Cheap flights from Houston to Panama from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Panama departing on 4/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:39 am - 2:15 pm
IAH
-
PTY
26h 36m
2 stops
Multiple Airlines Logo
3:10 pm - 8:23 am
PTY
-
IAH
17h 13m
2 stops
$398Multiple Airlines
Mon, Apr 20 - Mon, Apr 27
Multiple Airlines Logo
11:39 am - 2:15 pm
IAH
-
PTY
26h 36m
2 stops
Multiple Airlines Logo
5:55 pm - 8:23 am
PTY
-
IAH
14h 28m
2 stops
$400Multiple Airlines
Mon, Apr 20 - Mon, Apr 27
Multiple Airlines Logo
11:39 am - 7:20 pm
IAH
-
PTY
7h 41m
1 stop
Multiple Airlines Logo
9:33 pm - 8:18 am
PTY
-
IAH
10h 45m
1 stop
$418Multiple Airlines
Thu, Apr 30 - Sun, May 17
Multiple Airlines Logo
6:17 pm - 8:06 am
IAH
-
PTY
13h 49m
1 stop
Multiple Airlines Logo
9:33 pm - 8:18 am
PTY
-
IAH
10h 45m
1 stop
$419Multiple Airlines
Wed, May 6 - Wed, May 13
Delta Logo
6:00 am - 1:02 pm
HOU
-
PTY
7h 02m
1 stop
Delta Logo
2:27 pm - 11:07 pm
PTY
-
HOU
8h 40m
1 stop
$841Delta
Mon, Apr 20 - Mon, Apr 27
Delta Logo
6:00 am - 1:02 pm
HOU
-
PTY
7h 02m
1 stop
Delta Logo
2:27 pm - 11:07 pm
PTY
-
HOU
8h 40m
1 stop
$845Delta
Mon, Apr 27 - Wed, May 6
American Airlines Logo
4:18 pm - 12:46 pm
HOU
-
PTY
20h 28m
2 stops
American Airlines Logo
1:49 pm - 9:26 am
PTY
-
HOU
19h 37m
2 stops
$849American Airlines
Tue, May 5 - Tue, May 12
Delta Logo
5:23 pm - 1:02 pm
HOU
-
PTY
19h 39m
1 stop
Delta Logo
2:27 pm - 11:07 pm
PTY
-
HOU
8h 40m
1 stop
$858Delta
Sun, Apr 26 - Tue, May 5
American Airlines Logo
12:46 pm - 12:14 pm
HOU
-
PTY
23h 28m
2 stops
American Airlines Logo
3:20 pm - 8:59 am
PTY
-
HOU
17h 39m
2 stops
$874American Airlines
Sat, Aug 1 - Thu, Aug 13
American Airlines Logo
4:15 pm - 12:14 pm
HOU
-
PTY
19h 59m
2 stops
American Airlines Logo
1:14 pm - 9:05 am
PTY
-
HOU
19h 51m
2 stops
$879American Airlines
Thu, May 28 - Mon, Jul 20

American Airlines flights from Houston to Panama

Our best American Airlines deals on Houston to Panama flight tickets
American Airlines
May 5
HOU4:18 pmHouston Hobby
20h 28m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 12
PTY1:49 pmPanama City Tocumen Intl
19h 37m
2 stops
HOU9:26 amHouston Hobby
$849
American Airlines
Aug 1
HOU12:46 pmHouston Hobby
23h 28m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Aug 13
PTY3:20 pmPanama City Tocumen Intl
17h 39m
2 stops
HOU8:59 amHouston Hobby
$874
American Airlines
May 28
HOU4:15 pmHouston Hobby
19h 59m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 20
PTY1:14 pmPanama City Tocumen Intl
19h 51m
2 stops
HOU9:05 amHouston Hobby
$879

Delta flights from Houston to Panama

Our best Delta deals on Houston to Panama flight tickets
Delta
Apr 20
HOU6:00 amHouston Hobby
7h 02m
1 stop
PTY1:02 pmPanama City Tocumen Intl
Apr 27
PTY2:27 pmPanama City Tocumen Intl
8h 40m
1 stop
HOU11:07 pmHouston Hobby
$841
Delta
Apr 27
HOU6:00 amHouston Hobby
7h 02m
1 stop
PTY1:02 pmPanama City Tocumen Intl
May 6
PTY2:27 pmPanama City Tocumen Intl
8h 40m
1 stop
HOU11:07 pmHouston Hobby
$845
Delta
Apr 26
HOU5:23 pmHouston Hobby
19h 39m
1 stop
PTY1:02 pmPanama City Tocumen Intl
May 5
PTY2:27 pmPanama City Tocumen Intl
8h 40m
1 stop
HOU11:07 pmHouston Hobby
$858

momondo Fare Finder

 
Customize your flight search to find flights from Houston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Houston to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Mon 4/20

