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Cheap flights from Des Moines to Santiago from $549

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santiago departing on 1/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:35 am - 6:10 am
DSM
-
SCL
21h 35m1 stop
Delta Logo
9:30 pm - 10:41 am
SCL
-
DSM
16h 11m1 stop
$764Delta
Tue, Jan 13 - Tue, Jan 20
Delta Logo
6:19 am - 7:40 am
DSM
-
SCL
22h 21m2 stops
Delta Logo
10:10 pm - 10:39 am
SCL
-
DSM
14h 29m1 stop
$769Delta
Thu, Mar 5 - Mon, Mar 9
LATAM Airlines Logo
11:26 am - 2:30 pm
DSM
-
SCL
24h 04m3 stops
LATAM Airlines Logo
7:15 am - 10:41 am
SCL
-
DSM
30h 26m3 stops
$799LATAM Airlines
Mon, Jan 19 - Mon, Feb 9
LATAM Airlines Logo
5:27 am - 6:55 am
DSM
-
SCL
22h 28m2 stops
LATAM Airlines Logo
10:30 pm - 10:38 pm
SCL
-
DSM
26h 08m2 stops
$802LATAM Airlines
Thu, Mar 5 - Mon, Mar 9
United Airlines Logo
6:48 pm - 8:50 am
DSM
-
SCL
35h 02m2 stops
United Airlines Logo
10:45 pm - 2:33 pm
SCL
-
DSM
18h 48m2 stops
$809United Airlines
Sun, Jan 18 - Sun, Jan 25
United Airlines Logo
7:15 am - 8:50 am
DSM
-
SCL
22h 35m1 stop
United Airlines Logo
9:45 pm - 2:18 pm
SCL
-
DSM
18h 33m1 stop
$814United Airlines
Thu, Mar 5 - Mon, Mar 9
LATAM Airlines Logo
5:15 pm - 11:25 pm
DSM
-
SCL
27h 10m2 stops
LATAM Airlines Logo
10:10 pm - 10:39 am
SCL
-
DSM
14h 29m1 stop
$817LATAM Airlines
Thu, Mar 5 - Mon, Mar 9
United Airlines Logo
6:48 pm - 8:50 am
DSM
-
SCL
35h 02m2 stops
United Airlines Logo
10:45 pm - 10:30 pm
SCL
-
DSM
26h 45m1 stop
$818United Airlines
Sun, Jan 18 - Sun, Jan 25
LATAM Airlines Logo
5:16 pm - 2:05 pm
DSM
-
SCL
17h 49m2 stops
LATAM Airlines Logo
8:10 am - 10:29 pm
SCL
-
DSM
17h 19m2 stops
$833LATAM Airlines
Fri, Jan 16 - Fri, Jan 23
United Airlines Logo
6:48 pm - 8:50 am
DSM
-
SCL
59h 02m2 stops
United Airlines Logo
10:45 pm - 10:30 pm
SCL
-
DSM
26h 45m1 stop
$834United Airlines
Sat, Jan 17 - Sat, Jan 24

United Airlines flights from Des Moines to Santiago

Our best United Airlines deals on Des Moines to Santiago flight tickets
United Airlines
Jan 18
DSM6:48 pmDes Moines
35h 02m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Jan 25
SCL10:45 pmSantiago Arturo Merino Benitez
18h 48m
2 stops
DSM2:33 pmDes Moines
$809
Find similar
United Airlines
Mar 5
DSM7:15 amDes Moines
22h 35m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Mar 9
SCL9:45 pmSantiago Arturo Merino Benitez
18h 33m
1 stop
DSM2:18 pmDes Moines
$814
Find similar
United Airlines
Jan 18
DSM6:48 pmDes Moines
35h 02m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Jan 25
SCL10:45 pmSantiago Arturo Merino Benitez
26h 45m
1 stop
DSM10:30 pmDes Moines
$818
Find similar

