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Cheap flights from Des Moines to Sao Paulo from $643

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Sao Paulo departing on 11/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
6:37 pm - 4:10 pm
DSM
-
GRU
19h 33m
2 stops
LATAM Airlines Logo
11:00 pm - 1:34 pm
GRU
-
DSM
16h 34m
2 stops
$1,266LATAM Airlines
Wed, Jul 8 - Wed, Jul 15
LATAM Airlines Logo
6:30 pm - 8:00 pm
DSM
-
GRU
23h 30m
2 stops
LATAM Airlines Logo
11:45 pm - 6:00 pm
GRU
-
DSM
20h 15m
2 stops
$1,283LATAM Airlines
Sun, Sep 13 - Sun, Sep 20
American Airlines Logo
4:13 pm - 9:00 am
DSM
-
GRU
14h 47m
1 stop
American Airlines Logo
10:30 pm - 3:22 pm
GRU
-
DSM
18h 52m
2 stops
$1,301American Airlines
Sun, Sep 13 - Sun, Sep 20
American Airlines Logo
6:30 am - 9:00 am
DSM
-
GRU
24h 30m
1 stop
American Airlines Logo
10:30 pm - 3:22 pm
GRU
-
DSM
18h 52m
2 stops
$1,311American Airlines
Sun, Sep 13 - Sun, Sep 20
LATAM Airlines Logo
6:37 pm - 5:40 am
DSM
-
GRU
33h 03m
1 stop
LATAM Airlines Logo
5:45 pm - 10:45 am
GRU
-
DSM
19h 00m
2 stops
$1,313LATAM Airlines
Tue, Jul 7 - Tue, Jul 14
LATAM Airlines Logo
2:15 pm - 8:00 pm
DSM
-
GRU
27h 45m
2 stops
LATAM Airlines Logo
9:40 pm - 10:43 am
GRU
-
DSM
39h 03m
2 stops
$1,314LATAM Airlines
Sun, Sep 13 - Sun, Sep 20
LATAM Airlines Logo
2:15 pm - 5:40 am
DSM
-
GRU
13h 25m
1 stop
LATAM Airlines Logo
11:45 pm - 6:00 pm
GRU
-
DSM
20h 15m
2 stops
$1,318LATAM Airlines
Sun, Sep 13 - Sun, Sep 20
American Airlines Logo
4:14 pm - 9:00 am
DSM
-
GRU
14h 46m
1 stop
American Airlines Logo
11:15 pm - 7:23 pm
GRU
-
DSM
22h 08m
2 stops
$1,323American Airlines
Sun, Sep 13 - Sun, Sep 20
American Airlines Logo
4:14 pm - 9:00 am
DSM
-
GRU
14h 46m
1 stop
American Airlines Logo
10:00 pm - 11:13 pm
GRU
-
DSM
27h 13m
1 stop
$1,329American Airlines
Sun, Sep 13 - Sun, Sep 20
United Airlines Logo
3:02 pm - 6:30 am
DSM
-
GRU
13h 28m
1 stop
United Airlines Logo
10:20 pm - 2:20 pm
GRU
-
DSM
18h 00m
1 stop
$1,358United Airlines
Sun, Sep 13 - Sun, Sep 20

LATAM Airlines flights from Des Moines to Sao Paulo Guarulhos Intl Airport

Our best LATAM Airlines deals on Des Moines to Sao Paulo Guarulhos Intl Airport flight tickets
LATAM Airlines
Jul 8
DSM6:37 pmDes Moines
19h 33m
2 stops
GRU4:10 pmSao Paulo Guarulhos Intl
Jul 15
GRU11:00 pmSao Paulo Guarulhos Intl
16h 34m
2 stops
DSM1:34 pmDes Moines
$1,266
LATAM Airlines
Sep 13
DSM6:30 pmDes Moines
23h 30m
2 stops
GRU8:00 pmSao Paulo Guarulhos Intl
Sep 20
GRU11:45 pmSao Paulo Guarulhos Intl
20h 15m
2 stops
DSM6:00 pmDes Moines
$1,283
LATAM Airlines
Jul 7
DSM6:37 pmDes Moines
33h 03m
1 stop
GRU5:40 amSao Paulo Guarulhos Intl
Jul 14
GRU5:45 pmSao Paulo Guarulhos Intl
19h 00m
2 stops
DSM10:45 amDes Moines
$1,313

