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Cheap flights from Greenville to Detroit from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Detroit departing on 2/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville to Detroit

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:39 pm - 11:41 pm
GSP
-
DTW
7h 02m
1 stop
Multiple Airlines Logo
6:36 pm - 8:58 am
DTW
-
GSP
14h 22m
1 stop
$222Multiple Airlines
Fri, Jan 30 - Sun, Feb 8
Multiple Airlines Logo
4:39 pm - 10:54 am
GSP
-
DTW
18h 15m
1 stop
Multiple Airlines Logo
2:36 pm - 8:58 am
DTW
-
GSP
18h 22m
2 stops
$249Multiple Airlines
Mon, Feb 2 - Thu, Feb 5
Multiple Airlines Logo
4:39 pm - 11:39 am
GSP
-
DTW
19h 00m
2 stops
Multiple Airlines Logo
1:43 pm - 8:58 am
DTW
-
GSP
19h 15m
1 stop
$251Multiple Airlines
Fri, Jan 30 - Sun, Feb 1
Multiple Airlines Logo
5:45 pm - 10:05 am
GSP
-
DTW
16h 20m
1 stop
Multiple Airlines Logo
1:43 pm - 8:58 am
DTW
-
GSP
19h 15m
1 stop
$252Multiple Airlines
Thu, Jan 29 - Sun, Feb 1
Multiple Airlines Logo
4:39 pm - 11:41 pm
GSP
-
DTW
7h 02m
1 stop
Multiple Airlines Logo
7:14 pm - 8:58 am
DTW
-
GSP
13h 44m
2 stops
$258Multiple Airlines
Fri, Jan 30 - Sun, Feb 8
Multiple Airlines Logo
4:39 pm - 10:54 am
GSP
-
DTW
18h 15m
1 stop
Multiple Airlines Logo
10:54 am - 8:58 am
DTW
-
GSP
22h 04m
1 stop
$269Multiple Airlines
Mon, Feb 2 - Thu, Feb 5
Multiple Airlines Logo
3:04 pm - 9:11 am
GSP
-
DTW
18h 07m
1 stop
Multiple Airlines Logo
8:52 am - 4:27 pm
DTW
-
GSP
7h 35m
1 stop
$270Multiple Airlines
Thu, Feb 19 - Sun, Feb 22
Multiple Airlines Logo
2:12 pm - 9:11 am
GSP
-
DTW
18h 59m
1 stop
Multiple Airlines Logo
7:43 pm - 7:38 pm
DTW
-
GSP
23h 55m
1 stop
$272Multiple Airlines
Thu, Feb 19 - Sun, Feb 22
Multiple Airlines Logo
5:45 pm - 10:05 am
GSP
-
DTW
16h 20m
1 stop
Multiple Airlines Logo
10:54 am - 8:58 am
DTW
-
GSP
22h 04m
1 stop
$282Multiple Airlines
Thu, Jan 29 - Thu, Feb 5
Multiple Airlines Logo
4:39 pm - 2:21 pm
GSP
-
DTW
21h 42m
1 stop
Multiple Airlines Logo
1:43 pm - 8:58 am
DTW
-
GSP
19h 15m
1 stop
$287Multiple Airlines
Fri, Jan 30 - Sun, Feb 1

Southwest flights from Greenville to Detroit Metropolitan Wayne County Airport

Our best Southwest deals on Greenville to Detroit Metropolitan Wayne County Airport flight tickets
Southwest
Jan 29
GSP11:15 amGreenville
11h 15m
2 stops
DTW10:30 pmDetroit Metropolitan Wayne County
Feb 5
DTW12:30 pmDetroit Metropolitan Wayne County
7h 50m
2 stops
GSP8:20 pmGreenville
$304
Southwest
Jan 26
GSP11:15 amGreenville
3h 50m
1 stop
DTW3:05 pmDetroit Metropolitan Wayne County
Jan 28
DTW3:45 pmDetroit Metropolitan Wayne County
4h 05m
1 stop
GSP7:50 pmGreenville
$343
Southwest
Jan 26
GSP11:15 amGreenville
3h 50m
1 stop
DTW3:05 pmDetroit Metropolitan Wayne County
Jan 28
DTW5:25 amDetroit Metropolitan Wayne County
12h 10m
2 stops
GSP5:35 pmGreenville
$348

