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Cheap flights from Knoxville to the Cayman Islands from $505

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to the Cayman Islands

Cheap round-trip flights

United Airlines Logo
5:45 am - 4:35 pmTYS-GCM
10h 50m1 stop
United Airlines Logo
5:10 pm - 11:59 pmGCM-TYS
6h 49m1 stop
$505United Airlines
Find Deal
Tue, Dec 23 - Sun, Dec 28
American Airlines Logo
5:00 am - 8:18 pmTYS-GCM
15h 18m2 stops
American Airlines Logo
12:50 pm - 6:31 pmGCM-TYS
5h 41m1 stop
$539American Airlines
Find Deal
Tue, Dec 23 - Sun, Dec 28
Delta Logo
5:30 am - 11:35 amTYS-GCM
7h 05m1 stop
Delta Logo
1:00 pm - 9:43 pmGCM-TYS
7h 43m1 stop
$550Delta
Find Deal
Tue, Mar 10 - Wed, Mar 11
Delta Logo
8:25 am - 2:27 pmTYS-GCM
6h 02m1 stop
Delta Logo
3:42 pm - 9:15 pmGCM-TYS
5h 33m1 stop
$596Delta
Find Deal
Wed, Dec 24 - Sun, Dec 28
American Airlines Logo
7:18 am - 2:20 pmTYS-GCM
8h 02m2 stops
American Airlines Logo
3:15 pm - 2:05 pmGCM-TYS
21h 50m2 stops
$664American Airlines
Find Deal
Tue, Mar 10 - Wed, Mar 11
American Airlines Logo
5:00 am - 8:18 pmTYS-GCM
15h 18m2 stops
American Airlines Logo
7:30 am - 6:23 pmGCM-TYS
10h 53m1 stop
$674American Airlines
Find Deal
Tue, Dec 23 - Sat, Dec 27
American Airlines Logo
8:31 pm - 11:25 amTYS-GCM
15h 54m1 stop
American Airlines Logo
3:15 pm - 9:32 amGCM-TYS
17h 17m2 stops
$694American Airlines
Find Deal
Sun, Oct 5 - Sat, Oct 11
Multiple Airlines Logo
12:01 pm - 11:35 amTYS-GCM
23h 34m2 stops
Multiple Airlines Logo
11:55 am - 10:55 pmGCM-TYS
11h 00m1 stop
$719Multiple Airlines
Find Deal
Wed, Dec 24 - Sun, Dec 28
Air Canada Logo
11:00 am - 12:25 pmTYS-GCM
25h 25m2 stops
Air Canada Logo
1:30 pm - 5:00 pmGCM-TYS
27h 30m2 stops
$2,123Air Canada
Find Deal
Wed, Dec 24 - Sun, Dec 28
WestJet Logo
6:57 pm - 1:44 pmTYS-GCM
42h 47m2 stops
WestJet Logo
2:50 pm - 8:46 pmGCM-TYS
29h 56m2 stops
$3,690WestJet
Find Deal
Tue, Dec 23 - Sun, Dec 28

United Airlines flights from Knoxville to Cayman Islands

Our best United Airlines deals on Knoxville to Cayman Islands flight tickets
United Airlines
Dec 23
TYS5:45 amKnoxville McGhee Tyson
10h 50m
1 stop
GCM4:35 pmGeorge Town Owen Roberts Intl
Dec 28
GCM5:10 pmGeorge Town Owen Roberts Intl
6h 49m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$505
Find similar
United Airlines
Dec 24
TYS5:45 amKnoxville McGhee Tyson
10h 50m
1 stop
GCM4:35 pmGeorge Town Owen Roberts Intl
Dec 27
GCM5:30 pmGeorge Town Owen Roberts Intl
17h 26m
1 stop
TYS10:56 amKnoxville McGhee Tyson
$705
Find similar

