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Cheap flights from Knoxville to the Cayman Islands from $610

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to the Cayman Islands departing on 10/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to the Cayman Islands

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:56 pm - 4:05 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
19h 09m1 stop Tampa St. Petersburg
Multiple Airlines Logo
7:00 am - 9:31 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
37h 31m2 stops Miami Philadelphia
$610Multiple Airlines
Fri, Oct 2 - Sun, Oct 11
American Airlines Logo
5:47 am - 11:46 amTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
5h 59m1 stop Miami
American Airlines Logo
1:05 pm - 11:53 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
10h 48m1 stop Charlotte Douglas
$636American Airlines
Thu, Dec 17 - Tue, Dec 22
American Airlines Logo
5:47 am - 7:52 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
14h 05m1 stop Miami
American Airlines Logo
12:36 pm - 12:33 amGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
11h 57m1 stop Miami
$636American Airlines
Fri, Dec 18 - Thu, Dec 24
Multiple Airlines Logo
9:56 pm - 4:05 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
19h 09m1 stop Tampa St. Petersburg
Multiple Airlines Logo
12:40 pm - 8:23 amGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
18h 43m1 stop Tampa
$636Multiple Airlines
Fri, Oct 2 - Sun, Oct 11
American Airlines Logo
5:47 am - 7:52 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
14h 05m1 stop Miami
American Airlines Logo
8:30 am - 7:31 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
11h 01m2 stops Miami Charlotte Douglas
$641American Airlines
Fri, Dec 18 - Thu, Dec 24
American Airlines Logo
8:13 pm - 11:30 amTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
16h 17m1 stop Charlotte Douglas
American Airlines Logo
11:55 am - 10:59 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
10h 04m1 stop Miami
$671American Airlines
Sun, Oct 4 - Sat, Oct 10
American Airlines Logo
8:13 pm - 1:10 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
17h 57m2 stops Charlotte Douglas Miami
American Airlines Logo
11:55 am - 10:59 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
10h 04m1 stop Miami
$676American Airlines
Sun, Oct 4 - Sat, Oct 10
American Airlines Logo
9:16 am - 2:35 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
5h 19m1 stop Charlotte Douglas
American Airlines Logo
12:36 pm - 9:57 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
9h 21m2 stops Miami Charlotte Douglas
$676American Airlines
Thu, Dec 17 - Tue, Dec 22
American Airlines Logo
6:00 am - 11:00 amTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
6h 00m1 stop Miami
American Airlines Logo
3:30 pm - 11:31 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
8h 01m1 stop Dallas/Fort Worth
$679American Airlines
Sat, Oct 31 - Sat, Nov 7
United Airlines Logo
7:15 am - 12:25 pmTYS  Knoxville McGhee Tyson-GCM George Town Owen Roberts Intl
6h 10m1 stop Houston George Bush Intcntl
United Airlines Logo
1:35 pm - 9:55 pmGCM  George Town Owen Roberts Intl-TYS Knoxville McGhee Tyson
7h 20m1 stop Houston George Bush Intcntl
$681United Airlines
Sat, Sep 26 - Sat, Oct 3

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United Airlines flights from Knoxville to Cayman Islands

Our best United Airlines deals on Knoxville to Cayman Islands flight tickets
United Airlines
Oct 31
TYS7:00 amKnoxville McGhee Tyson
9h 00m
1 stop
GCM3:00 pmGeorge Town Owen Roberts Intl
Nov 7
GCM2:55 pmGeorge Town Owen Roberts Intl
18h 58m
1 stop
TYS9:53 amKnoxville McGhee Tyson
$691
United Airlines
Jan 31
TYS7:00 amKnoxville McGhee Tyson
6h 45m
1 stop
GCM1:45 pmGeorge Town Owen Roberts Intl
Feb 4
GCM2:50 pmGeorge Town Owen Roberts Intl
22h 28m
1 stop
TYS1:18 pmKnoxville McGhee Tyson
$741
United Airlines
Aug 29
TYS7:15 amKnoxville McGhee Tyson
6h 10m
1 stop
GCM12:25 pmGeorge Town Owen Roberts Intl
Sep 5
GCM1:35 pmGeorge Town Owen Roberts Intl
7h 10m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
$786

