In general, October is the cheapest month to fly from United States to Iquitos. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $674. If you’re not able to fly to Iquitos in October, then November is your next best option. Flight prices from United States to Iquitos during November average around $735.
In general, most travelers find the cheapest time to book a flight to Iquitos is about 52 days prior to their departure date when tickets on average are $870. However, in the past 72 hours, people saw flights from United States for as low as $345.
Currently, Peru travel restrictions include travel to Iquitos. Peru has restricted entry to all travelers except Peruvian nationals and residents until at least July 31, 2020. They must present a completed "Declaracion Jurada de Salud" upon arrival, and will be subject to quarantine for 14 days, Airline crew must self-isolate at a hotel for the entire duration of their stay. If you are planning to travel to Iquitos at this time, it is recommended that you stay up to date on current restrictions and follow proper safety measures while in public.