American Airlines flights from Greenville to Detroit Metropolitan Wayne County Airport

Our best American Airlines deals on Greenville to Detroit Metropolitan Wayne County Airport flight tickets
American Airlines
Feb 27
GSP12:55 pmGreenville
9h 42m
1 stop
DTW10:37 pmDetroit Metropolitan Wayne County
Mar 3
DTW12:00 pmDetroit Metropolitan Wayne County
10h 08m
1 stop
GSP10:08 pmGreenville
$330
American Airlines
Mar 6
GSP7:20 amGreenville
9h 28m
1 stop
DTW4:48 pmDetroit Metropolitan Wayne County
Mar 9
DTW10:01 amDetroit Metropolitan Wayne County
9h 06m
1 stop
GSP7:07 pmGreenville
$352
American Airlines
Feb 20
GSP12:55 pmGreenville
9h 42m
1 stop
DTW10:37 pmDetroit Metropolitan Wayne County
Feb 27
DTW4:01 pmDetroit Metropolitan Wayne County
6h 39m
1 stop
GSP10:40 pmGreenville
$382

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Detroit Metropolitan Wayne County Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from Greenville to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 1/30

4:39 pm-11:41 pm

1 stop7h 02m

Detroit Metropolitan Wayne County

Sun 2/8

6:36 pm-8:58 am

1 stop14h 22m

$222

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 2/2

4:39 pm-10:54 am

1 stop18h 15m

Detroit Metropolitan Wayne County

Thu 2/5

2:36 pm-8:58 am

2 stops18h 22m

$249

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 1/30

4:39 pm-11:39 am

2 stops19h 00m

Detroit Metropolitan Wayne County

Sun 2/1

1:43 pm-8:58 am

1 stop19h 15m

$251

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Thu 1/29

5:45 pm-10:05 am

1 stop16h 20m

Detroit Metropolitan Wayne County

Sun 2/1

1:43 pm-8:58 am

1 stop19h 15m

$252

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 1/30

4:39 pm-11:41 pm

1 stop7h 02m

Detroit Metropolitan Wayne County

Sun 2/8

7:14 pm-8:58 am

2 stops13h 44m

$258

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 2/2

4:39 pm-10:54 am

1 stop18h 15m

Detroit Metropolitan Wayne County

Thu 2/5

10:54 am-8:58 am

1 stop22h 04m

$269

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Thu 2/19

3:04 pm-9:11 am

1 stop18h 07m

Detroit Metropolitan Wayne County

Sun 2/22

8:52 am-4:27 pm

1 stop7h 35m

$270

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Thu 2/19

2:12 pm-9:11 am

1 stop18h 59m

Detroit Metropolitan Wayne County

Sun 2/22

7:43 pm-7:38 pm

1 stop23h 55m

$272

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Thu 1/29

5:45 pm-10:05 am

1 stop16h 20m

Detroit Metropolitan Wayne County

Thu 2/5

10:54 am-8:58 am

1 stop22h 04m

$282

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 1/30

4:39 pm-2:21 pm

1 stop21h 42m

Detroit Metropolitan Wayne County

Sun 2/1

1:43 pm-8:58 am

1 stop19h 15m

$287

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Detroit from

How to get the cheapest flight ticket from Greenville to Detroit Metropolitan Wayne County Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Detroit Metropolitan Wayne County Airport?

The cheapest month to fly to Detroit Metropolitan Wayne County Airport from Greenville is in May. Flight prices, which tend to average around $366, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of May, then book flights to Detroit Metropolitan Wayne County Airport from Greenville during April instead. Flights to Detroit Metropolitan Wayne County Airport in April, while not as cheap as those in May, still average around $439.

What is the cheapest day to depart on your flight to Detroit Metropolitan Wayne County Airport?

The cheapest day to depart from Greenville to Detroit Metropolitan Wayne County Airport is on a Thursday when prices can be found for as low as $443. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Detroit Metropolitan Wayne County Airport on Sunday is $668.

