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Cheap flights from Indianapolis to Panama from $266

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Indianapolis to Panama departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Indianapolis to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:00 am - 12:59 pmIND  Indianapolis-PTY Panama City Tocumen Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:24 pm - 12:35 amPTY  Panama City Tocumen Intl-IND Indianapolis
9h 11m1 stop Atlanta Hartsfield-Jackson
$597Delta
Tue, Oct 13 - Tue, Oct 20
United Airlines Logo
7:00 am - 1:45 pmIND  Indianapolis-PTY Panama City Tocumen Intl
7h 45m1 stop Houston George Bush Intcntl
United Airlines Logo
7:55 am - 11:19 pmPTY  Panama City Tocumen Intl-IND Indianapolis
14h 24m1 stop Houston George Bush Intcntl
$597United Airlines
Mon, Oct 26 - Thu, Oct 29
United Airlines Logo
6:20 am - 8:02 pmIND  Indianapolis-PTY Panama City Tocumen Intl
13h 42m1 stop Newark
United Airlines Logo
10:00 am - 8:22 pmPTY  Panama City Tocumen Intl-IND Indianapolis
10h 22m1 stop Newark
$597United Airlines
Wed, Nov 25 - Tue, Dec 1
American Airlines Logo
4:57 pm - 2:16 pmIND  Indianapolis-PTY Panama City Tocumen Intl
21h 19m2 stops Washington, D.C. Reagan-National Miami
American Airlines Logo
3:15 pm - 10:28 amPTY  Panama City Tocumen Intl-IND Indianapolis
19h 13m2 stops Miami Philadelphia
$601American Airlines
Thu, Nov 26 - Tue, Dec 1
American Airlines Logo
5:34 pm - 1:02 pmIND  Indianapolis-PTY Panama City Tocumen Intl
20h 28m2 stops New York LaGuardia Miami
American Airlines Logo
2:02 pm - 8:59 amPTY  Panama City Tocumen Intl-IND Indianapolis
17h 57m2 stops Miami Chicago O'Hare Intl
$601American Airlines
Mon, Oct 26 - Thu, Oct 29
Delta Logo
7:10 am - 2:05 pmIND  Indianapolis-PTY Panama City Tocumen Intl
6h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:30 pm - 12:32 amPTY  Panama City Tocumen Intl-IND Indianapolis
9h 02m1 stop Atlanta Hartsfield-Jackson
$631Delta
Fri, Dec 11 - Mon, Dec 14
Copa Airlines Logo
9:20 am - 7:38 pmIND  Indianapolis-PTY Panama City Tocumen Intl
10h 18m1 stop Houston George Bush Intcntl
Copa Airlines Logo
11:35 am - 3:57 pmPTY  Panama City Tocumen Intl-IND Indianapolis
28h 22m1 stop Houston George Bush Intcntl
$658Copa Airlines
Wed, Dec 2 - Tue, Jan 5
Copa Airlines Logo
7:30 pm - 2:14 pmIND  Indianapolis-PTY Panama City Tocumen Intl
19h 44m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
Copa Airlines Logo
9:45 am - 8:37 pmPTY  Panama City Tocumen Intl-IND Indianapolis
9h 52m1 stop Newark
$741Copa Airlines
Sun, Sep 6 - Thu, Sep 10
Avianca Logo
7:44 pm - 10:30 amIND  Indianapolis-PTY Panama City Tocumen Intl
14h 46m2 stops Washington, D.C. Dulles Intl San Salvador El Salvador Intl
Avianca Logo
11:25 am - 2:16 pmPTY  Panama City Tocumen Intl-IND Indianapolis
26h 51m3 stops San José Juan Santamaria Intl Guatemala City La Aurora Washington, D.C. Dulles Intl
$757Avianca
Wed, Jan 20 - Tue, Jan 26
Avianca Logo
9:50 am - 10:30 amIND  Indianapolis-PTY Panama City Tocumen Intl
24h 40m2 stops Washington, D.C. Dulles Intl San Salvador El Salvador Intl
Avianca Logo
11:25 am - 2:16 pmPTY  Panama City Tocumen Intl-IND Indianapolis
26h 51m3 stops San José Juan Santamaria Intl Guatemala City La Aurora Washington, D.C. Dulles Intl
$765Avianca
Thu, Nov 26 - Tue, Dec 1

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Delta flights from Indianapolis to Panama

Our best Delta deals on Indianapolis to Panama flight tickets
Delta
Oct 3
IND6:00 amIndianapolis
7h 58m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Oct 11
PTY2:24 pmPanama City Tocumen Intl
9h 11m
1 stop
IND12:35 amIndianapolis
$665
Delta
Sep 12
IND7:05 amIndianapolis
6h 53m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 21
PTY2:23 pmPanama City Tocumen Intl
9h 09m
1 stop
IND12:32 amIndianapolis
$773

