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Cheap flights from Des Moines to Sao Paulo from $574

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Sao Paulo departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
5:15 pm - 9:35 amDSM-GRU
14h 20m1 stop
Delta Logo
10:40 am - 10:28 pmGRU-DSM
13h 48m1 stop
$1,100Delta
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Mon, Mar 23 - Wed, Mar 25
Delta Logo
10:15 am - 5:40 amDSM-GRU
17h 25m2 stops
Delta Logo
11:45 pm - 4:56 pmGRU-DSM
19h 11m2 stops
$1,105Delta
Find Deal
Mon, Mar 23 - Wed, Mar 25
United Airlines Logo
6:49 pm - 7:15 amDSM-GRU
33h 26m1 stop
United Airlines Logo
9:45 pm - 2:27 pmGRU-DSM
19h 42m1 stop
$1,153United Airlines
Find Deal
Sun, Feb 15 - Sun, Feb 22
United Airlines Logo
6:49 pm - 7:15 amDSM-GRU
33h 26m1 stop
United Airlines Logo
10:15 pm - 2:27 pmGRU-DSM
19h 12m2 stops
$1,157United Airlines
Find Deal
Sun, Feb 15 - Sun, Feb 22
American Airlines Logo
11:26 am - 8:05 amDSM-GRU
17h 39m2 stops
American Airlines Logo
12:15 am - 6:34 pmGRU-DSM
21h 19m2 stops
$1,190American Airlines
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Sun, Feb 15 - Sat, Feb 21
Multiple Airlines Logo
2:16 pm - 5:40 amDSM-GRU
12h 24m1 stop
Multiple Airlines Logo
4:35 pm - 10:36 pmGRU-DSM
33h 01m2 stops
$1,272Multiple Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17
American Airlines Logo
3:25 pm - 8:10 amDSM-GRU
13h 45m1 stop
American Airlines Logo
12:15 am - 11:59 pmGRU-DSM
26h 44m1 stop
$1,282American Airlines
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Sun, Feb 15 - Sat, Feb 21
Multiple Airlines Logo
2:56 pm - 1:35 amDSM-GRU
31h 39m3 stops
Multiple Airlines Logo
4:30 pm - 3:03 pmGRU-DSM
25h 33m3 stops
$1,327Multiple Airlines
Find Deal
Sun, Dec 14 - Sun, Dec 21
LATAM Airlines Logo
2:16 pm - 2:10 pmDSM-GRU
20h 54m3 stops
LATAM Airlines Logo
12:55 pm - 5:47 pmGRU-DSM
31h 52m2 stops
$1,384LATAM Airlines
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Wed, Dec 10 - Wed, Dec 17
LATAM Airlines Logo
2:16 pm - 8:20 pmDSM-GRU
51h 04m2 stops
LATAM Airlines Logo
3:55 am - 10:31 pmGRU-DSM
21h 36m2 stops
$1,386LATAM Airlines
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Sun, Dec 14 - Sat, Dec 20

Delta flights from Des Moines to Sao Paulo Guarulhos Intl Airport

Our best Delta deals on Des Moines to Sao Paulo Guarulhos Intl Airport flight tickets
Delta
Mar 23
DSM5:15 pmDes Moines
14h 20m
1 stop
GRU9:35 amSao Paulo Guarulhos Intl
Mar 25
GRU10:40 amSao Paulo Guarulhos Intl
13h 48m
1 stop
DSM10:28 pmDes Moines
$1,100
Find similar
Delta
Mar 23
DSM10:15 amDes Moines
17h 25m
2 stops
GRU5:40 amSao Paulo Guarulhos Intl
Mar 25
GRU11:45 pmSao Paulo Guarulhos Intl
19h 11m
2 stops
DSM4:56 pmDes Moines
$1,105
Find similar
Delta
Dec 10
DSM11:23 amDes Moines
19h 12m
1 stop
GRU9:35 amSao Paulo Guarulhos Intl
Dec 17
GRU11:45 pmSao Paulo Guarulhos Intl
16h 46m
1 stop
DSM1:31 pmDes Moines
$1,340
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Copa Airlines flights from Des Moines to Sao Paulo Guarulhos Intl Airport

Our best Copa Airlines deals on Des Moines to Sao Paulo Guarulhos Intl Airport flight tickets
Copa Airlines
Dec 13
DSM8:00 amDes Moines
19h 30m
2 stops
GRU6:30 amSao Paulo Guarulhos Intl
Dec 19
GRU1:30 amSao Paulo Guarulhos Intl
19h 35m
2 stops
DSM6:05 pmDes Moines
$1,684
Find similar
Copa Airlines
Dec 14
DSM8:00 amDes Moines
19h 30m
2 stops
GRU6:30 amSao Paulo Guarulhos Intl
Dec 20
GRU1:30 amSao Paulo Guarulhos Intl
19h 35m
2 stops
DSM6:05 pmDes Moines
$2,031
Find similar
Copa Airlines
Dec 13
DSM8:00 amDes Moines
19h 30m
2 stops
GRU6:30 amSao Paulo Guarulhos Intl
Dec 19
GRU1:40 amSao Paulo Guarulhos Intl
19h 25m
2 stops
DSM6:05 pmDes Moines
$2,159
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Sao Paulo Guarulhos Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 31, 2025.
Use the filters below to find and compare flights from Des Moines to Sao Paulo Guarulhos Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 3/23