American Airlines flights from Knoxville to Cayman Islands

Our best American Airlines deals on Knoxville to Cayman Islands flight tickets
American Airlines
Dec 18
TYS5:47 amKnoxville McGhee Tyson
14h 05m
1 stop
GCM7:52 pmGeorge Town Owen Roberts Intl
Dec 24
GCM8:30 amGeorge Town Owen Roberts Intl
11h 01m
2 stops
TYS7:31 pmKnoxville McGhee Tyson
$641
American Airlines
Oct 4
TYS8:13 pmKnoxville McGhee Tyson
16h 17m
1 stop
GCM11:30 amGeorge Town Owen Roberts Intl
Oct 10
GCM11:55 amGeorge Town Owen Roberts Intl
10h 04m
1 stop
TYS10:59 pmKnoxville McGhee Tyson
$671
American Airlines
Oct 4
TYS8:13 pmKnoxville McGhee Tyson
17h 57m
2 stops
GCM1:10 pmGeorge Town Owen Roberts Intl
Oct 10
GCM11:55 amGeorge Town Owen Roberts Intl
10h 04m
1 stop
TYS10:59 pmKnoxville McGhee Tyson
$676

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Knoxville to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Fri 10/2

9:56 pm-4:05 pm

1 stop19h 09m

George Town Owen Roberts Intl

Sun 10/11

7:00 am-9:31 pm

2 stops37h 31m

$610

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Thu 12/17

5:47 am-11:46 am

1 stop5h 59m

George Town Owen Roberts Intl

Tue 12/22

1:05 pm-11:53 pm

1 stop10h 48m

$636

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Fri 12/18

5:47 am-7:52 pm

1 stop14h 05m

George Town Owen Roberts Intl

Thu 12/24

12:36 pm-12:33 am

1 stop11h 57m

$636

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Fri 10/2

9:56 pm-4:05 pm

1 stop19h 09m

George Town Owen Roberts Intl

Sun 10/11

12:40 pm-8:23 am

1 stop18h 43m

$636

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Fri 12/18

5:47 am-7:52 pm

1 stop14h 05m

George Town Owen Roberts Intl

Thu 12/24

8:30 am-7:31 pm

2 stops11h 01m

$641

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Sun 10/4

8:13 pm-11:30 am

1 stop16h 17m

George Town Owen Roberts Intl

Sat 10/10

11:55 am-10:59 pm

1 stop10h 04m

$671

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Sun 10/4

8:13 pm-1:10 pm

2 stops17h 57m

George Town Owen Roberts Intl

Sat 10/10

11:55 am-10:59 pm

1 stop10h 04m

$676

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Thu 12/17

9:16 am-2:35 pm

1 stop5h 19m

George Town Owen Roberts Intl

Tue 12/22

12:36 pm-9:57 pm

2 stops9h 21m

$676

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Sat 10/31

6:00 am-11:00 am

1 stop6h 00m

George Town Owen Roberts Intl

Sat 11/7

3:30 pm-11:31 pm

1 stop8h 01m

$679
Quickest round-trip

KnoxvilleGeorge Town

TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl

TYSGCM

Knoxville McGhee Tyson

Sat 9/26

7:15 am-12:25 pm

1 stop6h 10m

George Town Owen Roberts Intl

Sat 10/3

1:35 pm-9:55 pm

1 stop7h 20m

$681

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from Knoxville to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of November, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $540.

Can stopping save me money on Knoxville to Cayman Islands flights?

You could potentially save up to 14% on your flight if you consider stops on a Knoxville to Cayman Islands flight.

Cheap Knoxville to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Cayman Islands

Fastest flight time

6h 10m

Direct flights

None
The fastest flight from Knoxville to Cayman Islands takes 6h 10m
There are no direct flights from Knoxville to Cayman Islands. There are no popular flight routes from Knoxville to Cayman Islands.
Search flight deals

Frequently asked questions about flying from Knoxville to the Cayman Islands

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

    Prices for flights from Knoxville McGhee Tyson Airport to Cayman Islands are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Cayman Islands?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The required travel and health documents for your Cayman Islands trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Cayman Islands. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to Cayman Islands

Compare and see reviews for airlines that fly from Knoxville to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $480Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Cayman Islands?

It is quick and easy to find Knoxville to Cayman Islands flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Cayman Islands that suits you.

Can I find flights from Knoxville to Cayman Islands with flexible booking policies on momondo?

Yes. All flights to Cayman Islands from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to Cayman Islands?

Once all potential Knoxville to Cayman Islands flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Cayman Islands right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Cayman Islands now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Cayman Islands and let you know when they change.

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