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Cheap flights from Knoxville to the Cayman Islands from $646

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:07 pm - 10:45 am
TYS
-
GCM
17h 38m
2 stops
American Airlines Logo
1:25 pm - 8:22 am
GCM
-
TYS
17h 57m
2 stops
$646American Airlines
Sun, Oct 4 - Sat, Oct 10
American Airlines Logo
4:51 pm - 11:00 am
TYS
-
GCM
19h 09m
1 stop
American Airlines Logo
1:25 pm - 8:22 am
GCM
-
TYS
17h 57m
2 stops
$653American Airlines
Sun, Oct 4 - Sat, Oct 10
Delta Logo
6:00 am - 11:31 am
TYS
-
GCM
6h 31m
1 stop
Delta Logo
1:04 pm - 11:54 pm
GCM
-
TYS
9h 50m
1 stop
$656Delta
Sat, Aug 1 - Wed, Aug 12
Delta Logo
6:00 am - 11:31 am
TYS
-
GCM
6h 31m
1 stop
Delta Logo
1:04 pm - 8:10 pm
GCM
-
TYS
6h 06m
1 stop
$661Delta
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
8:05 pm - 11:25 am
TYS
-
GCM
16h 20m
1 stop
American Airlines Logo
5:10 pm - 11:59 pm
GCM
-
TYS
5h 49m
1 stop
$666American Airlines
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
6:00 am - 10:55 am
TYS
-
GCM
5h 55m
1 stop
American Airlines Logo
12:00 pm - 9:43 am
GCM
-
TYS
20h 43m
2 stops
$671American Airlines
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
6:15 am - 11:27 am
TYS
-
GCM
6h 12m
1 stop
American Airlines Logo
3:30 pm - 10:27 am
GCM
-
TYS
17h 57m
2 stops
$676American Airlines
Fri, Oct 2 - Fri, Oct 16
American Airlines Logo
6:15 am - 11:00 am
TYS
-
GCM
5h 45m
1 stop
American Airlines Logo
12:40 pm - 8:22 am
GCM
-
TYS
18h 42m
1 stop
$679American Airlines
Fri, Oct 2 - Fri, Oct 16
Delta Logo
5:40 am - 11:31 am
TYS
-
GCM
6h 51m
1 stop
Delta Logo
12:56 pm - 9:35 pm
GCM
-
TYS
7h 39m
1 stop
$681Delta
Mon, Jul 27 - Fri, Jul 31
American Airlines Logo
8:05 pm - 11:25 am
TYS
-
GCM
16h 20m
1 stop
American Airlines Logo
5:10 pm - 11:59 pm
GCM
-
TYS
5h 49m
1 stop
$686American Airlines
Thu, Jul 16 - Tue, Jul 21

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American Airlines flights from Knoxville to Cayman Islands

Our best American Airlines deals on Knoxville to Cayman Islands flight tickets
American Airlines
Oct 4
TYS6:07 pmKnoxville McGhee Tyson
17h 38m
2 stops
GCM10:45 amGeorge Town Owen Roberts Intl
Oct 10
GCM1:25 pmGeorge Town Owen Roberts Intl
17h 57m
2 stops
TYS8:22 amKnoxville McGhee Tyson
$646
American Airlines
Oct 4
TYS4:51 pmKnoxville McGhee Tyson
19h 09m
1 stop
GCM11:00 amGeorge Town Owen Roberts Intl
Oct 10
GCM1:25 pmGeorge Town Owen Roberts Intl
17h 57m
2 stops
TYS8:22 amKnoxville McGhee Tyson
$653
American Airlines
Aug 1
TYS6:00 amKnoxville McGhee Tyson
5h 55m
1 stop
GCM10:55 amGeorge Town Owen Roberts Intl
Aug 12
GCM12:00 pmGeorge Town Owen Roberts Intl
20h 43m
2 stops
TYS9:43 amKnoxville McGhee Tyson
$666

