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Cheap flights from Greenville to Detroit from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Detroit departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:43 pm - 11:46 pm
GSP
-
DTW
30h 03m
1 stop
Multiple Airlines Logo
5:09 pm - 9:48 am
DTW
-
GSP
16h 39m
2 stops
$225Multiple Airlines
Mon, Apr 13 - Sat, Apr 18
Multiple Airlines Logo
5:43 pm - 9:23 am
GSP
-
DTW
15h 40m
1 stop
Multiple Airlines Logo
8:43 pm - 7:38 pm
DTW
-
GSP
22h 55m
2 stops
$252Multiple Airlines
Mon, Apr 13 - Thu, Apr 16
Multiple Airlines Logo
5:43 pm - 11:46 pm
GSP
-
DTW
30h 03m
1 stop
Multiple Airlines Logo
5:25 pm - 9:48 am
DTW
-
GSP
16h 23m
1 stop
$257Multiple Airlines
Mon, Apr 13 - Sat, Apr 18
Multiple Airlines Logo
5:43 pm - 9:23 am
GSP
-
DTW
15h 40m
1 stop
Multiple Airlines Logo
7:05 pm - 3:04 pm
DTW
-
GSP
19h 59m
2 stops
$262Multiple Airlines
Mon, Apr 13 - Wed, Apr 15
Multiple Airlines Logo
5:43 pm - 12:46 am
GSP
-
DTW
7h 03m
1 stop
Multiple Airlines Logo
10:10 pm - 8:07 pm
DTW
-
GSP
21h 57m
1 stop
$269Multiple Airlines
Fri, Apr 17 - Sun, Apr 19
Multiple Airlines Logo
5:43 pm - 12:46 am
GSP
-
DTW
7h 03m
1 stop
Multiple Airlines Logo
10:10 pm - 8:07 pm
DTW
-
GSP
21h 57m
1 stop
$284Multiple Airlines
Fri, Apr 17 - Sun, Apr 19
Multiple Airlines Logo
5:43 pm - 12:39 am
GSP
-
DTW
6h 56m
1 stop
Multiple Airlines Logo
6:59 pm - 8:07 pm
DTW
-
GSP
25h 08m
1 stop
$286Multiple Airlines
Fri, Apr 10 - Sun, Apr 12
Multiple Airlines Logo
5:43 pm - 11:46 pm
GSP
-
DTW
30h 03m
1 stop
Multiple Airlines Logo
12:57 pm - 7:38 pm
DTW
-
GSP
6h 41m
1 stop
$293Multiple Airlines
Mon, Apr 13 - Fri, Apr 17
Multiple Airlines Logo
5:43 pm - 9:23 am
GSP
-
DTW
15h 40m
1 stop
Multiple Airlines Logo
8:43 pm - 7:38 pm
DTW
-
GSP
22h 55m
2 stops
$297Multiple Airlines
Mon, Apr 13 - Thu, Apr 16
Multiple Airlines Logo
5:43 pm - 12:46 am
GSP
-
DTW
7h 03m
1 stop
Multiple Airlines Logo
5:09 pm - 4:53 pm
DTW
-
GSP
23h 44m
2 stops
$302Multiple Airlines
Fri, Apr 17 - Sun, Apr 19

Southwest flights from Greenville to Detroit Metropolitan Wayne County Airport

Our best Southwest deals on Greenville to Detroit Metropolitan Wayne County Airport flight tickets
Southwest
Apr 14
GSP5:05 pmGreenville
4h 30m
1 stop
DTW9:35 pmDetroit Metropolitan Wayne County
Apr 21
DTW4:10 pmDetroit Metropolitan Wayne County
5h 30m
1 stop
GSP9:40 pmGreenville
$359
Southwest
Apr 14
GSP12:50 pmGreenville
9h 40m
2 stops
DTW10:30 pmDetroit Metropolitan Wayne County
Apr 21
DTW4:10 pmDetroit Metropolitan Wayne County
5h 30m
1 stop
GSP9:40 pmGreenville
$364
Southwest
Apr 30
GSP6:25 pmGreenville
3h 55m
1 stop
DTW10:20 pmDetroit Metropolitan Wayne County
May 6
DTW6:10 amDetroit Metropolitan Wayne County
6h 00m
1 stop
GSP12:10 pmGreenville
$367

