logo
7:59 pm - 11:30 am
TYS
-
GCM
16h 31m
1 stop
American Airlines Logo
12:01 pm - 8:34 am
GCM
-
TYS
19h 33m
2 stops
$616American Airlines
Sat, Jun 20 - Fri, Jun 26
Multiple Airlines Logo
9:40 pm - 4:05 pm
TYS
-
GCM
19h 25m
2 stops
Multiple Airlines Logo
12:40 pm - 9:48 pm
GCM
-
TYS
8h 08m
1 stop
$619Multiple Airlines
Thu, May 14 - Mon, May 18
American Airlines Logo
7:00 am - 1:10 pm
TYS
-
GCM
7h 10m
2 stops
American Airlines Logo
12:35 pm - 10:56 pm
GCM
-
TYS
9h 21m
1 stop
$620American Airlines
Sun, May 10 - Tue, May 19
American Airlines Logo
8:25 pm - 1:10 pm
TYS
-
GCM
17h 45m
2 stops
American Airlines Logo
2:10 pm - 9:10 am
GCM
-
TYS
18h 00m
2 stops
$621American Airlines
Fri, Aug 21 - Fri, Aug 28

American Airlines flights from Knoxville to Cayman Islands

Our best American Airlines deals on Knoxville to Cayman Islands flight tickets
American Airlines
Jun 20
TYS7:59 pmKnoxville McGhee Tyson
16h 31m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
Jun 26
GCM12:01 pmGeorge Town Owen Roberts Intl
19h 33m
2 stops
TYS8:34 amKnoxville McGhee Tyson
$596
American Airlines
Jun 20
TYS7:59 pmKnoxville McGhee Tyson
16h 31m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
Jun 26
GCM12:01 pmGeorge Town Owen Roberts Intl
19h 33m
2 stops
TYS8:34 amKnoxville McGhee Tyson
$616
American Airlines
May 10
TYS7:00 amKnoxville McGhee Tyson
7h 10m
2 stops
GCM1:10 pmGeorge Town Owen Roberts Intl
May 19
GCM12:35 pmGeorge Town Owen Roberts Intl
9h 21m
1 stop
TYS10:56 pmKnoxville McGhee Tyson
$620

United Airlines flights from Knoxville to Cayman Islands

Our best United Airlines deals on Knoxville to Cayman Islands flight tickets
United Airlines
Apr 9
TYS7:00 amKnoxville McGhee Tyson
6h 45m
1 stop
GCM12:45 pmGeorge Town Owen Roberts Intl
Apr 13
GCM1:50 pmGeorge Town Owen Roberts Intl
7h 44m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
$771
United Airlines
Apr 9
TYS7:05 amKnoxville McGhee Tyson
6h 25m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Apr 13
GCM1:50 pmGeorge Town Owen Roberts Intl
7h 44m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
$804
United Airlines
May 4
TYS3:40 pmKnoxville McGhee Tyson
21h 50m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
May 7
GCM1:35 pmGeorge Town Owen Roberts Intl
9h 09m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$840

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 5/14

4:31 pm-4:05 pm

1 stop24h 34m

George Town Owen Roberts Intl

Mon 5/18

12:40 pm-9:48 pm

1 stop8h 08m

$569

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 4/25

9:00 am-4:05 pm

1 stop8h 05m

George Town Owen Roberts Intl

Sun 5/3

12:40 pm-10:33 pm

1 stop8h 53m

$591

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 6/20

7:59 pm-11:30 am

1 stop16h 31m

George Town Owen Roberts Intl

Fri 6/26

12:01 pm-8:34 am

2 stops19h 33m

$596

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 4/25

9:00 am-4:05 pm

1 stop8h 05m

George Town Owen Roberts Intl

Sun 5/3

12:40 pm-10:33 pm

1 stop8h 53m

$604

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 4/25

12:56 pm-5:20 pm

2 stops29h 24m

George Town Owen Roberts Intl

Sun 5/3

12:40 pm-10:33 pm

1 stop8h 53m

$605

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 4/25

12:56 pm-5:20 pm

2 stops29h 24m

George Town Owen Roberts Intl

Sun 5/3

12:40 pm-10:33 pm

1 stop8h 53m

$615

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 6/20

7:59 pm-11:30 am

1 stop16h 31m

George Town Owen Roberts Intl

Fri 6/26

12:01 pm-8:34 am

2 stops19h 33m

$616

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-4:05 pm

2 stops19h 25m

George Town Owen Roberts Intl

Mon 5/18

12:40 pm-9:48 pm

1 stop8h 08m

$619
Quickest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sun 5/10

7:00 am-1:10 pm

2 stops7h 10m

George Town Owen Roberts Intl

Tue 5/19

12:35 pm-10:56 pm

1 stop9h 21m

$620

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 8/21

8:25 pm-1:10 pm

2 stops17h 45m

George Town Owen Roberts Intl

Fri 8/28

2:10 pm-9:10 am

2 stops18h 00m

$621

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Cheap Knoxville to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Cayman Islands

Fastest flight time

5h 05m

Direct flights

None
The fastest flight from Knoxville to Cayman Islands takes 5h 05m
There are no direct flights from Knoxville to Cayman Islands. There are no popular flight routes from Knoxville to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

    Prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The required travel and health documents for your Cayman Islands trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Cayman Islands. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Cayman Islands

Compare and see reviews for airlines that fly from Knoxville to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $540Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights

  • How do I get Price Alerts for flights from Knoxville to Cayman Islands?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Knoxville from Cayman Islands. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Knoxville to Cayman Islands with momondo?

    Plan your trips smart with the “Price Forecast” feature, which uses flight data to help you pick the best days to fly for the lowest fares. Our “Price Calendar” helps you get the most for your money by showing you when it’s most advantageous to fly. Curate your own travel experiences for less with “Explore”. Expert travel hacks to fuel your next adventure are a click away with “Discover” by momondo. Set up our “Price Alerts” to track fare changes and book when prices are at their lowest point.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Cayman Islands?

It is quick and easy to find Knoxville to Cayman Islands flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Cayman Islands that suits you.

Can I find flights from Knoxville to Cayman Islands with flexible booking policies on momondo?

Yes. All flights to Cayman Islands from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Cayman Islands?

Once all potential Knoxville to Cayman Islands flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Cayman Islands right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Cayman Islands now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Cayman Islands and let you know when they change.

An easier way to manage your Cayman Islands trip

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Tue 4/21
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Find better results for your trip to the Cayman Islands

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