What is the cheapest time of day to depart on your flight to Detroit Metropolitan Wayne County Airport?

Flying to Detroit Metropolitan Wayne County Airport from Greenville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $468 when looking at flights departing in the morning. Flights to Detroit Metropolitan Wayne County Airport are more costly in the afternoon, with an average ticket price of $662. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Greenville to Detroit Metropolitan Wayne County flight route?

Fly from Greenville to Detroit Metropolitan Wayne County for the best Greenville - Detroit Metropolitan Wayne County flight prices

What cabin class options are available on Greenville to Detroit Metropolitan Wayne County flights?

There are 4 cabin classes available to choose from on Greenville to Detroit Metropolitan Wayne County flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Greenville to Detroit Metropolitan Wayne County Airport flights?

You could potentially save up to 55% on your flight if you consider stops on a Greenville to Detroit Metropolitan Wayne County Airport flight.

How have Greenville to Detroit Metropolitan Wayne County Airport flight prices changed over time?

As of January 2026, prices for Greenville to Detroit Metropolitan Wayne County Airport flights are approximately 49% more expensive when compared to flights at the same time last year.

When to book flights from Greenville to Detroit Metropolitan Wayne County Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Detroit Metropolitan Wayne County Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Detroit Metropolitan Wayne County Airport (GSP to DTW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Detroit Metropolitan Wayne County Airport

Best Price Found

$153

Fastest flight time

1h 47m

Direct flights

Tue, Thu, Fri, Sat and Sun
The best one-way flight to Detroit Metropolitan Wayne County Airport from Greenville in the past 72 hours is $153. The best round-trip flight deal from Greenville to Detroit Metropolitan Wayne County Airport found on momondo in the last 72 hours is $407.
The fastest flight from Greenville to Detroit Metropolitan Wayne County Airport takes 1h 47m
Direct flights go from Greenville to Detroit Metropolitan Wayne County Airport on Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
Search flight deals

  • How far is Greenville to Detroit Metropolitan Wayne County by plane?

    Greenville and Detroit Metropolitan Wayne County are 511.4 mi apart from one another. By plane, this route typically takes 1h 47m.

  • When did momondo last update prices for flights from Greenville Airport to Detroit Metropolitan Wayne County Airport?

    Prices for flights from Greenville Airport to Detroit Metropolitan Wayne County Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to Detroit Metropolitan Wayne County Airport?

  • How old do you have to be to fly from Greenville Airport to Detroit Metropolitan Wayne County Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Detroit Metropolitan Wayne County Airport.

  • What documentation or ID do you need to fly to Detroit Metropolitan Wayne County Airport?

    The necessary travel and health documents for your Detroit Metropolitan Wayne County Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Greenville to Detroit Metropolitan Wayne County Airport?

  • What is the most popular airline from Greenville to Detroit Metropolitan Wayne County Airport?

Best airlines flying from Greenville to Detroit Metropolitan Wayne County Airport

Compare and see reviews for airlines that fly from Greenville to Detroit Metropolitan Wayne County Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $278Free CancellationRating
7.2
11,192 reviews
Search American Airlines flights
DeltaPriceFrom $399Free CancellationRating
7.9
8,110 reviews
Search Delta flights

  • Delta Flights From Greenville to Detroit Metropolitan Wayne County Airport

    The lowest priced Delta flight from Greenville to Detroit Metropolitan Wayne County Airport from the last 72 hours was $399. Generally, Delta has 10 flights on this route every week with an average price of $498. Delta is rated 7.9/10 by our users.

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
Put-in-Bay
Auburn Hills
Warren
Troy
Dearborn
Romulus
Southfield
Monroe
Novi
Livonia
Port Clinton
Port Huron
Roseville
Sterling Heights
Brighton
Ypsilanti
Pontiac
Dundee
Belleville
Royal Oak

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Detroit?

It is quick and easy to find Greenville to Detroit flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Detroit that suits you.

Can I find flights from Greenville to Detroit with flexible booking policies on momondo?

Flights from Greenville to Detroit with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Greenville to Detroit?

momondo helps you find the best flight between Greenville and Detroit by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to Detroit right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Greenville to Detroit flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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