United Airlines flights from Greenville to Detroit Metropolitan Wayne County Airport

Our best United Airlines deals on Greenville to Detroit Metropolitan Wayne County Airport flight tickets
United Airlines
Apr 4
GSP5:41 pmGreenville
4h 36m
1 stop
DTW10:17 pmDetroit Metropolitan Wayne County
Apr 8
DTW6:00 amDetroit Metropolitan Wayne County
5h 54m
1 stop
GSP11:54 amGreenville
$559
United Airlines
Apr 2
GSP5:41 pmGreenville
7h 35m
1 stop
DTW1:16 amDetroit Metropolitan Wayne County
Apr 7
DTW12:11 pmDetroit Metropolitan Wayne County
6h 48m
2 stops
GSP6:59 pmGreenville
$564
United Airlines
Mar 26
GSP6:30 amGreenville
11h 37m
2 stops
DTW6:07 pmDetroit Metropolitan Wayne County
Mar 29
DTW5:50 amDetroit Metropolitan Wayne County
5h 54m
1 stop
GSP11:44 amGreenville
$664

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Detroit Metropolitan Wayne County Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from Greenville to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 4/13

5:43 pm-11:46 pm

1 stop30h 03m

Detroit Metropolitan Wayne County

Sat 4/18

5:09 pm-9:48 am

2 stops16h 39m

$225

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 4/13

5:43 pm-9:23 am

1 stop15h 40m

Detroit Metropolitan Wayne County

Thu 4/16

8:43 pm-7:38 pm

2 stops22h 55m

$252

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 4/13

5:43 pm-11:46 pm

1 stop30h 03m

Detroit Metropolitan Wayne County

Sat 4/18

5:25 pm-9:48 am

1 stop16h 23m

$257

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 4/13

5:43 pm-9:23 am

1 stop15h 40m

Detroit Metropolitan Wayne County

Wed 4/15

7:05 pm-3:04 pm

2 stops19h 59m

$262
Quickest round-trip

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 4/17

5:43 pm-12:46 am

1 stop7h 03m

Detroit Metropolitan Wayne County

Sun 4/19

10:10 pm-8:07 pm

1 stop21h 57m

$269

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 4/17

5:43 pm-12:46 am

1 stop7h 03m

Detroit Metropolitan Wayne County

Sun 4/19

10:10 pm-8:07 pm

1 stop21h 57m

$284

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 4/10

5:43 pm-12:39 am

1 stop6h 56m

Detroit Metropolitan Wayne County

Sun 4/12

6:59 pm-8:07 pm

1 stop25h 08m

$286

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 4/13

5:43 pm-11:46 pm

1 stop30h 03m

Detroit Metropolitan Wayne County

Fri 4/17

12:57 pm-7:38 pm

1 stop6h 41m

$293

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Mon 4/13

5:43 pm-9:23 am

1 stop15h 40m

Detroit Metropolitan Wayne County

Thu 4/16

8:43 pm-7:38 pm

2 stops22h 55m

$297

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Fri 4/17

5:43 pm-12:46 am

1 stop7h 03m

Detroit Metropolitan Wayne County

Sun 4/19

5:09 pm-4:53 pm

2 stops23h 44m

$302

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Detroit from

How to get the cheapest flight ticket from Greenville to Detroit Metropolitan Wayne County Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Detroit Metropolitan Wayne County Airport?

The cheapest month to fly to Detroit Metropolitan Wayne County Airport from Greenville is in March. Flight prices, which tend to average around $409, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of March, then book flights to Detroit Metropolitan Wayne County Airport from Greenville during May instead. Flights to Detroit Metropolitan Wayne County Airport in May, while not as cheap as those in March, still average around $429.

What is the cheapest day to depart on your flight to Detroit Metropolitan Wayne County Airport?

The cheapest day to depart from Greenville to Detroit Metropolitan Wayne County Airport is on a Thursday when prices can be found for as low as $451. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Detroit Metropolitan Wayne County Airport on Monday is $637.

