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Cheap flights from Des Moines to Santiago from $493

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santiago departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:48 pm - 9:05 am
DSM
-
SCL
17h 17m
2 stops
American Airlines Logo
10:15 pm - 2:56 pm
SCL
-
DSM
18h 41m
1 stop
$925American Airlines
jue., mar. 12 - jue., mar. 19
Delta Logo
11:33 am - 7:40 am
DSM
-
SCL
18h 07m
1 stop
Delta Logo
7:25 am - 10:48 am
SCL
-
DSM
29h 23m
2 stops
$953Delta
sáb., mar. 21 - vie., mar. 27
LATAM Airlines Logo
11:33 am - 2:10 pm
DSM
-
SCL
24h 37m
3 stops
LATAM Airlines Logo
11:25 pm - 4:33 pm
SCL
-
DSM
19h 08m
2 stops
$958LATAM Airlines
sáb., mar. 21 - vie., mar. 27
United Airlines Logo
7:15 am - 7:50 am
DSM
-
SCL
22h 35m
1 stop
United Airlines Logo
9:45 pm - 2:18 pm
SCL
-
DSM
18h 33m
1 stop
$983United Airlines
jue., mar. 12 - jue., mar. 19
United Airlines Logo
3:04 pm - 8:50 am
DSM
-
SCL
14h 46m
1 stop
United Airlines Logo
10:45 pm - 2:17 pm
SCL
-
DSM
18h 32m
1 stop
$1,007United Airlines
mar., feb. 10 - mar., feb. 24
United Airlines Logo
11:30 am - 8:50 am
DSM
-
SCL
18h 20m
2 stops
United Airlines Logo
10:45 pm - 2:27 pm
SCL
-
DSM
18h 42m
2 stops
$1,012United Airlines
mar., feb. 10 - mar., feb. 24
Delta Logo
5:20 pm - 7:40 am
DSM
-
SCL
12h 20m
1 stop
Delta Logo
10:35 am - 10:48 am
SCL
-
DSM
26h 13m
2 stops
$1,018Delta
dom., mar. 15 - dom., mar. 22
LATAM Airlines Logo
5:16 pm - 5:35 am
DSM
-
SCL
33h 19m
2 stops
LATAM Airlines Logo
7:15 am - 11:19 am
SCL
-
DSM
31h 04m
3 stops
$1,069LATAM Airlines
mar., feb. 10 - mar., feb. 24
Delta Logo
7:30 am - 5:35 am
DSM
-
SCL
20h 05m
2 stops
Delta Logo
10:35 am - 11:28 am
SCL
-
DSM
26h 53m
2 stops
$1,196Delta
vie., mar. 13 - vie., mar. 20
American Airlines Logo
11:17 am - 7:00 am
DSM
-
SCL
17h 43m
1 stop
American Airlines Logo
10:15 pm - 11:42 pm
SCL
-
DSM
27h 27m
1 stop
$1,210American Airlines
dom., mar. 15 - dom., mar. 22

Delta flights from Des Moines to Santiago

Our best Delta deals on Des Moines to Santiago flight tickets
Delta
Mar 21
DSM11:33 amDes Moines
18h 07m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 27
SCL7:25 amSantiago Arturo Merino Benitez
29h 23m
2 stops
DSM10:48 amDes Moines
$953
Delta
Mar 15
DSM5:20 pmDes Moines
12h 20m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 22
SCL10:35 amSantiago Arturo Merino Benitez
26h 13m
2 stops
DSM10:48 amDes Moines
$1,018
Delta
Mar 13
DSM7:30 amDes Moines
20h 05m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Mar 20
SCL10:35 amSantiago Arturo Merino Benitez
26h 53m
2 stops
DSM11:28 amDes Moines
$1,196

United Airlines flights from Des Moines to Santiago

Our best United Airlines deals on Des Moines to Santiago flight tickets
United Airlines
Mar 12
DSM7:15 amDes Moines
22h 35m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Mar 19
SCL9:45 pmSantiago Arturo Merino Benitez
18h 33m
1 stop
DSM2:18 pmDes Moines
$983
United Airlines
Feb 10
DSM3:04 pmDes Moines
14h 46m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Feb 24
SCL10:45 pmSantiago Arturo Merino Benitez
18h 32m
1 stop
DSM2:17 pmDes Moines
$1,007
United Airlines
Feb 10
DSM11:30 amDes Moines
18h 20m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Feb 24
SCL10:45 pmSantiago Arturo Merino Benitez
18h 42m
2 stops
DSM2:27 pmDes Moines
$1,012

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

jue. 3/12

1:48 pm-9:05 am

2 stops17h 17m

Santiago Arturo Merino Benitez

jue. 3/19

10:15 pm-2:56 pm

1 stop18h 41m

$925

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

sáb. 3/21

11:33 am-7:40 am

1 stop18h 07m

Santiago Arturo Merino Benitez

vie. 3/27

7:25 am-10:48 am

2 stops29h 23m

$953

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

sáb. 3/21

11:33 am-2:10 pm

3 stops24h 37m

Santiago Arturo Merino Benitez

vie. 3/27

11:25 pm-4:33 pm

2 stops19h 08m

$958

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

jue. 3/12

7:15 am-7:50 am

1 stop22h 35m

Santiago Arturo Merino Benitez

jue. 3/19

9:45 pm-2:18 pm

1 stop18h 33m

$983

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

mar. 2/10

3:04 pm-8:50 am

1 stop14h 46m

Santiago Arturo Merino Benitez

mar. 2/24

10:45 pm-2:17 pm

1 stop18h 32m

$1,007

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

mar. 2/10

11:30 am-8:50 am

2 stops18h 20m

Santiago Arturo Merino Benitez

mar. 2/24

10:45 pm-2:27 pm

2 stops18h 42m

$1,012

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 3/15

5:20 pm-7:40 am

1 stop12h 20m

Santiago Arturo Merino Benitez

dom. 3/22

10:35 am-10:48 am

2 stops26h 13m

$1,018

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

mar. 2/10

5:16 pm-5:35 am

2 stops33h 19m

Santiago Arturo Merino Benitez

mar. 2/24

7:15 am-11:19 am

3 stops31h 04m

$1,069

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

vie. 3/13

7:30 am-5:35 am

2 stops20h 05m

Santiago Arturo Merino Benitez

vie. 3/20

10:35 am-11:28 am

2 stops26h 53m

$1,196

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 3/15

11:17 am-7:00 am

1 stop17h 43m

Santiago Arturo Merino Benitez

dom. 3/22

10:15 pm-11:42 pm

1 stop27h 27m

$1,210

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Santiago flights?

You could potentially save up to 23% on your flight if you consider stops on a Des Moines to Santiago flight.

When to book flights from Des Moines to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santiago (DSM to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santiago

Fastest flight time

14h 46m

Direct flights

None
The fastest flight from Des Moines to Santiago takes 14h 46m
There are no direct flights from Des Moines to Santiago. There are no popular flight routes from Des Moines to Santiago.
Search flight deals

  • How far is Des Moines to Santiago Arturo Merino Benitez by plane?

    Des Moines and Santiago Arturo Merino Benitez are 5382.1 mi apart from one another. 14h 46m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santiago?

Best airlines flying from Des Moines to Santiago

Compare and see reviews for airlines that fly from Des Moines to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $814Free CancellationRating
7.5
1,917 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from Des Moines.

Can I find flights from Des Moines to Santiago with flexible booking policies on momondo?

Flights from Des Moines to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Santiago?

momondo helps you find the best flight between Des Moines and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from Des Moines and alert you when they change.

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