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Cheap flights from Knoxville to the Cayman Islands from $643

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 6/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:11 pm - 1:35 pm
TYS
-
GCM
18h 24m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GCM
-
TYS
5h 47m
1 stop
$643American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
6:00 am - 4:10 pm
TYS
-
GCM
11h 10m
1 stop
American Airlines Logo
5:10 pm - 11:59 pm
GCM
-
TYS
5h 49m
1 stop
$646American Airlines
Mon, Jul 20 - Fri, Jul 24
American Airlines Logo
8:11 pm - 1:35 pm
TYS
-
GCM
18h 24m
1 stop
American Airlines Logo
12:01 pm - 8:34 am
GCM
-
TYS
19h 33m
2 stops
$647American Airlines
Sat, Jun 20 - Fri, Jun 26
American Airlines Logo
6:00 am - 4:10 pm
TYS
-
GCM
11h 10m
2 stops
American Airlines Logo
5:10 pm - 10:38 am
GCM
-
TYS
16h 28m
2 stops
$651American Airlines
Mon, Jul 20 - Fri, Jul 24
Delta Logo
5:40 am - 11:31 am
TYS
-
GCM
6h 51m
1 stop
Delta Logo
12:56 pm - 11:52 pm
GCM
-
TYS
9h 56m
1 stop
$656Delta
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
6:00 am - 4:10 pm
TYS
-
GCM
11h 10m
2 stops
American Airlines Logo
12:33 pm - 11:59 pm
GCM
-
TYS
10h 26m
2 stops
$661American Airlines
Thu, Jul 16 - Tue, Jul 21
American Airlines Logo
5:36 am - 1:36 pm
TYS
-
GCM
9h 00m
1 stop
American Airlines Logo
5:10 pm - 11:59 pm
GCM
-
TYS
5h 49m
1 stop
$681American Airlines
Thu, Jul 16 - Mon, Jul 20
American Airlines Logo
8:05 pm - 11:01 am
TYS
-
GCM
15h 56m
2 stops
American Airlines Logo
5:10 pm - 11:45 am
GCM
-
TYS
17h 35m
2 stops
$686American Airlines
Thu, Jul 16 - Mon, Jul 20
American Airlines Logo
8:48 pm - 11:31 am
TYS
-
GCM
15h 43m
2 stops
American Airlines Logo
5:11 pm - 10:36 am
GCM
-
TYS
16h 25m
2 stops
$756American Airlines
Mon, May 18 - Fri, May 22
American Airlines Logo
3:58 pm - 11:31 am
TYS
-
GCM
20h 33m
1 stop
American Airlines Logo
5:11 pm - 11:59 pm
GCM
-
TYS
5h 48m
1 stop
$759American Airlines
Tue, May 19 - Fri, May 22

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American Airlines flights from Knoxville to Cayman Islands

Our best American Airlines deals on Knoxville to Cayman Islands flight tickets
American Airlines
Jun 20
TYS7:59 pmKnoxville McGhee Tyson
16h 31m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
Jun 26
GCM12:01 pmGeorge Town Owen Roberts Intl
10h 58m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$631
American Airlines
Jun 20
TYS7:59 pmKnoxville McGhee Tyson
16h 31m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
Jun 26
GCM5:12 pmGeorge Town Owen Roberts Intl
16h 24m
2 stops
TYS10:36 amKnoxville McGhee Tyson
$636
American Airlines
Jun 20
TYS8:11 pmKnoxville McGhee Tyson
18h 24m
1 stop
GCM1:35 pmGeorge Town Owen Roberts Intl
Jun 26
GCM5:12 pmGeorge Town Owen Roberts Intl
5h 47m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$643

United Airlines flights from Knoxville to Cayman Islands

Our best United Airlines deals on Knoxville to Cayman Islands flight tickets
United Airlines
Aug 3
TYS7:15 amKnoxville McGhee Tyson
6h 15m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Aug 6
GCM1:35 pmGeorge Town Owen Roberts Intl
8h 37m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$784
United Airlines
Aug 3
TYS3:25 pmKnoxville McGhee Tyson
22h 05m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Aug 6
GCM1:35 pmGeorge Town Owen Roberts Intl
8h 37m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$800
United Airlines
Aug 3
TYS3:25 pmKnoxville McGhee Tyson
22h 05m
1 stop
GCM12:30 pmGeorge Town Owen Roberts Intl
Aug 6
GCM1:35 pmGeorge Town Owen Roberts Intl
8h 37m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$849

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 6/20

8:11 pm-1:35 pm

1 stop18h 24m

George Town Owen Roberts Intl

Fri 6/26

5:12 pm-11:59 pm

1 stop5h 47m

$643

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 7/20

6:00 am-4:10 pm

1 stop11h 10m

George Town Owen Roberts Intl

Fri 7/24

5:10 pm-11:59 pm

1 stop5h 49m

$646

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 6/20

8:11 pm-1:35 pm

1 stop18h 24m

George Town Owen Roberts Intl

Fri 6/26

12:01 pm-8:34 am

2 stops19h 33m

$647

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 7/20

6:00 am-4:10 pm

2 stops11h 10m

George Town Owen Roberts Intl

Fri 7/24

5:10 pm-10:38 am

2 stops16h 28m

$651

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

5:40 am-11:31 am

1 stop6h 51m

George Town Owen Roberts Intl

Tue 7/21

12:56 pm-11:52 pm

1 stop9h 56m

$656

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

6:00 am-4:10 pm

2 stops11h 10m

George Town Owen Roberts Intl

Tue 7/21

12:33 pm-11:59 pm

2 stops10h 26m

$661
Quickest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

5:36 am-1:36 pm

1 stop9h 00m

George Town Owen Roberts Intl

Mon 7/20

5:10 pm-11:59 pm

1 stop5h 49m

$681

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

8:05 pm-11:01 am

2 stops15h 56m

George Town Owen Roberts Intl

Mon 7/20

5:10 pm-11:45 am

2 stops17h 35m

$686

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Mon 5/18

8:48 pm-11:31 am

2 stops15h 43m

George Town Owen Roberts Intl

Fri 5/22

5:11 pm-10:36 am

2 stops16h 25m

$756

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Tue 5/19

3:58 pm-11:31 am

1 stop20h 33m

George Town Owen Roberts Intl

Fri 5/22

5:11 pm-11:59 pm

1 stop5h 48m

$759

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Knoxville to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of July, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $480.

Cheap Knoxville to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Cayman Islands

Fastest flight time

6h 15m

Direct flights

None
The fastest flight from Knoxville to Cayman Islands takes 6h 15m
There are no direct flights from Knoxville to Cayman Islands. There are no popular flight routes from Knoxville to Cayman Islands.
Search flight deals

Frequently asked questions about flying from Knoxville to the Cayman Islands

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

    Prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The required travel and health documents for your Cayman Islands trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Cayman Islands. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Cayman Islands

Compare and see reviews for airlines that fly from Knoxville to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $480Free CancellationRating
7.1
11,672 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Cayman Islands?

It is quick and easy to find Knoxville to Cayman Islands flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Cayman Islands that suits you.

Can I find flights from Knoxville to Cayman Islands with flexible booking policies on momondo?

Yes. All flights to Cayman Islands from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Cayman Islands?

Once all potential Knoxville to Cayman Islands flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Cayman Islands right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Cayman Islands now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Cayman Islands and let you know when they change.

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Find better results for your trip to the Cayman Islands

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