United Airlines flights from Knoxville to Cayman Islands

Our best United Airlines deals on Knoxville to Cayman Islands flight tickets
United Airlines
Jul 3
TYS7:15 amKnoxville McGhee Tyson
6h 15m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Jul 7
GCM1:35 pmGeorge Town Owen Roberts Intl
8h 37m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$906
United Airlines
Jul 3
TYS7:15 amKnoxville McGhee Tyson
6h 15m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Jul 11
GCM1:50 pmGeorge Town Owen Roberts Intl
29h 58m
1 stop
TYS8:48 pmKnoxville McGhee Tyson
$907
United Airlines
Nov 2
TYS5:15 pmKnoxville McGhee Tyson
23h 15m
1 stop
GCM4:30 pmGeorge Town Owen Roberts Intl
Nov 4
GCM5:45 pmGeorge Town Owen Roberts Intl
27h 57m
1 stop
TYS9:42 pmKnoxville McGhee Tyson
$934

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sun 10/4

6:07 pm-10:45 am

2 stops17h 38m

George Town Owen Roberts Intl

Sat 10/10

1:25 pm-8:22 am

2 stops17h 57m

$646

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sun 10/4

4:51 pm-11:00 am

1 stop19h 09m

George Town Owen Roberts Intl

Sat 10/10

1:25 pm-8:22 am

2 stops17h 57m

$653

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 8/1

6:00 am-11:31 am

1 stop6h 31m

George Town Owen Roberts Intl

Wed 8/12

1:04 pm-11:54 pm

1 stop9h 50m

$656
Quickest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 8/1

6:00 am-11:31 am

1 stop6h 31m

George Town Owen Roberts Intl

Wed 8/12

1:04 pm-8:10 pm

1 stop6h 06m

$661

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

8:05 pm-11:25 am

1 stop16h 20m

George Town Owen Roberts Intl

Tue 7/21

5:10 pm-11:59 pm

1 stop5h 49m

$666

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 8/1

6:00 am-10:55 am

1 stop5h 55m

George Town Owen Roberts Intl

Wed 8/12

12:00 pm-9:43 am

2 stops20h 43m

$671

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 10/2

6:15 am-11:27 am

1 stop6h 12m

George Town Owen Roberts Intl

Fri 10/16

3:30 pm-10:27 am

2 stops17h 57m

$676

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 10/2

6:15 am-11:00 am

1 stop5h 45m

George Town Owen Roberts Intl

Fri 10/16

12:40 pm-8:22 am

1 stop18h 42m

$679

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 7/27

5:40 am-11:31 am

1 stop6h 51m

George Town Owen Roberts Intl

Fri 7/31

12:56 pm-9:35 pm

1 stop7h 39m

$681

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

8:05 pm-11:25 am

1 stop16h 20m

George Town Owen Roberts Intl

Tue 7/21

5:10 pm-11:59 pm

1 stop5h 49m

$686

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Knoxville to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of November, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $480.

Can stopping save me money on Knoxville to Cayman Islands flights?

You could potentially save up to 14% on your flight if you consider stops on a Knoxville to Cayman Islands flight.

Cheap Knoxville to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Cayman Islands

Fastest flight time

6h 15m

Direct flights

None
The fastest flight from Knoxville to Cayman Islands takes 6h 15m
There are no direct flights from Knoxville to Cayman Islands. There are no popular flight routes from Knoxville to Cayman Islands.
Search flight deals

Frequently asked questions about flying from Knoxville to the Cayman Islands

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

    Prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The required travel and health documents for your Cayman Islands trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Cayman Islands. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Cayman Islands

Compare and see reviews for airlines that fly from Knoxville to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $540Free CancellationRating
7.1
11,726 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Cayman Islands?

It is quick and easy to find Knoxville to Cayman Islands flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Cayman Islands that suits you.

Can I find flights from Knoxville to Cayman Islands with flexible booking policies on momondo?

Yes. All flights to Cayman Islands from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Cayman Islands?

Once all potential Knoxville to Cayman Islands flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Cayman Islands right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Cayman Islands now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Cayman Islands and let you know when they change.

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Find better results for your trip to the Cayman Islands

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