American Airlines flights from Des Moines to Sao Paulo Guarulhos Intl Airport

Our best American Airlines deals on Des Moines to Sao Paulo Guarulhos Intl Airport flight tickets
American Airlines
Sep 13
DSM4:13 pmDes Moines
14h 47m
1 stop
GRU9:00 amSao Paulo Guarulhos Intl
Sep 20
GRU10:30 pmSao Paulo Guarulhos Intl
18h 52m
2 stops
DSM3:22 pmDes Moines
$1,301
American Airlines
Sep 13
DSM6:30 amDes Moines
24h 30m
1 stop
GRU9:00 amSao Paulo Guarulhos Intl
Sep 20
GRU10:30 pmSao Paulo Guarulhos Intl
18h 52m
2 stops
DSM3:22 pmDes Moines
$1,311
American Airlines
Sep 13
DSM4:14 pmDes Moines
14h 46m
1 stop
GRU9:00 amSao Paulo Guarulhos Intl
Sep 20
GRU11:15 pmSao Paulo Guarulhos Intl
22h 08m
2 stops
DSM7:23 pmDes Moines
$1,323

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Sao Paulo Guarulhos Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Des Moines to Sao Paulo Guarulhos Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Wed 7/8

6:37 pm-4:10 pm

2 stops19h 33m

Sao Paulo Guarulhos Intl

Wed 7/15

11:00 pm-1:34 pm

2 stops16h 34m

$1,266

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

6:30 pm-8:00 pm

2 stops23h 30m

Sao Paulo Guarulhos Intl

Sun 9/20

11:45 pm-6:00 pm

2 stops20h 15m

$1,283

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

4:13 pm-9:00 am

1 stop14h 47m

Sao Paulo Guarulhos Intl

Sun 9/20

10:30 pm-3:22 pm

2 stops18h 52m

$1,301

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

6:30 am-9:00 am

1 stop24h 30m

Sao Paulo Guarulhos Intl

Sun 9/20

10:30 pm-3:22 pm

2 stops18h 52m

$1,311

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Tue 7/7

6:37 pm-5:40 am

1 stop33h 03m

Sao Paulo Guarulhos Intl

Tue 7/14

5:45 pm-10:45 am

2 stops19h 00m

$1,313

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

2:15 pm-8:00 pm

2 stops27h 45m

Sao Paulo Guarulhos Intl

Sun 9/20

9:40 pm-10:43 am

2 stops39h 03m

$1,314

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

2:15 pm-5:40 am

1 stop13h 25m

Sao Paulo Guarulhos Intl

Sun 9/20

11:45 pm-6:00 pm

2 stops20h 15m

$1,318

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

4:14 pm-9:00 am

1 stop14h 46m

Sao Paulo Guarulhos Intl

Sun 9/20

11:15 pm-7:23 pm

2 stops22h 08m

$1,323

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

4:14 pm-9:00 am

1 stop14h 46m

Sao Paulo Guarulhos Intl

Sun 9/20

10:00 pm-11:13 pm

1 stop27h 13m

$1,329
Quickest round-trip

Des MoinesSao Paulo

DSM - GRU

DSMGRU

Des Moines

Sun 9/13

3:02 pm-6:30 am

1 stop13h 28m

Sao Paulo Guarulhos Intl

Sun 9/20

10:20 pm-2:20 pm

1 stop18h 00m

$1,358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Sao Paulo from

How to get the cheapest flight ticket from Des Moines to Sao Paulo Guarulhos Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Sao Paulo Guarulhos Intl?

American Airlines, United Airlines, and Copa Airlines are the most popular carriers operating from Des Moines to Sao Paulo Guarulhos Intl

When to book flights from Des Moines to Sao Paulo Guarulhos Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Sao Paulo Guarulhos Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Sao Paulo Guarulhos Intl Airport (DSM to GRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Sao Paulo Guarulhos Intl Airport

Fastest flight time

33h 35m

Direct flights

None
The fastest flight from Des Moines to Sao Paulo Guarulhos Intl Airport takes 33h 35m
There are no direct flights from Des Moines to Sao Paulo Guarulhos Intl Airport. There are no popular flight routes from Des Moines to Sao Paulo Guarulhos Intl Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to Sao Paulo Guarulhos Intl Airport

  • How far is Des Moines to Sao Paulo Guarulhos Intl by plane?

    The distance between Des Moines and Sao Paulo Guarulhos Intl is about 5406.4 mi. A reasonable flight in good conditions will take 33h 35m.

  • When did momondo last update prices for flights from Des Moines Airport to Sao Paulo Guarulhos Intl Airport?

    Prices for flights from Des Moines Airport to Sao Paulo Guarulhos Intl Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Des Moines Airport to Sao Paulo Guarulhos Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Sao Paulo Guarulhos Intl Airport.

  • What documentation or ID do you need to fly to Sao Paulo Guarulhos Intl Airport?

    The required travel and health documents for your Sao Paulo Guarulhos Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Sao Paulo Guarulhos Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Sao Paulo?

Book flights to Sao Paulo if you plan to visit one of these locations
Guarulhos
Santos
Guarujá
Campinas
Aparecida

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Sao Paulo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Des Moines to Sao Paulo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Des Moines to Sao Paulo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Sao Paulo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Sao Paulo?

momondo helps you find the best flight between Des Moines and Sao Paulo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Sao Paulo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Sao Paulo, momondo offers a useful price alert feature which will track prices for flights to Sao Paulo from Des Moines and alert you when they change.

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