What airlines fly to Santiago?

American Airlines, Delta and LATAM Airlines are the top three most popular airlines that fly to Santiago from Des Moines according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

Prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport are updated daily.

How many operators does momondo search for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

The number of operators available for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport is 3 as of August 2025.

How old do you have to be to fly from Des Moines Airport to Santiago Arturo Merino Benitez Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santiago Arturo Merino Benitez Airport.

What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$760 Cheap Flights from Des Moines to Santiago (DSM-SCL) in 2025

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Find the cheapest flights from Des Moines to Santiago (DSM-SCL)

Round-trip

One-way

Cheap round-trip flights

2:13 pm - 7:00 amDSM-SCL

14h 47m1 stop

9:40 pm - 1:28 pmSCL-DSM

17h 48m1 stop

$783LATAM Airlines

Find Deal

Wed, Oct 8 - Wed, Oct 15

6:39 pm - 2:25 pmDSM-SCL

17h 46m2 stops

9:40 pm - 10:05 amSCL-DSM

14h 25m1 stop

$784Delta

Find Deal

Thu, Oct 9 - Thu, Oct 16

2:17 pm - 2:30 pmDSM-SCL

21h 13m3 stops

10:25 pm - 10:23 pmSCL-DSM

26h 58m2 stops

$788LATAM Airlines

Find Deal

Mon, Dec 1 - Sun, Dec 14

6:39 pm - 2:25 pmDSM-SCL

17h 46m2 stops

12:25 am - 5:44 pmSCL-DSM

19h 19m2 stops

$790LATAM Airlines

Find Deal

Thu, Oct 9 - Wed, Oct 15

6:39 pm - 3:00 pmDSM-SCL

18h 21m2 stops

12:25 am - 5:44 pmSCL-DSM

19h 19m2 stops

$791LATAM Airlines

Find Deal

Thu, Oct 9 - Wed, Oct 15

9:44 pm - 8:50 amDSM-SCL

32h 06m2 stops

10:45 pm - 9:37 pmSCL-DSM

25h 52m2 stops

$828United Airlines

Find Deal

Sun, Nov 30 - Sun, Dec 14

9:44 pm - 8:50 amDSM-SCL

56h 06m2 stops

10:45 pm - 2:34 pmSCL-DSM

18h 49m2 stops

$844United Airlines

Find Deal

Sat, Nov 29 - Fri, Dec 12

2:17 pm - 5:35 amDSM-SCL

36h 18m2 stops

6:30 pm - 10:18 amSCL-DSM

18h 48m2 stops

$845Delta

Find Deal

Sun, Nov 30 - Sat, Dec 13

11:21 am - 8:00 amDSM-SCL

18h 39m2 stops

9:55 pm - 3:19 pmSCL-DSM

19h 24m2 stops

$865American Airlines

Find Deal

Fri, Oct 10 - Fri, Oct 17

6:07 am - 8:00 amDSM-SCL

23h 53m2 stops

9:55 pm - 5:42 pmSCL-DSM

21h 47m2 stops

$867American Airlines

Find Deal

Sat, Oct 11 - Sat, Oct 18

LATAM Airlines flights from Des Moines to Santiago

Our best LATAM Airlines deals on Des Moines to Santiago flight tickets

LATAM Airlines

Oct 8

DSM2:13 pmDes Moines

14h 47m

1 stop

SCL7:00 amSantiago Arturo Merino Benitez

Oct 15

SCL9:40 pmSantiago Arturo Merino Benitez

17h 48m

1 stop

DSM1:28 pmDes Moines

$783

Find similar

LATAM Airlines

Dec 1

DSM2:17 pmDes Moines

21h 13m

3 stops

SCL2:30 pmSantiago Arturo Merino Benitez

Dec 14

SCL10:25 pmSantiago Arturo Merino Benitez

26h 58m

2 stops

DSM10:23 pmDes Moines

$788

Find similar

LATAM Airlines

Oct 9

DSM6:39 pmDes Moines

17h 46m

2 stops

SCL2:25 pmSantiago Arturo Merino Benitez

Oct 15

SCL12:25 amSantiago Arturo Merino Benitez

19h 19m

2 stops

DSM5:44 pmDes Moines

$790

Find similar

American Airlines flights from Des Moines to Santiago

Our best American Airlines deals on Des Moines to Santiago flight tickets

American Airlines

Oct 10

DSM11:21 amDes Moines

18h 39m

2 stops

SCL8:00 amSantiago Arturo Merino Benitez

Oct 17

SCL9:55 pmSantiago Arturo Merino Benitez

19h 24m

2 stops

DSM3:19 pmDes Moines

$865

Find similar

American Airlines

Oct 11

DSM6:07 amDes Moines

23h 53m

2 stops

SCL8:00 amSantiago Arturo Merino Benitez

Oct 18

SCL9:55 pmSantiago Arturo Merino Benitez

21h 47m

2 stops

DSM5:42 pmDes Moines

$867

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 10/8

2:13 pm-7:00 am

1 stop14h 47m

Santiago Arturo Merino Benitez

Wed 10/15

9:40 pm-1:28 pm

1 stop17h 48m

$783

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 10/9

6:39 pm-2:25 pm

2 stops17h 46m

Santiago Arturo Merino Benitez

Thu 10/16

9:40 pm-10:05 am

1 stop14h 25m

$784

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 12/1

2:17 pm-2:30 pm

3 stops21h 13m

Santiago Arturo Merino Benitez