What is the cheapest time of day to depart on your flight to Detroit Metropolitan Wayne County Airport?

Flying to Detroit Metropolitan Wayne County Airport from Greenville in the morning is the least expensive time of day to depart. momondo users have found prices as low as $466 when looking at flights departing in the morning. Flights to Detroit Metropolitan Wayne County Airport are more costly in the afternoon, with an average ticket price of $670. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Greenville to Detroit Metropolitan Wayne County flight route?

Fly from Greenville to Detroit Metropolitan Wayne County for the best Greenville - Detroit Metropolitan Wayne County flight prices

What cabin class options are available on Greenville to Detroit Metropolitan Wayne County flights?

There are 4 cabin classes available to choose from on Greenville to Detroit Metropolitan Wayne County flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Greenville to Detroit Metropolitan Wayne County Airport flights?

You could potentially save up to 41% on your flight if you consider stops on a Greenville to Detroit Metropolitan Wayne County Airport flight.

How have Greenville to Detroit Metropolitan Wayne County Airport flight prices changed over time?

As of March 2026, prices for Greenville to Detroit Metropolitan Wayne County Airport flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from Greenville to Detroit Metropolitan Wayne County Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Detroit Metropolitan Wayne County Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Detroit Metropolitan Wayne County Airport (GSP to DTW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Detroit Metropolitan Wayne County Airport

Best Price Found

$267

Fastest flight time

1h 44m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun
The best one-way flight to Detroit Metropolitan Wayne County Airport from Greenville in the past 72 hours is $267. The best round-trip flight deal from Greenville to Detroit Metropolitan Wayne County Airport found on momondo in the last 72 hours is $399.
The fastest flight from Greenville to Detroit Metropolitan Wayne County Airport takes 1h 44m
Direct flights go from Greenville to Detroit Metropolitan Wayne County Airport on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
Search flight deals

  • How far is Greenville to Detroit Metropolitan Wayne County by plane?

    Greenville and Detroit Metropolitan Wayne County are 511.4 mi apart from one another. By plane, this route typically takes 1h 44m.

  • When did momondo last update prices for flights from Greenville Airport to Detroit Metropolitan Wayne County Airport?

    Prices for flights from Greenville Airport to Detroit Metropolitan Wayne County Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to Detroit Metropolitan Wayne County Airport?

  • How old do you have to be to fly from Greenville Airport to Detroit Metropolitan Wayne County Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Detroit Metropolitan Wayne County Airport.

  • What documentation or ID do you need to fly to Detroit Metropolitan Wayne County Airport?

    The necessary travel and health documents for your Detroit Metropolitan Wayne County Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Greenville to Detroit Metropolitan Wayne County Airport?

  • What is the most popular airline from Greenville to Detroit Metropolitan Wayne County Airport?

Best airlines flying from Greenville to Detroit Metropolitan Wayne County Airport

Compare and see reviews for airlines that fly from Greenville to Detroit Metropolitan Wayne County Airport with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights
DeltaPriceFrom $399Free CancellationRating
7.9
8,313 reviews
Search Delta flights

  • Delta Flights From Greenville to Detroit Metropolitan Wayne County Airport

    The lowest priced Delta flight from Greenville to Detroit Metropolitan Wayne County Airport from the last 72 hours was $399. Generally, Delta has 14 flights on this route every week with an average price of $474. Delta is rated 7.9/10 by our users.

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
Put-in-Bay
Auburn Hills
Warren
Dearborn
Romulus
Troy
Monroe
Southfield
Novi
Livonia
Port Clinton
Roseville
Port Huron
Sterling Heights
Brighton
Dundee
Ypsilanti
Pontiac
Farmington Hills
Plymouth

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Detroit?

It is quick and easy to find Greenville to Detroit flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Detroit that suits you.

Can I find flights from Greenville to Detroit with flexible booking policies on momondo?

Flights from Greenville to Detroit with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Greenville to Detroit?

momondo helps you find the best flight between Greenville and Detroit by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to Detroit right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Greenville to Detroit flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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