5:15 pm-9:35 am

1 stop14h 20m

Sao Paulo Guarulhos Intl

Wed 3/25

10:40 am-10:28 pm

1 stop13h 48m

$1,100

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Mon 3/23

10:15 am-5:40 am

2 stops17h 25m

Sao Paulo Guarulhos Intl

Wed 3/25

11:45 pm-4:56 pm

2 stops19h 11m

$1,105

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 2/15

6:49 pm-7:15 am

1 stop33h 26m

Sao Paulo Guarulhos Intl

Sun 2/22

9:45 pm-2:27 pm

1 stop19h 42m

$1,153

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 2/15

6:49 pm-7:15 am

1 stop33h 26m

Sao Paulo Guarulhos Intl

Sun 2/22

10:15 pm-2:27 pm

2 stops19h 12m

$1,157

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 2/15

11:26 am-8:05 am

2 stops17h 39m

Sao Paulo Guarulhos Intl

Sat 2/21

12:15 am-6:34 pm

2 stops21h 19m

$1,190

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 12/10

2:16 pm-5:40 am

1 stop12h 24m

Sao Paulo Guarulhos Intl

Wed 12/17

4:35 pm-10:36 pm

2 stops33h 01m

$1,272

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 2/15

3:25 pm-8:10 am

1 stop13h 45m

Sao Paulo Guarulhos Intl

Sat 2/21

12:15 am-11:59 pm

1 stop26h 44m

$1,282

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 12/14

2:56 pm-1:35 am

3 stops31h 39m

Sao Paulo Guarulhos Intl

Sun 12/21

4:30 pm-3:03 pm

3 stops25h 33m

$1,327

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 12/10

2:16 pm-2:10 pm

3 stops20h 54m

Sao Paulo Guarulhos Intl

Wed 12/17

12:55 pm-5:47 pm

2 stops31h 52m

$1,384

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 12/14

2:16 pm-8:20 pm

2 stops51h 04m

Sao Paulo Guarulhos Intl

Sat 12/20

3:55 am-10:31 pm

2 stops21h 36m

$1,386

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Sao Paulo Guarulhos Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Sao Paulo Guarulhos Intl Airport?

On average, the least expensive day to fly to Sao Paulo Guarulhos Intl Airport from Des Moines is on a Sunday. momondo users have found tickets for Sunday departures for as low as $747. However, this price may fluctuate depending on the airline, the season, and holidays. The most expensive day to fly to Sao Paulo Guarulhos Intl Airport is Saturday, with ticket prices averaging around $1,633.

What is the cheapest time of day to depart on your flight to Sao Paulo Guarulhos Intl Airport?

Our data shows that the cheapest Des Moines to Sao Paulo Guarulhos Intl Airport flights are usually those with departure times in the afternoon. Our users have found flights to Sao Paulo Guarulhos Intl Airport in the afternoon for as low as $997. Flights in the morning are often more expensive with an average ticket price of $1,394.

When to book flights from Des Moines to Sao Paulo Guarulhos Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Sao Paulo Guarulhos Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Sao Paulo Guarulhos Intl Airport (DSM to GRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Sao Paulo Guarulhos Intl Airport

Direct flights

None
There are no direct flights from Des Moines to Sao Paulo Guarulhos Intl Airport. There are no popular flight routes from Des Moines to Sao Paulo Guarulhos Intl Airport.
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  • How far is Des Moines to Sao Paulo Guarulhos Intl by plane?

    The distance between Des Moines and Sao Paulo Guarulhos Intl is about 5406.4 mi. A reasonable flight in good conditions will take 12h 24m.

  • When did momondo last update prices for flights from Des Moines Airport to Sao Paulo Guarulhos Intl Airport?

    Prices for flights from Des Moines Airport to Sao Paulo Guarulhos Intl Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Sao Paulo Guarulhos Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Sao Paulo Guarulhos Intl Airport.

  • What documentation or ID do you need to fly to Sao Paulo Guarulhos Intl Airport?

    The required travel and health documents for your Sao Paulo Guarulhos Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Sao Paulo Guarulhos Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Sao Paulo?

Book flights to Sao Paulo if you plan to visit one of these locations
Guarulhos
Santos
Campinas
Guarujá
Aparecida

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Sao Paulo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Sao Paulo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Sao Paulo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Sao Paulo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Sao Paulo?

momondo helps you find the best flight between Des Moines and Sao Paulo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Sao Paulo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Sao Paulo, momondo offers a useful price alert feature which will track prices for flights to Sao Paulo from Des Moines and alert you when they change.

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