Sun 12/14

10:25 pm-10:23 pm

2 stops26h 58m

$788

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 10/9

6:39 pm-2:25 pm

2 stops17h 46m

Santiago Arturo Merino Benitez

Wed 10/15

12:25 am-5:44 pm

2 stops19h 19m

$790

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 10/9

6:39 pm-3:00 pm

2 stops18h 21m

Santiago Arturo Merino Benitez

Wed 10/15

12:25 am-5:44 pm

2 stops19h 19m

$791

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 11/30

9:44 pm-8:50 am

2 stops32h 06m

Santiago Arturo Merino Benitez

Sun 12/14

10:45 pm-9:37 pm

2 stops25h 52m

$828

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sat 11/29

9:44 pm-8:50 am

2 stops56h 06m

Santiago Arturo Merino Benitez

Fri 12/12

10:45 pm-2:34 pm

2 stops18h 49m

$844

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 11/30

2:17 pm-5:35 am

2 stops36h 18m

Santiago Arturo Merino Benitez

Sat 12/13

6:30 pm-10:18 am

2 stops18h 48m

$845

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Fri 10/10

11:21 am-8:00 am

2 stops18h 39m

Santiago Arturo Merino Benitez

Fri 10/17

9:55 pm-3:19 pm

2 stops19h 24m

$865

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sat 10/11

6:07 am-8:00 am

2 stops23h 53m

Santiago Arturo Merino Benitez

Sat 10/18

9:55 pm-5:42 pm

2 stops21h 47m

$867

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $958. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Thursday is $1,692.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Des Moines to Santiago when you can find flight prices for as low as $768. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,081 per ticket.

Can stopping save me money on Des Moines to Santiago flights?

You could potentially save up to 23% on your flight if you consider stops on a Des Moines to Santiago flight.

When to book flights from Des Moines to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santiago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Santiago (DSM to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santiago

Direct flights	None

There are no direct flights from Des Moines to Santiago. There are no popular flight routes from Des Moines to Santiago.

Search flight deals

How far is Des Moines to Santiago Arturo Merino Benitez by plane?
Des Moines and Santiago Arturo Merino Benitez are 5382.1 mi apart from one another. 13h 46m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?
Prices for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport are updated daily.
How many operators does momondo search for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport?
The number of operators available for flights from Des Moines Airport to Santiago Arturo Merino Benitez Airport is 3 as of August 2025.
How old do you have to be to fly from Des Moines Airport to Santiago Arturo Merino Benitez Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santiago Arturo Merino Benitez Airport.
What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?
The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Santiago?
Based on momondo bookings for flights between Des Moines and Santiago, the leading airline is American Airlines, making up 35% of the total bookings. Other popular airlines include Delta with 32% and LATAM Airlines with 32%.

Best airlines flying from Des Moines to Santiago

Compare and see reviews for airlines that fly from Des Moines to Santiago with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $742	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
Delta	PriceFrom $782	Free Cancellation	Rating 7.9 7,977 reviews	Search Delta flights
LATAM Airlines	PriceFrom $843	Free Cancellation	Rating 7.5 1,841 reviews	Search LATAM Airlines flights

Viña del Mar

Santa Cruz

Valparaíso

Valle Nevado

San Fernando

Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from Des Moines.

Can I find flights from Des Moines to Santiago with flexible booking policies on momondo?

Flights from Des Moines to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Santiago?

momondo helps you find the best flight between Des Moines and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from Des Moines and alert you when they change.