American Airlines flights from Des Moines to Santiago

Our best American Airlines deals on Des Moines to Santiago flight tickets
American Airlines
Jan 18
DSM4:00 pmDes Moines
13h 15m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Jan 25
SCL10:35 pmSantiago Arturo Merino Benitez
28h 24m
1 stop
DSM11:59 pmDes Moines
$841
Find similar
American Airlines
Jan 18
DSM7:40 amDes Moines
22h 20m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Jan 25
SCL10:30 pmSantiago Arturo Merino Benitez
15h 20m
1 stop
DSM10:50 amDes Moines
$845
Find similar
American Airlines
Jan 17
DSM11:42 amDes Moines
18h 18m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Jan 24
SCL11:55 pmSantiago Arturo Merino Benitez
19h 06m
2 stops
DSM4:01 pmDes Moines
$850
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 1/13

5:35 am-6:10 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Tue 1/20

9:30 pm-10:41 am

1 stop16h 11m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

6:19 am-7:40 am

2 stops22h 21m

Santiago Arturo Merino Benitez

Mon 3/9

10:10 pm-10:39 am

1 stop14h 29m

$769

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 1/19

11:26 am-2:30 pm

3 stops24h 04m

Santiago Arturo Merino Benitez

Mon 2/9

7:15 am-10:41 am

3 stops30h 26m

$799

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

5:27 am-6:55 am

2 stops22h 28m

Santiago Arturo Merino Benitez

Mon 3/9

10:30 pm-10:38 pm

2 stops26h 08m

$802

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 1/18

6:48 pm-8:50 am

2 stops35h 02m

Santiago Arturo Merino Benitez

Sun 1/25

10:45 pm-2:33 pm

2 stops18h 48m

$809

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

7:15 am-8:50 am

1 stop22h 35m

Santiago Arturo Merino Benitez

Mon 3/9

9:45 pm-2:18 pm

1 stop18h 33m

$814

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

5:15 pm-11:25 pm

2 stops27h 10m

Santiago Arturo Merino Benitez

Mon 3/9

10:10 pm-10:39 am

1 stop14h 29m

$817

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 1/18

6:48 pm-8:50 am

2 stops35h 02m

Santiago Arturo Merino Benitez

Sun 1/25

10:45 pm-10:30 pm

1 stop26h 45m

$818

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Fri 1/16

5:16 pm-2:05 pm

2 stops17h 49m

Santiago Arturo Merino Benitez

Fri 1/23

8:10 am-10:29 pm

2 stops17h 19m

$833

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sat 1/17

6:48 pm-8:50 am

2 stops59h 02m

Santiago Arturo Merino Benitez

Sat 1/24

10:45 pm-10:30 pm

1 stop26h 45m

$834

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Des Moines to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $958. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Thursday is $1,692.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Des Moines to Santiago when you can find flight prices for as low as $768. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,081 per ticket.

Can stopping save me money on Des Moines to Santiago flights?

You could potentially save up to 23% on your flight if you consider stops on a Des Moines to Santiago flight.

When to book flights from Des Moines to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santiago (DSM to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santiago

Fastest flight time

14h 57m

Direct flights

None
The fastest flight from Des Moines to Santiago takes 14h 57m
There are no direct flights from Des Moines to Santiago. There are no popular flight routes from Des Moines to Santiago.
Search flight deals

  • How far is Des Moines to Santiago Arturo Merino Benitez by plane?

    Des Moines and Santiago Arturo Merino Benitez are 5382.1 mi apart from one another. 12h 20m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santiago?

Best airlines flying from Des Moines to Santiago

Compare and see reviews for airlines that fly from Des Moines to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $814Free CancellationRating
7.5
1,890 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from Des Moines.

Can I find flights from Des Moines to Santiago with flexible booking policies on momondo?

Flights from Des Moines to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Santiago?

momondo helps you find the best flight between Des Moines and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from Des Moines and alert you when they change.

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