Copa Airlines flights from Indianapolis to Panama

Our best Copa Airlines deals on Indianapolis to Panama flight tickets
Copa Airlines
Dec 2
IND9:20 amIndianapolis
10h 18m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Jan 5
PTY11:35 amPanama City Tocumen Intl
28h 22m
1 stop
IND3:57 pmIndianapolis
$658
Copa Airlines
Sep 6
IND7:30 pmIndianapolis
19h 44m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Sep 10
PTY9:45 amPanama City Tocumen Intl
9h 52m
1 stop
IND8:37 pmIndianapolis
$741
Copa Airlines
Sep 6
IND6:57 pmIndianapolis
10h 07m
1 stop
PTY4:04 amPanama City Tocumen Intl
Sep 10
PTY10:00 amPanama City Tocumen Intl
12h 30m
1 stop
IND11:30 pmIndianapolis
$776

momondo Fare Finder

 
Customize your flight search to find flights from Indianapolis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Indianapolis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Tue 10/13

7:00 am-12:59 pm

1 stop6h 59m

Panama City Tocumen Intl

Tue 10/20

2:24 pm-12:35 am

1 stop9h 11m

$597

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Mon 10/26

7:00 am-1:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Thu 10/29

7:55 am-11:19 pm

1 stop14h 24m

$597

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Wed 11/25

6:20 am-8:02 pm

1 stop13h 42m

Panama City Tocumen Intl

Tue 12/1

10:00 am-8:22 pm

1 stop10h 22m

$597

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Thu 11/26

4:57 pm-2:16 pm

2 stops21h 19m

Panama City Tocumen Intl

Tue 12/1

3:15 pm-10:28 am

2 stops19h 13m

$601

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Mon 10/26

5:34 pm-1:02 pm

2 stops20h 28m

Panama City Tocumen Intl

Thu 10/29

2:02 pm-8:59 am

2 stops17h 57m

$601
Quickest round-trip

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Fri 12/11

7:10 am-2:05 pm

1 stop6h 55m

Panama City Tocumen Intl

Mon 12/14

3:30 pm-12:32 am

1 stop9h 02m

$631

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Wed 12/2

9:20 am-7:38 pm

1 stop10h 18m

Panama City Tocumen Intl

Tue 1/5

11:35 am-3:57 pm

1 stop28h 22m

$658

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Sun 9/6

7:30 pm-2:14 pm

2 stops19h 44m

Panama City Tocumen Intl

Thu 9/10

9:45 am-8:37 pm

1 stop9h 52m

$741

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Wed 1/20

7:44 pm-10:30 am

2 stops14h 46m

Panama City Tocumen Intl

Tue 1/26

11:25 am-2:16 pm

3 stops26h 51m

$757

IndianapolisPanama City

IND Indianapolis - PTY Panama City Tocumen Intl

INDPTY

Indianapolis

Thu 11/26

9:50 am-10:30 am

2 stops24h 40m

Panama City Tocumen Intl

Tue 12/1

11:25 am-2:16 pm

3 stops26h 51m

$765

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Indianapolis to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of February is, on average, the cheapest month to fly to Panama from Indianapolis, with most prices found around $559. If you don’t want to visit Panama in February, then you should wait until January to fly from Indianapolis, when ticket prices are also cheap, with an average price of $612.

Can stopping save me money on Indianapolis to Panama flights?

You could potentially save up to 23% on your flight if you consider stops on a Indianapolis to Panama flight.

Cheap Indianapolis to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to Panama

Fastest flight time

6h 55m

Direct flights

None
The fastest flight from Indianapolis to Panama takes 6h 55m
There are no direct flights from Indianapolis to Panama. There are no popular flight routes from Indianapolis to Panama.
Search flight deals

Frequently asked questions about flying from Indianapolis to Panama

  • When did momondo last update prices for flights from Indianapolis Airport to Panama?

    Prices for flights from Indianapolis Airport to Panama refresh daily.

  • How many operators does momondo search for flights from Indianapolis Airport to Panama?

  • How old do you have to be to fly from Indianapolis Airport to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Indianapolis Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Indianapolis to Panama

Compare and see reviews for airlines that fly from Indianapolis to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $426Free CancellationRating
7.8
8,506 reviews
Search Delta flights
United AirlinesPriceFrom $510Free CancellationRating
7.4
10,101 reviews
Search United Airlines flights
American AirlinesPriceFrom $519Free CancellationRating
7.1
11,903 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $556Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to Panama?

Finding the right flight to Panama from Indianapolis is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama quick and easy, saving you time and money.

Can I find flights from Indianapolis to Panama with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama from Indianapolis with this policy.

How can momondo help me find flights from Indianapolis to Panama?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama from Indianapolis.

I’m not ready to book a flight from Indianapolis to Panama right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama, momondo offers a useful price alert feature which will track prices for flights to Panama from Indianapolis and alert you when they change.

An easier way to manage your Panama trip

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