11:39 am-2:15 pm

2 stops26h 36m

Panama City Tocumen Intl

Mon 4/27

3:10 pm-8:23 am

2 stops17h 13m

$398

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Mon 4/20

11:39 am-2:15 pm

2 stops26h 36m

Panama City Tocumen Intl

Mon 4/27

5:55 pm-8:23 am

2 stops14h 28m

$400

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Thu 4/30

11:39 am-7:20 pm

1 stop7h 41m

Panama City Tocumen Intl

Sun 5/17

9:33 pm-8:18 am

1 stop10h 45m

$418

HoustonPanama City

IAH - PTY

IAHPTY

Houston George Bush Intcntl

Wed 5/6

6:17 pm-8:06 am

1 stop13h 49m

Panama City Tocumen Intl

Wed 5/13

9:33 pm-8:18 am

1 stop10h 45m

$419
Quickest round-trip

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Mon 4/20

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Mon 4/27

2:27 pm-11:07 pm

1 stop8h 40m

$841

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Mon 4/27

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Wed 5/6

2:27 pm-11:07 pm

1 stop8h 40m

$845

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Tue 5/5

4:18 pm-12:46 pm

2 stops20h 28m

Panama City Tocumen Intl

Tue 5/12

1:49 pm-9:26 am

2 stops19h 37m

$849

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Sun 4/26

5:23 pm-1:02 pm

1 stop19h 39m

Panama City Tocumen Intl

Tue 5/5

2:27 pm-11:07 pm

1 stop8h 40m

$858

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Sat 8/1

12:46 pm-12:14 pm

2 stops23h 28m

Panama City Tocumen Intl

Thu 8/13

3:20 pm-8:59 am

2 stops17h 39m

$874

HoustonPanama City

HOU - PTY

HOUPTY

Houston Hobby

Thu 5/28

4:15 pm-12:14 pm

2 stops19h 59m

Panama City Tocumen Intl

Mon 7/20

1:14 pm-9:05 am

2 stops19h 51m

$879

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Houston to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of January is, on average, the cheapest month to fly to Panama from Houston, with most prices found around $788. If you don’t want to visit Panama in January, then you should wait until March to fly from Houston, when ticket prices are also cheap, with an average price of $874.

What is the cheapest time of day to depart on your flight to Panama?

At noon is the cheapest time of day to fly from Houston to Panama when you can find flight prices for as low as $862. Flying to Panama at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $913 per ticket.

What is the cheapest Houston to Panama flight route?

Fly from Houston George Bush Intcntl to Panama City Tocumen Intl for the best Houston - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from Houston when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $918 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from Houston for as low as $728 on momondo.

What cabin class options are available on Houston to Panama flights?

There are 3 cabin classes available to choose from on Houston to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Panama

Fastest flight time

4h 11m

Direct flights

Every day

Airports in Panama

21 airports
The fastest flight from Houston to Panama takes 4h 11m
Direct flights go from Houston to Panama every day.
There are 21 airports in Panama. From Houston there are direct flights to Panama City Tocumen Intl (PTY).
  • When did momondo last update prices for flights from Houston to Panama?

    Prices for flights from Houston to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Panama?

  • How old do you have to be to fly from Houston to Panama?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Houston to Panama.

  • What documentation or ID do you need to fly to Panama?

    The necessary travel and health documents for your Panama trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Panama

Compare and see reviews for airlines that fly from Houston to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $559Free CancellationRating
7.5
1,579 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $738Free CancellationRating
7.4
9,489 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Houston to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Houston to Panama with flexible booking policies on momondo?

All flight searches from Houston to Panama on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Houston to Panama?

Once you have performed a search for Houston to Panama flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Panama right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Panama flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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1 adult
Sat 4/25
Sat 5/2

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Popular flights according to clicks in the last 7 days on momondo