American Airlines flights from Knoxville to Cayman Islands

Our best American Airlines deals on Knoxville to Cayman Islands flight tickets
American Airlines
Dec 23
TYS5:00 amKnoxville McGhee Tyson
15h 18m
2 stops
GCM8:18 pmGeorge Town Owen Roberts Intl
Dec 28
GCM12:50 pmGeorge Town Owen Roberts Intl
5h 41m
1 stop
TYS6:31 pmKnoxville McGhee Tyson
$539
Find similar
American Airlines
Mar 10
TYS7:18 amKnoxville McGhee Tyson
8h 02m
2 stops
GCM2:20 pmGeorge Town Owen Roberts Intl
Mar 11
GCM3:15 pmGeorge Town Owen Roberts Intl
21h 50m
2 stops
TYS2:05 pmKnoxville McGhee Tyson
$664
Find similar
American Airlines
Dec 23
TYS5:00 amKnoxville McGhee Tyson
15h 18m
2 stops
GCM8:18 pmGeorge Town Owen Roberts Intl
Dec 27
GCM7:30 amGeorge Town Owen Roberts Intl
10h 53m
1 stop
TYS6:23 pmKnoxville McGhee Tyson
$674
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 22, 2025.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 12/23

5:45 am-4:35 pm

1 stop10h 50m

George Town Owen Roberts Intl

Sun 12/28

5:10 pm-11:59 pm

1 stop6h 49m

$505

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 12/23

5:00 am-8:18 pm

2 stops15h 18m

George Town Owen Roberts Intl

Sun 12/28

12:50 pm-6:31 pm

1 stop5h 41m

$539

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 3/10

5:30 am-11:35 am

1 stop7h 05m

George Town Owen Roberts Intl

Wed 3/11

1:00 pm-9:43 pm

1 stop7h 43m

$550

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 12/24

8:25 am-2:27 pm

1 stop6h 02m

George Town Owen Roberts Intl

Sun 12/28

3:42 pm-9:15 pm

1 stop5h 33m

$596

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 3/10

7:18 am-2:20 pm

2 stops8h 02m

George Town Owen Roberts Intl

Wed 3/11

3:15 pm-2:05 pm

2 stops21h 50m

$664

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 12/23

5:00 am-8:18 pm

2 stops15h 18m

George Town Owen Roberts Intl

Sat 12/27

7:30 am-6:23 pm

1 stop10h 53m

$674

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sun 10/5

8:31 pm-11:25 am

1 stop15h 54m

George Town Owen Roberts Intl

Sat 10/11

3:15 pm-9:32 am

2 stops17h 17m

$694

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 12/24

12:01 pm-11:35 am

2 stops23h 34m

George Town Owen Roberts Intl

Sun 12/28

11:55 am-10:55 pm

1 stop11h 00m

$719

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 12/24

11:00 am-12:25 pm

2 stops25h 25m

George Town Owen Roberts Intl

Sun 12/28

1:30 pm-5:00 pm

2 stops27h 30m

$2,123

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 12/23

6:57 pm-1:44 pm

2 stops42h 47m

George Town Owen Roberts Intl

Sun 12/28

2:50 pm-8:46 pm

2 stops29h 56m

$3,690

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Knoxville to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Cayman Islands?

Our data shows that Friday is the least expensive day to fly to Cayman Islands. Tickets to fly out on this day can be as low as $542. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Cayman Islands on Saturday is $652.

Cheap Knoxville to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Cayman Islands

Direct flights

None
There are no direct flights from Knoxville to Cayman Islands. There are no popular flight routes from Knoxville to Cayman Islands.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

    Prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The required travel and health documents for your Cayman Islands trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Cayman Islands. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Cayman Islands

Compare and see reviews for airlines that fly from Knoxville to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $469Free CancellationRating
7.9
7,971 reviews
Search Delta flights
American AirlinesPriceFrom $519Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Cayman Islands?

It is quick and easy to find Knoxville to Cayman Islands flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Cayman Islands that suits you.

Can I find flights from Knoxville to Cayman Islands with flexible booking policies on momondo?

Yes. All flights to Cayman Islands from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Cayman Islands?

Once all potential Knoxville to Cayman Islands flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Cayman Islands right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Cayman Islands now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Cayman Islands and let you know when they change.

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